Volume 13; Issue 4

Organic Process Research & Development

Volume 13; Issue 4

1

Development of an Open-Air and Robust Method for Large-Scale Palladium-Catalyzed Cyanation of Aryl Halides: The Use of i-PrOH to Prevent Catalyst Poisoning by Oxygen

Ren, Yunlai, Liu, Zhifei, He, Shebin, Zhao, Shuang, Wang, Jianji, Niu, Ruiqi, Yin, Weiping

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 262 KB

english, 2009

2

Facile, Fast and Safe Process Development of Nitration and Bromination Reactions Using Continuous Flow Reactors

Pelleter, Jacques, Renaud, Fabrice

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 3.96 MB

english, 2009

3

The Process Development of Ravuconazole: An Efficient Multikilogram Scale Preparation of an Antifungal Agent(1)

Pesti, Jaan, Chen, Chien-Kuang, Spangler, Lori, DelMonte, Albert J., Benoit, Serge, Berglund, Derek, Bien, Jeffrey, Brodfuehrer, Paul, Chan, Yeung, Corbett, Elisabeth, Costello, Carrie, DeMena, Paul,

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 280 KB

english, 2009

4

A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carboxylic Acids

Rekha, Vamsi V., Ramani, Modukuri V., Ratnamala, A., Rupakalpana, Vempati, Subbaraju, Gottumukkala V., Satyanarayana, Chava, Rao, C. Someswara

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 155 KB

english, 2009

5

An Improved and Single Pot Process for the Production of Quetiapine Hemifumarate Substantially Free from Potential Impurities

Niphade, Navnath C., Mali, Anil C., Pandit, Bhushan S., Jagtap, Kunal M., Jadhav, Sanjay A., Jachak, Madhukar N., Mathad, Vijayavitthal T.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 324 KB

english, 2009

6

Kilogram-Scale Synthesis of the CXCR4 Antagonist GSK812397

Boggs, Sharon, Elitzin, Vassil I., Gudmundsson, Kristjan, Martin, Michael T., Sharp, Matthew J.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 169 KB

english, 2009

7

Practical Synthesis of 5-Fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a Key Intermediate in the Preparation of Potent Deoxycytidine Kinase Inhibitors

Zhang, Haiming, Yan, Jie, Kanamarlapudi, Ramanaiah C., Wu, Wenxue, Keyes, Philip

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 282 KB

english, 2009

8

Development of a Supply Route for the Synthesis of an iNOS Inhibitor: Complications of the Key S N 2 Reaction

Rassias, Geracimos, Hermitage, Stephen A., Sanganee, Mahesh J., Kincey, Peter M., Smith, Neil M., Andrews, Ian P., Borrett, Gary T., Slater, Graham R.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 174 KB

english, 2009

9

Development of an Acid-Washable Tag for the Separation of Enantiomers from Bioresolutions

Brossat, Maude, Moody, Thomas S., de Nanteuil, Florian, Taylor, Stephen J. C., Vaughan, Fatima

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 853 KB

english, 2009

10

A Convergent Synthesis of AR-C123196 Utilising Reaction Between a Cyclic Carbonate and a Phenol for Aryl Alkyl Ether Formation

Allsop, Glyn L., Cole, Andrea J., Giles, Melvyn E., Merifield, Eric, Noble, Allison J., Pritchett, Michael A., Purdie, Lindsay A., Singleton, John T.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 517 KB

english, 2009

11

A Facile, One-Pot Synthesis of Lacidipine Using in Situ Generation of Wittig Intermediates †

Prasada Raju, V. V. N. K. V., Ravindra, Vedantham, Mathad, Vijayavitthal T., Dubey, P. K., Pratap Reddy, Padi

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 826 KB

english, 2009

12

An Improved Synthesis of Antiulcerative Drug: Tenatoprazole

Sripathi, Somaiah, Bojja, Ramachandra Reddy, Karnati, Venugopal Reddy, Raju, V. V. N. K. V. Prasada, Khunt, Mayur D.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

13

An Efficient Process of Racemization of 3-(Carbamoylmethyl)-5-methylhexanoic acid: A Pregabalin Intermediate

Chavan, Anil B., Maikap, Golak C., Gurjar, Mukund K.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 153 KB

english, 2009

14

Model-Based Solvent Selection during Conceptual Process Design of a New Drug Manufacturing Process

Hsieh, Daniel, Marchut, Alexander J., Wei, Chenkou, Zheng, Bin, Wang, Steve S. Y., Kiang, San

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 2.73 MB

english, 2009

15

First Multigram Preparation of SCP-123, A Novel Water-Soluble Analgesic

Miao, Lei, Xu, Liang, Narducy, Kenneth W., Trudell, Mark L.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 190 KB

english, 2009

16

Adaptation of an Exothermic and Acylazide-Involving Synthesis Sequence to Microreactor Technology

Rumi, Luigi, Pfleger, Christophe, Spurr, Paul, Klinkhammer, Uwe, Bannwarth, Willi

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 280 KB

english, 2009

17

Preparative Chromatography Technique in the Removal of Isostructural Genotoxic Impurity in Rizatriptan: Use of Physicochemical Descriptors of Solute and Adsorbent †

Maddula, Srinivasula Reddy, Kharkar, Manoj, Manudhane, Kushal, Kale, Sandeep, Bhori, Abijar, Lali, Arvind, Dubey, P. K., Sarma, K. R. Janardana, Bhattacharya, Apurba, Bandichhor, Rakeshwar

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 231 KB

english, 2009

18

Orthogonal Experiments in the Development of Organic Synthetic Processes

Carlson, Rolf, Simonsen, Geir, Descomps, Alexandre, Carlson, Johan E.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 429 KB

english, 2009

19

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, García, Silvina, Pfeiffer, Matthew, Tilstam, Ulf, Zlota, Andrei A., Laird, Trevor

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1.83 MB

english, 2009

20

An Improved Process for the Preparation of Diphenylmethyl 7β-Phenylacetamido-3-hydroxymethyl-3-cephem-4-carboxylate

Yu, Keping, Sun, Nan, Fang, Shanzong, Mo, Weimin, Hu, Baoxiang, Shen, Zhenlu, Hu, Xinquan

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 699 KB

english, 2009

21

Practical Synthetic Method of (2 Z ,3 E )-1,4-Diphenylbutadiene T-2639, an Inhibitor of Plasminogen Activator Inhibitor-1 (PAI-1) Production

Miyazaki, Hiroshi, Ohmizu, Hiroshi, Ogiku, Tsuyoshi

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 262 KB

english, 2009

22

Process Development for A Novel Pleuromutilin-Derived Antibiotic

Andemichael, Yemane, Chen, Jun, Clawson, Jacalyn S., Dai, Wenning, Diederich, Ann, Downing, Susan V., Freyer, Alan J., Liu, Peng, Oh, Lynette M., Patience, Daniel B., Sharpe, Sonja, Sisko, Joseph, Tsu

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 3.24 MB

english, 2009

23

A Review of U.S. Patents in the Field of Organic Process Development Published During February and March 2009

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 1.18 MB

english, 2009

24

Controlling the Genotoxins Ethyl Chloride and Methyl Chloride Formed During the Preparation of Amine Hydrochloride Salts from Solutions of Ethanol and Methanol

Yang, Qiang, Haney, Brian P., Vaux, Alexander, Riley, Dean A., Heidrich, Linda, He, Ping, Mason, Paul, Tehim, Ashok, Fisher, Lawrence E., Maag, Hans, Anderson, Neal G.

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 139 KB

english, 2009

25

Octavio Augusto Ceva Antunes

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 44 KB

english, 2009

26

Scale-Up of Trisodium [(3β,5β,12α)-3-[[4( S )-4-[Bis[2-[bis[(carboxy- kO )methyl]amino- kN ]ethyl]amino- kN ]-4-(carboxy- kO )-1-oxobutyl]amino]-12-hydroxycholan-24-oato(6-)]gadolinate(3-)], a Gd(III) Complex under Development As a Contrast Agent for MRI Coronary Angiography

Anelli, Pier Lucio, Brocchetta, Marino, Lattuada, Luciano, Manfredi, Giuseppe, Morosini, Pierfrancesco, Murru, Marcella, Palano, Daniela, Sipioni, Marco, Visigalli, Massimo

Journal:

Organic Process Research & Development

Year:

2009

Language:

english

File:

PDF, 428 KB

english, 2009

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