Volume 15; Issue 3

Organic Process Research & Development

Volume 15; Issue 3

1

New Procedure for the Preparation of (Z)-2-(5-Amino-1,2,4-thiadiazole-3-yl)-2-trityloxyiminoacetic Acid

Zhong, Weihui, Zhang, Wendong, Chen, Yanhui, Liu, Yanbin, Yao, Yi

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1005 KB

english, 2011

2

Book Review of Pharmaceutical Process Chemistry for Synthesis, Rethinking the Routes to Scale-Up Pharmaceutical Process Chemistry for Synthesis, Rethinking the Routes to Scale-Up . By Peter J.Harrington. John Wiley & Sons : Hoboken, NJ . 2011 . 369 pp. Price £83.50/€100.20/$125.00. ISBN 978-0-470-57755-4 .

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 615 KB

english, 2011

3

Genotoxic Impurities: Strategies for Identification and Control Genotoxic Impurities: Strategies for Identification and Control . Edited by AndrewTeasdale. Wiley : Hoboken, NJ . 2011 . $125. 444 pages. ISBN: 978-0-470-49919-1 (Hardcover).

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 617 KB

english, 2011

4

A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

Wheeler, Rob C., Baxter, Emma, Campbell, Ian B., Macdonald, Simon J. F.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.79 MB

english, 2011

5

A Safe and Practical Procedure for the Difluoromethylation of Methyl 4-Hydroxy-3-iodobenzoate

Sperry, Jeffrey B., Sutherland, Karen

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.41 MB

english, 2011

6

Book Review of Handbook of Green Chemistry, Vols. 4, 5, and 6, Green Solvents Handbook of Green Chemistry, Vols. 4, 5, and 6, Green Solvents . Edited by Paul T. Anastas . Volume 4: Supercritical Solvents (Walter Leitner and Philip G. Jessop, Eds.), 495 + xxiii pp. Volume 5: Reactions in Water (Chao-Jun Li, Ed.), 427 + xviii pp. Volume 6: Ionic Liquids (Peter Wasserschied and Annegret Stark, Eds.), 352 + xxv pp. Wiley-VCH : Weinheim, Germany . 2011 . Price £410. ISBN 978-3-527-31574-1 .

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 618 KB

english, 2011

7

Development of a Fully Telescoped Synthesis of the S1P1 Agonist GSK1842799

Anson, Michael S., Graham, Jonathan P., Roberts, Alastair J.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

8

A Review of U.S. Patents in the Field of Organic Process Development Published During December 2010 and January 2011

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.17 MB

english, 2011

9

Self- and Cross-Aldol Condensation of Propanal Catalyzed by Anion-Exchange Resins in Aqueous Media

Pyo, Sang-Hyun, Hedström, Martin, Lundmark, Stefan, Rehnberg, Nicola, Hatti-Kaul, Rajni

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 871 KB

english, 2011

10

Development of a Scalable Synthesis of a GPR40 Receptor Agonist

Walker, Shawn D., Borths, Christopher J., DiVirgilio, Evan, Huang, Liang, Liu, Pingli, Morrison, Henry, Sugi, Kiyoshi, Tanaka, Masahide, Woo, Jacqueline C. S., Faul, Margaret M.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.10 MB

english, 2011

11

An Efficient Process for the Manufacture of Carmegliptin§

Abrecht, Stefan, Adam, Jean-Michel, Bromberger, Ulrike, Diodone, Ralph, Fettes, Alec, Fischer, Rolf, Goeckel, Volker, Hildbrand, Stefan, Moine, Gérard, Weber, Martin

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

12

Development of Scalable Syntheses of Selective PI3K inhibitors

Huang, Qinhua, Richardson, Paul F., Sach, Neal W., Zhu, Jinjiang, Liu, Kevin K.-C., Smith, Graham L., Bowles, Daniel M.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.03 MB

english, 2011

13

First, Second, and Third Generation Scalable Syntheses of Two Potent H 3 Antagonists

Pippel, Daniel J., Mills, John E., Pandit, Chennagiri R., Young, Lana K., Zhong, Hua M., Villani, Frank J., Mani, Neelakandha S.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

14

Development of a Scalable Synthesis of ( S )-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety

Adam, Jean-Michel, Foricher, Joseph, Hanlon, Steven, Lohri, Bruno, Moine, Gérard, Schmid, Rudolf, Stahr, Helmut, Weber, Martin, Wirz, Beat, Zutter, Ulrich

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

15

Noncryogenic Preparation of Functionalized Arylboronic Esters through a Magnesium−Iodine Exchange with in Situ Quench

Demory, Emilien, Blandin, Véronique, Einhorn, Jacques, Chavant, Pierre Y.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 852 KB

english, 2011

16

A Simplified Process for the Manufacture of AZD0530, a Potent SRC Kinase Inhibitor

Raw, Steven A., Taylor, Brian A., Tomasi, Simone

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.62 MB

english, 2011

17

Development of Safe, Scalable Nitric Acid Oxidation Using a Catalytic Amount of NaNO 2 for 3-Bromo-2,2-bis(bromomethyl)propanoic Acid: An Intermediate of S-013420

Osato, Hiroshi, Kabaki, Mikio, Shimizu, Sumio

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

18

Reactor Kinetics Studies via Process Raman Spectroscopy, Multivariate Chemometrics, and Kinetics Modeling

Assirelli, Melissa, Xu, Weiyin, Chew, Wee

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 4.18 MB

english, 2011

19

Controlled RAFT Polymerization in a Continuous Flow Microreactor

Hornung, Christian H., Guerrero-Sanchez, Carlos, Brasholz, Malte, Saubern, Simon, Chiefari, John, Moad, Graeme, Rizzardo, Ezio, Thang, San H.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 3.33 MB

english, 2011

20

In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization

Barrett, Mark, Hao, Hongxun, Maher, Anthony, Hodnett, Kieran, Glennon, Brian, Croker, Denise

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 4.15 MB

english, 2011

21

Application of Chemoselective Pancreatin Powder-Catalyzed Deacetylation Reaction in the Synthesis of Key Statin Side Chain Intermediate (4 R ,6 S )-4-( tert -Butyldimethylsilyloxy)-6-(hydroxymethyl)tetrahydropyran-2-one

Troiani, Vincent, Cluzeau, Jérôme, Časar, Zdenko

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.69 MB

english, 2011

22

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

Browne, Duncan L., Deadman, Benjamin J., Ashe, Robert, Baxendale, Ian R., Ley, Steven V.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 3.00 MB

english, 2011

23

Development of a Novel Catalytic Distillation Process for Cyclohexanol Production: Mini Plant Experiments and Complementary Process Simulations

Kumar, Rakesh, Katariya, Amit, Freund, Hannsjörg, Sundmacher, Kai

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 3.61 MB

english, 2011

24

Synthetic Route Discovery and Introductory Optimization of a Novel Process to Idebenone

Tsoukala, Anna, Bjørsvik, Hans-René

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.35 MB

english, 2011

25

A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions

Kelly, Christopher B., Lee, Christopher (Xiang), Mercadante, Michael A., Leadbeater, Nicholas E.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 986 KB

english, 2011

26

In-Process Monitoring and Control of Supersaturation in Seeded Batch Cooling Crystallisation of l -Glutamic Acid: From Laboratory to Industrial Pilot Plant

Khan, Shahid, Ma, Cai Y., Mahmud, Tariq, Penchev, Radoslav Y., Roberts, Kevin J., Morris, Julian, Özkan, Leyla, White, Graeme, Grieve, Bruce, Hall, Alan, Buser, Paul, Gibson, Neil, Keller, Patrik, Sh

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 7.85 MB

english, 2011

27

Optimization of the Neutralization Process for Cesium Catalyst Removal after Polyol Production

Rodríguez, Juan F., Villajos, María Teresa, Devic, Anne Chloe, Ramos, María Jesús, Gabaldón, Ana María, de Lucas, Antonio

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 3.32 MB

english, 2011

28

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, Delaney, Patrick, Zhao, Wenyi, Zlota, Andrei, Laird, Trevor

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

29

Application of Internal Seeding and Temperature Cycling for Reduction of Liquid Inclusion in the Crystallization of RDX

Kim, Jun-Woo, Kim, Jae-Kyeong, Kim, Hyoun-Soo, Koo, Kee-Kahb

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

30

Coupling Polymorphism/Solvatomorphism and Physical Stability Evaluation with Early Salt Synthesis Optimization of an Investigational Drug

Shevchenko, Anna, Belle, David Din, Tiittanen, Saara, Karjalainen, Arto, Tolvanen, Arto, Tanninen, Veli Pekka, Haarala, Jorma, Mäkelä, Mikko, Yliruusi, Jouko, Miroshnyk, Inna

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

31

Special Sections of Issues of OPR&D

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 609 KB

english, 2011

32

N -Amination of Indoles on Pilot-Plant Scale via Simultaneous and Proportional Metering of Reagents

Weiberth, Franz J., Hanna, Reda G., Lee, George E., Polverine, Yvonne, Klein, Joseph T.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 792 KB

english, 2011

33

The Preparation of Desflurane by the Vapor-Phase Fluorination of Isoflurane

Sivaramakrishnan, Hariharan, Upare, Abhay A., Satagopan, Damodharan, Chambers, Owen R.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.53 MB

english, 2011