Volume 15; Issue 6

Organic Process Research & Development

Volume 15; Issue 6

1

Screening Binary Systems of Chelating Agents Combined with Carbon or Silica Gel Adsorbents: The Development of a Cost-Effective Method to Remove Palladium from Pharmaceutical Intermediates and APIs

Wang, Lijun, Green, Leopold, Li, Zhen, McCabe Dunn, Jamie, Bu, Xiaodong, Welch, Christopher J., Li, Chunyu, Wang, Tiebang, Tu, Qiang, Bekos, Evan

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

2

Chemical Development of an α2δ Ligand, (3S,5R)-3-(Aminomethyl)-5-methyloctanoic Acid

Murtagh, Lorraine, Dunne, Catherine, Gabellone, Gino, Panesar, Niamh J., Field, Stuart, Reeder, Lisa M., Saenz, James, Smith, George P., Kissick, Kyle, Martinez, Carlos,

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.55 MB

english, 2011

3

Synthesis of a Bicyclic Piperazine from l-Aspartic Acid and Application of a Fluoride-Promoted SNAr Coupling

Sieser, Janice E., Singer, Robert A., McKinley, Jason D., Bourassa, Dennis E., Teixeira, John J., Long, James

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

4

Scaling up Metal Scavenging Operations for Pharmaceutical Pilot Plant Manufactures

Reginato, Gloriana, Sadler, Paul, Wilkes, Robin D.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.94 MB

english, 2011

5

Genotoxic Impurities: A Regulatory Toxicology Commentary on Recent Articles in Organic Process Research & Development

Snodin, David J

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 700 KB

english, 2011

6

An Improved and Impurity-Free Large-Scale Synthesis of Venlafaxine Hydrochloride

Saravanan, Mohanarangam, Satyanarayana, Bollikonda, Reddy, Padi Pratap

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 781 KB

english, 2011

7

Serendipitous Discovery of a Zidovudine Guanidine Complex: A Superior Process for the Production of Zidovudine

Radatus, Bruno K

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 909 KB

english, 2011

8

Commercial Synthesis of (S,S)-Reboxetine Succinate: A Journey To Find the Cheapest Commercial Chemistry for Manufacture

Hayes, Stewart T., Assaf, Georges, Checksfield, Graham, Cheung, Chi, Critcher, Doug, Harris, Laurence, Howard, Roger, Mathew, Suju, Regius, Christian, Scotney, Gemma

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.23 MB

english, 2011

9

A Safe Two-Step Process for Manufacturing Glycidyl Nitrate from Glycidol Involving Solid–Liquid Phase-Transfer Catalysis

Ochoa-Gómez, José R., Blanco-Gómez, Juan J.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 685 KB

english, 2011

10

Process Research Towards a Scalable Synthesis of the Muscarinic M 1 Receptor Subtype Selective Agonist MCD-386

Copp, Richard R., Abraham, Brent D., Farnham, James G., Twose, Trevor M.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 704 KB

english, 2011

11

A Simplified Process for the Manufacture of Imagabalin Hydrochloride (PD-0332334), an α2δ-Ligand for the Treatment of Generalised Anxiety Disorder

Birch, Melissa, Challenger, Stephen, Crochard, Jean-Philippe, Fradet, David, Jackman, Hayley, Luan, Amy, Madigan, Evelyn, Mathew, Jinu S., McDowall, Neil, Meldrum, Kevin, Gordon, Charles M., Peach, Ph

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 839 KB

english, 2011

12

Determination of Accurate Specific Heat Capacities of Liquids in a Reaction Calorimeter, by Statistical Design

Alozie, Diké-Michel, Courtes, Philippe, Ha, Benjamin, Prat, Denis

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.08 MB

english, 2011

13

A Review of U.S. Patents in the Field of Organic Process Development Published During June and July 2011

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.51 MB

english, 2011

14

Concise Synthesis of Two β-Adrenergic Blocking Agents in High Stereoselectivity Using the Readily Available Chiral Building Block (2 S ,2′ S ,2″ S )-Tris-(2,3-epoxypropyl)-isocyanurate

Sonawane, Swapnil P., Patil, Gulabrao D., Gurjar, Mukund K.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 813 KB

english, 2011

15

Facile One-Pot Process for Large-Scale Production of Highly Pure Bosentan Monohydrate, an Endothelin Receptor Antagonist

Niphade, Navnath C., Jagtap, Kunal M., Gaikawad, Chandrashekhar T., Jachak, Madhukar N., Mathad, Vijayavitthal T.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 901 KB

english, 2011

16

Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

Brocklehurst, Cara E., Lehmann, Hansjörg, La Vecchia, Luigi

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.06 MB

english, 2011

17

Development of a Potential Manufacturing Route to PF-00610355: A Novel Inhaled β 2 -Adrenoreceptor Agonist

de Koning, Pieter D., Castro, Nieves, Gladwell, Iain R., Morrison, Natalie A., Moses, Ian B., Panesar, Maninder S., Pettman, Alan J., Thomson, Nicholas M.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

18

Safe, Convenient ortho- Claisen Thermal Rearrangement Using a Flow Reactor

Rincón, Juan A., Barberis, Mario, González-Esguevillas, María, Johnson, Martin D., Niemeier, Jeffry K., Sun, Wei-Ming

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.47 MB

english, 2011

19

Process Development for a Key Synthetic Intermediate of LY2140023, a Clinical Candidate for the Treatment of Schizophrenia

Waser, Mario, Moher, Eric D., Borders, Sandy S. K., Hansen, Marvin M., Hoard, David W., Laurila, Michael E., LeTourneau, Michael E., Miller, Richard D., Phillips, Michael L., Sullivan, Kevin A., Ward,

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 911 KB

english, 2011

20

Application of PAT Tools for the Safe and Reliable Production of a Dihydro-1 H -imidazole

Barrios Sosa, Ana C., Conway, Ryan, Williamson, R. Thomas, Suchy, James P., Edwards, William, Cleary, Thomas

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 3.68 MB

english, 2011

21

A Versatile Lab to Pilot Scale Continuous Reaction System for Supercritical Fluid Processing

Hintermair, Ulrich, Roosen, Christoph, Kaever, Markus, Kronenberg, Horst, Thelen, Ralf, Aey, Stefan, Leitner, Walter, Greiner, Lasse

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.42 MB

english, 2011

22

Route Selection and Process Development for a 5-Piperazinylquinaldine Derivative for the Treatment of Depression and Anxiety

Cimarosti, Zadeo, Giubellina, Nicola, Stabile, Paolo, Laval, Gilles, Tinazzi, Francesco, Maton, William, Pachera, Roberta, Russo, Paola, Moretti, Ramona, Rossi, Sara, Cooke, Jason W. B., Westerduin, P

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.90 MB

english, 2011

23

The Safe Use of Sodium Hydride on Scale: The Process Development of a Chloropyrimidine Displacement

McCabe Dunn, Jamie M., Duran-Capece, Alicia, Meehan, Brendan, Ulis, James, Iwama, Tetsuo, Gloor, Guy, Wong, George, Bekos, Evan

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.78 MB

english, 2011

24

Pilot Plant Preparation of tert- Butyl-4-(2-hydroxyethyl)-4-(pyrrolidin-1-yl)-piperidine-1-carboxylate, An Intermediate of Novel Antiarteriosclerotics, Via a Safe, Scalable Reformatsky-Type Reaction

Osato, Hiroshi, Osaki, Motonari, Oyama, Takao, Takagi, Youhei, Hida, Takemasa, Nishi, Koichi, Kabaki, Mikio

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 818 KB

english, 2011

25

Scalable Synthesis of the Desoxy-biphenomycin B Core

Berwe, Mathias, Jöntgen, Winfried, Krüger, Jochen, Cancho-Grande, Yolanda, Lampe, Thomas, Michels, Martin, Paulsen, Holger, Raddatz, Siegfried, Weigand, Stefan

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

26

Development of an Enabling Route to PF-00610355: A Novel Inhaled β 2 -Adrenoreceptor Agonist

de Koning, Pieter D., Gladwell, Iain R., Moses, Ian B., Panesar, Maninder S., Pettman, Alan J., Thomson, Nicholas M.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 958 KB

english, 2011

27

Safety Notables: Information from the Literature

Barnhart, Richard, Ironside, Michael D., Vogt, Paul F.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 737 KB

english, 2011

28

Unlocking Hydrogenation for C–C Bond Formation: A Brief Overview of Enantioselective Methods

Hassan, Abbas, Krische, Michael J.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.51 MB

english, 2011

29

Determination of Epichlorohydrin in Active Pharmaceutical Ingredients by Gas Chromatography–Mass Spectrometry

Loda, Claudio, Bernabe, Elena, Nicoletti, Anna, Bacchi, Sergio, Dams, Riet

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

30

Design and Scale-Up of Diels–Alder Reactions for the Practical Synthesis of 5-Phenylbicyclo[2.2.2]oct-5-en-2-one

Funel, Jacques-Alexis, Schmidt, Gunther, Abele, Stefan

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 903 KB

english, 2011

31

“Help! I Need Somebody”

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 613 KB

english, 2011

32

Process Safety Evaluation of a Tungsten-Catalyzed Hydrogen Peroxide Epoxidation Resulting In a Runaway Laboratory Reaction

Shilcrat, Susan

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.89 MB

english, 2011

33

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, Zhao, Wenyi, Zlota, Andrei, Laird, Trevor

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1011 KB

english, 2011

34

Diarylketone Ketoreductase Screen and Synthesis Demonstration to Access mGlu2 Receptor Potentiators

Magnus, Nicholas A., Coffey, D. Scott, DeBaillie, Amy C., Jones, Chauncey D., Kaluzna, Iwona A., Kambourakis, Spiros, Pu, Yangwei J., Wang, Lin, Wepsiec, James P.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 815 KB

english, 2011

35

Prediction of Agglomerate Type during Scale-Up of a Batch Crystallization Using Computational Fluid Dynamics Models

Falk, Richard F., Marziano, Ivan, Kougoulos, Terry, Girard, Kevin P.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.94 MB

english, 2011

36

Invited Review

Caron, Stéphane, Senanayake, Chris

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 604 KB

english, 2011

37

Development of a Suitable Physical Form for a Sphingosine-1-phosphate Receptor Agonist

Morrison, Henry, Burke, Brenda, Lei, Dennis, Robertson, Vivian, Nagapudi, Karthik, Chan, Johann, Gore, Anu, Fang, Jan, Jona, Jonan

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

38

Heat Pipe-Mediated Control of Fast and Highly Exothermal Reactions

Ehm, N., Löwe, H.

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 2.73 MB

english, 2011

39

Safety of Chemical Processes 11

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 610 KB

english, 2011

40

Practical Synthetic Organic Chemistry, Reactions, Principles, and Techniques Practical Synthetic Organic Chemistry, Reactions, Principles, and Techniques . Edited by Stéphane Caron . John Wiley & Sons : Hoboken, NJ . 2011 . 856 pages. Price £60.50/€72.60/$99.95. ISBN 978-0-470-03733-1 .

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 618 KB

english, 2011

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