Volume 21; Issue 2

Organic Process Research & Development

Volume 21; Issue 2

1

Double Heck Route to a Dibenzoxepine and Convergent Suzuki Cross-Coupling Strategy for the Synthesis of an MR Antagonist

Hansen, Marvin M., Kallman, Neil J., Koenig, Thomas M., Linder, Ryan J., Richey, Rachel N., Rizzo, John R., Ward, Jeffrey A., Yu, Hannah, Zhang, Tony Y., Mitchell, David

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 503 KB

english, 2017

2

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Hugentobler, Katharina G., Rasparini, Marcello, Thompson, Lisa A., Jolley, Katherine E., Blacker, A. John, Turner, Nicholas J.

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 492 KB

english, 2017

3

In Situ Monitoring of Crystalline Transformation of Carbamazepine Using Probe-Type Low-Frequency Raman Spectroscopy

Inoue, Motoki, Hisada, Hiroshi, Koide, Tatsuo, Carriere, James, Heyler, Randy, Fukami, Toshiro

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 1.49 MB

english, 2017

4

Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

Daver, Sébastien, Rodeville, Nicolas, Pineau, Francois, Arlabosse, Jean-Marie, Moureou, Christine, Muller, Franck, Pierre, Romain, Bouquet, Karinne, Dumais, Laurence, Boiteau, Jean-Guy, Cardinaud, Isa

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 1.79 MB

english, 2017

5

One-Step Continuous Flow Synthesis of Antifungal WHO Essential Medicine Flucytosine Using Fluorine

Harsanyi, Antal, Conte, Annelyse, Pichon, Laurent, Rabion, Alain, Grenier, Sandrine, Sandford, Graham

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 331 KB

english, 2017

6

S N Ar Reactions in Aqueous Nanomicelles: From Milligrams to Grams with No Dipolar Aprotic Solvents Needed

Lee, Nicholas R., Gallou, Fabrice, Lipshutz, Bruce H.

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 6.47 MB

english, 2017

7

A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin

Li, Tinghan, Weng, Tianwei, Wang, Jubo, Wei, Zhihui, Zhao, Lu, Li, Zhiyu

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 553 KB

english, 2017

8

Process Safety Considerations for the Use of 1 M Borane Tetrahydrofuran Complex Under General Purpose Plant Conditions

Monteiro, Alexandre M., Flanagan, Roy C.

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 404 KB

english, 2017

9

Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P 1 Receptor Agonist

Hou, Xiaoping, Zhang, Huiping, Chen, Bang-Chi, Guo, Zhiwei, Singh, Amarjit, Goswami, Animesh, Gilmore, John L., Sheppeck, James E., Dyckman, Alaric J., Carter, Percy H., Mathur, Arvind

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 440 KB

english, 2017

10

Trace Analysis of Potentially Mutagenic Boronic Acids and Esters in Drug Substance by ICP-MS

Patel, Ila, Venkatramani, C. J., Stumpf, Andreas, Wigman, Larry, Yehl, Peter

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 655 KB

english, 2017

11

Process Development of a CRF 1 Receptor Antagonist Based on the Selective Chlorination of a Benzimidazolone via Chlorine Migration

Sawai, Yasuhiro, Yabe, Osamu, Nakaoka, Keiichiro, Ikemoto, Tomomi

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 535 KB

english, 2017

12

Continuous Crystallization with Impurity Complexation and Nanofiltration Recycle

Vartak, Shankul, Myerson, Allan S.

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 720 KB

english, 2017

13

From Raw Data to Process: The Path to a Batch or a Continuous Crystallizer Design for Ibuprofen

Rashid, Abdur, White, Edward, Howes, Tony, Litster, James, Marziano, Ivan

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 1015 KB

english, 2017

14

An Efficient and Scalable Synthesis of tert -Butyl (3a R ,6a S )-5-Oxohexahydrocyclo penta[ c ]pyrrole-2(1 H )-carboxylate: A Pharmacologically Important Intermediate

Bahekar, Rajesh H., Jadav, Pradip A., Goswami, Amitgiri D., Shah, Hardik A., Dave, Bhushan N., Joshi, Darshan A., Pethani, Jignesh P., Patel, Dipam, Agarwal, Sameer, Desai, Ranjit C.

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 545 KB

english, 2017

15

Sustainable and Scalable Fe/ppm Pd Nanoparticle Nitro Group Reductions in Water at Room Temperature

Gabriel, Christopher M., Parmentier, Michael, Riegert, Christian, Lanz, Marian, Handa, Sachin, Lipshutz, Bruce H., Gallou, Fabrice

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 1.46 MB

english, 2017

16

Scalable Synthesis and Purification of Acetylated Phosphatidyl Choline Headgroup

Subramaniam, Rajesh, Jagadeesan, Ramesh, Mathew, Iswarya, Cen, Yana, Balaz, Stefan

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 525 KB

english, 2017

17

In Praise of Short Papers for OPR&D

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 161 KB

english, 2017

18

Green Chemistry Articles of Interest to the Pharmaceutical Industry

Bryan, Marian C., Diorazio, Louis, Fei, Zhongbo, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, Hughes, Shaun, Humphreys, Luke, Richardson, Paul, Schober, Markus, Steven, Alan, White, Timothy, W

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 2.53 MB

english, 2017

19

Some Items of Interest to Process R&D Chemists and Engineers

Zhao, Wenyi, Zhao, Dongbo, Guizzetti, Sylvain, Schwindeman, James A., Daniels, David S. B., Guerrero, Carlos, Kargbo, Robert, Knight, John

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 3.13 MB

english, 2017

20

Issue Publication Information

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 158 KB

english, 2017

21

Issue Editorial Masthead

Journal:

Organic Process Research & Development

Year:

2017

Language:

english

File:

PDF, 156 KB

english, 2017