Volume 6; Issue 1

Organic Process Research & Development

Volume 6; Issue 1

1

Practical Large-Scale Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate: Atom Economical Self-Hydrogenolysis of a Crystalline Borane−Benzylamine Adduct

Couturier, Michel, Andresen, Brian M., Jorgensen, Jeffrey B., Tucker, John L., Busch, Frank R., Brenek, Steven J., Dubé,, Pascal, am Ende, David J., Negri, Joanna T.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

2

An Efficient and Selective 1- N -Monoethylation of Sisomicin: Process Development of Netilmicin

Nam, Ghilsoo, Kim, Sung Hoon, Kim, Joong-Hyup, Shin, Jung-Hyu, Jang, Eun-Sook

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 71 KB

english, 2002

3

The Synthesis of 17α-Methyl-11β-arylestradiol: Large-Scale Application of the Cerium (III)-Mediated Alkylation of a Ketone

Larkin, John Patrick, Wehrey, Christian, Boffelli, Philippe, Lagraulet, Henri, Lemaitre, Guy, Nedelec, Alban, Prat, Denis

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 103 KB

english, 2002

4

Improved Industrial Synthesis of Antidepressant Sertraline

Vukics, Krisztina, Fodor, Tamás, Fischer, János, Fellegvári, Irén, Lévai, Sándor

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 46 KB

english, 2002

5

Process Development of the Synthetic Route to ( R )-6-Amino-1-ethyl-4-methylhexahydro-1,4-diazepine

Hirokawa, Yoshimi, Horikawa, Tamaki, Noguchi, Hideto, Yamamoto, Katsuhisa, Kato, Shiro

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 97 KB

english, 2002

6

An Enantioselective Synthesis of (2 S ,3 R )-3-( N -Benzyloxycarbonyl)amino-1-chloro-4-phenylthiobutan-2-ol, a Central Intermediate of Nelfinavir 1

Ikunaka, Masaya, Matsumoto, Jun, Fujima, Yoshito, Hirayama, Yoshihiko

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

7

An Intramolecular Silyl Transfer from the Carboxylate to the Hydroxyl Group in Sodium 4-Hydroxybutyrate and Its Application to the Synthesis of Injectable Antifungal Posaconazole Derivative, Sch 59884

Renton, P., Shen, L., Eckert, J., Lee, G. M., Gala, D., Chen, G., Pramanik, B., Schumacher, D.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 77 KB

english, 2002

8

An Improved Process for the Preparation of Benzyl- N -vinyl Carbamate 1

Govindan, Cheruthur K.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 41 KB

english, 2002

9

Unexpected Silicon Group Transfer in Difunctional Alkoxy Silanes

Filipkowski, Michelle A., Petty, Herbert E., Westmeyer, Mark D., Schilling, Curtis L.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 61 KB

english, 2002

10

A Reliable Multikilogram-Scale Synthesis of 2-Acetamido-5-Vinylpyridine Using Catalytic BINAP in a Modified Heck Reaction

Raggon, Jeffrey W., Snyder, William M.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

11

The Chemical Process Industries Infrastructure: Function and Economics By T. R. Couper, O. T. Beasley, and W. R. Penney. Marcel Dekker: New York. 2001. 640 pp. $195 ISBN: 0-8247-0435-5.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 26 KB

english, 2002

12

Modern Carbonyl Chemistry Edited by J. Otera. Wiley-VCH: New York. 2000. 622 pp. £95. ISBN 3-527-29871-1.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 26 KB

english, 2002

13

The Importance of Experimental Data and Record Keeping

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 19 KB

english, 2002

14

Some Items of Interest to Process R&D Chemists and Engineers as Selected by Trevor Laird, Stephen A. Hermitage, and Ulf Tilstam

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

15

An Efficient Large-Scale Process for the Human Leukocyte Elastase Inhibitor, DMP 777 1

Storace, Louis, Anzalone, Luigi, Confalone, Pat N., Davis, Wayne P., Fortunak, Joseph M., Giangiordano, Mark, Haley, James J., Kamholz, Kenneth, Li, Hui-Yin, Ma, Philip, Nugent, William A., Parsons, R

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

16

Industrial Biotransformations By A. Liese, K. Seelbach, and C. Wandrey. Wiley-VCH: 2001. DM 198 (102 Eu). 425 pp. ISBN: 3-527-30094-5.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 26 KB

english, 2002

17

Green Chemical Syntheses and Processes Edited by P. T. Anastas, L. G. Heine, and T. C. Williamson. ACS Symposium Series 767. American Chemical Society: Washington, DC. 2000. 364 pp. ISBN 0-8412-3678-X.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 26 KB

english, 2002

18

Structural Determination of a Process Impurity in a Furan−Pyrrole Heteroatom Exchange Reaction

Li, Bryan, Kasthurikrishnan, Narasimhan, Ragan, John A., Young, Gregory R.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 46 KB

english, 2002

19

Synthesis of Injectable Antifungal Sch 59884.

Lee, Gary M., Eckert, Jefferey, Gala, Dinesh, Schwartz, Martin, Renton, Paul, Pergamen, Edward, Whittington, Michael, Schumacher, Doris, Heimark, Larry, Shipkova, Petia

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 26 KB

english, 2002

20

Process Development of 4-[ N -Methyl- N -(tetrahydropyran-4-yl)aminomethyl]aniline Dihydrochloride: A Key Intermediate for TAK-779, a Small-Molecule Nonpeptide CCR5 Antagonist

Hashimoto, Hideo, Ikemoto, Tomomi, Itoh, Tatsuya, Maruyama, Hideaki, Hanaoka, Tadashi, Wakimasu, Mitsuhiro, Mitsudera, Hiroyuki, Tomimatsu, Kiminori

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 51 KB

english, 2002

21

The Effect of Diglyme on the Kinetics of Chromium(III) Ethanoate-Catalyzed Reactions of Carboxylic Acids with Epichlorohydrin

Bukowski, Wiktor

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 60 KB

english, 2002