Volume 7; Issue 5

Organic Process Research & Development

Volume 7; Issue 5

1

Concepts of Nature in Organic Synthesis: Cascade Catalysis and Multistep Conversions in Concert

Bruggink, Alle, Schoevaart, Rob, Kieboom, Tom

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

2

Some Items of Interest to Process R&D Chemists and Engineers

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

3

Design of New Reaction Conditions for the Sugasawa Reaction Based on Mechanistic Insights ‡

Prasad, Kapa, Lee, George T., Chaudhary, Apurva, Girgis, Michael J., Streemke, James W., Repič, Oljan

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 431 KB

english, 2003

4

A Practical Synthesis of 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline and the Art of Removing Palladium from the Products of Pd-Catalyzed Reactions

Königsberger, Kurt, Chen, Guang-Pei, Wu, Raeann R., Girgis, Michael J., Prasad, Kapa, Repič, Oljan, Blacklock, Thomas J.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 327 KB

english, 2003

5

The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate SB-235349 to SB-214857-A

Atkins, Richard J., Banks, Adam, Bellingham, Richard K., Breen, Gary F., Carey, John S., Etridge, Stephen K., Hayes, Jerome F., Hussain, Nigel, Morgan, David O., Oxley, Paul, Passey, Stephen C., Walsg

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

6

Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors

Stadler, Alexander, Yousefi, Behrooz H., Dallinger, Doris, Walla, Peter, Van der Eycken, Erik, Kaval, Nadya, Kappe, C. Oliver

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 185 KB

english, 2003

7

An Improved Method for the Palladium Cross-Coupling Reaction of Oxazol-2-ylzinc Derivatives with Aryl Bromides

Reeder, Michael R., Gleaves, Harold E., Hoover, Sheree A., Imbordino, Rick J., Pangborn, Jeffrey J.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 61 KB

english, 2003

8

Temperature Selective Diastereo-Recognition (TSD): Enantiomeric Ibuprofen via Environmentally Benign Selective Crystallization

Bhattacharya, Apurba, Murphy, David

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 99 KB

english, 2003

9

An Efficient One-Pot Process for 10-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2- b ]pyridin-11-one, an Intermediate to SCH 66336

Fu, Xiaoyong, McAllister, Timothy L., Shi, Xiongwei, Thiruvengadam, T. K., Tann, Chou-Hong, Lee, Junning

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 161 KB

english, 2003

10

Kinetically Controlled Diastereoselective Synthesis of CPS124, a Carnitine Monothiophosphate

Prasad, Kapa, Xu, David D., Tempkin, Orin, Villhauer, Edwin B., Repič, Oljan

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 109 KB

english, 2003

11

Highly Chemoselective Heterogeneous Pd-Catalyzed Biaryl Synthesis from Haloarenes: Reaction in an Oil-in-Water Microemulsion

Mukhopadhyay, Sudip, Yaghmur, Anan, Baidossi, Mubeen, Kundu, Buddhadeb, Sasson, Yoel

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 33 KB

english, 2003

12

Kinetics of Liquid-Phase Catalytic Hydrogenation of Benzophenone to Benzhydrol

Bawane, Sunil P., Sawant, Sudhirprakash B.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 91 KB

english, 2003

13

The “Bookworm” Has Turned ...

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 18 KB

english, 2003

14

The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 1: Synthesis of the Key Intermediate 2,3,4,5-Tetrahydro-4-methyl-3-oxo-1 H -1,4-benzodiazepine-2-acetic Acid Methyl Ester, SB-235349

Andrews, Ian P., Atkins, Richard J., Breen, Gary F., Carey, John S., Forth, Michael A., Morgan, David O., Shamji, Amin, Share, Andrew C., Smith, Stephen A. C., Walsgrove, Timothy C., Wells, Andrew S.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 101 KB

english, 2003

15

A Novel Method for the Direct Sulfonation of CH 4 with SO 3 in the Presence of KO 2 and a Promoter

Mukhopadhyay, Sudip, Bell, Alexis T.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 60 KB

english, 2003

16

Isolation and Identification of the Major Extractable Impurity from Dowex 1×2 Resin

Tou, Jacob S., Kostelc, James G., Schlittler, Michael R., Violand, Bernard N.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 68 KB

english, 2003

17

Reactions in Closed Batch Reactors, Operational and Safety Issues: A Model To Predict How Degree of Filling and Rate of Heating Affect Reaction Times and Buildup of Internal Pressure

Galliani, Guido, Orlandi, Marco, Rindone, Bruno

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 114 KB

english, 2003

18

A Scalable Synthesis of ( R )-3,5-Dihydro-4 H -dinaphth[2,1- c :1‘2‘- e ]azepine

Ikunaka, Masaya, Maruoka, Keiji, Okuda, Yoshiaki, Ooi, Takashi

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 95 KB

english, 2003

19

Cross-Coupling Methods for the Large-Scale Preparation of an Imidazole−Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2- b ]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine

Ragan, J. A., Raggon, J. W., Hill, P. D., Jones, B. P., McDermott, R. E., Munchhof, M. J., Marx, M. A., Casavant, J. M., Cooper, B. A., Doty, J. L., Lu, Y.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

20

A Review of U.S. Patents in the Field of Organic Process Development Published during December 2002 through March 2003

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 11 KB

english, 2003

21

Practical Large-Scale Synthesis of the 2-Aminomethylpyrrolidin-4-ylthio-Containing Side Chain of the Novel Carbapenem Antibiotic Doripenem

Nishino, Yutaka, Komurasaki, Tadafumi, Yuasa, Tetsuya, Kakinuma, Makoto, Izumi, Kenji, Kobayashi, Makoto, Fujiie, Shinichiro, Gotoh, Teruhiro, Masui, Yoshiyuki, Hajima, Makoto, Takahira, Masayuki, Oku

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 93 KB

english, 2003

22

The Process Development of a Novel Aldose Reductase Inhibitor, FK366. Part 1. Improvement of Discovery Process and New Syntheses of 1-Substituted Quinazolinediones

Goto, Shunsuke, Tsuboi, Hiroyuki, Kanoda, Masami, Mukai, Koji, Kagara, Kooji

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

23

Identification and Control of a Process-Related Impurity in the Chlorination of 3-Hydroxy-3-carbacephem

Kumar, Yatendra, Tewari, Neera, Nizar, Hashim, Rai, Bishwa Prakash, Singh, Shailendra Kumar

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 52 KB

english, 2003

24

Continuous-Flow Generation of Anhydrous Diazonium Species: Monolithic Microfluidic Reactors for the Chemistry of Unstable Intermediates

Fortt, Robin, Wootton, Robert C. R., de Mello, Andrew J.

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 143 KB

english, 2003