Volume 8; Issue 1

Organic Process Research & Development

Volume 8; Issue 1

1

A New Approach to Rapid Parallel Development of Four Neurokinin Antagonists. Part 4. Synthesis of ZD2249 Methoxy Sulfoxide

Bowden, Sharon A., Burke, J. Nigel, Gray, Fiona, McKown, Steven, Moseley, Jonathan D., Moss, William O., Murray, Paul M., Welham, Matthew J., Young, Maureen J.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

2

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 5: Linkage of Fragments C1-6 and C7-24 and Finale

Mickel, Stuart J., Niederer, Daniel, Daeffler, Robert, Osmani, Adnan, Kuesters, Ernst, Schmid, Emil, Schaer, Karl, Gamboni, Remo, Chen, Weichun, Loeser, Eric

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 522 KB

english, 2004

3

Pilot Plant Preparation of an α v β 3 Integrin Antagonist. Part 1. Process Research and Development of a ( S )-β-Amino Acid Ester Intermediate: Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction

Clark, Jerry D., Weisenburger, Gerald A., Anderson, D. Keith, Colson, Pierre-Jean, Edney, Albert D., Gallagher, Donald J., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Moore, Christine M. V.,

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 323 KB

english, 2004

4

Environmentally Friendly and Efficient Process for the Preparation of β-Hydroxyl Ketones

Wang, Guan-Wu, Zhang, Ze, Dong, Ya-Wei

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 52 KB

english, 2004

5

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 1: Synthetic Strategy and Preparation of a Common Precursor

Mickel, Stuart J., Sedelmeier, Gottfried H., Niederer, Daniel, Daeffler, Robert, Osmani, Adnan, Schreiner, Klaus, Seeger-Weibel, Manuela, Bérod, Brigitte, Schaer, Karl, Gamboni, Remo, Chen, Stephen, C

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

6

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of Fragment C 7-24

Mickel, Stuart J., Sedelmeier, Gottfried H., Niederer, Daniel, Schuerch, Friedrich, Seger, Manuela, Schreiner, Klaus, Daeffler, Robert, Osmani, Adnan, Bixel, Dominique, Loiseleur, Olivier, Cercus, Jac

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

7

Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor

Harrington, Peter J., Brown, Jack D., Foderaro, Tommaso, Hughes, Robert C.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 98 KB

english, 2004

8

The Synthesis of the High-Potency Sweetener, NC-00637. Part 2: Preparation of the Pyridine Moiety

Ager, David J., Erickson, Robert A., Froen, Diane E., Prakash, Indra, Zhi, Ben

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 90 KB

english, 2004

9

Epoxidation of Propylene with Aqueous Hydrogen Peroxide on a Reaction-Controlled Phase-Transfer Catalyst

Gao, Shuang, Li, Meng, Lv, Ying, Zhou, Ning, Xi, Zuwei

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 27 KB

english, 2004

10

A New Approach to the Rapid Parallel Development of Four Neurokinin Antagonists. Part 5. Preparation of ZM374979 Cyanoacid and Selective Crystallisation of ZM374979 Atropisomers

Parker, Jeremy S., Smith, Neil A., Welham, Matthew J., Moss, William O.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 99 KB

english, 2004

11

Correction to Cover, Issue 6, 2003

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 13 KB

english, 2004

12

A Review of U.S. Patents in the Field of Organic Process Development Published between August and October 2003

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 138 KB

english, 2004

13

Efficient Preparation of a Key Intermediate in the Synthesis of Roxifiban by Enzymatic Dynamic Kinetic Resolution on Large Scale ¶

Pesti, Jaan A., Yin, Jinguao, Zhang, Lin-hua, Anzalone, Luigi, Waltermire, Robert E., Ma, Philip, Gorko, Edward, Confalone, Pat N., Fortunak, Joseph, Silverman, Charlotte, Blackwell, John, Chung, J. C

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 70 KB

english, 2004

14

Some Items of Interest to Process R&D Chemists and Engineers

Laird, Trevor, Hermitage, Stephen A., Tilstam, Ulf

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 13 KB

english, 2004

15

The Synthesis of the High-Potency Sweetener, NC-00637. Part 3: The Glutamyl Moiety and Coupling Reactions

Ager, David J., Babler, Scott, Erickson, Robert A., Froen, Diane E., Kittleson, Jeannine, Pantaleone, David P., Prakash, Indra, Zhi, Ben

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 202 KB

english, 2004

16

Some Items of Interest to Process R&D Chemists and Engineers

Hermitage, Stephen A., Tilstam, Ulf

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 205 KB

english, 2004

17

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 2: Synthesis of Fragments C 1-6 and C 9-14

Mickel, Stuart J., Sedelmeier, Gottfried H., Niederer, Daniel, Schuerch, Friedrich, Grimler, Dominique, Koch, Guido, Daeffler, Robert, Osmani, Adnan, Hirni, Alfred, Schaer, Karl, Gamboni, Remo, Bach,

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 100 KB

english, 2004

18

An Efficient Synthesis of a Key Intermediate for the Biologically Active Vitamin D Analogue, Seocalcitol

Sabroe, Thomas Peter, Pedersen, Henrik, Binderup, Ernst

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 67 KB

english, 2004

19

The Application of Microreactor Technology for the Synthesis of 1,2-Azoles

Wiles, Charlotte, Watts, Paul, Haswell, Stephen J., Pombo-Villar, Esteban

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 69 KB

english, 2004

20

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 3: Synthesis of Fragment C 15-21

Mickel, Stuart J., Sedelmeier, Gottfried H., Niederer, Daniel, Schuerch, Friedrich, Koch, Guido, Kuesters, E., Daeffler, Robert, Osmani, Adnan, Seeger-Weibel, Manuela, Schmid, E., Hirni, Alfred, Schae

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 116 KB

english, 2004

21

The Origins of Life and Chirality

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 16 KB

english, 2004

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