Volume 8; Issue 4

Organic Process Research & Development

Volume 8; Issue 4

1

An Efficient Amination Method for Manufacturing Cytidines

Komatsu, Hironori, Morizane, Kunihiko, Kohno, Toshiyuki, Tanikawa, Hiroharu

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 74 KB

english, 2004

2

A Practical Synthesis of 3,4-Dimethoxy- o -toluic Acid

Connolly, Terrence J., Matchett, Michael, McGarry, Patrick, Sukhtankar, Sunil, Zhu, Jiang

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 102 KB

english, 2004

3

An Efficient Synthesis of 2-Quinoxalinecarboxylic Acid

Harms, Arthur E.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 120 KB

english, 2004

4

Predictive Milling of Pharmaceutical Materials Using Nanoindentation of Single Crystals

Taylor, L. J., Papadopoulos, D. G., Dunn, P. J., Bentham, A. C., Dawson, N. J., Mitchell, J. C., Snowden, M. J.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 183 KB

english, 2004

5

Synthesis of Trifluoromethanesulfonic Acid from CHF 3

Mukhopadhyay, Sudip, Bell, Alexis T., Srinivas, R. Vijay, Smith, Gary S.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 77 KB

english, 2004

6

Development of a Manufacturing Process for Sibenadet Hydrochloride, the Active Ingredient of Viozan

Giles, Melvyn E., Thomson, Colin, Eyley, Stephen C., Cole, Andrea J., Goodwin, Christopher J., Hurved, Paul A., Morlin, Andrew J. G., Tornos, James, Atkinson, Stéphanie, Just, Cecelia, Dean, Janet C.,

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 341 KB

english, 2004

7

Streamlined Processes for the Synthesis of a Farnesyl Transferase Inhibitor Drug Candidate

Andresen, Brian M., Couturier, Michel, Cronin, Brian, D'Occhio, Michael, Ewing, Marcus D., Guinn, Mark, Hawkins, Joel M., Jasys, V. John, LaGreca, Susan D., Lyssikatos, Joseph P., Moraski, Garrett, Ng

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

8

Alternate Synthesis of a β-3 Adrenergic Receptor Agonist

Scott, Robert W., Fox, Darrell E., Wong, John W., Burns, Michael P.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 150 KB

english, 2004

9

Reduction of Maleic Acid to Succinic Acid on Titanium Cathode

Muzumdar, Arati V., Sawant, Sudhirprakash B., Pangarkar, Vishwas G.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 65 KB

english, 2004

10

A Review of U.S. Patents in the Field of Organic Process Development Published during March and April 2004

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 198 KB

english, 2004

11

0Oxidative Bromination of Activated Aromatic Compounds Using Aqueous Nitric Acid as an Oxidant

Joshi, Ashutosh V., Baidossi, Mubeen, Mukhopadhyay, Sudip, Sasson, Yoel

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 92 KB

english, 2004

12

First Safe and Practical Synthesis of 2-Amino-8-hydroxyquinoline

Storz, Thomas, Marti, Roger, Meier, Roland, Nury, Patrice, Roeder, Michael, Zhang, Kesheng

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 45 KB

english, 2004

13

Some Items of Interest to Process R&D Chemists and Engineers

Laird, Trevor, Hermitage, Stephen A., Tilstam, Ulf

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 234 KB

english, 2004

14

Lawesson's Reagent: A New Entry in the Preparation of 2-Azetidinones

Sharma, S. D., Kanwar, Seema

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 28 KB

english, 2004

15

Development of an Efficient Synthesis for a Nipecotate-Containing Immunopotentiator

Moher, Eric D., Tripp, Allie E., Creemer, Lawrence C., Vicenzi, Jeffrey T.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 54 KB

english, 2004

16

Process Research and Scale-Up for a β-3 Adrenergic Receptor Agonist

Vanderplas, Brian C., DeVries, Keith M., Fox, Darrell E., Raggon, Jeffrey W., Snyder, Michael W., Urban, Frank J.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 65 KB

english, 2004

17

Membrane Purification of an Antisense Oligonucleotide

Lajmi, Ajay R., Schwartz, Larry, Sanghvi, Yogesh S.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 87 KB

english, 2004

18

A Practical Building Block for the Synthesis of Discodermolide

Loiseleur, Olivier, Koch, Guido, Wagner, Trixie

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 102 KB

english, 2004

19

Pilot-Plant Preparation of an α v β 3 Integrin Antagonist. Part 2. Synthesis of N -[2-(5-Hydroxy-4,6-tetrahydropyrimidine)]-3-amino-5-hydroxybenzoic Acid

Clark, Jerry D., Collins, Joe T., Kleine, H. Peter, Weisenburger, Gerald A., Anderson, D. Keith

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

20

Development of a Safe and Scalable Oxidation Process for the Preparation of 6-Hydroxybuspirone: Application of In-Line Monitoring for Process Ruggedness and Product Quality

Watson, Daniel J., Dowdy, Eric D., DePue, Jeffrey S., Kotnis, Atul S., Leung, Simon, O'Reilly, Brian C.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 207 KB

english, 2004

21

Stereoselective Synthesis of Alkylphosphonates: A Facile Rearrangement of Cyanoethyl-Protected Nucleoside Phosphoramidites

Ravikumar, Vasulinga T., Kumar, R. Krishna

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 115 KB

english, 2004

22

Small Pharmaceutical Companies

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 16 KB

english, 2004

23

Drying an Organic Monohydrate: Crystal Form Instabilities and a Factory-Scale Drying Scheme to Ensure Monohydrate Preservation

Cypes, Stephen H., Wenslow, Robert M., Thomas, Scott M., Chen, Alex M., Dorwart, Jason G., Corte, John R., Kaba, Mahmoud

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 118 KB

english, 2004

24

Demethylation of 4-Methoxyphenylbutyric Acid Using Molten Pyridinium Hydrochloride on Multikilogram Scale

Schmid, Christopher R., Beck, Christopher A., Cronin, Jason S., Staszak, Michael A.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 89 KB

english, 2004

25

Reinvestigation of Phase-Transfer-Catalyzed Chlorpyrifos Synthesis

Fakhraian, H., Moghimi, A., Ghadiri, H., Dehnavi, M. A., Sadeghi, M.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 70 KB

english, 2004

26

Optimal Operation of a Seeded Pharmaceutical Crystallization with Growth-Dependent Dispersion

Patience, Daniel B., Dell'Orco, Philip C., Rawlings, James B.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 207 KB

english, 2004