Volume 18; Issue 8

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Pharmaceutical Research
Volume 18; Issue 8

Pharmaceutical Research

Volume 18; Issue 8

1

Receptor-Mediated Gene Targeting to Tissues In Vivo Following Intravenous Administration of Pegylated Immunoliposomes

Ningya Shi, Ruben J. Boado, William M. Pardridge

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 2.73 MB

english, 2001

2

Characterizing the Expression of CYP3A4 and Efflux Transporters (P-gp, MRP1, and MRP2) in CYP3A4-Transfected Caco-2 Cells After Induction with Sodium Butyrate and the Phorbol Ester 12-O-Tetradecanoylphorbol-13-Acetate

Carolyn L. Cummins, Lara M. Mangravite, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 1.92 MB

english, 2001

3

Sinusoidal Efflux of Taurocholate Is Enhanced in Mrp2-Deficient Rat Liver

Hidetaka Akita, Hiroshi Suzuki, Yuichi Sugiyama

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 237 KB

english, 2001

4

Intestinal First-Pass Metabolism of Eperisone in the Rat

Kiyoshi Mihara, Mina Matsumura, Eiji Yoshioka, Kazuhiko Hanada, Hiromitsu Nakasa, Shigeru Ohmori, Mitsukazu Kitada, Hiroyasu Ogata

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

5

The Effect of Polyethylene Glycol 400 on Gastrointestinal Transit: Implications for the Formulation of Poorly-Water Soluble Drugs

Abdul W. Basit, J. Michael Newton, Michael D. Short, Wendy A. Waddington, Peter J. Ell, Larry F. Lacey

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 82 KB

english, 2001

6

Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery

Pilar Calvo, Bruno Gouritin, Hélène Chacun, Didier Desmaële, Jean D'Angelo, Jean-Pierre Noel, Dominique Georgin, Elias Fattal, Jean P. Andreux, Patrick Couvreur

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 3.96 MB

english, 2001

7

A Pharmacokinetic Model to Predict the PK Interaction of L-Dopa and Benserazide in Rats

Susan Grange, Nicholas H. G. Holford, Theodor W. Guentert

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 221 KB

english, 2001

8

A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU

Yuko Tsukamoto, Yukio Kato, Masako Ura, Ikuo Horii, Hideo Ishitsuka, Hiroyuki Kusuhara, Yuichi Sugiyama

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 372 KB

english, 2001

9

Modeling and Simulation for Clinical Trial Design Involving a Categorical Response: A Phase II Case Study with Naratriptan

Ivan Nestorov, Gordon Graham, Stephen Duffull, Leon Aarons, Eliane Fuseau, Peter Coates

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 300 KB

english, 2001

10

Osmotic Properties of Sulfobutylether and Hydroxypropyl Cyclodextrins

Erika A. Zannou, William H. Streng, Valentino J. Stella

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 161 KB

english, 2001

11

Enzymatic Activities in the Microsomes Prepared from Rat Small Intestinal Epithelial Cells by Differential Procedures

Kiminori Mohri, Yoshihiro Uesawa

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

12

Sequential Processing of Human ProIL-1β by Caspase-1 and Subsequent Folding Determined by a Combined In Vitro and In Silico Approach

Peter W. Swaan, Daren L. Knoell, Freek Helsper, Mark D. Wewers

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 2.34 MB

english, 2001

13

Inhibition of HIV-1 in Cell Culture by Oligonucleotide-Loaded Nanoparticles

Myriam Berton, Priscilla Turelli, Didier Trono, Cy Stein, Eric Allémann, Robert Gurny

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 155 KB

english, 2001

14

Transport of Peptidomimetic Thrombin Inhibitors with a 3-Amidino-Phenylalanine Structure: Permeability and Efflux Mechanism in Monolayers of a Human Intestinal Cell Line (Caco-2)

Walter Kamm, Jörg Hauptmann, Isabel Behrens, Jörg Stürzebecher, Frank Dullweber, Holger Gohlke, Milton Stubbs, Gerhard Klebe, Thomas Kissel

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 269 KB

english, 2001

15

Mucosal Uptake of Gabapentin (Neurontin) vs. Pregabalin in the Small Intestine

Nusara Piyapolrungroj, Cheng Li, Howard Bockbrader, Guangyu Liu, David Fleisher

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

16

Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells

Isabel Behrens, Patric Stenberg, Per Artursson, Thomas Kissel

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 858 KB

english, 2001

17

Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low-Frequency Ultrasound

Samir Mitragotri, Joseph Kost

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 146 KB

english, 2001

18

Inhibitory Effects of Novel Hydrophilic Cyclodextrin Derivatives on Nitric Oxide Production in Macrophages Stimulated with Lipopolysaccharide

Hidetoshi Arima, Yoji Nishimoto, Keiichi Motoyama, Fumitoshi Hirayama, Kaneto Uekama

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 341 KB

english, 2001

19

Effects of Food on the Pharmacokinetics of Methylphenidate

K. K. Midha, G. McKay, M. J. Rawson, E. D. Korchinski, J. W. Hubbard

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

20

Kinetic Analysis of the Disposition of Insulin-Like Growth Factor 1 in Healthy Volunteers

Naomi Mizuno, Yukio Kato, Masato Iwamoto, Akinori Urae, Toshiaki Amamoto, Takuro Niwa, Yuichi Sugiyama

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

21

Optimizing Drug Development: Strategies to Assess Drug Metabolism/Transporter Interaction Potential—Toward a Consensus

Geoffrey T. Tucker, J. Brian Houston, Shiew-Mei Huang

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

22

Power Spectral Analysis of Heart Rate Variability in Rats as a Quantitative Tool in the PK-PD Analysis of the Parasympatholytic Activity of Atropine

Itay Perlstein, David Stepensky, Dan Sapoznikov, Amnon Hoffman

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 124 KB

english, 2001

23

The Measurement of Small Quantities of Amorphous Material—Should We Be Considering the Rigid Amorphous Fraction?

Duncan Q. M. Craig, Vicky L. Kett, John R. Murphy, Duncan M. Price

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 1.12 MB

english, 2001

24

AAPS Electronic Scientist

Journal:

Pharmaceutical Research

Year:

2001

File:

PDF, 1.68 MB

2001