Volume 25; Issue 8

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Pharmaceutical Research
Volume 25; Issue 8

Pharmaceutical Research

Volume 25; Issue 8

1

Physiologically Based Pharmacokinetic Modeling of Drug Disposition in Rat and Human: A Fuzzy Arithmetic Approach

Kok-Yong Seng, Ivan Nestorov, Paolo Vicini

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 612 KB

english, 2008

2

Safe and Effective Permeation Enhancers for Oral Drug Delivery

Kathryn Whitehead, Natalie Karr, Samir Mitragotri

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 214 KB

english, 2008

3

Semi-mechanistic Pharmacokinetic/Pharmacodynamic Modelling of the Antinociceptive Response in the Presence of Competitive Antagonism: The Interaction Between Tramadol and its Active Metabolite on μ-Opioid Agonism and Monoamine Reuptake Inhibition, in the Rat

Horst Beier, María J. Garrido, Thomas Christoph, Dirk Kasel, Iñaki F. Trocóniz

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 409 KB

english, 2008

4

Investigation of Drug Delivery by Iontophoresis in a Surgical Wound Utilizing Microdialysis

Heidi J. Holovics, Carter R. Anderson, Barry S. Levine, Ho-Wah Hui, Craig E. Lunte

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 279 KB

english, 2008

5

Synergistic Effect of Amlodipine and Atorvastatin in Reversing LDL-Induced Endothelial Dysfunction

R. Preston Mason, Ruslan Kubant, Gehan Heeba, Robert F. Jacob, Charles A. Day, Yehudi S. Medlin, Philipp Funovics, Tadeusz Malinski

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 242 KB

english, 2008

6

Effect of Silymarin Supplement on the Pharmacokinetics of Rosuvastatin

Jian Wei Deng, Ji-Hong Shon, Ho-Jung Shin, Soo-Jin Park, Chang-Woo Yeo, Hong-Hao Zhou, Im-Sook Song, Jae-Gook Shin

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 239 KB

english, 2008

7

On The Rate and Extent of Drug Delivery to the Brain

Margareta Hammarlund-Udenaes, Markus Fridén, Stina Syvänen, Anubha Gupta

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 401 KB

english, 2008

8

Role of Particle Size in Phagocytosis of Polymeric Microspheres

Julie A. Champion, Amanda Walker, Samir Mitragotri

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 225 KB

english, 2008

9

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases

Carlos G. Leon, Rita Tory, Jessica Jia, Olena Sivak, Kishor M. Wasan

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

10

Different Curcuminoids Inhibit T-Lymphocyte Proliferation Independently of Their Radical Scavenging Activities

Michael Deters, Heiko Knochenwefel, Daniel Lindhorst, Therese Koal, Hartmut H. Meyer, Wolfram Hänsel, Klaus Resch, Volkhard Kaever

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

11

Interplay Between Intestinal pH, Transit Time and Feed Status on theIn VivoPerformance of pH Responsive Ileo-Colonic Release Systems

Valentine C. Ibekwe, Hala M. Fadda, Emma L. McConnell, Mandeep K. Khela, David F. Evans, Abdul W. Basit

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 159 KB

english, 2008

12

New Predictive Models for Blood–Brain Barrier Permeability of Drug-like Molecules

Sandhya Kortagere, Dmitriy Chekmarev, William J. Welsh, Sean Ekins

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 335 KB

english, 2008

13

Penetration Profile of Taurine in the Human Skin and Its Distribution in Skin Layers

D. L. P. da Silva, S. B. Thiago, F. A. Pessôa, Y. Mrestani, H. H. Rüttinger, J. Wohlrab, R. H. H. Neubert

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 139 KB

english, 2008

14

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration ofIn Vitro, Pharmacokinetic Modeling, and Simulation Studies

Giulia Ghibellini, Elaine M. Leslie, Gary M. Pollack, Kim L. R. Brouwer

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

15

Selective Contrast Enhancement of Individual Alzheimer’s Disease Amyloid Plaques Using a Polyamine and Gd-DOTA Conjugated Antibody Fragment Against Fibrillar Aβ42 for Magnetic Resonance Molecular Imaging

Muthu Ramakrishnan, Thomas M. Wengenack, Karunya K. Kandimalla, Geoffry L. Curran, Emily J. Gilles, Marina Ramirez-Alvarado, Joseph Lin, Michael Garwood, Clifford R. Jack Jr., Joseph F. Poduslo

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 872 KB

english, 2008

16

Intravital Microscopic Analysis of Vascular Perfusion and Macromolecule Extravasation after Photodynamic Vascular Targeting Therapy

Chong He, Priyanka Agharkar, Bin Chen

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 255 KB

english, 2008

17

Fragmentation of a Recombinant Monoclonal Antibody at Various pH

Georgeen Gaza-Bulseco, Hongcheng Liu

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

18

The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling

Motohiro Kato, Yoshihisa Shitara, Hitoshi Sato, Kunihiro Yoshisue, Masaru Hirano, Toshihiko Ikeda, Yuichi Sugiyama

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 210 KB

english, 2008

19

QSAR Modeling of the Blood–Brain Barrier Permeability for Diverse Organic Compounds

Liying Zhang, Hao Zhu, Tudor I. Oprea, Alexander Golbraikh, Alexander Tropsha

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 306 KB

english, 2008

20

Telithromycin Pharmacokinetics in Rat Model of Diabetes Mellitus Induced by Alloxan or Streptozotocin

Joo H. Lee, Myung G. Lee

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 198 KB

english, 2008

21

In VitroandIn VivoInvestigation on PLA–TPGS Nanoparticles for Controlled and Sustained Small Molecule Chemotherapy

Zhiping Zhang, Sie Huey Lee, Chee Wee Gan, Si-Shen Feng

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 426 KB

english, 2008

22

Enhancement in Anti-proliferative Effects of Paclitaxel in Aortic Smooth Muscle Cells upon Co-administration with Ceramide using Biodegradable Polymeric Nanoparticles

Dipti Deshpande, Harikrishna Devalapally, Mansoor Amiji

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 680 KB

english, 2008

23

Multifunctional Nanoparticulate Polyelectrolyte Complexes

Sean M. Hartig, Rachel R. Greene, Jayasri DasGupta, Gianluca Carlesso, Mikhail M. Dikov, Ales Prokop, Jeffrey M. Davidson

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 40 KB

english, 2008

24

Flux Across Microneedle-treated Skin is Increased by Increasing Charge of Naltrexone and NaltrexolIn Vitro

Stan L. Banks, Raghotham R. Pinninti, Harvinder S. Gill, Peter A. Crooks, Mark R. Prausnitz, Audra L. Stinchcomb

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 41 KB

english, 2008

25

Investigation into the Role of Tumor-Associated Macrophages in the Antitumor Activity of Doxil

Manuela Banciu, Raymond M. Schiffelers, Gert Storm

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 184 KB

english, 2008

26

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

Vangelis Karalis, Panos Macheras, Achiel Van Peer, Vinod P. Shah

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 138 KB

english, 2008

27

AAPS Update

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 110 KB

english, 2008