Volume 8; Issue 2

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PLoS Genetics
Volume 8; Issue 2

PLoS Genetics

Volume 8; Issue 2

1

Loss of Function of the Cik1/Kar3 Motor Complex Results in Chromosomes with Syntelic Attachment That Are Sensed by the Tension Checkpoint

Jin, Fengzhi, Liu, Hong, Li, Ping, Yu, Hong-Guo, Wang, Yanchang, Copenhaver, Gregory P.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

2

Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes

Min, Josine L., Nicholson, George, Halgrimsdottir, Ingileif, Almstrup, Kristian, Petri, Andreas, Barrett, Amy, Travers, Mary, Rayner, Nigel W., Mägi, Reedik, Pettersson, Fredrik H., Broxholme, John, N

Journal:

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

3

Systematic Detection of Epistatic Interactions Based on Allele Pair Frequencies

Ackermann, Marit, Beyer, Andreas, Flint, Jonathan

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Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

4

Diced Triplets Expose Neurons to RISC

Rudnicki, Dobrila D., Margolis, Russell L., Pearson, Christopher E., Krzyzosiak, Wlodzimierz J., Copenhaver, Gregory P.

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Year:

2012

Language:

english

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PDF, 229 KB

english, 2012

5

Sequestration of Highly Expressed mRNAs in Cytoplasmic Granules, P-Bodies, and Stress Granules Enhances Cell Viability

Lavut, Anna, Raveh, Dina, Snyder, Michael

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Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

6

A Strong Deletion Bias in Nonallelic Gene Conversion

Assis, Raquel, Kondrashov, Alexey S., Schierup, Mikkel H.

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Year:

2012

Language:

english

File:

PDF, 250 KB

english, 2012

7

Upsetting the Dogma: Germline Selection in Human Males

Crow, James F., Payseur, Bret A.

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Year:

2012

Language:

english

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PDF, 107 KB

english, 2012

8

The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling

Avanesov, Andrei, Honeyager, Shawn M., Malicki, Jarema, Blair, Seth S., Perrimon, Norbert

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Year:

2012

Language:

english

File:

PDF, 3.99 MB

english, 2012

9

Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3

Ferdous, Maheen, Higgins, James D., Osman, Kim, Lambing, Christophe, Roitinger, Elisabeth, Mechtler, Karl, Armstrong, Susan J., Perry, Ruth, Pradillo, Mónica, Cuñado, Nieves, Franklin, F. Chris H., Ha

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Year:

2012

Language:

english

File:

PDF, 5.81 MB

english, 2012

10

Repression of a Potassium Channel by Nuclear Hormone Receptor and TGF-β Signaling Modulates Insulin Signaling in Caenorhabditis elegans

Park, Donha, Jones, Karen L., Lee, Hyojin, Snutch, Terrance P., Taubert, Stefan, Riddle, Donald L., Goodman, Miriam B.

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Year:

2012

Language:

english

File:

PDF, 2.12 MB

english, 2012

11

Reduction of NADPH-Oxidase Activity Ameliorates the Cardiovascular Phenotype in a Mouse Model of Williams-Beuren Syndrome

Campuzano, Victoria, Segura-Puimedon, Maria, Terrado, Verena, Sánchez-Rodríguez, Carolina, Coustets, Mathilde, Menacho-Márquez, Mauricio, Nevado, Julián, Bustelo, Xosé R., Francke, Uta, Pérez-Jurado,

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Year:

2012

Language:

english

File:

PDF, 534 KB

english, 2012

12

Phosphorylation of Chromosome Core Components May Serve as Axis Marks for the Status of Chromosomal Events during Mammalian Meiosis

Fukuda, Tomoyuki, Pratto, Florencia, Schimenti, John C., Turner, James M. A., Camerini-Otero, R. Daniel, Höög, Christer, Handel, Mary Ann

Journal:

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

13

Gene Expression and Stress Response Mediated by the Epigenetic Regulation of a Transposable Element Small RNA

McCue, Andrea D., Nuthikattu, Saivageethi, Reeder, Sarah H., Slotkin, R. Keith, Kakutani, Tetsuji

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Year:

2012

Language:

english

File:

PDF, 4.84 MB

english, 2012

14

Evaluation of the Role of Functional Constraints on the Integrity of an Ultraconserved Region in the Genus Drosophila

Díaz-Castillo, Carlos, Xia, Xiao-Qin, Ranz, José M., Noor, Mohamed A. F.

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Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

15

Cell Lineage Analysis of the Mammalian Female Germline

Reizel, Yitzhak, Itzkovitz, Shalev, Adar, Rivka, Elbaz, Judith, Jinich, Adrian, Chapal-Ilani, Noa, Maruvka, Yosef E., Nevo, Nava, Marx, Zipora, Horovitz, Inna, Wasserstrom, Adam, Mayo, Avi, Shur, Iren

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Year:

2012

Language:

english

File:

PDF, 717 KB

english, 2012

16

Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in Saccharomyces cerevisiae: Frequency, Effects, and Dominance

Gruber, Jonathan D., Vogel, Kara, Kalay, Gizem, Wittkopp, Patricia J., Akey, Joshua M.

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Year:

2012

Language:

english

File:

PDF, 781 KB

english, 2012

17

GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

Stafa, Klodjan, Trancikova, Alzbeta, Webber, Philip J., Glauser, Liliane, West, Andrew B., Moore, Darren J., Orr, Harry T.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

18

Raf1 Is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification

Buscaino, Alessia, White, Sharon A., Houston, Douglas R., Lejeune, Erwan, Simmer, Femke, de Lima Alves, Flavia, Diyora, Piyush T., Urano, Takeshi, Bayne, Elizabeth H., Rappsilber, Juri, Allshire, Robi

Journal:

Year:

2012

Language:

english

File:

PDF, 4.39 MB

english, 2012

19

Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants

Sun, Kailiang, Westholm, Jakub Orzechowski, Tsurudome, Kazuya, Hagen, Joshua W., Lu, Yubing, Kohwi, Minoree, Betel, Doron, Gao, Fen-Biao, Haghighi, A. Pejmun, Doe, Chris Q., Lai, Eric C., Sokol, Nick

Journal:

Year:

2012

Language:

english

File:

PDF, 5.14 MB

english, 2012

20

The Williams-Beuren Syndrome—A Window into Genetic Variants Leading to the Development of Cardiovascular Disease

Adams, Gregory N., Schmaier, Alvin H., Wilkie, Andrew O. M.

Journal:

Year:

2012

Language:

english

File:

PDF, 197 KB

english, 2012

21

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

Demirkan, Ayşe, van Duijn, Cornelia M., Ugocsai, Peter, Isaacs, Aaron, Pramstaller, Peter P., Liebisch, Gerhard, Wilson, James F., Johansson, Åsa, Rudan, Igor, Aulchenko, Yurii S., Kirichenko, Anatoly

Journal:

Year:

2012

Language:

english

File:

PDF, 654 KB

english, 2012

22

Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution

Kim, Jinho, Kim, Inhae, Yang, Jae-Seong, Shin, Young-Eun, Hwang, Jihye, Park, Solip, Choi, Yoon Sup, Kim, Sanguk, Snyder, Michael

Journal:

Year:

2012

Language:

english

File:

PDF, 2.71 MB

english, 2012

23

Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway

Taniguchi, Kenichiro, Anderson, Anoush E., Sutherland, Ann E., Wotton, David, Beier, David R.

Journal:

Year:

2012

Language:

english

File:

PDF, 9.87 MB

english, 2012

24

Discovery of a Modified Tetrapolar Sexual Cycle in Cryptococcus amylolentus and the Evolution of MAT in the Cryptococcus Species Complex

Findley, Keisha, Sun, Sheng, Fraser, James A., Hsueh, Yen-Ping, Averette, Anna Floyd, Li, Wenjun, Dietrich, Fred S., Heitman, Joseph, Madhani, Hiten D.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.82 MB

english, 2012

25

A Regulatory Network for Coordinated Flower Maturation

Reeves, Paul H., Ellis, Christine M., Ploense, Sara E., Wu, Miin-Feng, Yadav, Vandana, Tholl, Dorothea, Chételat, Aurore, Haupt, Ina, Kennerley, Brian J., Hodgens, Charles, Farmer, Edward E., Nagpal,

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Year:

2012

Language:

english

File:

PDF, 970 KB

english, 2012

26

The Caenorhabditis elegans Eph Receptor Activates NCK and N-WASP, and Inhibits Ena/VASP to Regulate Growth Cone Dynamics during Axon Guidance

Mohamed, Ahmed M., Boudreau, Jeffrey R., Yu, Fabian P. S., Liu, Jun, Chin-Sang, Ian D., Mango, Susan E.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.43 MB

english, 2012

27

The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals

Ladouceur, Martin, Dastani, Zari, Aulchenko, Yurii S., Greenwood, Celia M. T., Richards, J. Brent, Zeggini, Eleftheria

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Year:

2012

Language:

english

File:

PDF, 937 KB

english, 2012

28

Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease

Chen, Haoyan, Hayashi, Genki, Lai, Olivia Y., Dilthey, Alexander, Kuebler, Peter J., Wong, Tami V., Martin, Maureen P., Fernandez Vina, Marcelo A., McVean, Gil, Wabl, Matthias, Leslie, Kieron S., Maur

Journal:

Year:

2012

Language:

english

File:

PDF, 410 KB

english, 2012

29

Computational Prediction and Molecular Characterization of an Oomycete Effector and the Cognate Arabidopsis Resistance Gene

Goritschnig, Sandra, Krasileva, Ksenia V., Dahlbeck, Douglas, Staskawicz, Brian J., Guttman, David S.

Journal:

Year:

2012

Language:

english

File:

PDF, 3.24 MB

english, 2012

30

Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B

Choi, Soo-Kyung, Yoon, Song-Ro, Calabrese, Peter, Arnheim, Norman, Payseur, Bret A.

Journal:

Year:

2012

Language:

english

File:

PDF, 386 KB

english, 2012

31

Familial Identification: Population Structure and Relationship Distinguishability

Rohlfs, Rori V., Fullerton, Stephanie Malia, Weir, Bruce S., Gibson, Greg

Journal:

Year:

2012

Language:

english

File:

PDF, 533 KB

english, 2012

32

A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

Bañez-Coronel, Mónica, Porta, Silvia, Kagerbauer, Birgit, Mateu-Huertas, Elisabet, Pantano, Lorena, Ferrer, Isidre, Guzmán, Manuel, Estivill, Xavier, Martí, Eulàlia, Pearson, Christopher E.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.61 MB

english, 2012

33

Genomic Restructuring in the Tasmanian Devil Facial Tumour: Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour

Deakin, Janine E., Bender, Hannah S., Pearse, Anne-Maree, Rens, Willem, O'Brien, Patricia C. M., Ferguson-Smith, Malcolm A., Cheng, Yuanyuan, Morris, Katrina, Taylor, Robyn, Stuart, Andrew, Belov, Kat

Journal:

Year:

2012

Language:

english

File:

PDF, 3.09 MB

english, 2012

34

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

Huang, Xinhe, Liu, Jun, Dickson, Robert C., Kim, Stuart K.

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Year:

2012

Language:

english

File:

PDF, 2.51 MB

english, 2012

35

Developmental Transcriptional Networks Are Required to Maintain Neuronal Subtype Identity in the Mature Nervous System

Eade, Kevin T., Fancher, Hailey A., Ridyard, Marc S., Allan, Douglas W., Harris, William A.

Journal:

Year:

2012

Language:

english

File:

PDF, 5.02 MB

english, 2012

36

Nondisjunction of a Single Chromosome Leads to Breakage and Activation of DNA Damage Checkpoint in G2

Quevedo, Oliver, García-Luis, Jonay, Matos-Perdomo, Emiliano, Aragón, Luis, Machín, Félix, Lacefield, Soni

Journal:

Year:

2012

Language:

english

File:

PDF, 1.55 MB

english, 2012

37

Ultrafast Evolution and Loss of CRISPRs Following a Host Shift in a Novel Wildlife Pathogen, Mycoplasma gallisepticum

Delaney, Nigel F., Balenger, Susan, Bonneaud, Camille, Marx, Christopher J., Hill, Geoffrey E., Ferguson-Noel, Naola, Tsai, Peter, Rodrigo, Allen, Edwards, Scott V., Guttman, David S.

Journal:

Year:

2012

Language:

english

File:

PDF, 655 KB

english, 2012

38

The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer

Zhuang, Joanna, Jones, Allison, Lee, Shih-Han, Ng, Esther, Fiegl, Heidi, Zikan, Michal, Cibula, David, Sargent, Alexandra, Salvesen, Helga B., Jacobs, Ian J., Kitchener, Henry C., Teschendorff, Andrew

Journal:

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

39

Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

Parsa, Jahan-Yar, Ramachandran, Shaliny, Zaheen, Ahmad, Nepal, Rajeev M., Kapelnikov, Anat, Belcheva, Antoaneta, Berru, Maribel, Ronai, Diana, Martin, Alberto, Maizels, Nancy

Journal:

Year:

2012

Language:

english

File:

PDF, 873 KB

english, 2012

40

Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

Pierce, Brandon L., Kibriya, Muhammad G., Tong, Lin, Jasmine, Farzana, Argos, Maria, Roy, Shantanu, Paul-Brutus, Rachelle, Rahaman, Ronald, Rakibuz-Zaman, Muhammad, Parvez, Faruque, Ahmed, Alauddin, Q

Journal:

Year:

2012

Language:

english

File:

PDF, 602 KB

english, 2012

41

Mixed Effects Modeling of Proliferation Rates in Cell-Based Models: Consequence for Pharmacogenomics and Cancer

Im, Hae Kyung, Gamazon, Eric R., Stark, Amy L., Huang, R. Stephanie, Cox, Nancy J., Dolan, M. Eileen, Akey, Joshua M.

Journal:

Year:

2012

Language:

english

File:

PDF, 677 KB

english, 2012

42

Genome-Wide Association Study in East Asians Identifies Novel Susceptibility Loci for Breast Cancer

Long, Jirong, Cai, Qiuyin, Sung, Hyuna, Shi, Jiajun, Zhang, Ben, Choi, Ji-Yeob, Wen, Wanqing, Delahanty, Ryan J., Lu, Wei, Gao, Yu-Tang, Shen, Hongbing, Park, Sue K., Chen, Kexin, Shen, Chen-Yang, Ren

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Year:

2012

Language:

english

File:

PDF, 629 KB

english, 2012

43

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T., van Reijmersdal, Simon V., van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M., Geurts van Kessel, Ad, van Leeuwen, F

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Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

44

Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1

Nishimura, Taisuke, Molinard, Guillaume, Petty, Tom J., Broger, Larissa, Gabus, Caroline, Halazonetis, Thanos D., Thore, Stéphane, Paszkowski, Jerzy, Wierzbicki, Andrzej T.

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Year:

2012

Language:

english

File:

PDF, 823 KB

english, 2012

45

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity

Butler, Erin K., Voigt, Aaron, Lutz, A. Kathrin, Toegel, Jane P., Gerhardt, Ellen, Karsten, Peter, Falkenburger, Björn, Reinartz, Andrea, Winklhofer, Konstanze F., Schulz, Jörg B., Orr, Harry T.

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Year:

2012

Language:

english

File:

PDF, 2.98 MB

english, 2012

46

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

Leblond, Claire S., Heinrich, Jutta, Delorme, Richard, Proepper, Christian, Betancur, Catalina, Huguet, Guillaume, Konyukh, Marina, Chaste, Pauline, Ey, Elodie, Rastam, Maria, Anckarsäter, Henrik, Nyg

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Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

47

Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

Koslowski, Maureen J., Teltschik, Zora, Beisner, Julia, Schaeffeler, Elke, Wang, Guoxing, Kübler, Irmgard, Gersemann, Michael, Cooney, Rachel, Jewell, Derek, Reinisch, Walter, Vermeire, Séverine, Rutg

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Year:

2012

Language:

english

File:

PDF, 2.52 MB

english, 2012

48

The Retrohoming of Linear Group II Intron RNAs in Drosophila melanogaster Occurs by Both DNA Ligase 4–Dependent and –Independent Mechanisms

White, Travis B., Lambowitz, Alan M., Malik, Harmit S.

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Year:

2012

Language:

english

File:

PDF, 1.72 MB

english, 2012

49

Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium

Nallasamy, Shanmugasundaram, Li, Quanxi, Bagchi, Milan K., Bagchi, Indrani C., Matzuk, Martin M.

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Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

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