Volume 8; Issue 5

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PLoS Genetics
Volume 8; Issue 5

PLoS Genetics

Volume 8; Issue 5

1

New Insight into the History of Domesticated Apple: Secondary Contribution of the European Wild Apple to the Genome of Cultivated Varieties

Cornille, Amandine, Gladieux, Pierre, Smulders, Marinus J. M., Roldán-Ruiz, Isabel, Laurens, François, Le Cam, Bruno, Nersesyan, Anush, Clavel, Joanne, Olonova, Marina, Feugey, Laurence, Gabrielyan, I

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Year:

2012

Language:

english

File:

PDF, 2.26 MB

english, 2012

2

Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes

Aubert, Geraldine, Baerlocher, Gabriela M., Vulto, Irma, Poon, Steven S., Lansdorp, Peter M., Barsh, Gregory S.

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2012

Language:

english

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PDF, 908 KB

english, 2012

3

Histone H3 Localizes to the Centromeric DNA in Budding Yeast

Lochmann, Berit, Ivanov, Dmitri, Sullivan, Beth A.

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2012

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english

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PDF, 2.08 MB

english, 2012

4

Recombination Drives Vertebrate Genome Contraction

Nam, Kiwoong, Ellegren, Hans, Petrov, Dmitri A.

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2012

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english

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PDF, 319 KB

english, 2012

5

The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

Raveau, Matthieu, Lignon, Jacques M., Nalesso, Valérie, Duchon, Arnaud, Groner, Yoram, Sharp, Andrew J., Dembele, Doulaye, Brault, Véronique, Hérault, Yann, Fisher, Elizabeth M. C.

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2012

Language:

english

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PDF, 1.85 MB

english, 2012

6

Loss of Gnas Imprinting Differentially Affects REM/NREM Sleep and Cognition in Mice

Lassi, Glenda, Ball, Simon T., Maggi, Silvia, Colonna, Giovanni, Nieus, Thierry, Cero, Cheryl, Bartolomucci, Alessandro, Peters, Jo, Tucci, Valter, Ferguson-Smith, Anne C.

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2012

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english

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PDF, 644 KB

english, 2012

7

Functional Centromeres Determine the Activation Time of Pericentric Origins of DNA Replication in Saccharomyces cerevisiae

Pohl, Thomas J., Brewer, Bonita J., Raghuraman, M. K., Newlon, Carol S.

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2012

Language:

english

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PDF, 2.40 MB

english, 2012

8

LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes

Meier, Karin, Mathieu, Eve-Lyne, Finkernagel, Florian, Reuter, L. Maximilian, Scharfe, Maren, Doehlemann, Gunther, Jarek, Michael, Brehm, Alexander, Akhtar, Asifa

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2012

Language:

english

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PDF, 1.05 MB

english, 2012

9

Knowledge-Driven Analysis Identifies a Gene–Gene Interaction Affecting High-Density Lipoprotein Cholesterol Levels in Multi-Ethnic Populations

Ma, Li, Brautbar, Ariel, Boerwinkle, Eric, Sing, Charles F., Clark, Andrew G., Keinan, Alon, Williams, Scott M.

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Year:

2012

Language:

english

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PDF, 415 KB

english, 2012

10

Meiotic Chromosome Pairing Is Promoted by Telomere-Led Chromosome Movements Independent of Bouquet Formation

Lee, Chih-Ying, Conrad, Michael N., Dresser, Michael E., Lichten, Michael

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Year:

2012

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english

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PDF, 3.35 MB

english, 2012

11

Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice

Wang, Xiaofang, Wang, Suzhen, Li, Changcheng, Gao, Tian, Liu, Ying, Rangiani, Afsaneh, Sun, Yao, Hao, Jianjun, George, Anne, Lu, Yongbo, Groppe, Jay, Yuan, Baozhi, Feng, Jian Q., Qin, Chunlin, White,

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2012

Language:

english

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PDF, 1.83 MB

english, 2012

12

The C. elegans H3K27 Demethylase UTX-1 Is Essential for Normal Development, Independent of Its Enzymatic Activity

Vandamme, Julien, Lettier, Gaëlle, Sidoli, Simone, Di Schiavi, Elia, Nørregaard Jensen, Ole, Salcini, Anna Elisabetta, Chisholm, Andrew D.

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Year:

2012

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english

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PDF, 4.87 MB

english, 2012

13

Repeated, Selection-Driven Genome Reduction of Accessory Genes in Experimental Populations

Lee, Ming-Chun, Marx, Christopher J., Moran, Nancy A.

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2012

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english

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PDF, 1.62 MB

english, 2012

14

Histone H1 Depletion Impairs Embryonic Stem Cell Differentiation

Zhang, Yunzhe, Cooke, Marissa, Panjwani, Shiraj, Cao, Kaixiang, Krauth, Beth, Ho, Po-Yi, Medrzycki, Magdalena, Berhe, Dawit T., Pan, Chenyi, McDevitt, Todd C., Fan, Yuhong, Copenhaver, Gregory P.

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2012

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english

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PDF, 3.29 MB

english, 2012

15

ELK1 Uses Different DNA Binding Modes to Regulate Functionally Distinct Classes of Target Genes

Odrowaz, Zaneta, Sharrocks, Andrew D., Leprince, Dominique

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Year:

2012

Language:

english

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PDF, 1.30 MB

english, 2012

16

Genome-Wide Analysis of GLD-1–Mediated mRNA Regulation Suggests a Role in mRNA Storage

Scheckel, Claudia, Gaidatzis, Dimos, Wright, Jane E., Ciosk, Rafal, Mango, Susan E.

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2012

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english

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PDF, 1.90 MB

english, 2012

17

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho−/− Mice

Yuan, Quan, Sato, Tadatoshi, Densmore, Michael, Saito, Hiroaki, Schüler, Christiane, Erben, Reinhold G., Lanske, Beate, White, Kenneth E.

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Year:

2012

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english

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PDF, 4.87 MB

english, 2012

18

Separation of DNA Replication from the Assembly of Break-Competent Meiotic Chromosomes

Blitzblau, Hannah G., Chan, Clara S., Hochwagen, Andreas, Bell, Stephen P., Hawley, R. Scott

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Year:

2012

Language:

english

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PDF, 1.52 MB

english, 2012

19

Re-Patterning Sleep Architecture in Drosophila through Gustatory Perception and Nutritional Quality

Linford, Nancy J., Chan, Tammy P., Pletcher, Scott D., Sehgal, Amita

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Year:

2012

Language:

english

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PDF, 1.11 MB

english, 2012

20

MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats

Tan, Huiping, Poidevin, Mickael, Li, He, Chen, Dahua, Jin, Peng, Orr, Harry T.

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Year:

2012

Language:

english

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PDF, 2.79 MB

english, 2012

21

Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat

Fox, Caroline S., White, Charles C., Lohman, Kurt, Heard-Costa, Nancy, Cohen, Paul, Zhang, Yingying, Johnson, Andrew D., Emilsson, Valur, Liu, Ching-Ti, Chen, Y.-D. Ida, Taylor, Kent D., Allison, Matt

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2012

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english

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PDF, 257 KB

english, 2012

22

Bmps and Id2a Act Upstream of Twist1 To Restrict Ectomesenchyme Potential of the Cranial Neural Crest

Das, Ankita, Crump, J. Gage, Raible, David W.

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2012

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english

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PDF, 7.47 MB

english, 2012

23

Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

Galli, Giorgio Giacomo, Honnens de Lichtenberg, Kristian, Carrara, Matteo, Hans, Wolfgang, Wuelling, Manuela, Mentz, Bettina, Multhaupt, Hinke Arnolda, Fog, Cathrine Kolster, Jensen, Klaus Thorleif, R

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2012

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english

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PDF, 4.78 MB

english, 2012

24

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

Zhu, Jin, Pavelka, Norman, Bradford, William D., Rancati, Giulia, Li, Rong, Sullivan, Beth A.

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2012

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english

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PDF, 966 KB

english, 2012

25

Scientist Citizen: An Interview with Bruce Alberts

Gitschier, Jane

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Year:

2012

Language:

english

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PDF, 177 KB

english, 2012

26

IDN2 and Its Paralogs Form a Complex Required for RNA–Directed DNA Methylation

Zhang, Cui-Jun, Ning, Yong-Qiang, Zhang, Su-Wei, Chen, Qing, Shao, Chang-Rong, Guo, Yan-Wu, Zhou, Jin-Xing, Li, Lin, Chen, She, He, Xin-Jian, Henderson, Ian R.

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Year:

2012

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english

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PDF, 2.46 MB

english, 2012

27

Principles of Carbon Catabolite Repression in the Rice Blast Fungus: Tps1, Nmr1-3, and a MATE–Family Pump Regulate Glucose Metabolism during Infection

Fernandez, Jessie, Wright, Janet D., Hartline, David, Quispe, Cristian F., Madayiputhiya, Nandakumar, Wilson, Richard A., Hynes, Michael

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2012

Language:

english

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PDF, 3.07 MB

english, 2012

28

Neurospora COP9 Signalosome Integrity Plays Major Roles for Hyphal Growth, Conidial Development, and Circadian Function

Zhou, Zhipeng, Wang, Ying, Cai, Gaihong, He, Qun, Wei, Ning

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Year:

2012

Language:

english

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PDF, 1.60 MB

english, 2012

29

Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma

van Koolwijk, Leonieke M. E., Ramdas, Wishal D., Ikram, M. Kamran, Jansonius, Nomdo M., Pasutto, Francesca, Hysi, Pirro G., Macgregor, Stuart, Janssen, Sarah F., Hewitt, Alex W., Viswanathan, Ananth C

Journal:

Year:

2012

Language:

english

File:

PDF, 713 KB

english, 2012

30

Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster

Ober, Ulrike, Ayroles, Julien F., Stone, Eric A., Richards, Stephen, Zhu, Dianhui, Gibbs, Richard A., Stricker, Christian, Gianola, Daniel, Schlather, Martin, Mackay, Trudy F. C., Simianer, Henner, Wr

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Year:

2012

Language:

english

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PDF, 658 KB

english, 2012

31

Genome-Wide Copy Number Analysis Uncovers a New HSCR Gene: NRG3

Tang, Clara Sze-Man, Cheng, Guo, So, Man-Ting, Yip, Benjamin Hon-Kei, Miao, Xiao-Ping, Wong, Emily Hoi-Man, Ngan, Elly Sau-Wai, Lui, Vincent Chi-Hang, Song, You-Qiang, Chan, Danny, Cheung, Kenneth, Yu

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Year:

2012

Language:

english

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PDF, 503 KB

english, 2012

32

Acquisition Order of Ras and p53 Gene Alterations Defines Distinct Adrenocortical Tumor Phenotypes

Herbet, Maryline, Salomon, Aude, Feige, Jean-Jacques, Thomas, Michaël, Grimes, H. Leighton

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Year:

2012

Language:

english

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PDF, 10.30 MB

english, 2012

33

Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue

Parts, Leopold, Hedman, Åsa K., Keildson, Sarah, Knights, Andrew J., Abreu-Goodger, Cei, van de Bunt, Martijn, Guerra-Assunção, José Afonso, Bartonicek, Nenad, van Dongen, Stijn, Mägi, Reedik, Nisbet,

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2012

Language:

english

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PDF, 1.00 MB

english, 2012

34

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Chen, Xuqi, McClusky, Rebecca, Chen, Jenny, Beaven, Simon W., Tontonoz, Peter, Arnold, Arthur P., Reue, Karen, Attie, Alan

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Year:

2012

Language:

english

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PDF, 2.30 MB

english, 2012

35

Target Gene Analysis by Microarrays and Chromatin Immunoprecipitation Identifies HEY Proteins as Highly Redundant bHLH Repressors

Heisig, Julia, Weber, David, Englberger, Eva, Winkler, Anja, Kneitz, Susanne, Sung, Wing-Kin, Wolf, Elmar, Eilers, Martin, Wei, Chia-Lin, Gessler, Manfred, Gottgens, Berthold

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Year:

2012

Language:

english

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PDF, 1.50 MB

english, 2012

36

Chromosome Pairing: A Hidden Treasure No More

Bosco, Giovanni, Copenhaver, Gregory P.

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Year:

2012

Language:

english

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PDF, 156 KB

english, 2012

37

abd-A Regulation by the iab-8 Noncoding RNA

Gummalla, Maheshwar, Maeda, Robert K., Castro Alvarez, Javier J., Gyurkovics, Henrik, Singari, Swetha, Edwards, Kevin A., Karch, François, Bender, Welcome, Perrimon, Norbert

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Year:

2012

Language:

english

File:

PDF, 559 KB

english, 2012

38

DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi

Hou, Yu, Yuan, Jia, Zhou, Xiang, Fu, Xiazhou, Cheng, Hanhua, Zhou, Rongjia, Barsh, Gregory S.

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Year:

2012

Language:

english

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PDF, 2.19 MB

english, 2012

39

KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility

Smith, Lee B., Milne, Laura, Nelson, Nancy, Eddie, Sharon, Brown, Pamela, Atanassova, Nina, O'Bryan, Moira K., O'Donnell, Liza, Rhodes, Danielle, Wells, Sara, Napper, Diane, Nolan, Patrick, Lalanne, Z

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Year:

2012

Language:

english

File:

PDF, 7.83 MB

english, 2012

40

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

Morel, Anne-Pierre, Hinkal, George W., Thomas, Clémence, Fauvet, Frédérique, Courtois-Cox, Stéphanie, Wierinckx, Anne, Devouassoux-Shisheboran, Mojgan, Treilleux, Isabelle, Tissier, Agnès, Gras, Bapti

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Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

41

TBC-8, a Putative RAB-2 GAP, Regulates Dense Core Vesicle Maturation in Caenorhabditis elegans

Hannemann, Mandy, Sasidharan, Nikhil, Hegermann, Jan, Kutscher, Lena M., Koenig, Sabine, Eimer, Stefan, Goodman, Miriam B.

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Year:

2012

Language:

english

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PDF, 4.60 MB

english, 2012

42

Integrin α PAT-2/CDC-42 Signaling Is Required for Muscle-Mediated Clearance of Apoptotic Cells in Caenorhabditis elegans

Hsieh, Hsiao-Han, Hsu, Tsung-Yuan, Jiang, Hang-Shiang, Wu, Yi-Chun, Chisholm, Andrew D.

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Year:

2012

Language:

english

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PDF, 1.31 MB

english, 2012

43

Identification of Genes That Promote or Antagonize Somatic Homolog Pairing Using a High-Throughput FISH–Based Screen

Joyce, Eric F., Williams, Benjamin R., Xie, Tiao, Wu, C.-ting, Hawley, R. Scott

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Year:

2012

Language:

english

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PDF, 1.81 MB

english, 2012

44

YY1 Regulates Melanocyte Development and Function by Cooperating with MITF

Li, Juying, Song, Jun S., Bell, Robert J. A., Tran, Thanh-Nga T., Haq, Rizwan, Liu, Huifei, Love, Kevin T., Langer, Robert, Anderson, Daniel G., Larue, Lionel, Fisher, David E., Bosenberg, Marcus

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Year:

2012

Language:

english

File:

PDF, 3.12 MB

english, 2012

45

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

Li, Jian, Harris, R. Alan, Cheung, Sau Wai, Coarfa, Cristian, Jeong, Mira, Goodell, Margaret A., White, Lisa D., Patel, Ankita, Kang, Sung-Hae, Shaw, Chad, Chinault, A. Craig, Gambin, Tomasz, Gambin,

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Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

46

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Fox, Caroline S., Liu, Yongmei, White, Charles C., Feitosa, Mary, Smith, Albert V., Heard-Costa, Nancy, Lohman, Kurt, Johnson, Andrew D., Foster, Meredith C., Greenawalt, Danielle M., Griffin, Paula,

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Year:

2012

Language:

english

File:

PDF, 432 KB

english, 2012

47

UDP-Galactose 4′-Epimerase Activities toward UDP-Gal and UDP-GalNAc Play Different Roles in the Development of Drosophila melanogaster

Daenzer, Jennifer M. I., Sanders, Rebecca D., Hang, Darwin, Fridovich-Keil, Judith L., Berry, Gerard Thomas

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Year:

2012

Language:

english

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PDF, 970 KB

english, 2012

48

Drosophila Activated Cdc42 Kinase Has an Anti-Apoptotic Function

Schoenherr, Jessica A., Drennan, J. Michelle, Martinez, Juan S., Chikka, Madhusudana Rao, Hall, Mark C., Chang, Henry C., Clemens, James C., Steller, Hermann

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Year:

2012

Language:

english

File:

PDF, 9.01 MB

english, 2012

49

An Essential Role for Katanin p80 and Microtubule Severing in Male Gamete Production

O'Donnell, Liza, Rhodes, Danielle, Smith, Stephanie J., Merriner, D. Jo, Clark, Brett J., Borg, Claire, Whittle, Belinda, O'Connor, Anne E., Smith, Lee B., McNally, Francis J., de Kretser, David M., G

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Year:

2012

Language:

english

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PDF, 6.42 MB

english, 2012

50

Hypersensitive to Red and Blue 1 and Its Modification by Protein Phosphatase 7 Are Implicated in the Control of Arabidopsis Stomatal Aperture

Sun, Xiaodong, Kang, Xiaojun, Ni, Min, McClung, C. Robertson

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Year:

2012

Language:

english

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PDF, 2.52 MB

english, 2012

51

Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States

Kueng, Stephanie, Tsai-Pflugfelder, Monika, Oppikofer, Mariano, Ferreira, Helder C., Roberts, Emma, Tsai, Chinyen, Roloff, Tim-Christoph, Sack, Ragna, Gasser, Susan M., Madhani, Hiten D.

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Year:

2012

Language:

english

File:

PDF, 2.66 MB

english, 2012

52

Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis

Tran, Phuoc T., Shroff, Emelyn H., Burns, Timothy F., Thiyagarajan, Saravanan, Das, Sandhya T., Zabuawala, Tahera, Chen, Joy, Cho, Yoon-Jae, Luong, Richard, Tamayo, Pablo, Salih, Tarek, Aziz, Khaled,

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Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

53

Downregulation of Chloroplast RPS1 Negatively Modulates Nuclear Heat-Responsive Expression of HsfA2 and Its Target Genes in Arabidopsis

Yu, Hai-Dong, Yang, Xiao-Fei, Chen, Si-Ting, Wang, Yu-Ting, Li, Ji-Kai, Shen, Qi, Liu, Xun-Liang, Guo, Fang-Qing, Qu, Li-Jia

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Year:

2012

Language:

english

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PDF, 2.37 MB

english, 2012

54

Allelic Variation and Differential Expression of the mSIN3A Histone Deacetylase Complex Gene Arid4b Promote Mammary Tumor Growth and Metastasis

Winter, Scott F., Lukes, Luanne, Walker, Renard C., Welch, Danny R., Hunter, Kent W., Horwitz, Marshall S.

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Year:

2012

Language:

english

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PDF, 1.15 MB

english, 2012

55

Dynamic Deposition of Histone Variant H3.3 Accompanies Developmental Remodeling of the Arabidopsis Transcriptome

Wollmann, Heike, Holec, Sarah, Alden, Keith, Clarke, Neil D., Jacques, Pierre-Étienne, Berger, Frédéric, Kakutani, Tetsuji

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Year:

2012

Language:

english

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PDF, 892 KB

english, 2012

56

Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo

Misra, Chaitali, Sachan, Nita, McNally, Caryn Rothrock, Koenig, Sara N., Nichols, Haley A., Guggilam, Anuradha, Lucchesi, Pamela A., Pu, William T., Srivastava, Deepak, Garg, Vidu, Baldwin, Scott

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Year:

2012

Language:

english

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PDF, 4.57 MB

english, 2012

57

A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced Obesity in Mice and Men

Lacaria, Melanie, Saha, Pradip, Potocki, Lorraine, Bi, Weimin, Yan, Jiong, Girirajan, Santhosh, Burns, Brooke, Elsea, Sarah, Walz, Katherina, Chan, Lawrence, Lupski, James R., Gu, Wenli, Spinner, Nanc

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2012

Language:

english

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PDF, 2.14 MB

english, 2012

58

Slowing Replication in Preparation for Reduction

Lawrence, Katherine S., Engebrecht, JoAnne, Copenhaver, Gregory P.

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2012

Language:

english

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PDF, 115 KB

english, 2012

59

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

Pradeepa, Madapura M., Sutherland, Heidi G., Ule, Jernej, Grimes, Graeme R., Bickmore, Wendy A., Reik, Wolf

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Year:

2012

Language:

english

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PDF, 1.90 MB

english, 2012

60

Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator

Freddolino, Peter L., Goodarzi, Hani, Tavazoie, Saeed, Zhang, Jianzhi

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Year:

2012

Language:

english

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PDF, 1.03 MB

english, 2012

61

Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

Li, Rui, Brockschmidt, Felix F., Kiefer, Amy K., Stefansson, Hreinn, Nyholt, Dale R., Song, Kijoung, Vermeulen, Sita H., Kanoni, Stavroula, Glass, Daniel, Medland, Sarah E., Dimitriou, Maria, Waterwor

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Year:

2012

Language:

english

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PDF, 320 KB

english, 2012

62

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

Perry, John R. B., Voight, Benjamin F., Yengo, Loïc, Amin, Najaf, Dupuis, Josée, Ganser, Martha, Grallert, Harald, Navarro, Pau, Li, Man, Qi, Lu, Steinthorsdottir, Valgerdur, Scott, Robert A., Almgren

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Year:

2012

Language:

english

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PDF, 851 KB

english, 2012