Radiotherapy and Oncology

1

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

Cojocari, Dan, Vellanki, Ravi N., Sit, Brandon, Uehling, David, Koritzinsky, Marianne, Wouters, Bradly G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

2

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Schaaf, Marco B.E., Cojocari, Dan, Keulers, Tom G., Jutten, Barry, Starmans, Maud H., de Jong, Monique C., Begg, Adrian C., Savelkouls, Kim G.M., Bussink, Johan, Vooijs, Marc, Wouters, Bradly G., Rous

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.09 MB

english, 2013

3

Human papillomaviruses and cancer

Haedicke, Juliane, Iftner, Thomas

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 704 KB

english, 2013

4

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

Dubois, Ludwig, Peeters, Sarah G.J.A., van Kuijk, Simon J.A., Yaromina, Ala, Lieuwes, Natasja G., Saraya, Ruchi, Biemans, Rianne, Rami, Marouan, Parvathaneni, Nanda Kumar, Vullo, Daniela, Vooijs, Marc

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.70 MB

english, 2013

5

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g

Salendo, Junius, Spitzner, Melanie, Kramer, Frank, Zhang, Xin, Jo, Peter, Wolff, Hendrik A., Kitz, Julia, Kaulfuß, Silke, Beißbarth, Tim, Dobbelstein, Matthias, Ghadimi, Michael, Grade, Marian, Gaedck

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

6

Discovery of the cancer stem cell related determinants of radioresistance

Peitzsch, Claudia, Kurth, Ina, Kunz-Schughart, Leoni, Baumann, Michael, Dubrovska, Anna

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.72 MB

english, 2013

7

Clinical perspectives of cancer stem cell research in radiation oncology

Bütof, Rebecca, Dubrovska, Anna, Baumann, Michael

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 962 KB

english, 2013

8

Hypoxia and metastasis in an orthotopic cervix cancer xenograft model

Chaudary, Naz, Mujcic, Hilda, Wouters, Bradly G., Hill, Richard P.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1004 KB

english, 2013

9

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response

Nagelkerke, Anika, Bussink, Johan, van der Kogel, Albert J., Sweep, Fred C.G.J., Span, Paul N.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.77 MB

english, 2013

10

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells

Sørensen, Brita Singers, Busk, Morten, Olthof, Nadine, Speel, Ernst-Jan, Horsman, Michael R., Alsner, Jan, Overgaard, Jens

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 655 KB

english, 2013

11

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression

Groselj, Blaz, Kerr, Martin, Kiltie, Anne E.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 987 KB

english, 2013

12

Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

Vignard, Julien, Mirey, Gladys, Salles, Bernard

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.66 MB

english, 2013

13

Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin

Muaddi, Hala, Chowdhury, Sanjana, Vellanki, Ravi, Zamiara, Paul, Koritzinsky, Marianne

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 447 KB

english, 2013

14

HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1

Busch, Chia-Jung, Kriegs, Malte, Laban, Simon, Tribius, Silke, Knecht, Rainald, Petersen, Cordula, Dikomey, Ekkehard, Rieckmann, Thorsten

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

15

ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity

Boohaker, Rebecca J., Cui, Xiaoli, Stackhouse, Murray, Xu, Bo

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 748 KB

english, 2013

16

Exploratory geographical analysis of hypoxic subvolumes using 18F-MISO-PET imaging in patients with head and neck cancer in the course of primary chemoradiotherapy

Bittner, Martin-Immanuel, Wiedenmann, Nicole, Bucher, Sabine, Hentschel, Michael, Mix, Michael, Weber, Wolfgang A., Grosu, Anca-Ligia

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

17

Editorial Board

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 32 KB

english, 2013

18

Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity

Burrows, Natalie, Telfer, Brian, Brabant, Georg, Williams, Kaye J.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 819 KB

english, 2013

19

Molecular radiation biology/oncology at its best: Cutting edge research presented at the 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology

Baumann, Michael, Bodis, Stephan, Dikomey, Ekkehard, van der Kogel, Albert, Overgaard, Jens, Rodemann, Hans Peter, Wouters, Bradly

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 329 KB

english, 2013

21

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation

Krause, Mechthild, Kummer, Berit, Deparade, Andre, Eicheler, Wolfgang, Pfitzmann, Dorothee, Yaromina, Ala, Kunz-Schughart, Leoni A., Baumann, Michael

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 784 KB

english, 2013

22

Expression of EGFR and HPV-associated p16 in oropharyngeal carcinoma: Correlation and influence on prognosis after radiotherapy in the randomized DAHANCA 5 and 7 trials

Lassen, Pernille, Overgaard, Jens, Eriksen, Jesper Grau

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

23

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

Jutten, Barry, Keulers, Tom G., Schaaf, Marco B.E., Savelkouls, Kim, Theys, Jan, Span, Paul N., Vooijs, Marc A., Bussink, Johan, Rouschop, Kasper M.A.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 670 KB

english, 2013

24

Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial

Rademakers, Saskia E., Hoogsteen, Ilse J., Rijken, Paul F., Oosterwijk, Egbert, Terhaard, Chris H., Doornaert, Patricia A., Langendijk, Johannes A., van den Ende, Piet, Takes, Robert, De Bree, Remco,

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.13 MB

english, 2013

25

Osteopontin and splice variant expression level in human malignant glioma: Radiobiologic effects and prognosis after radiotherapy

Güttler, Antje, Giebler, Maria, Cuno, Peter, Wichmann, Henri, Keßler, Jacqueline, Ostheimer, Christian, Söling, Ariane, Strauss, Christian, Illert, Jörg, Kappler, Matthias, Vordermark, Dirk, Bache, Ma

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 857 KB

english, 2013

26

ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks

Köcher, Sabrina, Spies-Naumann, Anja, Kriegs, Malte, Dahm-Daphi, Jochen, Dornreiter, Irena

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 882 KB

english, 2013

27

Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland

Nanduri, Lalitha S.Y., Lombaert, Isabelle M.A., van der Zwaag, Marianne, Faber, Hette, Brunsting, Jeanette F., van Os, Ronald P., Coppes, Robert P.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 3.48 MB

english, 2013

28

Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice

Scharpfenecker, Marion, Floot, Ben, Russell, Nicola S., Coppes, Rob P., Stewart, Fiona A.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

29

Independent prospective validation of a predictive test for risk of radiation induced fibrosis based on the gene expression pattern in fibroblasts irradiated in vitro

Andreassen, Christian Nicolaj, Overgaard, Jens, Alsner, Jan

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 336 KB

english, 2013

30

Residual γH2AX foci predict local tumour control after radiotherapy

Koch, Ulrike, Höhne, Katharina, von Neubeck, Cläre, Thames, Howard D., Yaromina, Ala, Dahm-Daphi, Jochen, Baumann, Michael, Krause, Mechthild

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 405 KB

english, 2013

31

Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells

Saki, Mohammad, Toulany, Mahmoud, Rodemann, H. Peter

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 906 KB

english, 2013

32

111In-cetuximab-F(ab’)2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts

van Dijk, Laura K., Hoeben, Bianca A.W., Stegeman, Hanneke, Kaanders, Johannes H.A.M., Franssen, Gerben M., Boerman, Otto C., Bussink, Johan

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 880 KB

english, 2013

33

High NOTCH activity induces radiation resistance in non small cell lung cancer

Theys, Jan, Yahyanejad, Sanaz, Habets, Roger, Span, Paul, Dubois, Ludwig, Paesmans, Kim, Kattenbeld, Bo, Cleutjens, Jack, Groot, Arjan J., Schuurbiers, Olga C.J., Lambin, Philippe, Bussink, Jan, Vooij

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

34

Nuclear EGFR as a molecular target in cancer

Brand, Toni M., Iida, Mari, Luthar, Neha, Starr, Megan M., Huppert, Evan J., Wheeler, Deric L.

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

Volume 108; Issue 3

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Human papillomaviruses and cancer

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g

Discovery of the cancer stem cell related determinants of radioresistance

Clinical perspectives of cancer stem cell research in radiation oncology

Hypoxia and metastasis in an orthotopic cervix cancer xenograft model

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression

Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin

HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1

ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity

Exploratory geographical analysis of hypoxic subvolumes using 18F-MISO-PET imaging in patients with head and neck cancer in the course of primary chemoradiotherapy

Editorial Board

Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity

Contents

Molecular radiation biology/oncology at its best: Cutting edge research presented at the 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation

Expression of EGFR and HPV-associated p16 in oropharyngeal carcinoma: Correlation and influence on prognosis after radiotherapy in the randomized DAHANCA 5 and 7 trials

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial

Osteopontin and splice variant expression level in human malignant glioma: Radiobiologic effects and prognosis after radiotherapy

ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks

Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland

Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice

Independent prospective validation of a predictive test for risk of radiation induced fibrosis based on the gene expression pattern in fibroblasts irradiated in vitro

Residual γH2AX foci predict local tumour control after radiotherapy

Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells

111In-cetuximab-F(ab’)2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts

High NOTCH activity induces radiation resistance in non small cell lung cancer

Nuclear EGFR as a molecular target in cancer