Radiotherapy and Oncology

1

EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms

Michael Baumann, Mechthild Krause, Ekkehard Dikomey, Klaus Dittmann, Wolfgang Dörr, Ulla Kasten-Pisula, H. Peter Rodemann

Journal:

Year:

2007

Language:

english

File:

PDF, 175 KB

english, 2007

2

EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: Differential response of cancer stem cells and nontumourigenic cells?

Mechthild Krause, Jenny Prager, Xuanjing Zhou, Ala Yaromina, Annegret Dörfler, Wolfgang Eicheler, Michael Baumann

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 348 KB

english, 2007

3

Homologous recombination and prostate cancer: A model for novel DNA repair targets and therapies

Robert G. Bristow, Hilmi Ozcelik, Farid Jalali, Norman Chan, Danny Vesprini

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 865 KB

english, 2007

4

Transcriptional response to ionizing radiation in human radiation sensitive cell lines

H. Landmark, S.A. Nahas, J. Aarøe, R. Gatti, A.-L. Børresen-Dale, O.K. Rødningen

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 191 KB

english, 2007

5

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

Ludwig Dubois, Kim Douma, Claudiu T. Supuran, Roland K. Chiu, Marc A.M.J. van Zandvoort, Silvia Pastoreková, Andrea Scozzafava, Bradly G. Wouters, Philippe Lambin

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 519 KB

english, 2007

6

Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation

Ala Yaromina, Marie Krause, Howard Thames, Andrea Rosner, Mechthild Krause, Franziska Hessel, Reidar Grenman, Daniel Zips, Michael Baumann

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 118 KB

english, 2007

7

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

Marianne Nordsmark, Jesper Grau Eriksen, Val Gebski, Jan Alsner, Michael R. Horsman, Jens Overgaard

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 195 KB

english, 2007

8

Interrelation amongst differentiation, senescence and genetic instability in long-term cultures of fibroblasts exposed to different radiation qualities

Claudia Fournier, Marcus Winter, Sebastian Zahnreich, Elena Nasonova, Larissa Melnikova, Sylvia Ritter

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 183 KB

english, 2007

9

Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis

Ulla Kasten-Pisula, Sabine Windhorst, Jochen Dahm-Daphi, Georg Mayr, Ekkehard Dikomey

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 323 KB

english, 2007

10

Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance

Sherry A. Weppler, Younan Li, Ludwig Dubois, Natasja Lieuwes, Barry Jutten, Philippe Lambin, Bradly G. Wouters, Guido Lammering

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 401 KB

english, 2007

11

Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia

Twan van den Beucken, Michael G. Magagnin, Kim Savelkouls, Philippe Lambin, Marianne Koritzinsky, Bradly G. Wouters

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 322 KB

english, 2007

12

Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress

Michaël G. Magagnin, Kjell Sergeant, Twan van den Beucken, Kasper M.A. Rouschop, Barry Jutten, Renaud Seigneuric, Philippe Lambin, Bart Devreese, Marianne Koritzinsky, Bradly G. Wouters

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 460 KB

english, 2007

13

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH

Brita Singers Sørensen, Jan Alsner, Jens Overgaard, Michael R. Horsman

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 99 KB

english, 2007

14

ATM missense variant P1054R predisposes to prostate cancer

Andreas Meyer, Bettina Wilhelm, Thilo Dörk, Michael Bremer, Rolf Baumann, Johann Hinrich Karstens, Stefan Machtens

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 89 KB

english, 2007

15

Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII

Hugo J.W.L. Aerts, Ludwig Dubois, Tilman M. Hackeng, Roel Straathof, Roland K. Chiu, Natasja G. Lieuwes, Barry Jutten, Sherry A. Weppler, Guido Lammering, Bradly G. Wouters, Philippe Lambin

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 1.32 MB

english, 2007

16

Phosphorylation of eIF2α is required for mRNA translation inhibition and survival during moderate hypoxia

Marianne Koritzinsky, Kasper M.A. Rouschop, Twan van den Beucken, Michaël G. Magagnin, Kim Savelkouls, Philippe Lambin, Bradly G. Wouters

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 536 KB

english, 2007

17

DNA damage-induced signalling in ataxia-telangiectasia and related syndromes

Martin F. Lavin, Sergei Kozlov

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 873 KB

english, 2007

18

Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice

Christina Schütze, Ralf Bergmann, Ala Yaromina, Franziska Hessel, Jörg Kotzerke, Jörg Steinbach, Michael Baumann, Bettina Beuthien-Baumann

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

19

Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis

Jan Alsner, Olaug K. Rødningen, Jens Overgaard

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 188 KB

english, 2007

20

Impact of supervised gene signatures of early hypoxia on patient survival

Renaud Seigneuric, Maud H.W. Starmans, Glenn Fung, Balaji Krishnapuram, Dimitry S.A. Nuyten, Arie van Erk, Michael G. Magagnin, Kasper M. Rouschop, Sriram Krishnan, R. Bharat Rao, Chris T.A. Evelo, Ad

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 611 KB

english, 2007

21

Sensing radiosensitivity of human epidermal stem cells

Walid Rachidi, Ghida Harfourche, Gilles Lemaitre, Franck Amiot, Pierre Vaigot, Michèle T. Martin

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 806 KB

english, 2007

22

Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study

Jesper Grau Eriksen, Jens Overgaard

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

23

TGFβ-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFβ-receptor I signalling

Erwin M. Wiegman, Marcel A. Blaese, Heidi Loeffler, Rob P. Coppes, H. Peter Rodemann

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 400 KB

english, 2007

24

Hypoxia-imaging with 18F-Misonidazole and PET: Changes of kinetics during radiotherapy of head-and-neck cancer

Susanne Martina Eschmann, Frank Paulsen, Claudia Bedeshem, Hans-Jürgen Machulla, Thomas Hehr, Michael Bamberg, Roland Bares

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 347 KB

english, 2007

25

Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy

Mark W. Dewhirst, Yiting Cao, Chuan Yuan Li, Benjamin Moeller

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 3.68 MB

english, 2007

26

Translational research in radiotherapy – Getting closer to the bedside

Jens Overgaard, Michael Baumann

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 57 KB

english, 2007

27

Editorial Board

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 44 KB

english, 2007

28

Important ESTRO dates

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 45 KB

english, 2007

30

Calendar of Events

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 15 KB

english, 2007

31

Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1α in human glioma in vitro and in vivo

Said, Harun M., Hagemann, Carsten, Staab, Adrian, Stojic, Jelena, Kühnel, Siglinde, Vince, Giles H., Flentje, Michael, Roosen, Klaus, Vordermark, Dirk

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 597 KB

english, 2007

Volume 83; Issue 3

EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms

EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: Differential response of cancer stem cells and nontumourigenic cells?

Homologous recombination and prostate cancer: A model for novel DNA repair targets and therapies

Transcriptional response to ionizing radiation in human radiation sensitive cell lines

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

Interrelation amongst differentiation, senescence and genetic instability in long-term cultures of fibroblasts exposed to different radiation qualities

Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis

Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance

Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia

Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH

ATM missense variant P1054R predisposes to prostate cancer

Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII

Phosphorylation of eIF2α is required for mRNA translation inhibition and survival during moderate hypoxia

DNA damage-induced signalling in ataxia-telangiectasia and related syndromes

Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice

Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis

Impact of supervised gene signatures of early hypoxia on patient survival

Sensing radiosensitivity of human epidermal stem cells

Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study

TGFβ-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFβ-receptor I signalling

Hypoxia-imaging with 18F-Misonidazole and PET: Changes of kinetics during radiotherapy of head-and-neck cancer

Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy

Translational research in radiotherapy – Getting closer to the bedside

Editorial Board

Contents

Important ESTRO dates

Calendar of Events

Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1α in human glioma in vitro and in vivo