Regulatory Toxicology and Pharmacology

1

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: A combination study design in support of a Paediatric Investigation Plan

David M. Cross, Gary Chmielewski, Elise M. Lewis, Lei Liu, Michael S. Modesitt, Sharon L. Ripp, Christopher M. Sawaryn, Christopher J. Bowman

Journal:

Year:

2012

Language:

english

File:

PDF, 310 KB

english, 2012

2

Oral bioaccessibility testing and read-across hazard assessment of nickel compounds

Rayetta G. Henderson, Danielle Cappellini, Steven K. Seilkop, Hudson K. Bates, Adriana R. Oller

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 450 KB

english, 2012

3

Application of computational toxicological approaches in human health risk assessment. I. A tiered surrogate approach

Nina Ching Yi Wang, Q. Jay Zhao, Scott C. Wesselkamper, Jason C. Lambert, Dan Petersen, Janet K. Hess-Wilson

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 579 KB

english, 2012

4

Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation

Carsten Goebel, Pierre Aeby, Nadège Ade, Nathalie Alépée, Aynur Aptula, Daisuke Araki, Eric Dufour, Nicola Gilmour, Jalila Hibatallah, Detlef Keller, Petra Kern, Annette Kirst, Monique Marrec-Fairley,

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 627 KB

english, 2012

5

Workshop: Combined exposure to chemicals

E.C. Hennes, M. Galay Burgos, M. Hamer, M. Pemberton, K. Travis, C. Rodriguez

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 136 KB

english, 2012

6

Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: Was causality adequately ascertained?

Rolf Teschke, Christian Frenzel, Johannes Schulze, Axel Eickhoff

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

7

Assessment of potential asbestos exposures from jet engine overhaul work

S.P. Mlynarek, D.R. Van Orden

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 564 KB

english, 2012

8

Consumer inhalation exposure to formaldehyde from the use of personal care products/cosmetics

Marc-André Lefebvre, Wim J.A. Meuling, Roel Engel, Manuela C. Coroama, Gerald Renner, Wolfgang Pape, Gerhard J. Nohynek

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 340 KB

english, 2012

9

A regulatory approach to assess the potency of substances toxic to the reproduction

Andre Muller, Marie-Noëlle Blaude, Christina Ihlemann, Christine Bjorge, Agneta Ohlsson, Tom Gebel

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 342 KB

english, 2012

10

MetaPath: An electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism

Richard C. Kolanczyk, Patricia Schmieder, William J. Jones, Ovanes G. Mekenyan, Atanas Chapkanov, Stanislav Temelkov, Stefan Kotov, Maria Velikova, Verginia Kamenska, Krasimir Vasilev, Gilman D. Veith

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 3.44 MB

english, 2012

11

Comparative toxicokinetics of low-viscosity mineral oil in Fischer 344 rats, Sprague–Dawley rats, and humans – Implications for an Acceptable Daily Intake (ADI)

Peter J. Boogaard, Katy O. Goyak, Robert W. Biles, Leo L.P. van Stee, Matthew S. Miller, Mary Jo Miller

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 366 KB

english, 2012

12

Toxicity assay in repeated doses of Dermatophagoides siboney allergen extract in mice

Yana González, Alexis Labrada, Bárbara González, Ana M. Bada, Axel Mancebo, Dasha Fuentes, Avelina León, María E. Arteaga

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

13

Mentholated cigarettes and smoking-related cancers revisited: An ecologic examination

Geoffrey C. Kabat, Nitin Shivappa, James R. Hébert

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 627 KB

english, 2012

14

Risk assessment of gamma-hydroxybutyric acid (GHB) in the Netherlands

Jan G.C. van Amsterdam, Margriet van Laar, Tibor M. Brunt, Wim van den Brink

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 279 KB

english, 2012

15

Safety assessment of methanol extract of red dragon fruit (Hylocereus polyrhizus): Acute and subchronic toxicity studies

Sook Yee Hor, Mariam Ahmad, Elham Farsi, Mun Fei Yam, Mohd Akmal Hashim, Chung Pin Lim, Amirin Sadikun, Mohd. Zaini Asmawi

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 463 KB

english, 2012

16

Acetylcholinesterase inhibition dose–response modeling for chlorpyrifos and chlorpyrifos-oxon

Richard Reiss, Barbara Neal, James C. Lamb IV, Daland R Juberg

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 317 KB

english, 2012

17

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: A workshop report

Jan Willem van der Laan, Robert E. Chapin, Bert Haenen, Abigail C. Jacobs, Aldert Piersma

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 255 KB

english, 2012

18

Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy

Judith C. Madden, Mark Hewitt, Katarzyna Przybylak, Rob J. Vandebriel, Aldert H. Piersma, Mark T.D. Cronin

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 410 KB

english, 2012

19

Safety evaluation of a high lipid Whole Algalin Flour (WAF) from Chlorella protothecoides

Nancy J. Szabo, Ray A. Matulka, Linda Kiss, Peter Licari

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 423 KB

english, 2012

20

Menthol smoking in relation to time to first cigarette and cotinine: Results from a community-based study

Joshua E. Muscat, Hsiao-Pin Liu, Steven D. Stellman, John P. Richie Jr.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 184 KB

english, 2012

21

Cover 2–Editorial Board

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 35 KB

english, 2012

22

Reviewer Acknowledgment

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 119 KB

english, 2012

Volume 63; Issue 1

Regulatory Toxicology and Pharmacology

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: A combination study design in support of a Paediatric Investigation Plan

Oral bioaccessibility testing and read-across hazard assessment of nickel compounds

Application of computational toxicological approaches in human health risk assessment. I. A tiered surrogate approach

Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation

Workshop: Combined exposure to chemicals

Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: Was causality adequately ascertained?

Assessment of potential asbestos exposures from jet engine overhaul work

Consumer inhalation exposure to formaldehyde from the use of personal care products/cosmetics

A regulatory approach to assess the potency of substances toxic to the reproduction

MetaPath: An electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism

Comparative toxicokinetics of low-viscosity mineral oil in Fischer 344 rats, Sprague–Dawley rats, and humans – Implications for an Acceptable Daily Intake (ADI)

Toxicity assay in repeated doses of Dermatophagoides siboney allergen extract in mice

Mentholated cigarettes and smoking-related cancers revisited: An ecologic examination

Risk assessment of gamma-hydroxybutyric acid (GHB) in the Netherlands

Safety assessment of methanol extract of red dragon fruit (Hylocereus polyrhizus): Acute and subchronic toxicity studies

Acetylcholinesterase inhibition dose–response modeling for chlorpyrifos and chlorpyrifos-oxon

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: A workshop report

Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy

Safety evaluation of a high lipid Whole Algalin Flour (WAF) from Chlorella protothecoides

Menthol smoking in relation to time to first cigarette and cotinine: Results from a community-based study

Cover 2–Editorial Board

Table of Contents

Reviewer Acknowledgment