Regulatory Toxicology and Pharmacology

1

Use of category approaches, read-across and (Q)SAR: General considerations

Patlewicz, Grace, Ball, Nicholas, Booth, Ewan D., Hulzebos, Etje, Zvinavashe, Elton, Hennes, Christa

Journal:

Year:

2013

Language:

english

File:

PDF, 401 KB

english, 2013

2

An empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty

Wheeler, Matthew W., Bailer, A. John

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 738 KB

english, 2013

3

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities

Sutter, Andreas, Amberg, Alexander, Boyer, Scott, Brigo, Alessandro, Contrera, Joseph F., Custer, Laura L., Dobo, Krista L., Gervais, Veronique, Glowienke, Susanne, Gompel, Jacky van, Greene, Nigel, M

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

4

Pressor mechanism evaluation for phytochemical compounds using in silico compound–protein interaction prediction

He, Min, Cao, Dong-Sheng, Liang, Yi-Zeng, Li, Ya-Ping, Liu, Ping-Le, Xu, Qing-Song, Huang, Ren-Bin

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

5

Use of low-dose clinical pharmacodynamic and pharmacokinetic data to establish an occupational exposure limit for dapagliflozin, a potent inhibitor of the renal sodium glucose co-transporter 2

Gould, Janet C., Kasichayanula, Sreeneeranj, Shepperly, David C., Boulton, David W.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 549 KB

english, 2013

6

A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies

Chapman, Kathryn, Sewell, Fiona, Allais, Linda, Delongeas, Jean-Luc, Donald, Elizabeth, Festag, Matthias, Kervyn, Sophie, Ockert, Deborah, Nogues, Vicente, Palmer, Helen, Popovic, Marija, Roosen, Wend

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.89 MB

english, 2013

7

Relative source allocation of TDI to drinking water for derivation of a criterion for chloroform: A Monte-Carlo and multi-exposure assessment

Niizuma, Shun, Matsui, Yoshihiko, Ohno, Koichi, Itoh, Sadahiko, Matsushita, Taku, Shirasaki, Nobutaka

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 920 KB

english, 2013

8

Preclinical safety evaluation of rAd5-hTERTC27 by intravenous injection

Yue, Pei-jian, He, Lei, Li, Yi, Shen, Qing-yu, Li, Mei, Huang, Da-quan, Huang, Jun-Jian, Peng, Ying

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1016 KB

english, 2013

9

Potency matters: Thresholds govern endocrine activity

Borgert, Christopher J., Baker, Stephen P., Matthews, John C.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 299 KB

english, 2013

10

Gene batteries and synexpression groups applied in a multivariate statistical approach to dose–response analysis of toxicogenomic data

Parfett, C., Williams, A., Zheng, J.L., Zhou, G.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

11

Cover 2–Editorial Board

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 35 KB

english, 2013

12

Qualification of cardiac troponins for nonclinical use: A regulatory perspective

Hausner, E.A., Hicks, K.A., Leighton, J.K., Szarfman, A., Thompson, A.M., Harlow, P.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 334 KB

english, 2013

13

How rapidly does the excess risk of lung cancer decline following quitting smoking? A quantitative review using the negative exponential model

Fry, John S., Lee, Peter N., Forey, Barbara A., Coombs, Katharine J.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 417 KB

english, 2013

14

Volume 67; Issue 1

Regulatory Toxicology and Pharmacology

Use of category approaches, read-across and (Q)SAR: General considerations

An empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities

Pressor mechanism evaluation for phytochemical compounds using in silico compound–protein interaction prediction

Use of low-dose clinical pharmacodynamic and pharmacokinetic data to establish an occupational exposure limit for dapagliflozin, a potent inhibitor of the renal sodium glucose co-transporter 2

A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies

Relative source allocation of TDI to drinking water for derivation of a criterion for chloroform: A Monte-Carlo and multi-exposure assessment

Preclinical safety evaluation of rAd5-hTERTC27 by intravenous injection

Potency matters: Thresholds govern endocrine activity

Gene batteries and synexpression groups applied in a multivariate statistical approach to dose–response analysis of toxicogenomic data

Cover 2–Editorial Board

Qualification of cardiac troponins for nonclinical use: A regulatory perspective

How rapidly does the excess risk of lung cancer decline following quitting smoking? A quantitative review using the negative exponential model

Table of Contents