Regulatory Toxicology and Pharmacology

1

Acute and sub-chronic toxicity studies of honokiol microemulsion

Zhang, Qianqian, Li, Jianguo, Zhang, Wei, An, Quan, Wen, Jianhua, Wang, Aiping, Jin, Hongtao, Chen, Shizhong

Journal:

Year:

2015

Language:

english

File:

PDF, 1.88 MB

english, 2015

2

The combination of two novel tobacco blends and filter technologies to reduce the in vitro genotoxicity and cytotoxicity of prototype cigarettes

Crooks, Ian, Scott, Ken, Dalrymple, Annette, Dillon, Debbie, Meredith, Clive

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

3

An FDA oncology analysis of antibody-drug conjugates

Saber, Haleh, Leighton, John K.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 946 KB

english, 2015

4

Estimating skin sensitization potency from a single dose LLNA

Roberts, David W.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 699 KB

english, 2015

5

Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines

Skare, Julie A., Blackburn, Karen, Wu, Shengde, Re, Thomas A., Duche, Daniel, Ringeissen, Stephanie, Bjerke, Donald L., Srinivasan, Viny, Eisenmann, Carol

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 2.17 MB

english, 2015

6

Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration

Fei, Chenzhong, Zhang, Jie, Lin, Yang, Wang, Xiaoyang, Zhang, Keyu, Zhang, Lifang, Zheng, Wenli, Wang, Mi, Li, Tao, Xiao, Sui, Xue, Feiqun, Wang, Chunmei

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 518 KB

english, 2015

7

An evaluation of in-house and off-the-shelf in silico models: Implications on guidance for mutagenicity assessment

Jolly, Robert, Riaz Ahmed, Kausar Begam, Zwickl, Craig, Watson, Ian, Gombar, Vijay

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

8

Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential

Che, Jeong-Hwan, Yun, Jun-Won, Kim, Yun-Soon, Kim, Seung-Hyun, You, Ji-Ran, Jang, Ja-June, Kim, Hee Chan, Kim, Hyeon Hoe, Kang, Byeong-Cheol

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

9

Acute and subchronic (28days) oral toxicity studies of Codonopsis lanceolata extract in Sprague–Dawley rats

Lee, Jong Seok, Kim, Young-Hyun, Kim, Dan-Bi, Shin, Gi-Hae, Lee, Jin-Ha, Cho, Ju-Hyun, Lee, Boo-Yong, Lee, Ok-Hwan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 657 KB

english, 2015

10

Increased use in propofol and reported patterns of adverse events among anesthetics in Korea

Park, Hyo-Ju, Shin, Ju-Young, Kim, Mi-Hee, Park, Byung-Joo

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 562 KB

english, 2015

11

Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: Propofol, midazolam, diazepam, and lorazepam

Shin, Ju-Young, Lee, Shin Haeng, Shin, Sun Mi, Kim, Mi Hee, Park, Sung Geon, Park, Byung-Joo

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 768 KB

english, 2015

12

Genotoxicity studies on the root extract of Polygala tenuifolia Willdenow

Shin, Ki Young, Won, Beom Young, Ha, Hyun Jee, Yun, Yeo Sang, Lee, Hyung Gun

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 300 KB

english, 2015

13

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

Patlewicz, Grace, Simon, Ted W., Rowlands, J. Craig, Budinsky, Robert A., Becker, Richard A.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.38 MB

english, 2015

14

A critical examination of the mode of action of quinacrine in the reproductive tract in a 2-year rat cancer bioassay and its implications for human clinical use

Haseman, Joseph K., Growe, Roger G., Zeiger, Errol, McConnell, Ernest E., Luster, Michael I., Lippes, Jack

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 454 KB

english, 2015

15

Endocrine activity of alternatives to BPA found in thermal paper in Switzerland

Goldinger, Daniela M., Demierre, Anne-Laure, Zoller, Otmar, Rupp, Heinz, Reinhard, Hans, Magnin, Roxane, Becker, Thomas W., Bourqui-Pittet, Martine

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

16

A first-generation physiologically based pharmacokinetic (PBPK) model of alpha-tocopherol in human influenza vaccine adjuvant

Tegenge, Million A., Mitkus, Robert J.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

17

Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: Alternative approaches

Buist, H.E., Devito, S., Goldbohm, R.A., Stierum, R.H., Venhorst, J., Kroese, E.D.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.92 MB

english, 2015

18

Safety evaluation of standardized allergen extract of Japanese cedar pollen for sublingual immunotherapy

Mitobe, Yuko, Yokomoto, Yasuki, Ohashi-Doi, Katsuyo

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

19

Cover 2–Editorial Board

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 33 KB

english, 2015

20

Animal rights activists: Misconceived proposals

Vivarelli, Fabio, Canistro, Donatella, Marquillas, Clara Babot, Sapone, Andrea, Paolini, Moreno

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 194 KB

english, 2015

22

Variation in tobacco and mainstream smoke toxicant yields from selected commercial cigarette products

Eldridge, A., Betson, T.R., Gama, M. Vinicius, McAdam, K.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1007 KB

english, 2015

23

An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept

Becker, Richard A., Friedman, Katie Paul, Simon, Ted W., Marty, M. Sue, Patlewicz, Grace, Rowlands, J. Craig

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 3.34 MB

english, 2015

24

Safety evaluation of metal exposure from commonly used moisturizing and skin-lightening creams in Nigeria

Iwegbue, Chukwujindu M.A., Bassey, Francisca I., Tesi, Godswill O., Onyeloni, Sunday O., Obi, Grace, Martincigh, Bice S.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 313 KB

english, 2015

25

Do group responses mask the effects of air pollutants on potentially sensitive individuals in controlled human exposure studies?

Goodman, Julie E., Seeley, Mara, Mattuck, Rosemary, Thakali, Sagar

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 789 KB

english, 2015

26

Response to “A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice.”

Heinemann, Jack A., Agapito-Tenfen, Sarah Z., Kurenbach, Brigitta

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 214 KB

english, 2015

27

Authors’ Response to Letter to the Editor by Heinemann et al. “Response to ‘A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice.’” 2015

Petrick, Jay S., Moore, William M., Heydens, William F., Koch, Michael S., Sherman, James H., Lemke, Shawna L.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 208 KB

english, 2015

28

A study to investigate changes in the levels of biomarkers of exposure to selected cigarette smoke constituents in Japanese adult male smokers who switched to a non-combustion inhaler type of tobacco product

Miura, Naoki, Yuki, Dai, Minami, Naoki, Kakehi, Aoi, Futamura, Yasuyuki

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 436 KB

english, 2015

29

Mode of action and human relevance of pronamide-induced rat thyroid tumors

Papineni, Sabitha, Marty, M. Sue, Rasoulpour, Reza J., LeBaron, Matthew J., Pottenger, Lynn H., Eisenbrandt, David L.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 906 KB

english, 2015

30

Tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine (Sus scrofa domestica) as it relates to withdrawal methods for international export

Mason, Sharon E., Wu, Huali, Yeatts, Jim E., Baynes, Ronald E.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 470 KB

english, 2015

31

Evaluating the validity and applicable domain of the toxic load model: Impact of concentration vs. time profile on inhalation lethality of hydrogen cyanide

Sweeney, Lisa M., Sommerville, Douglas R., Channel, Stephen R., Sharits, Brian C., Gargas, Nathan M., Gut, Chester P.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.29 MB

english, 2015

Volume 71; Issue 3

Regulatory Toxicology and Pharmacology

Acute and sub-chronic toxicity studies of honokiol microemulsion

The combination of two novel tobacco blends and filter technologies to reduce the in vitro genotoxicity and cytotoxicity of prototype cigarettes

An FDA oncology analysis of antibody-drug conjugates

Estimating skin sensitization potency from a single dose LLNA

Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines

Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration

An evaluation of in-house and off-the-shelf in silico models: Implications on guidance for mutagenicity assessment

Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential

Acute and subchronic (28days) oral toxicity studies of Codonopsis lanceolata extract in Sprague–Dawley rats

Increased use in propofol and reported patterns of adverse events among anesthetics in Korea

Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: Propofol, midazolam, diazepam, and lorazepam

Genotoxicity studies on the root extract of Polygala tenuifolia Willdenow

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

A critical examination of the mode of action of quinacrine in the reproductive tract in a 2-year rat cancer bioassay and its implications for human clinical use

Endocrine activity of alternatives to BPA found in thermal paper in Switzerland

A first-generation physiologically based pharmacokinetic (PBPK) model of alpha-tocopherol in human influenza vaccine adjuvant

Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: Alternative approaches

Safety evaluation of standardized allergen extract of Japanese cedar pollen for sublingual immunotherapy

Cover 2–Editorial Board

Table of Contents

Animal rights activists: Misconceived proposals

Variation in tobacco and mainstream smoke toxicant yields from selected commercial cigarette products

An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept

Safety evaluation of metal exposure from commonly used moisturizing and skin-lightening creams in Nigeria

Do group responses mask the effects of air pollutants on potentially sensitive individuals in controlled human exposure studies?

Response to “A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice.”

Authors’ Response to Letter to the Editor by Heinemann et al. “Response to ‘A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice.’” 2015

A study to investigate changes in the levels of biomarkers of exposure to selected cigarette smoke constituents in Japanese adult male smokers who switched to a non-combustion inhaler type of tobacco product

Mode of action and human relevance of pronamide-induced rat thyroid tumors

Tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine (Sus scrofa domestica) as it relates to withdrawal methods for international export

Evaluating the validity and applicable domain of the toxic load model: Impact of concentration vs. time profile on inhalation lethality of hydrogen cyanide