Volume 13; Issue 3

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The AAPS Journal
Volume 13; Issue 3

The AAPS Journal

Volume 13; Issue 3

1

Dissolution Testing for Generic Drugs: An FDA Perspective

Om Anand, Lawrence X. Yu, Dale P. Conner, Barbara M. Davit

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 349 KB

english, 2011

2

Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

U. V. R. Vijaya Saradhi, Sneha V. Gupta, Ming Chiu, Jiang Wang, Yonghua Ling, Zhongfa Liu, David J. Newman, Joseph M. Covey, A. Douglas Kinghorn, Guido Marcucci, David M. Lucas, Michael R. Grever, Mit

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 407 KB

english, 2011

3

Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents

Nidhi Kaushal, Matthew J. Robson, Harsha Vinnakota, Sanju Narayanan, Bonnie A. Avery, Christopher R. McCurdy, Rae R. Matsumoto

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 350 KB

english, 2011

4

Erratum to: Translational Biomarkers: from Preclinical to Clinical a Report of 2009 AAPS/ACCP Biomarker Workshop

Jane P. F. Bai, Robert Bell, ShaAvhree Buckman, Gilbert J. Burckart, Hans-Georg Eichler, Kenneth C. Fang, Federico M. Goodsaid, William J. Jusko, Lawrence L. Lesko, Bernd Meibohm, Scott D. Patterson,

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 81 KB

english, 2011

5

Resistance to the Translation Initiation Inhibitor Silvestrol is Mediated byABCB1/P-Glycoprotein Overexpression in Acute Lymphoblastic Leukemia Cells

Sneha V. Gupta, Ellen J. Sass, Melanie E. Davis, Ryan B. Edwards, Gerard Lozanski, Nyla A. Heerema, Amy Lehman, Xiaoli Zhang, David Jarjoura, John C. Byrd, Li Pan, Kenneth K. Chan, A. Douglas Kinghorn

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 379 KB

english, 2011

6

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In VitroandIn VivoEvidences

Li Zhang, Chenrui Li, Ge Lin, Peter Krajcsi, Zhong Zuo

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 570 KB

english, 2011

7

Editorial: A New Series of Commentaries Entitled “Landmark Publications in the Pharmaceutical Sciences: The Backstory”

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 91 KB

english, 2011

8

Novel Molecular Targets ofAzadirachta indicaAssociated with Inhibition of Tumor Growth in Prostate Cancer

Saswati Mahapatra, R. Jeffrey Karnes, Michael W. Holmes, Charles Y. F. Young, John C. Cheville, Manish Kohli, Eric W. Klee, Donald J. Tindall, Krishna Vanaja Donkena

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 909 KB

english, 2011

9

Levy G, Hayes B, “Physiochemical Basis of the Buffered Acetylsalicylic Acid Controversy New Engl. J. Med. 262:1053–1058 (1960)”—The Backstory

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 107 KB

english, 2011

10

Vaccinomics: Current Findings, Challenges and Novel Approaches for Vaccine Development

Inna G. Ovsyannikova, Gregory A. Poland

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 302 KB

english, 2011

11

Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model

Julie Bertrand, Céline M. Laffont, France Mentré, Marylore Chenel, Emmanuelle Comets

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 874 KB

english, 2011

12

Hidalgo, I. J., Raub, T. J., and Borchardt, R. T.: Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability,Gastroenterology, 96, 736–749, 1989—The Backstory

Ronald T. Borchardt

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 131 KB

english, 2011

13

Modeling the Effects of Vaccination and Treatment on Pandemic Influenza

Zhilan Feng, Sherry Towers, Yiding Yang

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

14

AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development

Sandhya Girish, Steven W Martin, Mark C Peterson, Lei K. Zhang, Hong Zhao, Joseph Balthasar, Raymond Evers, Honghui Zhou, Min Zhu, Lewis Klunk, Chao Han, Eva Gil Berglund, Shiew-Mei Huang, Amita Joshi

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 464 KB

english, 2011

15

Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans

Yanke Yu, Suzanna Zick, Xiaoqin Li, Peng Zou, Benjamin Wright, Duxin Sun

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 399 KB

english, 2011

16

Multinomial Logistic Functions in Markov Chain Models of Sleep Architecture: Internal and External Validation and Covariate Analysis

Roberto Bizzotto, Stefano Zamuner, Enrica Mezzalana, Giuseppe De Nicolao, Roberto Gomeni, Andrew C. Hooker, Mats O. Karlsson

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 2.60 MB

english, 2011

17

Characterization of Microchannels Created by Metal Microneedles: Formation and Closure

Haripriya Kalluri, Chandra Sekhar Kolli, Ajay K. Banga

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 819 KB

english, 2011

18

A Fast Method for Testing Covariates in Population PK/PD Models

Akash Khandelwal, Kajsa Harling, E. Niclas Jonsson, Andrew C. Hooker, Mats O. Karlsson

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

19

Combined Use ofIn VitroPhototoxic Assessments and Cassette Dosing Pharmacokinetic Study for Phototoxicity Characterization of Fluoroquinolones

Yoshiki Seto, Ryo Inoue, Masanori Ochi, Graham Gandy, Shizuo Yamada, Satomi Onoue

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 544 KB

english, 2011