Volume 14; Issue 4

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The AAPS Journal
Volume 14; Issue 4

The AAPS Journal

Volume 14; Issue 4

1

Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?

Diab, Roudayna, Jaafar-Maalej, Chiraz, Fessi, Hatem, Maincent, Philippe

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 306 KB

english, 2012

2

Drug Repurposing: Far Beyond New Targets for Old Drugs

Oprea, T. I., Mestres, J.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 219 KB

english, 2012

3

Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Generic Drug Products by the US Food and Drug Administration

Davit, Barbara M., Chen, Mei-Ling, Conner, Dale P., Haidar, Sam H., Kim, Stephanie, Lee, Christina H., Lionberger, Robert A., Makhlouf, Fairouz T., Nwakama, Patrick E., Patel, Devvrat T., Schuirmann,

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 404 KB

english, 2012

4

Effective Absorption Modeling in Relative Bioavailability Study Risk Assessment

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 391 KB

english, 2012

5

Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs

Gao, Ping, Shi, Yi

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 588 KB

english, 2012

6

Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds

Kesisoglou, Filippos, Mitra, Amitava

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 389 KB

english, 2012

7

Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development

Thomas, Nicky, Holm, René, Rades, Thomas, Müllertz, Anette

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 423 KB

english, 2012

8

Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site

Mohammed, Diar, Matts, Paul J., Hadgraft, Jonathan, Lane, Majella E.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 305 KB

english, 2012

9

Guidelines for the Quality Control of Population Pharmacokinetic–Pharmacodynamic Analyses: an Industry Perspective

Bonate, P. L., Strougo, A., Desai, A., Roy, M., Yassen, A., Walt, J. S., Kaibara, A., Tannenbaum, S.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 278 KB

english, 2012

10

Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics

Xu, Xin, Vugmeyster, Yulia

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 284 KB

english, 2012

11

Statistics on BCS Classification of Generic Drug Products Approved Between 2000 and 2011 in the USA

Nair, Anil K., Anand, Om, Chun, Nam, Conner, Dale P., Mehta, Mehul U., Nhu, Duong T., Polli, James E., Yu, Lawrence X., Davit, Barbara M.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 197 KB

english, 2012

12

Use of Partial Area under the Curve Metrics to Assess Bioequivalence of Methylphenidate Multiphasic Modified Release Formulations

Stier, Ethan M., Davit, Barbara M., Chandaroy, Parthapratim, Chen, Mei-Ling, Fourie-Zirkelbach, Jeanne, Jackson, Andre, Kim, Stephanie, Lionberger, Robert, Mehta, Mehul, Uppoor, Ramana S., Wang, Yanin

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 145 KB

english, 2012

13

Regulatory Pathways for ATP-binding Cassette Transport Proteins in Kidney Proximal Tubules

Masereeuw, Rosalinde, Russel, Frans G. M.

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 378 KB

english, 2012

14

Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice

Rozewski, Darlene M., Herman, Sarah E. M., Towns, William H., Mahoney, Emilia, Stefanovski, Matthew R., Shin, Jungook D., Yang, Xiaoxia, Gao, Yue, Li, Xiaobai, Jarjoura, David, Byrd, John C., Johnson,

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 317 KB

english, 2012

15

Bioequivalence Requirements in the European Union: Critical Discussion

GarcÃa-Arieta, Alfredo, Gordon, John

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 207 KB

english, 2012

16

Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions

Vugmeyster, Yulia, Harrold, John, Xu, Xin

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 869 KB

english, 2012

17

Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints

Anders Viberg, Giovanni Martino, Etienne Lessard, Jennifer M. A. Laird

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 489 KB

english, 2012

18

Effect of Device Design on theIn VitroPerformance and Comparability for Capsule-Based Dry Powder Inhalers

Jagdeep Shur, Sau Lee, Wallace Adams, Robert Lionberger, James Tibbatts…

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 505 KB

english, 2012

19

Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry

Robert Erb, Katharina Leithner, Andreas Bernkop-Schnürch…

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 576 KB

english, 2012

20

Rationalizing Structure and Target Relationships between Current Drugs

Ye Hu, Jürgen Bajorath

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 481 KB

english, 2012

21

A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS

Buyun Chen, Michael Bartlett

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 613 KB

english, 2012

22

International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States

Chantal Lainesse

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 130 KB

english, 2012

23

ADME of Antibody–Maytansinoid Conjugates

Hans K. Erickson, John M. Lambert

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 857 KB

english, 2012

24

Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations

Laszlo Endrenyi, Laszlo Tothfalusi

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 252 KB

english, 2012

25

Monoamine Transporter Structure, Function, Dynamics, and Drug Discovery: A Computational Perspective

Sankar Manepalli, Christopher K. Surratt, Jeffry D. Madura…

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 769 KB

english, 2012

26

Functional and Molecular Aspects of Biotin UptakeviaSMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells

Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Dhananjay Pal…

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 442 KB

english, 2012

27

Universal Immunoassay Applied During Early Development of Large Molecules to Understand Impact of Immunogenicity on Biotherapeutic Exposure

Ami C. Bautista, Hossein Salimi-Moosavi, Vibha Jawa

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 469 KB

english, 2012

28

Evaluation of a Catenary PBPK Model for Predicting theIn VivoDisposition of mAbs Engineered for High-Affinity Binding to FcRn

Yang Chen, Joseph P. Balthasar

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 311 KB

english, 2012

29

Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats

Nieves Vélez de Mendizábal, Dalia Vásquez-Bahena…

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 792 KB

english, 2012

30

Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact

Xu Steven Xu, Min Yuan, Mats O. Karlsson, Adrian Dunne, Partha Nandy…

Journal:

The AAPS Journal

Year:

2012

Language:

english

File:

PDF, 587 KB

english, 2012