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Volume 14; Issue 4
Main
The AAPS Journal
Volume 14; Issue 4
The AAPS Journal
Volume 14; Issue 4
1
Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?
Diab, Roudayna
,
Jaafar-Maalej, Chiraz
,
Fessi, Hatem
,
Maincent, Philippe
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 306 KB
Your tags:
english, 2012
2
Drug Repurposing: Far Beyond New Targets for Old Drugs
Oprea, T. I.
,
Mestres, J.
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 219 KB
Your tags:
english, 2012
3
Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Generic Drug Products by the US Food and Drug Administration
Davit, Barbara M.
,
Chen, Mei-Ling
,
Conner, Dale P.
,
Haidar, Sam H.
,
Kim, Stephanie
,
Lee, Christina H.
,
Lionberger, Robert A.
,
Makhlouf, Fairouz T.
,
Nwakama, Patrick E.
,
Patel, Devvrat T.
,
Schuirmann,
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 404 KB
Your tags:
english, 2012
4
Effective Absorption Modeling in Relative Bioavailability Study Risk Assessment
Rose, John P.
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 391 KB
Your tags:
english, 2012
5
Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs
Gao, Ping
,
Shi, Yi
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 588 KB
Your tags:
english, 2012
6
Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds
Kesisoglou, Filippos
,
Mitra, Amitava
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 389 KB
Your tags:
english, 2012
7
Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development
Thomas, Nicky
,
Holm, René
,
Rades, Thomas
,
Müllertz, Anette
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 423 KB
Your tags:
english, 2012
8
Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site
Mohammed, Diar
,
Matts, Paul J.
,
Hadgraft, Jonathan
,
Lane, Majella E.
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 305 KB
Your tags:
english, 2012
9
Guidelines for the Quality Control of Population Pharmacokinetic–Pharmacodynamic Analyses: an Industry Perspective
Bonate, P. L.
,
Strougo, A.
,
Desai, A.
,
Roy, M.
,
Yassen, A.
,
Walt, J. S.
,
Kaibara, A.
,
Tannenbaum, S.
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 278 KB
Your tags:
english, 2012
10
Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics
Xu, Xin
,
Vugmeyster, Yulia
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 284 KB
Your tags:
english, 2012
11
Statistics on BCS Classification of Generic Drug Products Approved Between 2000 and 2011 in the USA
Nair, Anil K.
,
Anand, Om
,
Chun, Nam
,
Conner, Dale P.
,
Mehta, Mehul U.
,
Nhu, Duong T.
,
Polli, James E.
,
Yu, Lawrence X.
,
Davit, Barbara M.
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 197 KB
Your tags:
english, 2012
12
Use of Partial Area under the Curve Metrics to Assess Bioequivalence of Methylphenidate Multiphasic Modified Release Formulations
Stier, Ethan M.
,
Davit, Barbara M.
,
Chandaroy, Parthapratim
,
Chen, Mei-Ling
,
Fourie-Zirkelbach, Jeanne
,
Jackson, Andre
,
Kim, Stephanie
,
Lionberger, Robert
,
Mehta, Mehul
,
Uppoor, Ramana S.
,
Wang, Yanin
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 145 KB
Your tags:
english, 2012
13
Regulatory Pathways for ATP-binding Cassette Transport Proteins in Kidney Proximal Tubules
Masereeuw, Rosalinde
,
Russel, Frans G. M.
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 378 KB
Your tags:
english, 2012
14
Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice
Rozewski, Darlene M.
,
Herman, Sarah E. M.
,
Towns, William H.
,
Mahoney, Emilia
,
Stefanovski, Matthew R.
,
Shin, Jungook D.
,
Yang, Xiaoxia
,
Gao, Yue
,
Li, Xiaobai
,
Jarjoura, David
,
Byrd, John C.
,
Johnson,
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 317 KB
Your tags:
english, 2012
15
Bioequivalence Requirements in the European Union: Critical Discussion
GarcÃa-Arieta, Alfredo
,
Gordon, John
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 207 KB
Your tags:
english, 2012
16
Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions
Vugmeyster, Yulia
,
Harrold, John
,
Xu, Xin
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 869 KB
Your tags:
english, 2012
17
Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints
Anders Viberg, Giovanni Martino, Etienne Lessard, Jennifer M. A. Laird
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 489 KB
Your tags:
english, 2012
18
Effect of Device Design on theIn VitroPerformance and Comparability for Capsule-Based Dry Powder Inhalers
Jagdeep Shur, Sau Lee, Wallace Adams, Robert Lionberger, James Tibbatts…
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 505 KB
Your tags:
english, 2012
19
Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry
Robert Erb, Katharina Leithner, Andreas Bernkop-Schnürch…
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 576 KB
Your tags:
english, 2012
20
Rationalizing Structure and Target Relationships between Current Drugs
Ye Hu, Jürgen Bajorath
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 481 KB
Your tags:
english, 2012
21
A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS
Buyun Chen, Michael Bartlett
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 613 KB
Your tags:
english, 2012
22
International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States
Chantal Lainesse
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 130 KB
Your tags:
english, 2012
23
ADME of Antibody–Maytansinoid Conjugates
Hans K. Erickson, John M. Lambert
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 857 KB
Your tags:
english, 2012
24
Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations
Laszlo Endrenyi, Laszlo Tothfalusi
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 252 KB
Your tags:
english, 2012
25
Monoamine Transporter Structure, Function, Dynamics, and Drug Discovery: A Computational Perspective
Sankar Manepalli, Christopher K. Surratt, Jeffry D. Madura…
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 769 KB
Your tags:
english, 2012
26
Functional and Molecular Aspects of Biotin UptakeviaSMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells
Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Dhananjay Pal…
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 442 KB
Your tags:
english, 2012
27
Universal Immunoassay Applied During Early Development of Large Molecules to Understand Impact of Immunogenicity on Biotherapeutic Exposure
Ami C. Bautista, Hossein Salimi-Moosavi, Vibha Jawa
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 469 KB
Your tags:
english, 2012
28
Evaluation of a Catenary PBPK Model for Predicting theIn VivoDisposition of mAbs Engineered for High-Affinity Binding to FcRn
Yang Chen, Joseph P. Balthasar
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 311 KB
Your tags:
english, 2012
29
Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats
Nieves Vélez de Mendizábal, Dalia Vásquez-Bahena…
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 792 KB
Your tags:
english, 2012
30
Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact
Xu Steven Xu, Min Yuan, Mats O. Karlsson, Adrian Dunne, Partha Nandy…
Journal:
The AAPS Journal
Year:
2012
Language:
english
File:
PDF, 587 KB
Your tags:
english, 2012
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