Volume 15; Issue 1

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The AAPS Journal
Volume 15; Issue 1

The AAPS Journal

Volume 15; Issue 1

1

Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products

Chang, Rong-Kun, Raw, Andre, Lionberger, Robert, Yu, Lawrence

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 222 KB

english, 2013

2

Determination of the Dominant Arachidonic Acid Cytochrome P450 Monooxygenases in Rat Heart, Lung, Kidney, and Liver: Protein Expression and Metabolite Kinetics

El-Sherbeni, Ahmed A., Aboutabl, Mona E., Zordoky, Beshay N. M., Anwar-Mohamed, Anwar, El-Kadi, Ayman O. S.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 341 KB

english, 2013

3

How Promiscuous Are Pharmaceutically Relevant Compounds? A Data-Driven Assessment

Hu, Ye, Bajorath, Jürgen

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 497 KB

english, 2013

4

The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance

Gao, Mingming, Liu, Dexi

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 818 KB

english, 2013

5

Case Studies for Practical Food Effect Assessments across BCS/BDDCS Class Compounds usingIn Silico,In Vitro, and PreclinicalIn VivoData

Heimbach, Tycho, Xia, Binfeng, Lin, Tsu-han, He, Handan

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 859 KB

english, 2013

6

Amino-Terminated Generation 2 Poly(amidoamine) Dendrimer as a Potential Broad-Spectrum, Nonresistance-Inducing Antibacterial Agent

Xue, Xiaoyan, Chen, Xiaoqing, Mao, Xinggang, Hou, Zheng, Zhou, Ying, Bai, Hui, Meng, Jingru, Da, Fei, Sang, Guojun, Wang, Yukun, Luo, Xiaoxing

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

7

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

Gupta, Subash C., Patchva, Sridevi, Aggarwal, Bharat B.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 864 KB

english, 2013

8

A Novel Beads-Based Dissolution Method for theIn VitroEvaluation of Extended Release HPMC Matrix Tablets and the Correlation with theIn VivoData

KlanÄar, UroÅ¡, Markun, BoÅ¡tjan, Baumgartner, SaÅ¡a, Legen, Igor

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 356 KB

english, 2013

9

Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells

Pawaskar, Dipti K., Straubinger, Robert M., Fetterly, Gerald J., Ma, Wen W., Jusko, William J.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 357 KB

english, 2013

10

Study Reanalysis Using a Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes

Fang, Jing, Landersdorfer, Cornelia B., Cirincione, Brenda, Jusko, William J.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

11

A Stability Analysis of a Modified Version of the Chi-Square Ratio Statistic: Implications for Equivalence Testing of Aerodynamic Particle Size Distribution

Weber, Benjamin, Hochhaus, Guenther, Adams, Wallace, Lionberger, Robert, Li, Bing, Tsong, Yi, Lee, Sau L.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 365 KB

english, 2013

12

A Pharmacokinetic Simulation Tool for Inhaled Corticosteroids

Weber, Benjamin, Hochhaus, Guenther

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 326 KB

english, 2013

13

Common Reasons for “For-Cause” Inspections in Bioequivalence Studies Submitted to the Food and Drug Administration

Li, Bing V., Davit, Barbara M., Lee, Christina H., Pabba, Santhosh K., Mahadevan, Chitra, Caramenico, Hoainhon T., Haidar, Sam H, Sanchez, Aida L., Sigler, Aaron W., Stier, Ethan M., Conner, Dale P.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 194 KB

english, 2013

14

Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) Enhance the Bioavailability of the Poorly Water-Soluble Drug Simvastatin in Dogs

Thomas, Nicky, Holm, RenÃ©, Garmer, Mats, Karlsson, Jens Jakob, MÃ¼llertz, Anette, Rades, Thomas

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 214 KB

english, 2013

15

In VitroandIn VivoEvaluation of a Water-in-Oil Microemulsion System for Enhanced Peptide Intestinal Delivery

Liu, Dongyun, Kobayashi, Taku, Russo, Steven, Li, Fengling, Plevy, Scott E., Gambling, Todd M., Carson, Johnny L., Mumper, Russell J.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 741 KB

english, 2013

16

Mechanistic Models Describing Active Renal Reabsorption and Secretion: A Simulation-Based Study

Felmlee, Melanie A., Dave, Rutwij A., Morris, Marilyn E.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 706 KB

english, 2013

17

Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease

Wang, Li, Sweet, Douglas H.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 306 KB

english, 2013

18

Pocket-Based Drug Design: Exploring Pocket Space

Zheng, Xiliang, Gan, LinFeng, Wang, Erkang, Wang, Jin

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 714 KB

english, 2013

19

In VivoQuantification of Active Decitabine-Triphosphate Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia

Wang, Hongyan, Chen, Ping, Wang, Jiang, Santhanam, Ramasamy, Aimiuwu, Josephine, Saradhi, U. V. Vijaya, Liu, Zhongfa, Schwind, Sebastian, Mims, Alice, Byrd, John C., Grever, Michael R., Villalona-Cale

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 395 KB

english, 2013

20

Stratification of Antibody-Positive Subjects by Antibody Level Reveals an Impact of Immunogenicity on Pharmacokinetics

Lei Zhou, Sarah A. Hoofring, Yu Wu, Thuy Vu, Peiming Ma…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 714 KB

english, 2013

21

Specific Method Validation and Sample Analysis Approaches for Biocomparability Studies of Denosumab Addressing Method and Manufacture Site Changes

Ramak Pourvasei, Ed Lee, Michael Eschenberg, Vimal Patel…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 281 KB

english, 2013

22

Biodegradable Particles as Vaccine Delivery Systems: Size Matters

Vijaya B. Joshi, Sean M. Geary, Aliasger K. Salem

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 470 KB

english, 2013

23

Pilot Investigation on Long-Term Subcutaneous Microdialysis: Proof of Principle in Humans

Franziska Simmel, Claudia Kirbs, Zeynep Erdogan, Edith Lackner…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 273 KB

english, 2013

24

Validation of a Ligand Binding Assay Using Dried Blood Spot Sampling

Daniel Burns, Laura Brunner, Surendran Rajendran, Beth Johnson, Mark Ma…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 363 KB

english, 2013

25

The Utility of Modeling and Simulation Approaches to Evaluate Immunogenicity Effect on the Therapeutic Protein Pharmacokinetics

Juan Jose Perez Ruixo, Peiming Ma, Andrew T. Chow

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 643 KB

english, 2013

26

Target-Mediated Disposition Model Describing the Dynamics of IL12 and IFNγ after Administration of a Mifepristone-Inducible Adenoviral Vector for IL-12 Expression in Mice

Zinnia Patricia Parra-Guillen, Alvaro Janda, Pilar Alzuguren…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 825 KB

english, 2013

27

Integrated Pharmacokinetic-Driven Approach to Screen Candidate Anticancer Drugs for Brain Tumor Chemotherapy

Hua Lv, Xiaoping Zhang, Jyoti Sharma, M. V. Ramana Reddy…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 236 KB

english, 2013

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