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Volume 15; Issue 2
Main
The AAPS Journal
Volume 15; Issue 2
The AAPS Journal
Volume 15; Issue 2
1
Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis
Teeple, Erin
,
Jay, Gregory D.
,
Elsaid, Khaled A.
,
Fleming, Braden C.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 185 KB
Your tags:
english, 2013
2
Drug Discovery and Regulatory Considerations for ImprovingIn SilicoandIn VitroPredictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements
Larregieu, Caroline A.
,
Benet, Leslie Z.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 346 KB
Your tags:
english, 2013
3
Highly Stabilized Curcumin Nanoparticles Tested in anIn VitroBlood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice
Cheng, Kwok Kin
,
Yeung, Chin Fung
,
Ho, Shuk Wai
,
Chow, Shing Fung
,
Chow, Albert H. L.
,
Baum, Larry
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 580 KB
Your tags:
english, 2013
4
Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney
Motohashi, Hideyuki
,
Inui, Ken-ichi
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 289 KB
Your tags:
english, 2013
5
In VivoQuantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates
Goutelle, Sylvain
,
Bourguignon, Laurent
,
Bleyzac, Nathalie
,
Berry, Johanna
,
Clavel-Grabit, Fannie
,
Tod, Michel
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 438 KB
Your tags:
english, 2013
6
In VitroandIn VivoEvaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound
Chiang, Po-Chang
,
Cui, Yong
,
Ran, Yingqing
,
Lubach, Joe
,
Chou, Kang-Jye
,
Bao, Linda
,
Jia, Wei
,
La, Hank
,
Hau, Jonathan
,
Sambrone, Amy
,
Qin, Ann
,
Deng, Yuzhong
,
Wong, Harvey
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 288 KB
Your tags:
english, 2013
7
Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler—a Case Study on Aerolizer®Foradile®
Zhou, Qi Tony
,
Tong, Zhenbo
,
Tang, Patricia
,
Citterio, Mauro
,
Yang, Runyu
,
Chan, Hak-Kim
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 855 KB
Your tags:
english, 2013
8
A Sensitivity Analysis of the Modified Chi-square Ratio Statistic for Equivalence Testing of Aerodynamic Particle Size Distribution
Weber, Benjamin
,
Lee, Sau L.
,
Lionberger, Robert
,
Li, Bing V.
,
Tsong, Yi
,
Hochhaus, Guenther
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 365 KB
Your tags:
english, 2013
9
Simultaneous Pharmacokinetic Model for Rolofylline and both M1-trans and M1-cis Metabolites
Stroh, Mark
,
Hutmacher, Matthew M.
,
Pang, Jianmei
,
Lutz, Ryan
,
Magara, Hiroshi
,
Stone, Julie
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 407 KB
Your tags:
english, 2013
10
Coexistence of Passive and Proton Antiporter-Mediated Processes in Nicotine Transport at the Mouse Blood–Brain Barrier
Salvatore Cisternino, Hélène Chapy, Pascal André, Maria Smirnova…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 265 KB
Your tags:
english, 2013
11
External Validation of the Bilirubin–Atazanavir Nomogram for Assessment of Atazanavir Plasma Exposure in HIV-1-Infected Patients
Dinko Rekić, Daniel Röshammar, Martin Bergstrand, Joel Tarning…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 378 KB
Your tags:
english, 2013
12
Pharmacokinetics of Levodopa, Carbidopa, and 3-O-Methyldopa Following 16-hour Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease Patients
Dag Nyholm, Per Odin, Anders Johansson, Krai Chatamra, Charles Locke…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 261 KB
Your tags:
english, 2013
13
Simultaneous Analysis of Multiple Monoclonal Antibody Biotherapeutics by LC-MS/MS Method in Rat Plasma Following Cassette-Dosing
Hongyan Li, Robert Ortiz, Linh T. B. Tran, Hossein Salimi-Moosavi…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 611 KB
Your tags:
english, 2013
14
The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane
Arik Dahan, Avital Beig, Viktoriya Ioffe-Dahan, Riad Agbaria…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 467 KB
Your tags:
english, 2013
15
Translational Pharmacokinetic-Pharmacodynamic Modeling from Nonclinical to Clinical Development: A Case Study of Anticancer Drug, Crizotinib
Shinji Yamazaki
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 591 KB
Your tags:
english, 2013
16
Controlled Release of Simvastatin fromIn situForming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells
Yoon Shin Park, Allan E. David, Kyung Min Park, Chia-Ying Lin…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 665 KB
Your tags:
english, 2013
17
Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches
Hannah M. Jones, Kapil Mayawala, Patrick Poulin
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 431 KB
Your tags:
english, 2013
18
Regulatory Administrative Databases in FDA's Center for Biologics Evaluation and Research: Convergence Toward a Unified Database
Jeffrey K. Smith
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 473 KB
Your tags:
english, 2013
19
TargetHunter: AnIn SilicoTarget Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database
Lirong Wang, Chao Ma, Peter Wipf, Haibin Liu, Weiwei Su, Xiang-Qun Xie
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 662 KB
Your tags:
english, 2013
20
Improper Selection of a Pre-specified Primary Dose–Response Analysis Delays Regulatory Drug Approval
Jiang Liu, Pravin Jadhav, Yaning Wang, Jogarao Gobburu
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 426 KB
Your tags:
english, 2013
21
Strategic Applications of Gene Expression: From Drug Discovery/Development to Bedside
Jane P. F. Bai, Alexander V. Alekseyenko, Alexander Statnikov…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 340 KB
Your tags:
english, 2013
22
Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants
Jane P. F. Bai, Jeffrey S. Barrett, Gibert J. Burckart, Bernd Meibohm…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 177 KB
Your tags:
english, 2013
23
A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam
A. R. Maharaj, J. S. Barrett, A. N. Edginton
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 425 KB
Your tags:
english, 2013
24
The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using19F-NMR
Jianqin Zhuang, De-Ping Yang, Spyros P. Nikas, Jianhong Zhao…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 211 KB
Your tags:
english, 2013
25
Chemical Imaging of Drug Delivery Systems with Structured Surfaces–a Combined Analytical Approach of Confocal Raman Microscopy and Optical Profilometry
Birthe Kann, Maike Windbergs
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 530 KB
Your tags:
english, 2013
26
Nonaqueous Gel for the Transdermal Delivery of a DTPA Penta-ethyl Ester Prodrug
Yong Zhang, Matthew P. Sadgrove, Katsuhiko Sueda, Yu-Tsai Yang…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 261 KB
Your tags:
english, 2013
27
Predictions ofIn VivoProlactin Levels fromIn Vitro KiValues of D2Receptor Antagonists Using an Agonist–Antagonist Interaction Model
Klas J. Petersson, An M. Vermeulen, Lena E. Friberg
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 1.35 MB
Your tags:
english, 2013
28
Modeling NSCLC Progression: Recent Advances and Opportunities Available
Ahmed Abbas Suleiman, Lucia Nogova, Uwe Fuhr
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 217 KB
Your tags:
english, 2013
29
Modeling, Simulation, and Translation Framework for the Preclinical Development of Monoclonal Antibodies
Kenneth T. Luu, Eugenia Kraynov, Bing Kuang, Paolo Vicini…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 366 KB
Your tags:
english, 2013
30
Population-Based Efficacy Modeling of Omalizumab in Patients with Severe Allergic Asthma Inadequately Controlled with Standard Therapy
Rui Zhu, Yanan Zheng, Wendy S. Putnam, Jennifer Visich, Mark D. Eisner…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 572 KB
Your tags:
english, 2013
31
Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects
Hwa Yoon, Hea-Young Cho, Hee-Doo Yoo, Se-Mi Kim, Yong-Bok Lee
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 337 KB
Your tags:
english, 2013
32
Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine
Moran Fairstein, Rotem Swissa, Arik Dahan
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 437 KB
Your tags:
english, 2013
33
The Challenges of Assessing Osteoarthritis and Postoperative Pain in Dogs
Michele Sharkey
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 205 KB
Your tags:
english, 2013
34
Direct and Rapid Genotyping ofSLCO1B1388A>G and 521T>C in Human Blood Specimens Using the SmartAmp-2 Method
Kenta Yoshida, Junichi Takano, Yuri Ishizu, Alexander Lezhava…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 223 KB
Your tags:
english, 2013
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