Volume 15; Issue 2

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The AAPS Journal
Volume 15; Issue 2

The AAPS Journal

Volume 15; Issue 2

1

Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

Teeple, Erin, Jay, Gregory D., Elsaid, Khaled A., Fleming, Braden C.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 185 KB

english, 2013

2

Drug Discovery and Regulatory Considerations for ImprovingIn SilicoandIn VitroPredictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

Larregieu, Caroline A., Benet, Leslie Z.

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 346 KB

english, 2013

3

Highly Stabilized Curcumin Nanoparticles Tested in anIn VitroBlood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

Cheng, Kwok Kin, Yeung, Chin Fung, Ho, Shuk Wai, Chow, Shing Fung, Chow, Albert H. L., Baum, Larry

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 580 KB

english, 2013

4

Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney

Motohashi, Hideyuki, Inui, Ken-ichi

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 289 KB

english, 2013

5

In VivoQuantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates

Goutelle, Sylvain, Bourguignon, Laurent, Bleyzac, Nathalie, Berry, Johanna, Clavel-Grabit, Fannie, Tod, Michel

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 438 KB

english, 2013

6

In VitroandIn VivoEvaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

Chiang, Po-Chang, Cui, Yong, Ran, Yingqing, Lubach, Joe, Chou, Kang-Jye, Bao, Linda, Jia, Wei, La, Hank, Hau, Jonathan, Sambrone, Amy, Qin, Ann, Deng, Yuzhong, Wong, Harvey

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

7

Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler—a Case Study on Aerolizer®Foradile®

Zhou, Qi Tony, Tong, Zhenbo, Tang, Patricia, Citterio, Mauro, Yang, Runyu, Chan, Hak-Kim

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 855 KB

english, 2013

8

A Sensitivity Analysis of the Modified Chi-square Ratio Statistic for Equivalence Testing of Aerodynamic Particle Size Distribution

Weber, Benjamin, Lee, Sau L., Lionberger, Robert, Li, Bing V., Tsong, Yi, Hochhaus, Guenther

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 365 KB

english, 2013

9

Simultaneous Pharmacokinetic Model for Rolofylline and both M1-trans and M1-cis Metabolites

Stroh, Mark, Hutmacher, Matthew M., Pang, Jianmei, Lutz, Ryan, Magara, Hiroshi, Stone, Julie

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 407 KB

english, 2013

10

Coexistence of Passive and Proton Antiporter-Mediated Processes in Nicotine Transport at the Mouse Blood–Brain Barrier

Salvatore Cisternino, Hélène Chapy, Pascal André, Maria Smirnova…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 265 KB

english, 2013

11

External Validation of the Bilirubin–Atazanavir Nomogram for Assessment of Atazanavir Plasma Exposure in HIV-1-Infected Patients

Dinko Rekić, Daniel Röshammar, Martin Bergstrand, Joel Tarning…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 378 KB

english, 2013

12

Pharmacokinetics of Levodopa, Carbidopa, and 3-O-Methyldopa Following 16-hour Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease Patients

Dag Nyholm, Per Odin, Anders Johansson, Krai Chatamra, Charles Locke…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 261 KB

english, 2013

13

Simultaneous Analysis of Multiple Monoclonal Antibody Biotherapeutics by LC-MS/MS Method in Rat Plasma Following Cassette-Dosing

Hongyan Li, Robert Ortiz, Linh T. B. Tran, Hossein Salimi-Moosavi…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 611 KB

english, 2013

14

The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane

Arik Dahan, Avital Beig, Viktoriya Ioffe-Dahan, Riad Agbaria…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 467 KB

english, 2013

15

Translational Pharmacokinetic-Pharmacodynamic Modeling from Nonclinical to Clinical Development: A Case Study of Anticancer Drug, Crizotinib

Shinji Yamazaki

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 591 KB

english, 2013

16

Controlled Release of Simvastatin fromIn situForming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells

Yoon Shin Park, Allan E. David, Kyung Min Park, Chia-Ying Lin…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 665 KB

english, 2013

17

Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches

Hannah M. Jones, Kapil Mayawala, Patrick Poulin

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 431 KB

english, 2013

18

Regulatory Administrative Databases in FDA's Center for Biologics Evaluation and Research: Convergence Toward a Unified Database

Jeffrey K. Smith

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 473 KB

english, 2013

19

TargetHunter: AnIn SilicoTarget Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database

Lirong Wang, Chao Ma, Peter Wipf, Haibin Liu, Weiwei Su, Xiang-Qun Xie

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 662 KB

english, 2013

20

Improper Selection of a Pre-specified Primary Dose–Response Analysis Delays Regulatory Drug Approval

Jiang Liu, Pravin Jadhav, Yaning Wang, Jogarao Gobburu

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 426 KB

english, 2013

21

Strategic Applications of Gene Expression: From Drug Discovery/Development to Bedside

Jane P. F. Bai, Alexander V. Alekseyenko, Alexander Statnikov…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 340 KB

english, 2013

22

Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants

Jane P. F. Bai, Jeffrey S. Barrett, Gibert J. Burckart, Bernd Meibohm…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 177 KB

english, 2013

23

A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam

A. R. Maharaj, J. S. Barrett, A. N. Edginton

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 425 KB

english, 2013

24

The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using19F-NMR

Jianqin Zhuang, De-Ping Yang, Spyros P. Nikas, Jianhong Zhao…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 211 KB

english, 2013

25

Chemical Imaging of Drug Delivery Systems with Structured Surfaces–a Combined Analytical Approach of Confocal Raman Microscopy and Optical Profilometry

Birthe Kann, Maike Windbergs

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 530 KB

english, 2013

26

Nonaqueous Gel for the Transdermal Delivery of a DTPA Penta-ethyl Ester Prodrug

Yong Zhang, Matthew P. Sadgrove, Katsuhiko Sueda, Yu-Tsai Yang…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 261 KB

english, 2013

27

Predictions ofIn VivoProlactin Levels fromIn Vitro KiValues of D2Receptor Antagonists Using an Agonist–Antagonist Interaction Model

Klas J. Petersson, An M. Vermeulen, Lena E. Friberg

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

28

Modeling NSCLC Progression: Recent Advances and Opportunities Available

Ahmed Abbas Suleiman, Lucia Nogova, Uwe Fuhr

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 217 KB

english, 2013

29

Modeling, Simulation, and Translation Framework for the Preclinical Development of Monoclonal Antibodies

Kenneth T. Luu, Eugenia Kraynov, Bing Kuang, Paolo Vicini…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 366 KB

english, 2013

30

Population-Based Efficacy Modeling of Omalizumab in Patients with Severe Allergic Asthma Inadequately Controlled with Standard Therapy

Rui Zhu, Yanan Zheng, Wendy S. Putnam, Jennifer Visich, Mark D. Eisner…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 572 KB

english, 2013

31

Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects

Hwa Yoon, Hea-Young Cho, Hee-Doo Yoo, Se-Mi Kim, Yong-Bok Lee

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 337 KB

english, 2013

32

Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine

Moran Fairstein, Rotem Swissa, Arik Dahan

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 437 KB

english, 2013

33

The Challenges of Assessing Osteoarthritis and Postoperative Pain in Dogs

Michele Sharkey

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 205 KB

english, 2013

34

Direct and Rapid Genotyping ofSLCO1B1388A>G and 521T>C in Human Blood Specimens Using the SmartAmp-2 Method

Kenta Yoshida, Junichi Takano, Yuri Ishizu, Alexander Lezhava…

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 223 KB

english, 2013