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Volume 15; Issue 4
Main
The AAPS Journal
Volume 15; Issue 4
The AAPS Journal
Volume 15; Issue 4
1
International Guidelines for Bioequivalence of Systemically Available Orally Administered Generic Drug Products: A Survey of Similarities and Differences
Davit, Barbara
,
Braddy, April C.
,
Conner, Dale P.
,
Yu, Lawrence X.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 303 KB
Your tags:
english, 2013
2
Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests?
Gao, Hongying
,
Jacobs, Abigail
,
White, Ronald E.
,
Booth, Brian P.
,
Obach, R. Scott
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 148 KB
Your tags:
english, 2013
3
Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood–Brain Barrier—Towards a Mechanistic IVIVE-Based Approach
Ball, Kathryn
,
Bouzom, François
,
Scherrmann, Jean-Michel
,
Walther, Bernard
,
Declèves, Xavier
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 797 KB
Your tags:
english, 2013
4
A Simplified PBPK Modeling Approach for Prediction of Pharmacokinetics of Four Primarily Renally Excreted and CYP3A Metabolized Compounds During Pregnancy
Xia, Binfeng
,
Heimbach, Tycho
,
Gollen, Rakesh
,
Nanavati, Charvi
,
He, Handan
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 556 KB
Your tags:
english, 2013
5
A Report from the Pediatric Formulations Task Force: Perspectives on the State of Child-Friendly Oral Dosage Forms
Zajicek, Anne
,
Fossler, Michael J.
,
Barrett, Jeffrey S.
,
Worthington, Jeffrey H.
,
Ternik, Robert
,
Charkoftaki, Georgia
,
Lum, Susan
,
Breitkreutz, Jörg
,
Baltezor, Mike
,
Macheras, Panos
,
Khan, Mansoor
,
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 1016 KB
Your tags:
english, 2013
6
Impact of Osmotically Active Excipients on Bioavailability and Bioequivalence of BCS Class III Drugs
Chen, Mei-Ling
,
Sadrieh, Nakissa
,
Yu, Lawrence
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 261 KB
Your tags:
english, 2013
7
Immunogenicity of Subcutaneously Administered Therapeutic Proteins—a Mechanistic Perspective
Fathallah, Anas M.
,
Bankert, Richard B.
,
Balu-Iyer, Sathy V.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 218 KB
Your tags:
english, 2013
8
First Characterization of AKB-48 Metabolism, a Novel Synthetic Cannabinoid, Using Human Hepatocytes and High-Resolution Mass Spectrometry
Gandhi, Adarsh S.
,
Zhu, Mingshe
,
Pang, Shaokun
,
Wohlfarth, Ariane
,
Scheidweiler, Karl B.
,
Liu, Hua-fen
,
Huestis, Marilyn A.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 598 KB
Your tags:
english, 2013
9
Epigenetic Cancer Prevention Mechanisms in Skin Cancer
Saha, Kamalika
,
Hornyak, Thomas J.
,
Eckert, Richard L.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 208 KB
Your tags:
english, 2013
10
Effects of Selected OATP and/or ABC Transporter Inhibitors on the Brain and Whole-Body Distribution of Glyburide
Tournier, Nicolas
,
Saba, Wadad
,
Cisternino, Salvatore
,
Peyronneau, Marie-Anne
,
Damont, Annelaure
,
Goutal, Sébastien
,
Dubois, Albertine
,
Dollé, Frédéric
,
Scherrmann, Jean-Michel
,
Valette, Héric
,
K
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 338 KB
Your tags:
english, 2013
11
Functional Analysis of Novel Polymorphisms in the HumanSLCO1A2Gene that Encodes the Transporter OATP1A2
Fanfan Zhou, Jian Zheng, Ling Zhu, Andreas Jodal, Pei H. Cui, Mark Wong…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 540 KB
Your tags:
english, 2013
12
Population Pharmacodynamic Modeling of Hyperglycemic Clamp and Meal Tolerance Tests in Patients with Type 2 Diabetes Mellitus
Ying Hong, Jasper Dingemanse, Patricia Sidharta, Donald E. Mager
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 884 KB
Your tags:
english, 2013
13
Multiple Imputation of Missing Covariates in NONMEM and Evaluation of the Method’s Sensitivity to η-Shrinkage
Åsa M. Johansson, Mats O. Karlsson
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 281 KB
Your tags:
english, 2013
14
Quantification of Swelling and Erosion in the Controlled Release of a Poorly Water-Soluble Drug Using Synchrotron X-ray Computed Microtomography
Xianzhen Yin, Haiyan Li, Zhen Guo, Li Wu, Fangwei Chen, Marcel de Matas…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 732 KB
Your tags:
english, 2013
15
Intraperitoneal Injection of Clodronate Liposomes Eliminates Visceral Adipose Macrophages and Blocks High-fat Diet-induced Weight Gain and Development of Insulin Resistance
Le Bu, Mingming Gao, Shen Qu, Dexi Liu
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 691 KB
Your tags:
english, 2013
16
Perspectives on the Role of Isoflavones in Prostate Cancer
Aamir Ahmad, Bernhard Biersack, Yiwei Li, Bin Bao, Dejuan Kong…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 243 KB
Your tags:
english, 2013
17
Silica Colloidal Crystals as Emerging Materials for High-Throughput Protein Electrophoresis
Nadine K. Njoya, Robert E. Birdsall, Mary J. Wirth
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 549 KB
Your tags:
english, 2013
18
Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention
Gregory W. Watson, Laura M. Beaver, David E. Williams…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 410 KB
Your tags:
english, 2013
19
Emerging Applications of Metabolomics in Studying Chemopreventive Phytochemicals
Lei Wang, Chi Chen
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 476 KB
Your tags:
english, 2013
20
Therapeutic Protein Drug–Drug Interactions: Navigating the Knowledge Gaps–Highlights from the 2012 AAPS NBC Roundtable and IQ Consortium/FDA Workshop
Jane R. Kenny, Maggie M. Liu, Andrew T. Chow, Justin C. Earp…
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 404 KB
Your tags:
english, 2013
21
Population Pharmacokinetics of Cyclosporine in Transplant Recipients
Kelong Han, Venkateswaran C. Pillai, Raman Venkataramanan
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 300 KB
Your tags:
english, 2013
22
Mass Spectrometry-Based Targeted Proteomics as a Tool to Elucidate the Expression and Function of Intestinal Drug Transporters
Oswald, Stefan
,
Gröer, Christian
,
Drozdzik, Marek
,
Siegmund, Werner
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 668 KB
Your tags:
english, 2013
23
Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin
Chiang, Po-Chang
,
Wong, Harvey
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 417 KB
Your tags:
english, 2013
24
Comparison of Methods for Handling Missing Covariate Data
Johansson, Åsa M.
,
Karlsson, Mats O.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 383 KB
Your tags:
english, 2013
25
Structure Activity Relationships in Alkylammonium C12-Gemini Surfactants Used as Dermal Permeation Enhancers
Silva, Sérgio M. C.
,
Sousa, João J. S.
,
Marques, Eduardo F.
,
Pais, Alberto A. C. C.
,
Michniak-Kohn, Bozena B.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 518 KB
Your tags:
english, 2013
26
Effect of PEG Surface Conformation on Anticancer Activity and Blood Circulation of Nanoemulsions Loaded with Tocotrienol-Rich Fraction of Palm Oil
Alayoubi, Alaadin
,
Alqahtani, Saeed
,
Kaddoumi, Amal
,
Nazzal, Sami
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 529 KB
Your tags:
english, 2013
27
Impact of Genetic Polymorphism on Drug-Drug Interactions Mediated by Cytochromes: A General Approach
Tod, Michel
,
Nkoud-Mongo, Christina
,
Gueyffier, François
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 309 KB
Your tags:
english, 2013
28
Flow Imaging Microscopy for Protein Particle Analysis—A Comparative Evaluation of Four Different Analytical Instruments
Zölls, Sarah
,
Weinbuch, Daniel
,
Wiggenhorn, Michael
,
Winter, Gerhard
,
Friess, Wolfgang
,
Jiskoot, Wim
,
Hawe, Andrea
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 770 KB
Your tags:
english, 2013
29
Novel Hybrid GPU–CPU Implementation of Parallelized Monte Carlo Parametric Expectation Maximization Estimation Method for Population Pharmacokinetic Data Analysis
C. M. Ng
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 250 KB
Your tags:
english, 2013
30
A Mathematical Model of the Effect of Immunogenicity on Therapeutic Protein Pharmacokinetics
Chen, Xiaoying
,
Hickling, Timothy
,
Kraynov, Eugenia
,
Kuang, Bing
,
Parng, Chuenlei
,
Vicini, Paolo
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 964 KB
Your tags:
english, 2013
31
2012 AAPS National Biotech Conference Open Forum: A Perspective on the Current State of Immunogenicity Prediction and Risk Management
Rajadhyaksha, Manoj
,
Subramanyam, Meena
,
Rup, Bonnie
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 150 KB
Your tags:
english, 2013
32
Statistical and Bioanalytical Considerations for Establishing a Depletion Criterion for Specificity Testing During Immunogenicity Assessment of a Biotherapeutic
Driscoll, R. O.
,
Zhou, L.
,
Moxness, M.
,
Mytych, D.
,
Chirmule, N.
,
Jawa, V.
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 311 KB
Your tags:
english, 2013
33
Radionuclide Decorporation: Matching the Biokinetics of Actinides by Transdermal Delivery of Pro-chelators
Zhang, Yong
,
Sadgrove, Matthew P.
,
Mumper, Russell J.
,
Jay, Michael
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 269 KB
Your tags:
english, 2013
34
A Markov Chain Model to Evaluate the Effect ofCYP3A5andABCB1Polymorphisms on Adverse Events Associated with Tacrolimus in Pediatric Renal Transplantation
Sy, Sherwin K. B.
,
Heuberger, Jules
,
Shilbayeh, Sireen
,
Conrado, Daniela J.
,
Derendorf, Hartmut
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 283 KB
Your tags:
english, 2013
35
Stable Isotope Dilution Mass Spectrometry for Membrane Transporter Quantitation
Farrokhi, Vahid
,
McShane, Adam J.
,
Nemati, Reza
,
Yao, Xudong
Journal:
The AAPS Journal
Year:
2013
Language:
english
File:
PDF, 339 KB
Your tags:
english, 2013
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