Volume 16; Issue 4

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The AAPS Journal
Volume 16; Issue 4

The AAPS Journal

Volume 16; Issue 4

1

Anti-HIV Drug Development Through Computational Methods

Gu, Wan-Gang, Zhang, Xuan, Yuan, Jun-Fa

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 245 KB

english, 2014

2

Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications

Paredes-Gonzalez, Ximena, Fuentes, Francisco, Su, Zheng-Yuan, Kong, Ah-Ng Tony

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

3

Quantitative Targeted Proteomics for Membrane Transporter Proteins: Method and Application

Qiu, Xi, Zhang, Hui, Lai, Yurong

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

4

Understanding Pharmaceutical Quality by Design

Yu, Lawrence X., Amidon, Gregory, Khan, Mansoor A., Hoag, Stephen W., Polli, James, Raju, G. K., Woodcock, Janet

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 523 KB

english, 2014

5

Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays

van der Maaden, Koen, Sekerdag, Emine, Jiskoot, Wim, Bouwstra, Joke

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 501 KB

english, 2014

6

Many Approved Drugs Have Bioactive Analogs With Different Target Annotations

Hu, Ye, Lounkine, Eugen, Bajorath, Jürgen

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.83 MB

english, 2014

7

Curcumin Inhibits the AKT/NF-κB Signaling via CpG Demethylation of the Promoter and Restoration of NEP in the N2a Cell Line

Y. Deng, X. Lu, L. Wang, T. Li, Y. Ding, H. Cao, Y. Zhang, X. Guo, G. Yu

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 3.15 MB

english, 2014

8

In VitroCharacterization of a Novel Polymeric System for Preparation of Amorphous Solid Drug Dispersions

Mahmoudi, Zahra N., Upadhye, Sampada B., Ferrizzi, David, Rajabi-Siahboomi, Ali R.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 4.16 MB

english, 2014

9

Simplification of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies

Mohamed Elmeliegy,Philip Lowe,Wojciech Krzyzanski

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

10

Mechanistic Modeling of Monocarboxylate Transporter-Mediated Toxicokinetic/Toxicodynamic Interactions Between γ-Hydroxybutyrate andl-Lactate

Morse, Bridget L., Vijay, Nisha, Morris, Marilyn E.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 445 KB

english, 2014

11

When Assay Format Matters: a Case Study on the Evaluation of Three Assay Formats to Support a Clinical Pharmacokinetic Study

Peng, Kun, Baker, Dana, Brignoli, Suzanne, Cabuhat, Janis, Fischer, Saloumeh K.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 478 KB

english, 2014

12

Assessment and Reporting of the Clinical Immunogenicity of Therapeutic Proteins and Peptides—Harmonized Terminology and Tactical Recommendations

Shankar, G., Arkin, S., Cocea, L., Devanarayan, V., Kirshner, S., Kromminga, A., Quarmby, V., Richards, S., Schneider, C. K., Subramanyam, M., Swanson, S., Verthelyi, D., Yim, S.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 514 KB

english, 2014

13

Optimized Approaches for Quantification of Drug Transporters in Tissues and Cells by MRM Proteomics

Prasad, Bhagwat, Unadkat, Jashvant D.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 2.44 MB

english, 2014

14

Practical Considerations for Dose Selection in Pediatric Patients to Ensure Target Exposure Requirements

Barbour, April M., Fossler, Michael J., Barrett, Jeffrey

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 627 KB

english, 2014

15

Nanomedicine Drug Development: A Scientific Symposium Entitled “Charting a Roadmap to Commercialization”

Finch, Gregory, Havel, Henry, Analoui, Mostafa, Barton, Randall W., Diwan, Anil R., Hennessy, Meliessa, Reddy, Vijayapal, Sadrieh, Nakissa, Tamarkin, Lawrence, Wolfgang, Marc, Yerxa, Benjamin, Zolnik,

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 177 KB

english, 2014

16

Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention

Morris, Marilyn E., Dave, Rutwij A.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 544 KB

english, 2014

17

Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define theIn VitroDrug Release Profile

Yang, Shuo, Yin, Xianzhen, Wang, Caifen, Li, Haiyan, He, You, Xiao, Tiqiao, Sun, Lixin, Li, Jiasheng, York, Peter, He, Jun, Zhang, Jiwen

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 6.63 MB

english, 2014

18

Measurement of Subvisible Particulates in LyophilisedErwinia chrysanthemil-asparaginase and Relationship with Clinical Experience

Gervais, David, Corn, Tim, Downer, Andrew, Smith, Stuart, Jennings, Alan

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 447 KB

english, 2014

19

Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

Varma, Manthena V. S., Scialis, Renato J., Lin, Jian, Bi, Yi-An, Rotter, Charles J., Goosen, Theunis C., Yang, Xin

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

20

Permeability Comparison between Hepatocyte and Low Efflux MDCKII Cell Monolayer

Li, Rui, Bi, Yi-An, Lai, Yurong, Sugano, Kiyohiko, Steyn, Stefanus J., Trapa, Patrick E., Di, Li

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 670 KB

english, 2014

21

The Gender of Cell Lines Matters When Screening for Novel Anti-Cancer Drugs

Nunes, Larissa M., Robles-Escajeda, Elisa, Santiago-Vazquez, Yahaira, Ortega, Nora M., Lema, Carolina, Muro, Almendra, Almodovar, Gladys, Das, Umashankar, Das, Swagatika, Dimmock, Johnatan R., Aguiler

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 559 KB

english, 2014

22

Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs III — the Effect of Fed State Conditions on theIn VitroRelease and Degradation of Desmopressin

Christophersen, Philip C., Vaghela, Dimple, Müllertz, Anette, Yang, Mingshi, Nielsen, Hanne M., Mu, Huiling

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 275 KB

english, 2014

23

A Sequential Bioequivalence Design with a Potential Ethical Advantage

Fuglsang, Anders

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 379 KB

english, 2014

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