Volume 16; Issue 6

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The AAPS Journal
Volume 16; Issue 6

The AAPS Journal

Volume 16; Issue 6

1

Reliability and Extension of Quantitative Prediction of CYP3A4-Mediated Drug Interactions Based on Clinical Data

Loue, Constance, Tod, Michel

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 473 KB

english, 2014

2

Design and Evaluation of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugates as Antigen-Presenting Cell-Selective siRNA Carriers

Motoyama, Keiichi, Mitsuyasu, Ryosuke, Akao, Chiho, Tanaka, Takahiro, Ohyama, Ayumu, Sato, Nana, Higashi, Taishi, Arima, Hidetoshi

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 934 KB

english, 2014

3

Method Transfer, Partial Validation, and Cross Validation: Recommendations for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team

Briggs, R. J., Nicholson, R., Vazvaei, F., Busch, J., Mabuchi, M., Mahesh, K. S., Brudny-Kloeppel, M., Weng, N., Galvinas, P. A. R., Duchene, P., Hu, Pei, Abbott, R. W.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 327 KB

english, 2014

4

The Poorly Membrane Permeable Antipsychotic Drugs Amisulpride and Sulpiride Are Substrates of the Organic Cation Transporters from the SLC22 Family

Dos Santos Pereira, Joao N., Tadjerpisheh, Sina, Abed, Manar Abu, Saadatmand, Ali R., Weksler, Babette, Romero, Ignacio A., Couraud, Pierre-Olivier, Brockmöller, Jürgen, Tzvetkov, Mladen V.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 575 KB

english, 2014

5

Toward the Establishment of StandardizedIn VitroTests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels

Sassene, Philip, Kleberg, Karen, Williams, Hywel D., Bakala-N’Goma, Jean-Claude, Carrière, Frédéric, Calderone, Marilyn, Jannin, Vincent, Igonin, Annabel, Partheil, Anette, Marchaud, Delphine, Jule, E

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

6

Repeat Analysis and Incurred Sample Reanalysis: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team

Fluhler, Eric, Vazvaei, Faye, Singhal, Puran, Vinck, Petra, Li, Wenkui, Bhatt, Jignesh, de Boer, Theo, Chaudhary, Ajai, Tangiuchi, Masahiro, Rezende, Vinicius, Zhong, Dafang

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 175 KB

english, 2014

7

Reference Datasets for 2-Treatment, 2-Sequence, 2-Period Bioequivalence Studies

Schütz, Helmut, Labes, Detlew, Fuglsang, Anders

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 342 KB

english, 2014

8

Predicting Pediatric Age-Matched Weight and Body Mass Index

Sy, Sherwin K. B., Asin-Prieto, Eduardo, Derendorf, Hartmut, Samara, Emil

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

9

Evaluation of Acoustic Membrane Microparticle (AMMP) Technology for a Sensitive Ligand Binding Assay to Support Pharmacokinetic Determinations of a Biotherapeutic

Chilewski, Shannon D., Dickerson, W. Matthew, Mora, Johanna R., Saab, Ashley, Alderman, Edward M.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.29 MB

english, 2014

10

Systematic Verification of Bioanalytical Similarity Between a Biosimilar and a Reference Biotherapeutic: Committee Recommendations for the Development and Validation of a Single Ligand-Binding Assay to Support Pharmacokinetic Assessments

Marini, Joseph C., Anderson, Michael, Cai, Xiao-Yan, Chappell, John, Coffey, Todd, Gouty, Dominique, Kasinath, Aparna, Koppenburg, Vera, Oldfield, Philip, Rebarchak, Shannon, Bowsher, Ronald R.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.76 MB

english, 2014

11

The Use of Betaine HCl to Enhance Dasatinib Absorption in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Yago, Marc R., Frymoyer, Adam, Benet, Leslie Z., Smelick, Gillian S., Frassetto, Lynda A., Ding, Xiao, Dean, Brian, Salphati, Laurent, Budha, Nageshwar, Jin, Jin Y., Dresser, Mark J., Ware, Joseph A.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 327 KB

english, 2014

12

Next Generation Ligand Binding Assays—Review of Emerging Technologies’ Capabilities to Enhance Throughput and Multiplexing

Mora, Johanna, Chunyk, Allison Given, Dysinger, Mark, Purushothama, Shobha, Ricks, Claude, Österlund, Karolina, Theobald, Valerie

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

13

Fmoc-Conjugated PEG-Vitamin E2Micelles for Tumor-Targeted Delivery of Paclitaxel: Enhanced Drug-Carrier Interaction and Loading Capacity

Zhang, Yifei, Huang, Yixian, Zhao, Wenchen, Lu, Jianqin, Zhang, Peng, Zhang, Xiaolan, Li, Jiang, Gao, Xiang, Venkataramanan, Raman, Li, Song

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

14

A Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design

Peng, Joanna Z., Denney, William S., Musser, Bret J., Liu, Rong, Tsai, Kuenhi, Fang, Lanyan, Reitman, Marc L., Troyer, Matthew D., Engel, Samuel S., Xu, Lei, Stoch, Aubrey, Stone, Julie A., Kowalski,

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 833 KB

english, 2014

15

Structure, Size, and Solubility of Antigen Arrays Determines Efficacy in Experimental Autoimmune Encephalomyelitis

Sestak, Joshua O., Fakhari, Amir, Badawi, Ahmed H., Siahaan, Teruna J., Berkland, Cory

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 647 KB

english, 2014

16

Similarities and Differences in Gastrointestinal Physiology Between Neonates and Adults: a Physiologically Based Pharmacokinetic Modeling Perspective

Yu, Guo, Zheng, Qing-Shan, Li, Guo-Fu

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 141 KB

english, 2014

17

Retrospective Data Analysis and Proposal of a Practical Acceptance Criterion for Inter-laboratory Cross-validation of Bioanalytical Methods Using Liquid Chromatography/Tandem Mass Spectrometry

Yoneyama, Tomoki, Kudo, Takashi, Jinno, Fumihiro, Schmidt, Eric R., Kondo, Takahiro

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 666 KB

english, 2014

18

Introduction to the Proposals from the Global Bioanalysis Consortium Harmonization Team

Timmerman, Philip, Arnold, Mark, DeSilva, Binodh, Garofolo, Fabio, Golob, Michaela, van Amsterdam, Peter, Kudoh, Shinobu, Singhal, Puran, Tang, Daniel, Riccio, Maria Francesca, Barrientos, Rafael, Sav

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 124 KB

english, 2014

19

Population Pharmacokinetic/Pharmacodynamic Modeling of Guanfacine Effects on QTc and Heart Rate in Pediatric Patients

Knebel, William, Ermer, James, Purkayastha, Jaideep, Martin, Patrick, Gastonguay, Marc R.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 989 KB

english, 2014

20

Modeling of Bounded Outcome Scores with Data on the Boundaries: Application to Disability Assessment for Dementia Scores in Alzheimer’s Disease

Xu, Xu Steven, Samtani, Mahesh, Yuan, Min, Nandy, Partha

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.51 MB

english, 2014

21

A Therapeutic Microparticle-Based Tumor Lysate Vaccine Reduces Spontaneous Metastases in Murine Breast Cancer

Gross, Brett P., Wongrakpanich, Amaraporn, Francis, Meghan B., Salem, Aliasger K., Norian, Lyse A.

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 4.81 MB

english, 2014

22

Elucidation of Arctigenin Pharmacokinetics After Intravenous and Oral Administrations in Rats: Integration ofIn VitroandIn VivoFindingsviaSemi-mechanistic Pharmacokinetic Modeling

Gao, Qiong, Zhang, Yufeng, Wo, Siukwan, Zuo, Zhong

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 2.45 MB

english, 2014

23

Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway

Wang, Ling, Zhang, Chengyue, Guo, Yue, Su, Zheng-Yuan, Yang, Yuqing, Shu, Limin, Kong, Ah-Ng Tony

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 1.97 MB

english, 2014

24

Prediction of Drug Clearance in Children: an Evaluation of the Predictive Performance of Several Models

Mahmood, Iftekhar, Staschen, Carl-Michael, Goteti, Kosalaram

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 226 KB

english, 2014

25

Co-Delivery of Autoantigen and B7 Pathway Modulators Suppresses Experimental Autoimmune Encephalomyelitis

Northrup, Laura, Sestak, Joshua O., Sullivan, Bradley P., Thati, Sharadvi, Hartwell, Brittany L., Siahaan, Teruna J., Vines, Charlotte M., Berkland, Cory

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 785 KB

english, 2014