Volume 17; Issue 3

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The AAPS Journal
Volume 17; Issue 3

The AAPS Journal

Volume 17; Issue 3

1

Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

Ruigrok, Mitchel J. R., de Lange, Elizabeth C. M.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 707 KB

english, 2015

2

Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health

Bryan, Jeffrey N.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 218 KB

english, 2015

3

Safety of β2-Agonists in Asthma: Linking Mechanisms, Meta-Analyses and Regulatory Practice

Dissanayake, Sanjeeva. B.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 167 KB

english, 2015

4

Pharmacodynamic Studies to Demonstrate Bioequivalence of Oral Inhalation Products

Hendeles, Leslie, Daley-Yates, Peter T., Hermann, Robert, De Backer, Jan, Dissanayake, Sanjeeva, Horhota, Stephen T.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 814 KB

english, 2015

5

Influence of P-Glycoprotein Inhibition or Deficiency at the Blood–Brain Barrier on18F-2-Fluoro-2-Deoxy-d-glucose (18F-FDG) Brain Kinetics

Tournier, Nicolas, Saba, Wadad, Goutal, Sébastien, Gervais, Philippe, Valette, Héric, Scherrmann, Jean-Michel, Bottlaender, Michel, Cisternino, Salvatore

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.00 MB

english, 2015

6

Mesenchymal Stromal/Stem Cell and Minocycline-Loaded Hydrogels Inhibit the Growth ofStaphylococcus aureusthat Evades Immunomodulation of Blood-Derived Leukocytes

Guerra, Alberto Daniel, Cantu, David Antonio, Vecchi, Joseph T., Rose, Warren E., Hematti, Peiman, Kao, Weiyuan John

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 3.97 MB

english, 2015

7

Structural and Activity Profile Relationships Between Drug Scaffolds

Hu, Ye, Bajorath, Jürgen

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 822 KB

english, 2015

8

Antibody Drug Conjugates: Preclinical Considerations

Bornstein, Gadi G.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 461 KB

english, 2015

9

Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family

Feng, Zhiwei, Ma, Shifan, Hu, Guanxing, Xie, Xiang-Qun

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 14.56 MB

english, 2015

10

International Guidelines for Bioequivalence of Locally Acting Orally Inhaled Drug Products: Similarities and Differences

Lu, Dongmei, Lee, Sau L., Lionberger, Robert A., Choi, Stephanie, Adams, Wallace, Caramenico, Hoainhon N., Chowdhury, Badrul A., Conner, Dale P., Katial, Rohit, Limb, Susan, Peters, John R., Yu, Lawre

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 339 KB

english, 2015

11

Pilot and Repeat Trials as Development Tools Associated with Demonstration of Bioequivalence

Fuglsang, Anders

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 448 KB

english, 2015

12

Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA

Wohlfarth, Ariane, Castaneto, Marisol S., Zhu, Mingshe, Pang, Shaokun, Scheidweiler, Karl B., Kronstrand, Robert, Huestis, Marilyn A.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

13

Development of a Novel Oral Cavity Compartmental Absorption and Transit Model for Sublingual Administration: Illustration with Zolpidem

Xia, Binfeng, Yang, Zhen, Zhou, Haiying, Lukacova, Viera, Zhu, Wei, Milewski, Mikolaj, Kesisoglou, Filippos

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 2.13 MB

english, 2015

14

Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids

Dai, Peimin, Zhu, Lijun, Luo, Feifei, Lu, Linlin, Li, Qiang, Wang, Liping, Wang, Ying, Wang, Xinchun, Hu, Ming, Liu, Zhongqiu

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.80 MB

english, 2015

15

Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice

Gao, Mingming, Zhang, Chunbo, Ma, Yongjie, Liu, Dexi

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 15.68 MB

english, 2015

16

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Khan, Usman, Nicell, Jim

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 2.79 MB

english, 2015

17

Lipidomics Revealed Idiopathic Pulmonary Fibrosis-Induced Hepatic Lipid Disorders Corrected with Treatment of Baicalin in a Murine Model

Hu, Changfeng, Wang, Yiqi, Fan, Yongsheng, Li, Haichang, Wang, Chunyan, Zhang, Jida, Zhang, Shuijuan, Han, Xianlin, Wen, Chengping

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 3.36 MB

english, 2015

18

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

Leander, Jacob, Almquist, Joachim, Ahlström, Christine, Gabrielsson, Johan, Jirstrand, Mats

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 789 KB

english, 2015

19

Does the Recent Growth of Aquaculture Create Antibiotic Resistance Threats Different from those Associated with Land Animal Production in Agriculture?

Done, Hansa Y., Venkatesan, Arjun K., Halden, Rolf U.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.97 MB

english, 2015

20

Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control

Zeng, Kui, Geerlof-Vidavisky, Ilan, Gucinski, Ashley, Jiang, Xiaohui, Boyne, Michael T.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 501 KB

english, 2015

21

Pharmacokinetics of Orally Inhaled Drug Products

Hochhaus, Günther, Horhota, Stephen, Hendeles, Leslie, Suarez, Sandra, Rebello, Juliet

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 669 KB

english, 2015

22

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

Thakkar, Nilay, Lockhart, A. Craig, Lee, Wooin

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 345 KB

english, 2015

23

In Silico Evaluation of the Potential Impact of Bioanalytical Bias Difference between Two Therapeutic Protein Formulations for Pharmacokinetic Assessment in a Biocomparability Study

Thway, Theingi M., Macaraeg, Chris, Eschenberg, Michael, Ma, Mark

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 521 KB

english, 2015

24

Nonlinear Mixed-Effect Models for Prostate-Specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer: a Comparison by Simulation of Two-Stage and Joint Approaches

Desmée, Solène, Mentré, France, Veyrat-Follet, Christine, Guedj, Jérémie

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 3.02 MB

english, 2015

25

Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates

Tessier, Adrien, Bertrand, Julie, Chenel, Marylore, Comets, Emmanuelle

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.48 MB

english, 2015

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