Volume 17; Issue 5

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The AAPS Journal
Volume 17; Issue 5

The AAPS Journal

Volume 17; Issue 5

1

A Review of Clinical Translation of Inorganic Nanoparticles

Anselmo, Aaron C., Mitragotri, Samir

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 11.60 MB

english, 2015

2

Effect of Device Design and Formulation on theIn VitroComparability for Multi-Unit Dose Dry Powder Inhalers

Shur, Jagdeep, Saluja, Bhawana, Lee, Sau, Tibbatts, James, Price, Robert

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

3

Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors

Feng, Zhiwei, Hu, Guanxing, Ma, Shifan, Xie, Xiang-Qun

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 3.73 MB

english, 2015

4

Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples

Fung, Eliza N., Aubry, Anne-Françoise, Allentoff, Alban, Ji, Qin C.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 798 KB

english, 2015

5

Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration

Rosengren, Sanna, Dychter, Samuel S., Printz, Marie A., Huang, Lei, Schiff, Richard I., Schwarz, Hans-Peter, McVey, John K., Drake, Fred H., Maneval, Dan C., Kennard, Don A., Frost, Gregory I., Sugarm

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 654 KB

english, 2015

6

Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

Philippe, Michaël, Hénin, Emilie, Bertrand, Yves, Plantaz, Dominique, Goutelle, Sylvain, Bleyzac, Nathalie

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

7

Regulatory Considerations for Approval of Generic Inhalation Drug Products in the US, EU, Brazil, China, and India

Lee, Sau L., Saluja, Bhawana, García-Arieta, Alfredo, Santos, Gustavo Mendes Lima, Li, Ying, Lu, Sarah, Hou, Shuguang, Rebello, Juliet, Vaidya, Abhijit, Gogtay, Jaideep, Purandare, Shrinivas, Lyapusti

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

8

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

Olivares-Morales, Andrés, Lennernäs, Hans, Aarons, Leon, Rostami-Hodjegan, Amin

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

9

Antibody Drug Conjugates: Nonclinical Safety Considerations

Hinrichs, Mary Jane Masson, Dixit, Rakesh

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 315 KB

english, 2015

10

Regulation of Generic Drugs in Japan: the Current Situation and Future Prospects

Kuribayashi, Ryosuke, Matsuhama, Maki, Mikami, Kenichi

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 205 KB

english, 2015

11

Application of Absorption Modeling in Rational Design of Drug Product Under Quality-by-Design Paradigm

Kesisoglou, Filippos, Mitra, Amitava

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

12

Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model

Anderson, Gail D., Peterson, Todd C., Vonder Haar, Cole, Farin, Fred M., Bammler, Theo K., MacDonald, James W., Kantor, Eric D., Hoane, Michael R.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 631 KB

english, 2015

13

Prevention of Collagen-Induced Platelet Binding and Activation by Thermosensitive Nanoparticles

McMasters, James, Panitch, Alyssa

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 766 KB

english, 2015

14

Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

Kim, Tae Hwan, Shin, Soyoung, Landersdorfer, Cornelia B., Chi, Yong Ha, Paik, Soo Heui, Myung, Jayhyuk, Yadav, Rajbharan, Horkovics-Kovats, Stefan, Bulitta, Jürgen B., Shin, Beom Soo

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

15

Cellular Uptake Mechanism of Paclitaxel Nanocrystals Determined by Confocal Imaging and Kinetic Measurement

Chen, Yan, Li, Tonglei

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 2.94 MB

english, 2015

16

Current Scientific and Regulatory Approaches for Development of Orally Inhaled and Nasal Drug Products: Overview of the IPAC-RS/University of Florida Orlando Inhalation Conference

Hochhaus, Guenther, Davis-Cutting, Craig, Oliver, Martin, Lee, Sau L., Lyapustina, Svetlana

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 175 KB

english, 2015

17

Versatility of Particulate Carriers: Development of Pharmacodynamically Optimized Drug-Loaded Microparticles for Treatment of Peritoneal Cancer

Au, Jessie L.-S., Lu, Ze, Wientjes, M. Guillaume

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

18

CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48

Holm, Niels Bjerre, Nielsen, Line Marie, Linnet, Kristian

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 611 KB

english, 2015

19

Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone Analogs

Moradi, Shayli Varasteh, Varamini, Pegah, Toth, Istvan

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

20

A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

Kuruvilla, Denison J., Widness, John A., Nalbant, Demet, Schmidt, Robert L., Mock, Donald M., Veng-Pedersen, Peter

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 503 KB

english, 2015

21

Drug Carriers: Not an Innocent Delivery Man

Yeo, Yoon, Kim, Bieong-Kil

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 2.89 MB

english, 2015

22

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central VenousVersusPeripheral Sampling Site

Helen Musther,Katherine L. Gill,Manoranjenni Chetty…

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 738 KB

english, 2015

23

Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

Kristensen, Mie, Franzyk, Henrik, Klausen, Mia Thorne, Iversen, Anne, Bahnsen, Jesper Søborg, Skyggebjerg, Rikke Bjerring, Foderà, Vito, Nielsen, Hanne Mørck

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

24

A PrioriIdentifiability of Target-Mediated Drug Disposition Models and Approximations

Eudy, Rena J., Riggs, Matthew M., Gastonguay, Marc R.

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 145 KB

english, 2015