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Volume 18; Issue 4
Main
The AAPS Journal
Volume 18; Issue 4
The AAPS Journal
Volume 18; Issue 4
1
Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation
Feng, Zhiwei
,
Pearce, Larry V.
,
Zhang, Yu
,
Xing, Changrui
,
Herold, Brienna K. A.
,
Ma, Shifan
,
Hu, Ziheng
,
Turcios, Noe A.
,
Yang, Peng
,
Tong, Qin
,
McCall, Anna K.
,
Blumberg, Peter M.
,
Xie, Xiang-Qun
Journal:
The AAPS Journal
Year:
2016
File:
PDF, 1.24 MB
Your tags:
2016
2
Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation
Feng, Zhiwei
,
Pearce, Larry V.
,
Zhang, Yu
,
Xing, Changrui
,
Herold, Brienna K. A.
,
Ma, Shifan
,
Hu, Ziheng
,
Turcios, Noe A.
,
Yang, Peng
,
Tong, Qin
,
McCall, Anna K.
,
Blumberg, Peter M.
,
Xie, Xiang-Qun
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 1.24 MB
Your tags:
english, 2016
3
Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)
Singh, Aman P.
,
Maass, Katie F.
,
Betts, Alison M.
,
Wittrup, K. Dane
,
Kulkarni, Chethana
,
King, Lindsay E.
,
Khot, Antari
,
Shah, Dhaval K.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 1017 KB
Your tags:
english, 2016
4
Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer
Thomas, Veena A.
,
Balthasar, Joseph P.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 623 KB
Your tags:
english, 2016
5
Monitoring Quality of Biotherapeutic Products Using Multivariate Data Analysis
Rathore, Anurag S.
,
Pathak, Mili
,
Jain, Renu
,
Jadaun, Gaurav Pratap Singh
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 945 KB
Your tags:
english, 2016
6
Environmental Risk Assessment of Pharmaceutical Mixtures: Demands, Gaps, and Possible Bridges
Backhaus, Thomas
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 341 KB
Your tags:
english, 2016
7
Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1Antibody in Cynomolgus Monkey
Ng, Chee M.
,
Fielder, Paul J.
,
Jin, Jin
,
Deng, Rong
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 665 KB
Your tags:
english, 2016
8
Porous Silica-Supported Solid Lipid Particles for Enhanced Solubilization of Poorly Soluble Drugs
Yasmin, Rokhsana
,
Rao, Shasha
,
Bremmell, Kristen E.
,
Prestidge, Clive A.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 1.58 MB
Your tags:
english, 2016
9
PK/PD Modelling of the QT Interval: a Step Towards Defining the Translational Relationship BetweenIn Vitro, Awake Beagle Dogs, and Humans
Marostica, Eleonora
,
Van Ammel, Karel
,
Teisman, Ard
,
Gallacher, David
,
Van Bocxlaer, Jan
,
De Ridder, Filip
,
Boussery, Koen
,
Vermeulen, An
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 1.34 MB
Your tags:
english, 2016
10
Use of Modeling and Simulation Tools for Understanding the Impact of Formulation on the Absorption of a Low Solubility Compound: Ciprofloxacin
Martinez, Marilyn
,
Mistry, Bipin
,
Lukacova, Viera
,
Polli, Jim
,
Hoag, Stephen
,
Dowling, Thomas
,
Kona, Ravikanth
,
Fahmy, Raafat
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 1.06 MB
Your tags:
english, 2016
11
Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended Approaches
Cardot, J.-M.
,
Garcia Arieta, A.
,
Paixao, P.
,
Tasevska, I.
,
Davit, B.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 292 KB
Your tags:
english, 2016
12
A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain
Juul, Rasmus V
,
Knøsgaard, Katrine R
,
Olesen, Anne E
,
Pedersen, Katja V
,
Kreilgaard, Mads
,
Christrup, Lona L
,
Osther, Palle J
,
Drewes, Asbjørn M
,
Lund, Trine M
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 657 KB
Your tags:
english, 2016
13
Development and Validation of Electrochemiluminescence Assays to Measure Free and Total sSLAMF7 in Human Serum in the Absence and Presence of Elotuzumab
Postelnek, Jennifer
,
Neely, Robert J.
,
Robbins, Michael D.
,
Gleason, Carol R.
,
Peterson, Jon E.
,
Piccoli, Steven P.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 503 KB
Your tags:
english, 2016
14
The FDA’s Experience with Emerging Genomics Technologies—Past, Present, and Future
Xu, Joshua
,
Thakkar, Shraddha
,
Gong, Binsheng
,
Tong, Weida
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 266 KB
Your tags:
english, 2016
15
Therapeutic Application of Pharmacogenomics in Oncology
Zhang, Yingqi
,
Somtakoune, Seumsack Dennis
,
Cheung, Christina
,
Listiawan, Mario
,
Feng, Xiaodong
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 345 KB
Your tags:
english, 2016
16
Evolutionary Dynamics of Chronic Myeloid Leukemia Progression: the Progression-Inhibitory Effect of Imatinib
Jackson, Robert C.
,
Radivoyevitch, Tomas
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 434 KB
Your tags:
english, 2016
17
The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters—an Update
Zhang, Wenpeng
,
Li, Yanyan
,
Zou, Peng
,
Wu, Man
,
Zhang, Zhenqing
,
Zhang, Tao
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 468 KB
Your tags:
english, 2016
18
Critical Importance and Quality Evaluation of Drug Delivery Autoinjectors in the FDA-DOD Shelf Life Extension Program (SLEP)
Khan, Saeed R.
,
Mohammad, Adil
,
Khan, Mansoor A.
,
Faustino, Patrick J.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 231 KB
Your tags:
english, 2016
19
Synthesis and Physicochemical Characterization of a Diethyl Ester Prodrug of DTPA and Its Investigation as an Oral Decorporation Agent in Rats
Huckle, James E.
,
Sadgrove, Matthew P.
,
Leed, Marina G. D.
,
Yang, Yu-Tsai
,
Mumper, Russell J.
,
Semelka, Richard C.
,
Jay, Michael
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 528 KB
Your tags:
english, 2016
20
Clinical, Pharmacokinetic, andIn VitroStudies to Support Bioequivalence of Ophthalmic Drug Products
Choi, Stephanie H.
,
Lionberger, Robert A.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 489 KB
Your tags:
english, 2016
21
Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations
Villiger, Angela
,
Stillhart, Cordula
,
Parrott, Neil
,
Kuentz, Martin
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 828 KB
Your tags:
english, 2016
22
Quantifying Trace Amounts of Aggregates in Biopharmaceuticals Using Analytical Ultracentrifugation Sedimentation Velocity: Bayesian Analyses andFStatistics
Wafer, Lucas
,
Kloczewiak, Marek
,
Luo, Yin
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 851 KB
Your tags:
english, 2016
23
Effect of Gastric Fluid Volume on theIn VitroDissolution andIn VivoAbsorption of BCS Class II Drugs: a Case Study with Nifedipine
Nader, Ahmed M.
,
Quinney, Sara K.
,
Fadda, Hala M.
,
Foster, David R.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 459 KB
Your tags:
english, 2016
24
The Use of Cellulose Membrane to Eliminate Burst Release from Intravaginal Rings
Helbling, Ignacio M.
,
Ibarra, Juan C. D.
,
Luna, Julio A.
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 1.58 MB
Your tags:
english, 2016
25
Cell-Based Therapies Formulations: Unintended components
Atouf, Fouad
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 263 KB
Your tags:
english, 2016
26
Dual Outcomes of Rosiglitazone Treatment on Fatty Liver
Gao, Mingming
,
Ma, Yongjie
,
Alsaggar, Mohammad
,
Liu, Dexi
Journal:
The AAPS Journal
Year:
2016
Language:
english
File:
PDF, 8.97 MB
Your tags:
english, 2016
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