Volume 18; Issue 4

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The AAPS Journal
Volume 18; Issue 4

The AAPS Journal

Volume 18; Issue 4

1

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation

Feng, Zhiwei, Pearce, Larry V., Zhang, Yu, Xing, Changrui, Herold, Brienna K. A., Ma, Shifan, Hu, Ziheng, Turcios, Noe A., Yang, Peng, Tong, Qin, McCall, Anna K., Blumberg, Peter M., Xie, Xiang-Qun

Journal:

The AAPS Journal

Year:

2016

File:

PDF, 1.24 MB

2016

2

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation

Feng, Zhiwei, Pearce, Larry V., Zhang, Yu, Xing, Changrui, Herold, Brienna K. A., Ma, Shifan, Hu, Ziheng, Turcios, Noe A., Yang, Peng, Tong, Qin, McCall, Anna K., Blumberg, Peter M., Xie, Xiang-Qun

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

3

Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

Singh, Aman P., Maass, Katie F., Betts, Alison M., Wittrup, K. Dane, Kulkarni, Chethana, King, Lindsay E., Khot, Antari, Shah, Dhaval K.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1017 KB

english, 2016

4

Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer

Thomas, Veena A., Balthasar, Joseph P.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 623 KB

english, 2016

5

Monitoring Quality of Biotherapeutic Products Using Multivariate Data Analysis

Rathore, Anurag S., Pathak, Mili, Jain, Renu, Jadaun, Gaurav Pratap Singh

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 945 KB

english, 2016

6

Environmental Risk Assessment of Pharmaceutical Mixtures: Demands, Gaps, and Possible Bridges

Backhaus, Thomas

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 341 KB

english, 2016

7

Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1Antibody in Cynomolgus Monkey

Ng, Chee M., Fielder, Paul J., Jin, Jin, Deng, Rong

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 665 KB

english, 2016

8

Porous Silica-Supported Solid Lipid Particles for Enhanced Solubilization of Poorly Soluble Drugs

Yasmin, Rokhsana, Rao, Shasha, Bremmell, Kristen E., Prestidge, Clive A.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1.58 MB

english, 2016

9

PK/PD Modelling of the QT Interval: a Step Towards Defining the Translational Relationship BetweenIn Vitro, Awake Beagle Dogs, and Humans

Marostica, Eleonora, Van Ammel, Karel, Teisman, Ard, Gallacher, David, Van Bocxlaer, Jan, De Ridder, Filip, Boussery, Koen, Vermeulen, An

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

10

Use of Modeling and Simulation Tools for Understanding the Impact of Formulation on the Absorption of a Low Solubility Compound: Ciprofloxacin

Martinez, Marilyn, Mistry, Bipin, Lukacova, Viera, Polli, Jim, Hoag, Stephen, Dowling, Thomas, Kona, Ravikanth, Fahmy, Raafat

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1.06 MB

english, 2016

11

Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended Approaches

Cardot, J.-M., Garcia Arieta, A., Paixao, P., Tasevska, I., Davit, B.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 292 KB

english, 2016

12

A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

Juul, Rasmus V, Knøsgaard, Katrine R, Olesen, Anne E, Pedersen, Katja V, Kreilgaard, Mads, Christrup, Lona L, Osther, Palle J, Drewes, Asbjørn M, Lund, Trine M

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 657 KB

english, 2016

13

Development and Validation of Electrochemiluminescence Assays to Measure Free and Total sSLAMF7 in Human Serum in the Absence and Presence of Elotuzumab

Postelnek, Jennifer, Neely, Robert J., Robbins, Michael D., Gleason, Carol R., Peterson, Jon E., Piccoli, Steven P.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 503 KB

english, 2016

14

The FDA’s Experience with Emerging Genomics Technologies—Past, Present, and Future

Xu, Joshua, Thakkar, Shraddha, Gong, Binsheng, Tong, Weida

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 266 KB

english, 2016

15

Therapeutic Application of Pharmacogenomics in Oncology

Zhang, Yingqi, Somtakoune, Seumsack Dennis, Cheung, Christina, Listiawan, Mario, Feng, Xiaodong

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 345 KB

english, 2016

16

Evolutionary Dynamics of Chronic Myeloid Leukemia Progression: the Progression-Inhibitory Effect of Imatinib

Jackson, Robert C., Radivoyevitch, Tomas

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 434 KB

english, 2016

17

The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters—an Update

Zhang, Wenpeng, Li, Yanyan, Zou, Peng, Wu, Man, Zhang, Zhenqing, Zhang, Tao

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 468 KB

english, 2016

18

Critical Importance and Quality Evaluation of Drug Delivery Autoinjectors in the FDA-DOD Shelf Life Extension Program (SLEP)

Khan, Saeed R., Mohammad, Adil, Khan, Mansoor A., Faustino, Patrick J.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 231 KB

english, 2016

19

Synthesis and Physicochemical Characterization of a Diethyl Ester Prodrug of DTPA and Its Investigation as an Oral Decorporation Agent in Rats

Huckle, James E., Sadgrove, Matthew P., Leed, Marina G. D., Yang, Yu-Tsai, Mumper, Russell J., Semelka, Richard C., Jay, Michael

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 528 KB

english, 2016

20

Clinical, Pharmacokinetic, andIn VitroStudies to Support Bioequivalence of Ophthalmic Drug Products

Choi, Stephanie H., Lionberger, Robert A.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 489 KB

english, 2016

21

Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations

Villiger, Angela, Stillhart, Cordula, Parrott, Neil, Kuentz, Martin

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 828 KB

english, 2016

22

Quantifying Trace Amounts of Aggregates in Biopharmaceuticals Using Analytical Ultracentrifugation Sedimentation Velocity: Bayesian Analyses andFStatistics

Wafer, Lucas, Kloczewiak, Marek, Luo, Yin

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 851 KB

english, 2016

23

Effect of Gastric Fluid Volume on theIn VitroDissolution andIn VivoAbsorption of BCS Class II Drugs: a Case Study with Nifedipine

Nader, Ahmed M., Quinney, Sara K., Fadda, Hala M., Foster, David R.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 459 KB

english, 2016

24

The Use of Cellulose Membrane to Eliminate Burst Release from Intravaginal Rings

Helbling, Ignacio M., Ibarra, Juan C. D., Luna, Julio A.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1.58 MB

english, 2016

25

Cell-Based Therapies Formulations: Unintended components

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 263 KB

english, 2016

26

Dual Outcomes of Rosiglitazone Treatment on Fatty Liver

Gao, Mingming, Ma, Yongjie, Alsaggar, Mohammad, Liu, Dexi

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 8.97 MB

english, 2016