Volume 19; Issue 2

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The AAPS Journal
Volume 19; Issue 2

The AAPS Journal

Volume 19; Issue 2

1

Current Update of a Carboxymethylcellulose-PEG Conjugate Platform for Delivery of Insoluble Cytotoxic Agents to Tumors

Yang, Yang, Bteich, Joseph, Li, Shyh-Dar

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.97 MB

english, 2017

2

Validation of a Drug-Resistant Anti-Adalimumab Antibody Assay to Monitor Immunogenicity in the Presence of High Concentrations of Adalimumab

Bian, Sumin, Ferrante, Marc, Gils, Ann

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 581 KB

english, 2017

3

Erratum to: Intra-articular Injection of Urinary Bladder Matrix Reduces Osteoarthritis Development

Jacobs, Heather N., Rathod, Sona, Wolf, Matthew T., Elisseeff, Jennifer H.

Journal:

The AAPS Journal

Year:

2017

File:

PDF, 189 KB

2017

4

Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer

Yang, Tianzhi, Fogarty, Brittany, LaForge, Bret, Aziz, Salma, Pham, Thuy, Lai, Leanne, Bai, Shuhua

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.72 MB

english, 2017

5

Use of Spray-Dried Dispersions in Early Pharmaceutical Development: Theoretical and Practical Challenges

Li, Jinjiang, Patel, Dhaval, Wang, George

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 589 KB

english, 2017

6

Tumor Static Concentration Curves in Combination Therapy

Cardilin, Tim, Almquist, Joachim, Jirstrand, Mats, Sostelly, Alexandre, Amendt, Christiane, El Bawab, Samer, Gabrielsson, Johan

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 891 KB

english, 2017

7

Epigenetic CpG Methylation of the Promoter and Reactivation of the Expression of GSTP1 by Astaxanthin in Human Prostate LNCaP Cells

Yang, Yuqing, Fuentes, Francisco, Shu, Limin, Wang, Chao, Pung, Doug, Li, Wenji, Zhang, Chengyue, Guo, Yue, Kong, Ah-Ng

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 842 KB

english, 2017

8

GDF11 Treatment Attenuates the Recovery of Skeletal Muscle Function After Injury in Older Rats

Zhou, Yu, Sharma, Neel, Dukes, David, Myzithras, Maria B., Gupta, Priyanka, Khalil, Ashraf, Kahn, Julius, Ahlberg, Jennifer S., Hayes, David B., Franti, Michael, Criswell, Tracy

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.55 MB

english, 2017

9

A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

Tod, M., Bourguignon, L., Bleyzac, N., Goutelle, S.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

10

Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization

Deitchman, Amelia N., Heinrichs, M. Tobias, Khaowroongrueng, Vipada, Jadhav, Satyawan B., Derendorf, Hartmut

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 947 KB

english, 2017

11

Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling

Tiwari, Abhinav, Abraham, Anson K., Harrold, John M., Zutshi, Anup, Singh, Pratap

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 948 KB

english, 2017

12

Bioavailability and Bioequivalence Aspects of Oral Modified-Release Drug Products

Wang, Rong, Conner, Dale P., Li, Bing V.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 315 KB

english, 2017

13

Clinical Translation of the National Institutes of Health’s Investments in Nanodrug Products and Devices

Henderson, Lori A., Shankar, Lalitha K.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 791 KB

english, 2017

14

Exposure–Response and Tumor Growth Inhibition Analyses of the Monovalent Anti-c-MET Antibody Onartuzumab (MetMAb) in the Second- and Third-Line Non-Small Cell Lung Cancer

Han, Kelong, Chanu, Pascal, Jonsson, Fredrik, Winter, Helen, Bruno, René, Jin, Jin, Stroh, Mark

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 589 KB

english, 2017

15

Cardiovascular Ion Channel Inhibitor Drug-Drug Interactions with P-glycoprotein

Ledwitch, Kaitlyn V., Roberts, Arthur G.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1020 KB

english, 2017

16

Population Pharmacokinetics of an Extended-Release Formulation of Exenatide Following Single- and Multiple-Dose Administration

Cirincione, Brenda, Edwards, Jeffrey, Mager, Donald E.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

17

Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure

Herskovitz, Jonathan, Ryman, Josiah, Thway, Theingi, Lee, Stephanie, Zhou, Lei, Chirmule, Narendra, Meibohm, Bernd, Jawa, Vibha

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

18

Porous mannitol carrier for pulmonary delivery of cyclosporine A nanoparticles

Leung, Sharon Shui Yee, Wong, Jennifer, Guerra, Heloisa Victorino, Samnick, Kevin, Prud’homme, Robert K., Chan, Hak-Kim

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 842 KB

english, 2017

19

Identification of New Synthetic Cannabinoid ADB-CHMINACA (MAB-CHMINACA) Metabolites in Human Hepatocytes

Carlier, Jeremy, Diao, Xingxing, Sempio, Cristina, Huestis, Marilyn A.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 761 KB

english, 2017

20

Approaches to Mitigate the Unwanted Immunogenicity of Therapeutic Proteins during Drug Development

Salazar-Fontana, Laura I., Desai, Dharmesh D., Khan, Tarik A., Pillutla, Renuka C., Prior, Sandra, Ramakrishnan, Radha, Schneider, Jennifer, Joseph, Alexandra

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 326 KB

english, 2017

21

A Comparative Study of the Bone Regenerative Effect of Chemically Modified RNA Encoding BMP-2 or BMP-9

Khorsand, Behnoush, Elangovan, Satheesh, Hong, Liu, Dewerth, Alexander, Kormann, Michael S. D., Salem, Aliasger K.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

22

Tissue Concentration of Dodecafluoropentane (DDFP) Following Repeated IV Administration in the New Zealand White Rabbit

Arthur, Christine, Song, Lin, Culp, William, Brown, Aliza, Borrelli, Michael, Skinner, Robert, Hendrickson, Howard

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.64 MB

english, 2017

23

Microdialysis Monitoring in Clinical Traumatic Brain Injury and Its Role in Neuroprotective Drug Development

Thelin, Eric Peter, Carpenter, Keri L. H., Hutchinson, Peter J., Helmy, Adel

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 507 KB

english, 2017

24

An Integrated Assessment of the Effects of Immunogenicity on the Pharmacokinetics, Safety, and Efficacy of Elotuzumab

Passey, Chaitali, Mora, Johanna, Dodge, Robert, Gibiansky, Leonid, Sheng, Jennifer, Roy, Amit, Bello, Akintunde, Gupta, Manish

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 538 KB

english, 2017

25

Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients

Ahmed, Ghada F., Bathena, Sai Praneeth R., Brundage, Richard C., Leppik, Ilo E., Conway, Jeannine M., Schwartz, Janice B., Birnbaum, Angela K.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 583 KB

english, 2017

26

Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens:in vivoandin vitroevaluations

Siqueira, Scheyla D.V.S., Müllertz, Anette, Gräeser, Kirsten, Kasten, Georgia, Mu, Huiling, Rades, Thomas

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 398 KB

english, 2017

27

Insulin Formulation Characterization—the Thioflavin T Assays

Schlein, Morten

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

28

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions fromIn VitroData Using Nonlinear Mixed-Effects Modeling

Nicole A. Kratochwil,Christophe Meille,Stephen Fowler…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1002 KB

english, 2017

29

Erratum to: Tumor Static Concentration Curves in Combination Therapy

Tim Cardilin,Joachim Almquist,Mats Jirstand,Alexandre Soselly…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 207 KB

english, 2017

30

Erratum to: Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling

Abhinav Tiwari,Anson K. Abraham,John M. Harrold,Anup Zutshi…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 201 KB

english, 2017

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