Volume 19; Issue 3

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The AAPS Journal
Volume 19; Issue 3

The AAPS Journal

Volume 19; Issue 3

1

Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers

Hamitouche, Noureddine, Comets, Emmanuelle, Ribot, Mégane, Alvarez, Jean-Claude, Bellissant, Eric, Laviolle, Bruno

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

2

Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples

Vikingsson, Svante, Wohlfarth, Ariane, Andersson, Mikael, Gréen, Henrik, Roman, Markus, Josefsson, Martin, Kugelberg, Fredrik C, Kronstrand, Robert

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 547 KB

english, 2017

3

Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation

McVicar, Scott D., Rayavara, Kempaiah, Carney, Darrell H.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.84 MB

english, 2017

4

Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion

Vithani, Kapilkumar, Hawley, Adrian, Jannin, Vincent, Pouton, Colin, Boyd, Ben J.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.08 MB

english, 2017

5

Scientific and Regulatory Considerations for Generic Complex Drug Products Containing Nanomaterials

Zheng, Nan, Sun, Dajun D., Zou, Peng, Jiang, Wenlei

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 569 KB

english, 2017

6

A Heparin Purification Process Removes Spiked Transmissible Spongiform Encephalopathy Agent

Bett, Cyrus, Grgac, Ksenija, Long, Dianna, Karfunkle, Michael, Keire, David A., Asher, David M., Gregori, Luisa

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 547 KB

english, 2017

7

Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties

Gabrielsson, Johan, Peletier, Lambertus A.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.19 MB

english, 2017

8

Liposomal Drug Product Development and Quality: Current US Experience and Perspective

Kapoor, Mamta, Lee, Sau L., Tyner, Katherine M.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 3.15 MB

english, 2017

9

Spray-Dried Thiolated Chitosan-Coated Sodium Alginate Multilayer Microparticles for Vaginal HIV Microbicide Delivery

Meng, Jianing, Agrahari, Vivek, Ezoulin, Miezan J., Purohit, Sudhaunshu S., Zhang, Tao, Molteni, Agostino, Dim, Daniel, Oyler, Nathan A., Youan, Bi-Botti C.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 7.06 MB

english, 2017

10

Application of Pharmacokinetics and Pharmacodynamics in Product Life Cycle Management. A Case Study with a Carbidopa-Levodopa Extended-Release Formulation

Modi, Nishit B.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 528 KB

english, 2017

11

Colloidal Gels with Extracellular Matrix Particles and Growth Factors for Bone Regeneration in Critical Size Rat Calvarial Defects

Townsend, Jakob M., Dennis, S. Connor, Whitlow, Jonathan, Feng, Yi, Wang, Jinxi, Andrews, Brian, Nudo, Randolph J., Detamore, Michael S., Berkland, Cory J.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 8.16 MB

english, 2017

12

Advantageous Solubility-Permeability Interplay When Using Amorphous Solid Dispersion (ASD) Formulation for the BCS Class IV P-gp Substrate Rifaximin: Simultaneous Increase of Both the Solubility and the Permeability

Beig, Avital, Fine-Shamir, Noa, Lindley, David, Miller, Jonathan M, Dahan, Arik

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 788 KB

english, 2017

13

Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes

Morales, Javier O., Fathe, Kristin R., Brunaugh, Ashlee, Ferrati, Silvia, Li, Song, Montenegro-Nicolini, Miguel, Mousavikhamene, Zeynab, McConville, Jason T., Prausnitz, Mark R., Smyth, Hugh D. C.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 457 KB

english, 2017

14

Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies

Zhu, Rui, Lu, Dan, Chu, Yu-Waye, Chai, Akiko, Green, Michelle, Zhang, Nancy, Jin, Jin Yan

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.35 MB

english, 2017

15

Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis

Alsanea, Sary, Gao, Mingming, Liu, Dexi

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 5.58 MB

english, 2017

16

Aptamer-Conjugated Chitosan-Anchored Liposomal Complexes for Targeted Delivery of Erlotinib to EGFR-Mutated Lung Cancer Cells

Li, Fengqiao, Mei, Hao, Xie, Xiaodong, Zhang, Huijuan, Liu, Jian, Lv, Tingting, Nie, Huifang, Gao, Yu, Jia, Lee

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.85 MB

english, 2017

17

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

Bi, Yi-an, Scialis, Renato J., Lazzaro, Sarah, Mathialagan, Sumathy, Kimoto, Emi, Keefer, Julie, Zhang, Hui, Vildhede, Anna M., Costales, Chester, Rodrigues, A. David, Tremaine, Larry M., Varma, Manth

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

18

Modeling a Composite Score in Parkinson’s Disease Using Item Response Theory

Gottipati, Gopichand, Karlsson, Mats O., Plan, Elodie L.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

19

Structure-Promiscuity Relationship Puzzles—Extensively Assayed Analogs with Large Differences in Target Annotations

Hu, Ye, Jasial, Swarit, Gilberg, Erik, Bajorath, Jürgen

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.85 MB

english, 2017

20

Global Harmonization of Comparator Products for Bioequivalence Studies

Gwaza, Luther, Gordon, John, Leufkens, Hubert, Stahl, Matthias, García-Arieta, Alfredo

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 229 KB

english, 2017

21

A LC-MS All-in-One Workflow for Site-Specific Location, Identification and Quantification of N-/O- Glycosylation in Human Chorionic Gonadotropin Drug Products

Zhu, Hongbin, Qiu, Chen, Ruth, Ashley C., Keire, David A., Ye, Hongping

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

22

Pharmacokinetics of the Inhaled Selective Glucocorticoid Receptor Modulator AZD5423 Following Inhalation Using Different Devices

Melin, Johanna, Prothon, Susanne, Kloft, Charlotte, Cleton, Adriaan, Amilon, Carl, Jorup, Carin, Bäckman, Per, Olsson, Bo, Hamrén, Ulrika Wählby

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

23

Development Considerations for Nanocrystal Drug Products

Chen, Mei-Ling, John, Mathew, Lee, Sau L., Tyner, Katherine M.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 845 KB

english, 2017

24

Evaluation of the Potency, Neutralizing Antibody Response, and Stability of a Recombinant Fusion Protein Vaccine forStreptococcus pyogenes

Burlet, E., HogenEsch, H., Dunham, A., Morefield, G.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 884 KB

english, 2017

25

A Proposal to Redefine Clinical Immunogenicity Assessment

Mytych, Daniel T., Hock, M. Benjamin, Kroenke, Mark, Jawa, Vibha, Kaliyaperumal, Arunan, Zhou, Yanchen

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 232 KB

english, 2017

26

Current Trends in Ligand Binding Real-Time Measurement Technologies

Fraser, Stephanie, Shih, Judy Y., Ware, Mark, O’Connor, Edward, Cameron, Mark J., Schwickart, Martin, Zhao, Xuemei, Regnstrom, Karin

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.23 MB

english, 2017

27

Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing

Stillhart, Cordula, Parrott, Neil J., Lindenberg, Marc, Chalus, Pascal, Bentley, Darren, Szepes, Anikó

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

28

Exploring Canine-Human Differences in Product Performance. Part II: Use of Modeling and Simulation to Explore the Impact of Formulation on CiprofloxacinIn VivoAbsorption and Dissolution in Dogs

Martinez, M. N., Mistry, B., Lukacova, V., Lentz, K. A., Polli, J. E., Hoag, S. W., Dowling, T., Kona, R., Fahmy, R. M.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 5.22 MB

english, 2017

29

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

Yi-an Bi,Renato J. Scialis,Sarah Lazzaro,Sumathy Mathialagan…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 204 KB

english, 2017

30

Erratum to: Systematic Verification of Bioanalytical Similarity Between a Biosimilar and a Reference Biotherapeutic: Committee Recommendations for the Development and Validation of a Single Ligand-Binding Assay to Support Pharmacokinetic Assessments

Joseph C. Marini,Michael Anderson,Xiao-Yan Cai,John Chappell…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 206 KB

english, 2017

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