Volume 19; Issue 4

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The AAPS Journal
Volume 19; Issue 4

The AAPS Journal

Volume 19; Issue 4

1

The Two Main Goals of Bioequivalence Studies

Endrenyi, Laszlo, Blume, Henning H., Tothfalusi, Laszlo

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 266 KB

english, 2017

2

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations

Yamamoto, Yumi, Danhof, Meindert, de Lange, Elizabeth C. M.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.93 MB

english, 2017

3

The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption

Sutton, Steven C, Nause, Richard, Gandelman, Kuan

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 609 KB

english, 2017

4

Controlled Release of Vanadium from a Composite Scaffold Stimulates Mesenchymal Stem Cell Osteochondrogenesis

Schussler, S. D., Uske, K., Marwah, P., Kemp, F. W., Bogden, J. D., Lin, S. S., Livingston Arinzeh, Treena

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 9.98 MB

english, 2017

5

Dissolution comparisons using a Multivariate Statistical Distance (MSD) test and a comparison of various approaches for calculating the measurements of dissolution profile comparison

Cardot, J-M., Roudier, B., Schütz, H.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 865 KB

english, 2017

6

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

Lochhead, Jeffrey J., Ronaldson, Patrick T., Davis, Thomas P.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 430 KB

english, 2017

7

In VitroandIn VivoMetabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl

Watanabe, Shimpei, Vikingsson, Svante, Roman, Markus, Green, Henrik, Kronstrand, Robert, Wohlfarth, Ariane

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

8

Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1)

Singh, Aman P., Shah, Dhaval K.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.92 MB

english, 2017

9

Blood-Brain Barriers in Obesity

Rhea, Elizabeth M., Salameh, Therese S., Logsdon, Aric F., Hanson, Angela J., Erickson, Michelle A., Banks, William A.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 544 KB

english, 2017

10

How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities

Tyner, Katherine M., Zheng, Nan, Choi, Stephanie, Xu, Xiaoming, Zou, Peng, Jiang, Wenlei, Guo, Changning, Cruz, Celia N.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 921 KB

english, 2017

11

Physiologically Based Pharmacokinetic and Absorption Modeling for Osmotic Pump Products

Ni, Zhanglin, Talattof, Arjang, Fan, Jianghong, Tsakalozou, Eleftheria, Sharan, Satish, Sun, Dajun, Wen, Hong, Zhao, Liang, Zhang, Xinyuan

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.52 MB

english, 2017

12

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates

Tumey, L. Nathan, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Graziani, Edmund I., Puthenveetil, Sujiet, Casavant, Jeffrey, Marquette, Kimberly, Clark, Tracey, Bikker, Jac

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.96 MB

english, 2017

13

Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example forIn SilicoAssessment of Adaptive Dosing Strategies

Wojciechowski, Jessica, Upton, Richard N., Mould, Diane R., Wiese, Michael D., Foster, David J. R.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.46 MB

english, 2017

14

Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 byCunninghamella elegans

Shimpei Watanabe,Unnikrishnan Kuzhiumparambil,My Ann Nguyen…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.09 MB

english, 2017

15

Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke

Sifat, Ali Ehsan, Vaidya, Bhuvaneshwar, Abbruscato, Thomas J.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 945 KB

english, 2017

16

Controlled Release of Second Generation mTOR Inhibitors to Restrain Inflammation in Primary Immune Cells

Gosselin, Emily A., Tostanoski, Lisa H., Jewell, Christopher M.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.77 MB

english, 2017

17

Minipig and Human Metabolism of Aldehyde Oxidase Substrates:In Vitro–In VivoComparisons

Wilkinson, David J., Southall, Rosalind L., Li, Mingguang, Wright, Lisa M., Corfield, Lindsay J., Heeley, Thomas A., Bratby, Benjamin, Mannu, Ranbir, Johnson, Sarah L., Shaw, Victoria, Friett, Holly L

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 364 KB

english, 2017

18

Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity

Ali Akbari Ghavimi, Soheila, Tata, Rama Rao, Greenwald, Andrew J., Allen, Brittany N., Grant, David A., Grant, Sheila A., Lee, Mark W., Ulery, Bret D.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.19 MB

english, 2017

19

Evolution of Choice of Solubility and Dissolution Media After Two Decades of Biopharmaceutical Classification System

Bou-Chacra, Nadia, Melo, Katherine Jasmine Curo, Morales, Ivan Andrés Cordova, Stippler, Erika S., Kesisoglou, Filippos, Yazdanian, Mehran, Löbenberg, Raimar

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 459 KB

english, 2017

20

Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys

Gu, Jian-Ming, Zhao, Xiao-Yan, Schwarz, Thomas, Schuhmacher, Joachim, Baumann, Andreas, Ho, Elena, Subramanyan, Babu, Tran, Kathy, Myles, Timothy, Patel, Chandra, Koellnberger, Maria

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 565 KB

english, 2017

21

Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females

Lee, Jieon, Kim, Andrew HyoungJin, Yi, SoJeong, Lee, SeungHwan, Yoon, Seo Hyun, Yu, Kyung-Sang, Jang, In-Jin, Cho, Joo-Youn

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 716 KB

english, 2017

22

Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples

Loebrich, Sven, Shen, Mingfang, Cohen, Erika, Payne, Gillian, Chen, Ying, Bogalhas, Megan, Zhao, Yiwei

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.20 MB

english, 2017

23

Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy

Han, Hadas, Mann, Aniv, Ekstein, Dana, Eyal, Sara

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1008 KB

english, 2017

24

Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin

Soderstrom, Catherine, Berstein, Gabriel, Zhang, Weidong, Valdez, Hernan, Fitz, Lori, Kuhn, Max, Fraser, Stephanie

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 288 KB

english, 2017

25

Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

Abdullahi, Wazir, Davis, Thomas P., Ronaldson, Patrick T.

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 783 KB

english, 2017

26

IntegratedIn SilicoFragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5

Bian, Yuemin, Feng, Zhiwei, Yang, Peng, Xie, Xiang-Qun

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 6.66 MB

english, 2017

27

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs

Rose, Rachel H., Turner, David B., Neuhoff, Sibylle, Jamei, Masoud

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 726 KB

english, 2017

28

Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations

Yumi Yamamoto,Meindert Danhof,Elizabeth C. M. de Lange

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 949 KB

english, 2017

29

QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models

Yougan Cheng,Craig J. Thalhauser,Shepard Smithline,Jyotsna Pagidala…

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 4.53 MB

english, 2017

30

Neurovascular Alterations in Alzheimer’s Disease: Transporter Expression Profiles and CNS Drug Access

Mitchell P. McInerney,Jennifer L. Short,Joseph A. Nicolazzo

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.80 MB

english, 2017

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