Volume 184; Issue 3

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The Journal of Immunology
Volume 184; Issue 3

The Journal of Immunology

Volume 184; Issue 3

1

A New Strategy for the Identification of Novel Molecules with Targeted Proresolution of Inflammation Properties

Navarro-Xavier, R. A., Newson, J., Silveira, V. L. F., Farrow, S. N., Gilroy, D. W., Bystrom, J.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.46 MB

english, 2010

2

Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism

Yachimovich-Cohen, N., Even-Ram, S., Shufaro, Y., Rachmilewitz, J., Reubinoff, B.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

3

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

Dietl, K., Renner, K., Dettmer, K., Timischl, B., Eberhart, K., Dorn, C., Hellerbrand, C., Kastenberger, M., Kunz-Schughart, L. A., Oefner, P. J., Andreesen, R., Gottfried, E., Kreutz, M. P.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

4

Cutting Edge: Bortezomib-Treated Tumors Sensitized to NK Cell Apoptosis Paradoxically Acquire Resistance to Antigen-Specific T Cells

Lundqvist, A., Su, S., Rao, S., Childs, R.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

5

Regulation of Fc RI Expression during Murine Basophil Maturation: The Interplay between IgE, Cell Division, and Fc RI Synthetic Rate

Zaidi, A. K., MacGlashan, D. W.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

6

Autoimmune Disease in Lyn-Deficient Mice Is Dependent on an Inflammatory Environment Established by IL-6

Tsantikos, E., Oracki, S. A., Quilici, C., Anderson, G. P., Tarlinton, D. M., Hibbs, M. L.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 825 KB

english, 2010

7

Early Recycling Compartment Trafficking of CD1a Is Essential for Its Intersection and Presentation of Lipid Antigens

Cernadas, M., Cavallari, M., Watts, G., Mori, L., De Libero, G., Brenner, M. B.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

8

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

Inoue, S., Unsinger, J., Davis, C. G., Muenzer, J. T., Ferguson, T. A., Chang, K., Osborne, D. F., Clark, A. T., Coopersmith, C. M., McDunn, J. E., Hotchkiss, R. S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 775 KB

english, 2010

9

Plugging the Leaky Pre-B Cell Receptor

Conley, M. E., Burrows, P. D.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 648 KB

english, 2010

10

Loss of CD34 Leads To Exacerbated Autoimmune Arthritis through Increased Vascular Permeability

Blanchet, M.-R., Gold, M., Maltby, S., Bennett, J., Petri, B., Kubes, P., Lee, D. M., McNagny, K. M.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

11

T Cells Are Required for the Production of Blister-Inducing Autoantibodies in Experimental Epidermolysis Bullosa Acquisita

Sitaru, A. G., Sesarman, A., Mihai, S., Chiriac, M. T., Zillikens, D., Hultman, P., Solbach, W., Sitaru, C.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

12

Progenitor Cell Origin Plays a Role in Fate Choices of Mature B Cells

Fossati, V., Kumar, R., Snoeck, H.-W.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.30 MB

english, 2010

13

IL-17 Regulates CXCL1 mRNA Stability via an AUUUA/Tristetraprolin-Independent Sequence

Datta, S., Novotny, M., Pavicic, P. G., Zhao, C., Herjan, T., Hartupee, J., Hamilton, T.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

14

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

Boulkroun, S., Guenin-Mace, L., Thoulouze, M.-I., Monot, M., Merckx, A., Langsley, G., Bismuth, G., Di Bartolo, V., Demangel, C.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

15

A Small, Variable, and Irregular Killer Cell Ig-Like Receptor Locus Accompanies the Absence of MHC-C and MHC-G in Gibbons

Abi-Rached, L., Kuhl, H., Roos, C., ten Hallers, B., Zhu, B., Carbone, L., de Jong, P. J., Mootnick, A. R., Knaust, F., Reinhardt, R., Parham, P., Walter, L.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.35 MB

english, 2010

16

Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells

Zhao, D.-M., Yu, S., Zhou, X., Haring, J. S., Held, W., Badovinac, V. P., Harty, J. T., Xue, H.-H.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

17

Roles of Sema4D-Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis

Okuno, T., Nakatsuji, Y., Moriya, M., Takamatsu, H., Nojima, S., Takegahara, N., Toyofuku, T., Nakagawa, Y., Kang, S., Friedel, R. H., Sakoda, S., Kikutani, H., Kumanogoh, A.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.39 MB

english, 2010

18

Broad Volume Distributions Indicate Nonsynchronized Growth and Suggest Sudden Collapses of Germinal Center B Cell Populations

Wittenbrink, N., Weber, T. S., Klein, A., Weiser, A. A., Zuschratter, W., Sibila, M., Schuchhardt, J., Or-Guil, M.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 984 KB

english, 2010

19

Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN- Production

Mattarollo, S. R., Rahimpour, A., Choyce, A., Godfrey, D. I., Leggatt, G. R., Frazer, I. H.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.54 MB

english, 2010

20

Defective Ribosomal Products Are the Major Source of Antigenic Peptides Endogenously Generated from Influenza A Virus Neuraminidase

Dolan, B. P., Li, L., Takeda, K., Bennink, J. R., Yewdell, J. W.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.31 MB

english, 2010

21

Cutting Edge: HLA-DM-Mediated Peptide Exchange Functions Normally on MHC Class II-Peptide Complexes That Have Been Weakened by Elimination of a Conserved Hydrogen Bond

Ferrante, A., Gorski, J.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 706 KB

english, 2010

22

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

Reeves, E. P., Williamson, M., Byrne, B., Bergin, D. A., Smith, S. G. J., Greally, P., O'Kennedy, R., O'Neill, S. J., McElvaney, N. G.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 943 KB

english, 2010

23

Commensal Microbiota and CD8+ T Cells Shape the Formation of Invariant NKT Cells

Wei, B., Wingender, G., Fujiwara, D., Chen, D. Y., McPherson, M., Brewer, S., Borneman, J., Kronenberg, M., Braun, J.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 558 KB

english, 2010

24

IN THIS ISSUE

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 773 KB

english, 2010

25

The Alarmin Cytokine, High Mobility Group Box 1, Is Produced by Viable Cardiomyocytes and Mediates the Lipopolysaccharide-Induced Myocardial Dysfunction via a TLR4/Phosphatidylinositol 3-Kinase Pathway

Xu, H., Su, Z., Wu, J., Yang, M., Penninger, J. M., Martin, C. M., Kvietys, P. R., Rui, T.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

26

Cell Type-Specific Recognition of Human Metapneumoviruses (HMPVs) by Retinoic Acid-Inducible Gene I (RIG-I) and TLR7 and Viral Interference of RIG-I Ligand Recognition by HMPV-B1 Phosphoprotein

Goutagny, N., Jiang, Z., Tian, J., Parroche, P., Schickli, J., Monks, B. G., Ulbrandt, N., Ji, H., Kiener, P. A., Coyle, A. J., Fitzgerald, K. A.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1007 KB

english, 2010

27

Stromal Interaction Molecules 1 and 2 Are Key Regulators of Autoreactive T Cell Activation in Murine Autoimmune Central Nervous System Inflammation

Schuhmann, M. K., Stegner, D., Berna-Erro, A., Bittner, S., Braun, A., Kleinschnitz, C., Stoll, G., Wiendl, H., Meuth, S. G., Nieswandt, B.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.96 MB

english, 2010

28

Structural Basis for the Blockage of IL-2 Signaling by Therapeutic Antibody Basiliximab

Du, J., Yang, H., Zhang, D., Wang, J., Guo, H., Peng, B., Guo, Y., Ding, J.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.40 MB

english, 2010

29

Phylogenetic and Functional Analysis Identifies Ets-1 as a Novel Regulator of the Th2 Cytokine Gene Locus

Strempel, J. M., Grenningloh, R., Ho, I-C., Vercelli, D.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.40 MB

english, 2010

30

IL-10 Induction by Bordetella parapertussis Limits a Protective IFN- Response

Wolfe, D. N., Karanikas, A. T., Hester, S. E., Kennett, M. J., Harvill, E. T.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 683 KB

english, 2010

31

Regulation of Lentivirus Neurovirulence by Lipopolysaccharide Conditioning: Suppression of CXCL10 in the Brain by IL-10

Maingat, F., Viappiani, S., Zhu, Y., Vivithanaporn, P., Ellestad, K. K., Holden, J., Silva, C., Power, C.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.67 MB

english, 2010

32

Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells

Su, X., Ye, J., Hsueh, E. C., Zhang, Y., Hoft, D. F., Peng, G.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

33

TLR4-Mediated Podosome Loss Discriminates Gram-Negative from Gram-Positive Bacteria in Their Capacity to Induce Dendritic Cell Migration and Maturation

van Helden, S. F. G., van den Dries, K., Oud, M. M., Raymakers, R. A. P., Netea, M. G., van Leeuwen, F. N., Figdor, C. G.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.18 MB

english, 2010

34

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

Rankin, A. L., Mumm, J. B., Murphy, E., Turner, S., Yu, N., McClanahan, T. K., Bourne, P. A., Pierce, R. H., Kastelein, R., Pflanz, S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.72 MB

english, 2010

35

A Recombinant Bispecific Single-Chain Fragment Variable Specific for HLA Class II and Fc RI (CD89) Recruits Polymorphonuclear Neutrophils for Efficient Lysis of Malignant B Lymphoid Cells

Guettinger, Y., Barbin, K., Peipp, M., Bruenke, J., Dechant, M., Horner, H., Thierschmidt, D., Valerius, T., Repp, R., Fey, G. H., Stockmeyer, B.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 446 KB

english, 2010

36

IL-4R , a new member that associates with Syk kinase: implication in IL-4-induced human neutrophil functions

Ennaciri, J., Girard, D.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 71 KB

english, 2010

37

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

Silva, G. K., Gutierrez, F. R. S., Guedes, P. M. M., Horta, C. V., Cunha, L. D., Mineo, T. W. P., Santiago-Silva, J., Kobayashi, K. S., Flavell, R. A., Silva, J. S., Zamboni, D. S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

38

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

Matsumoto, S., Hara, T., Mitsuyama, K., Yamamoto, M., Tsuruta, O., Sata, M., Scheller, J., Rose-John, S., Kado, S.-i., Takada, T.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.54 MB

english, 2010

39

Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3

Kim, S., Prout, M., Ramshaw, H., Lopez, A. F., LeGros, G., Min, B.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

40

A Single TCR -Chain with Dominant Peptide Recognition in the Allorestricted HER2/neu-Specific T Cell Repertoire

Liang, X., Weigand, L. U., Schuster, I. G., Eppinger, E., van der Griendt, J. C., Schub, A., Leisegang, M., Sommermeyer, D., Anderl, F., Han, Y., Ellwart, J., Moosmann, A., Busch, D. H., Uckert, W., P

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.49 MB

english, 2010

41

Critical Role of IL-1 Receptor-Associated Kinase-M in Regulating Chemokine-Dependent Deleterious Inflammation in Murine Influenza Pneumonia

Seki, M., Kohno, S., Newstead, M. W., Zeng, X., Bhan, U., Lukacs, N. W., Kunkel, S. L., Standiford, T. J.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 680 KB

english, 2010

42

Human Plasmacytoid Dendritic Cells Support Th17 Cell Effector Function in Response to TLR7 Ligation

Yu, C.-F., Peng, W.-M., Oldenburg, J., Hoch, J., Bieber, T., Limmer, A., Hartmann, G., Barchet, W., Eis-Hubinger, A. M., Novak, N.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.48 MB

english, 2010

43

Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate T Cells Is Controlled by Strength of TCR Signaling and Id3

Alonzo, E. S., Gottschalk, R. A., Das, J., Egawa, T., Hobbs, R. M., Pandolfi, P. P., Pereira, P., Nichols, K. E., Koretzky, G. A., Jordan, M. S., Sant'Angelo, D. B.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.02 MB

english, 2010

44

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression

Juelich, T., Sutcliffe, E., Denton, A., He, Y., Doherty, P. C., Parish, C., Turner, S. J., Tremethick, D., Rao, S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 415 KB

english, 2010

45

Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition

Wang, Y., Zhu, M., Yu, P., Fu, Y.-X.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

46

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

Michaud, J., Im, D.-S., Hla, T.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 919 KB

english, 2010

47

Diabetes-Induced Oxidative Stress Is Mediated by Ca2+-Independent Phospholipase A2 in Neutrophils

Ayilavarapu, S., Kantarci, A., Fredman, G., Turkoglu, O., Omori, K., Liu, H., Iwata, T., Yagi, M., Hasturk, H., Van Dyke, T. E.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 953 KB

english, 2010

48

Matrix Metalloproteinase-8 Inactivates Macrophage Inflammatory Protein-1 To Reduce Acute Lung Inflammation and Injury in Mice

Quintero, P. A., Knolle, M. D., Cala, L. F., Zhuang, Y., Owen, C. A.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

49

TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection

Burns, E., Eliyahu, T., Uematsu, S., Akira, S., Nussbaum, G.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 488 KB

english, 2010

50

SHP-1 Deficient Mast Cells Are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung

Zhang, L., Oh, S. Y., Wu, X., Oh, M. H., Wu, F., Schroeder, J. T., Takemoto, C. M., Zheng, T., Zhu, Z.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 978 KB

english, 2010

51

B Cells Delay Neutrophil Migration toward the Site of Stimulus: Tardiness Critical for Effective Bacillus Calmette-Guerin Vaccination against Tuberculosis Infection in Mice

Kondratieva, T. K., Rubakova, E. I., Linge, I. A., Evstifeev, V. V., Majorov, K. B., Apt, A. S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1000 KB

english, 2010

52

T Cell-Dendritic Cell Interaction Dynamics during the Induction of Respiratory Tolerance and Immunity

Bakocevic, N., Worbs, T., Davalos-Misslitz, A., Forster, R.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.69 MB

english, 2010

53

LL-37 Promotes Rapid Sensing of CpG Oligodeoxynucleotides by B Lymphocytes and Plasmacytoid Dendritic Cells

Hurtado, P., Au Peh, C.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

54

IFN- Regulates the Requirement for IL-17 in Proteoglycan-Induced Arthritis

Doodes, P. D., Cao, Y., Hamel, K. M., Wang, Y., Rodeghero, R. L., Mikecz, K., Glant, T. T., Iwakura, Y., Finnegan, A.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

55

Recruitment and Differentiation of Conventional Dendritic Cell Precursors in Tumors

Diao, J., Zhao, J., Winter, E., Cattral, M. S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 881 KB

english, 2010

56

Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection

Gosselin, A., Monteiro, P., Chomont, N., Diaz-Griffero, F., Said, E. A., Fonseca, S., Wacleche, V., El-Far, M., Boulassel, M.-R., Routy, J.-P., Sekaly, R.-P., Ancuta, P.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.50 MB

english, 2010

57

Formation of a Mast Cell Synapse: Fc RI Membrane Dynamics upon Binding Mobile or Immobilized Ligands on Surfaces

Carroll-Portillo, A., Spendier, K., Pfeiffer, J., Griffiths, G., Li, H., Lidke, K. A., Oliver, J. M., Lidke, D. S., Thomas, J. L., Wilson, B. S., Timlin, J. A.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.19 MB

english, 2010

58

Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production

Boyd, C. R., Orr, S. J., Spence, S., Burrows, J. F., Elliott, J., Carroll, H. P., Brennan, K., Ni Gabhann, J., Coulter, W. A., Johnston, J. A., Jefferies, C. A.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 217 KB

english, 2010

59

Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis

Zhang, Q., Shi, S., Liu, Y., Uyanne, J., Shi, Y., Shi, S., Le, A. D.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 19 KB

english, 2010

60

Critical Protective Role for MCP-1 in Pneumonic Burkholderia mallei Infection

Goodyear, A., Jones, A., Troyer, R., Bielefeldt-Ohmann, H., Dow, S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 730 KB

english, 2010

61

Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-

Hashiramoto, A., Yamane, T., Tsumiyama, K., Yoshida, K., Komai, K., Yamada, H., Yamazaki, F., Doi, M., Okamura, H., Shiozawa, S.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 1.68 MB

english, 2010

62

TCR Feedback Signals Inhibit the Coupling of Recombinationally Accessible V 14 Segments with DJ Complexes

Yang-Iott, K. S., Carpenter, A. C., Rowh, M. A. W., Steinel, N., Brady, B. L., Hochedlinger, K., Jaenisch, R., Bassing, C. H.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 896 KB

english, 2010

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