Volume 42; Issue 4

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Toxicologic Pathology
Volume 42; Issue 4

Toxicologic Pathology

Volume 42; Issue 4

1

Evaluation of von Willebrand Factor and von Willebrand Factor Propeptide in Models of Vascular Endothelial Cell Activation, Perturbation, and/or Injury

Brott, D. A., Katein, A., Thomas, H., Lawton, M., Montgomery, R. R., Richardson, R. J., Louden, C. S.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 867 KB

english, 2014

2

The Relationship of Glucokinase Activator-induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies

Pettersen, J. C., Litchfield, J., Neef, N., Schmidt, S. P., Shirai, N., Walters, K. M., Enerson, B. E., Chatman, L. A., Pfefferkorn, J. A.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

3

Vascular Origin of Vildagliptin-induced Skin Effects in Cynomolgus Monkeys: Pathomechanistic Role of Peripheral Sympathetic System and Neuropeptide Y

Hoffmann, P., Bentley, P., Sahota, P., Schoenfeld, H., Martin, L., Longo, L., Spaet, R., Moulin, P., Pantano, S., Dubost, V., Lapadula, D., Burkey, B., Kaushik, V., Zhou, W., Hayes, M., Flavahan, N.,

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

4

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes: Review and Case Studies

Rojko, J. L., Evans, M. G., Price, S. A., Han, B., Waine, G., DeWitte, M., Haynes, J., Freimark, B., Martin, P., Raymond, J. T., Evering, W., Rebelatto, M. C., Schenck, E., Horvath, C.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 3.10 MB

english, 2014

5

Characterization, Biomarkers, and Reversibility of a Monoclonal Antibody-induced Immune Complex Disease in Cynomolgus Monkeys (Macaca fascicularis)

Heyen, J. R., Rojko, J., Evans, M., Brown, T. P., Bobrowski, W. F., Vitsky, A., Dalton, S., Tripathi, N., Bollini, S. S., Johnson, T., Lin, J. C., Khan, N., Han, B.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 598 KB

english, 2014

6

Nonclinical Safety Biomarkers of Drug-induced Vascular Injury: Current Status and Blueprint for the Future

Mikaelian, I., Cameron, M., Dalmas, D. A., Enerson, B. E., Gonzalez, R. J., Guionaud, S., Hoffmann, P. K., King, N. M. P., Lawton, M. P., Scicchitano, M. S., Smith, H. W., Thomas, R. A., Weaver, J. L.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 999 KB

english, 2014

7

The Role of eNOS Phosphorylation in Causing Drug-induced Vascular Injury

Tobin, G. A. M., Zhang, J., Goodwin, D., Stewart, S., Xu, L., Knapton, A., Gonzalez, C., Bancos, S., Zhang, L., Lawton, M. P., Enerson, B. E., Weaver, J. L.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

8

Hemodynamic Correlates of Drug-induced Vascular Injury in the Rat Using High-frequency Ultrasound Imaging

Swanson, T. A., Conte, T., Deeley, B., Portugal, S., Kreeger, J. M., Obert, L. A., Joseph, E. C., Wisialowski, T. A., Sokolowski, S. A., Rief, C., Nugent, P., Lawton, M. P., Enerson, B. E.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 542 KB

english, 2014

9

Perspectives on Drug-induced Vascular Injury

Morton, D., Houle, C. D., Tomlinson, L.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 49 KB

english, 2014

10

Quantitative Evaluation of Drug-induced Microvascular Constriction in Mice Kidney Using a Novel Tool for 3D Geometrical Analysis of Ex vivo Organ Vasculature

Ramot, Y., Brauner, R., Kang, K., Heymach, J. V., Furtado, S., Nyska, A.

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 987 KB

english, 2014

11

Translation Strategy for the Qualification of Drug-induced Vascular Injury Biomarkers

Bendjama, K., Guionaud, S., Aras, G., Arber, N., Badimon, L., Bamberger, U., Bratfalean, D., Brott, D., David, M., Doessegger, L., Firat, H., Gallas, J.-F., Gautier, J.-C., Hoffmann, P., Kraus, S., Pa

Journal:

Toxicologic Pathology

Year:

2014

Language:

english

File:

PDF, 953 KB

english, 2014