Toxicological Sciences

1

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R., Elcombe, C. R.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

2

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

Ni, M., Li, X., Yin, Z., Jiang, H., Sidoryk-Wegrzynowicz, M., Milatovic, D., Cai, J., Aschner, M.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 866 KB

english, 2010

3

Goniothalamin Induces Coronary Artery Smooth Muscle Cells Apoptosis: The p53-Dependent Caspase-2 Activation Pathway

Chan, K. M., Rajab, N. F., Siegel, D., Din, L. B., Ross, D., Inayat-Hussain, S. H.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

4

Nicotine Diminishes Testicular Gametogenesis, Steroidogenesis, and Steroidogenic Acute Regulatory Protein Expression in Adult Albino Rats: Possible Influence on Pituitary Gonadotropins and Alteration of Testicular Antioxidant Status

Jana, K., Samanta, P. K., De, D. K.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 663 KB

english, 2010

5

Silver Nanoparticles Disrupt GDNF/Fyn kinase Signaling in Spermatogonial Stem Cells

Braydich-Stolle, L. K., Lucas, B., Schrand, A., Murdock, R. C., Lee, T., Schlager, J. J., Hussain, S. M., Hofmann, M.-C.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

6

Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review

Bruin, J. E., Gerstein, H. C., Holloway, A. C.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 191 KB

english, 2010

7

Paraquat Exposure Induces Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and the Activation of the Nitric Oxide-GAPDH-Siah Cell Death Cascade

Ortiz-Ortiz, M. A., Moran, J. M., Ruiz-Mesa, L. M., Bravo-San Pedro, J. M., Fuentes, J. M.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 626 KB

english, 2010

8

What Do We Need to Know prior to Thinking about Incorporating an Epigenetic Evaluation into Safety Assessments?2

Goodman, J. I., Augustine, K. A., Cunnningham, M. L., Dixon, D., Dragan, Y. P., Falls, J. G., Rasoulpour, R. J., Sills, R. C., Storer, R. D., Wolf, D. C., Pettit, S. D.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 103 KB

english, 2010

9

Development of a Prolonged Calcium Plateau in Hippocampal Neurons in Rats Surviving Status Epilepticus Induced by the Organophosphate Diisopropylfluorophosphate

Deshpande, L. S., Carter, D. S., Blair, R. E., DeLorenzo, R. J.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 347 KB

english, 2010

10

Genetic and Maternal Effects on Valproic Acid Teratogenesis in C57BL/6J and DBA/2J Mice

Downing, C., Biers, J., Larson, C., Kimball, A., Wright, H., Ishii, T., Gilliam, D., Johnson, T.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 889 KB

english, 2010

11

Modeling the Interaction of Binary and Ternary Mixtures of Estradiol with Bisphenol A and Bisphenol AF in an In Vitro Estrogen-Mediated Transcriptional Activation Assay (T47D-KBluc)

Bermudez, D. S., Gray, L. E., Wilson, V. S.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 907 KB

english, 2010

12

Sulforaphane- and Phenethyl Isothiocyanate-Induced Inhibition of Aflatoxin B1-Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression

Gross-Steinmeyer, K., Stapleton, P. L., Tracy, J. H., Bammler, T. K., Strom, S. C., Eaton, D. L.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 229 KB

english, 2010

13

Determination of the Di-(2-Ethylhexyl) Phthalate NOAEL for Reproductive Development in the Rat: Importance of the Retention of Extra Animals to Adulthood

Blystone, C. R., Kissling, G. E., Bishop, J. B., Chapin, R. E., Wolfe, G. W., Foster, P. M. D.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 220 KB

english, 2010

14

Advantages of Human Hepatocyte-Derived Transformants Expressing a Series of Human Cytochrome P450 Isoforms for Genotoxicity Examination

Hashizume, T., Yoshitomi, S., Asahi, S., Uematsu, R., Matsumura, S., Chatani, F., Oda, H.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 639 KB

english, 2010

15

Type I Interferon Signaling Contributes to Chronic Inflammation in a Murine Model of Silicosis

Giordano, G., van den Brule, S., Lo Re, S., Triqueneaux, P., Uwambayinema, F., Yakoub, Y., Couillin, I., Ryffel, B., Michiels, T., Renauld, J.-C., Lison, D., Huaux, F.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 597 KB

english, 2010

16

Allethrin Differentially Modulates Voltage-Gated Calcium Channel Subtypes in Rat PC12 Cells

Neal, A. P., Yuan, Y., Atchison, W. D.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 551 KB

english, 2010

17

Paracelsus and Formaldehyde 2010: The Dose to the Target Organ Makes the Poison

Lehman-McKeeman, L.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 98 KB

english, 2010

18

Kinetics of Satratoxin G Tissue Distribution and Excretion Following Intranasal Exposure in the Mouse

Amuzie, C. J., Islam, Z., Kim, J. K., Seo, J.-H., Pestka, J. J.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 171 KB

english, 2010

20

Editorial Board

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 615 KB

english, 2010

21

Benzo[a]pyrene Increases the Nrf2 Content by Downregulating the Keap1 Message

Nguyen, P. M., Park, M. S., Chow, M., Chang, J. H., Wrischnik, L., Chan, W. K.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 807 KB

english, 2010

22

COVER

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 375 KB

english, 2010

23

Tungsten Effects on Phosphate-Dependent Biochemical Pathways are Species and Liver Cell Line Dependent

Johnson, D. R., Ang, C., Bednar, A. J., Inouye, L. S.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 469 KB

english, 2010

24

Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing

Seidle, T., Robinson, S., Holmes, T., Creton, S., Prieto, P., Scheel, J., Chlebus, M.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 1.25 MB

english, 2010

25

Aryl Hydrocarbon Receptor Activation Reduces Dendritic Cell Function during Influenza Virus Infection

Jin, G.-B., Moore, A. J., Head, J. L., Neumiller, J. J., Lawrence, B. P.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 352 KB

english, 2010

26

Predicting Mutagenicity of Aromatic Amines by Various Machine Learning Approaches

Leong, M. K., Lin, S.-W., Chen, H.-B., Tsai, F.-Y.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 472 KB

english, 2010

27

SUBSCRIPTIONS

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 34 KB

english, 2010

28

Repetitive Nicotine Exposure Leads to a More Malignant and Metastasis-Prone Phenotype of SCLC: A Molecular Insight into the Importance of Quitting Smoking during Treatment

Martinez-Garcia, E., Irigoyen, M., Gonzalez-Moreno, O., Corrales, L., Teijeira, A., Salvo, E., Rouzaut, A.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 751 KB

english, 2010

29

Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria

Hardas, S. S., Butterfield, D. A., Sultana, R., Tseng, M. T., Dan, M., Florence, R. L., Unrine, J. M., Graham, U. M., Wu, P., Grulke, E. A., Yokel, R. A.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 1.51 MB

english, 2010

30

Role of UDP-Glucuronosyltransferase (UGT) 2B2 in Metabolism of Triiodothyronine: Effect of Microsomal Enzyme Inducers in Sprague Dawley and UGT2B2-Deficient Fischer 344 Rats

Richardson, T. A., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 682 KB

english, 2010

31

Erratum

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 18 KB

english, 2010

32

Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity

Houze, P., Mager, D. E., Risede, P., Baud, F. J.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 464 KB

english, 2010

33

Acute Cobalt-Induced Lung Injury and the Role of Hypoxia-Inducible Factor 1 in Modulating Inflammation

Saini, Y., Greenwood, K. K., Merrill, C., Kim, K. Y., Patial, S., Parameswaran, N., Harkema, J. R., LaPres, J. J.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 1018 KB

english, 2010

34

Distribution of DNA Adducts Caused by Inhaled Formaldehyde Is Consistent with Induction of Nasal Carcinoma but Not Leukemia

Lu, K., Collins, L. B., Ru, H., Bermudez, E., Swenberg, J. A.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 772 KB

english, 2010

35

Diagnostic Performance of Traditional Hepatobiliary Biomarkers of Drug-Induced Liver Injury in the Rat

Ennulat, D., Magid-Slav, M., Rehm, S., Tatsuoka, K. S.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

Volume 116; Issue 2

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

Goniothalamin Induces Coronary Artery Smooth Muscle Cells Apoptosis: The p53-Dependent Caspase-2 Activation Pathway

Nicotine Diminishes Testicular Gametogenesis, Steroidogenesis, and Steroidogenic Acute Regulatory Protein Expression in Adult Albino Rats: Possible Influence on Pituitary Gonadotropins and Alteration of Testicular Antioxidant Status

Silver Nanoparticles Disrupt GDNF/Fyn kinase Signaling in Spermatogonial Stem Cells

Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review

Paraquat Exposure Induces Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and the Activation of the Nitric Oxide-GAPDH-Siah Cell Death Cascade

What Do We Need to Know prior to Thinking about Incorporating an Epigenetic Evaluation into Safety Assessments?2

Development of a Prolonged Calcium Plateau in Hippocampal Neurons in Rats Surviving Status Epilepticus Induced by the Organophosphate Diisopropylfluorophosphate

Genetic and Maternal Effects on Valproic Acid Teratogenesis in C57BL/6J and DBA/2J Mice

Modeling the Interaction of Binary and Ternary Mixtures of Estradiol with Bisphenol A and Bisphenol AF in an In Vitro Estrogen-Mediated Transcriptional Activation Assay (T47D-KBluc)

Sulforaphane- and Phenethyl Isothiocyanate-Induced Inhibition of Aflatoxin B1-Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression

Determination of the Di-(2-Ethylhexyl) Phthalate NOAEL for Reproductive Development in the Rat: Importance of the Retention of Extra Animals to Adulthood

Advantages of Human Hepatocyte-Derived Transformants Expressing a Series of Human Cytochrome P450 Isoforms for Genotoxicity Examination

Type I Interferon Signaling Contributes to Chronic Inflammation in a Murine Model of Silicosis

Allethrin Differentially Modulates Voltage-Gated Calcium Channel Subtypes in Rat PC12 Cells

Paracelsus and Formaldehyde 2010: The Dose to the Target Organ Makes the Poison

CONTENTS

Kinetics of Satratoxin G Tissue Distribution and Excretion Following Intranasal Exposure in the Mouse

Editorial Board

Benzo[a]pyrene Increases the Nrf2 Content by Downregulating the Keap1 Message

COVER

Tungsten Effects on Phosphate-Dependent Biochemical Pathways are Species and Liver Cell Line Dependent

Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing

Aryl Hydrocarbon Receptor Activation Reduces Dendritic Cell Function during Influenza Virus Infection

Predicting Mutagenicity of Aromatic Amines by Various Machine Learning Approaches

SUBSCRIPTIONS

Repetitive Nicotine Exposure Leads to a More Malignant and Metastasis-Prone Phenotype of SCLC: A Molecular Insight into the Importance of Quitting Smoking during Treatment

Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria

Role of UDP-Glucuronosyltransferase (UGT) 2B2 in Metabolism of Triiodothyronine: Effect of Microsomal Enzyme Inducers in Sprague Dawley and UGT2B2-Deficient Fischer 344 Rats

Erratum

Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity

Acute Cobalt-Induced Lung Injury and the Role of Hypoxia-Inducible Factor 1 in Modulating Inflammation

Distribution of DNA Adducts Caused by Inhaled Formaldehyde Is Consistent with Induction of Nasal Carcinoma but Not Leukemia

Diagnostic Performance of Traditional Hepatobiliary Biomarkers of Drug-Induced Liver Injury in the Rat