Volume 142; Issue 1

Main
Toxicological Sciences
Volume 142; Issue 1

Toxicological Sciences

Volume 142; Issue 1

1

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

Yamada, T., Okuda, Y., Kushida, M., Sumida, K., Takeuchi, H., Nagahori, H., Fukuda, T., Lake, B. G., Cohen, S. M., Kawamura, S.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 9.71 MB

english, 2014

2

SLC19A1, SLC46A1 and SLCO1B1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients

Lima, A., Bernardes, M., Azevedo, R., Monteiro, J., Sousa, H., Medeiros, R., Seabra, V.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 2.14 MB

english, 2014

3

P450-Mediated O-Demethylated Metabolite Is Responsible for Rat Hepatobiliary Toxicity of Pyridyltriazine-Containing PI3K Inhibitors

Subramanian, R., Aidasani, D., Bailey, K., Branstetter, D., Everds, N., Jiang, J., Norman, M. H., Primack, R., Skiles, G. L., Soto, I., Stec, M. M., Wagner, M., Wu, T., Zhu, X., Lebrec, H.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 6.74 MB

english, 2014

4

A Systematic Assessment of Mitochondrial Function Identified Novel Signatures for Drug-Induced Mitochondrial Disruption in Cells

Li, N., Oquendo, E., Capaldi, R. A., Robinson, J. P., He, Y. D., Hamadeh, H. K., Afshari, C. A., Lightfoot-Dunn, R., Narayanan, P. K.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 2.46 MB

english, 2014

5

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

Guo, P., Pi, H., Xu, S., Zhang, L., Li, Y., Li, M., Cao, Z., Tian, L., Xie, J., Li, R., He, M., Lu, Y., Liu, C., Duan, W., Yu, Z., Zhou, Z.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 8.42 MB

english, 2014

6

Normalization of Nano-Sized TiO2-Induced Clastogenicity, Genotoxicity and Mutagenicity by Chlorophyllin Administration in Mice Brain, Liver, and Bone Marrow Cells

A. El-Ghor, A., Noshy, M. M., Galal, A., Mohamed, H. R. H.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 5.17 MB

english, 2014

7

The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells

Chen, S., Dobrovolsky, V. N., Liu, F., Wu, Y., Zhang, Z., Mei, N., Guo, L.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

8

Stable Isotope Labeling Method for the Investigation of Protein Haptenation by Electrophilic Skin Sensitizers

Parkinson, E., Boyd, P., Aleksic, M., Cubberley, R., O'Connor, D., Skipp, P.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 502 KB

english, 2014

9

Autoantibodies Associated with Prenatal and Childhood Exposure to Environmental Chemicals in Faroese Children

Osuna, C. E., Grandjean, P., Weihe, P., El-Fawal, H. A. N.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 430 KB

english, 2014

10

Comparison of Anorectic and Emetic Potencies of Deoxynivalenol (Vomitoxin) to the Plant Metabolite Deoxynivalenol-3-Glucoside and Synthetic Deoxynivalenol Derivatives EN139528 and EN139544

Wu, W., Zhou, H.-R., Bursian, S. J., Pan, X., Link, J. E., Berthiller, F., Adam, G., Krantis, A., Durst, T., Pestka, J. J.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 6.51 MB

english, 2014

11

Homologous Recombination Repair Signaling in Chemical Carcinogenesis: Prolonged Particulate Hexavalent Chromium Exposure Suppresses the Rad51 Response in Human Lung Cells

Qin, Q., Xie, H., Wise, S. S., Browning, C. L., Thompson, K. N., Holmes, A. L., Wise, J. P.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 2.58 MB

english, 2014

12

Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Hardwick, R. N., Clarke, J. D., Lake, A. D., Canet, M. J., Anumol, T., Street, S. M., Merrell, M. D., Goedken, M. J., Snyder, S. A., Cherrington, N. J.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 18.56 MB

english, 2014

13

Characterization of Nuclear Receptor-Mediated Murine Hepatocarcinogenesis of the Herbicide Pronamide and Its Human Relevance

LeBaron, M. J., Rasoulpour, R. J., Gollapudi, B. B., Sura, R., Kan, H. L., Schisler, M. R., Pottenger, L. H., Papineni, S., Eisenbrandt, D. L.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 2.43 MB

english, 2014

14

Arsenic Exposure Disrupts the Normal Function of the FA/BRCA Repair Pathway

Peremarti, J., Ramos, F., Marcos, R., Hernandez, A.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 4.92 MB

english, 2014

15

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

Wetmore, B. A., Allen, B., Clewell, H. J., Parker, T., Wambaugh, J. F., Almond, L. M., Sochaski, M. A., Thomas, R. S.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 1.98 MB

english, 2014

16

Impairment of Glutamate Signaling in Mouse Central Nervous System Neurons In Vitro by Tri-Ortho-Cresyl Phosphate at Noncytotoxic Concentrations

Hausherr, V., van Thriel, C., Krug, A., Leist, M., Schobel, N.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 3.14 MB

english, 2014

17

Novel Hg2+-Induced Nephropathy in Rats and Mice Lacking Mrp2: Evidence of Axial Heterogeneity in the Handling of Hg2+ Along the Proximal Tubule

Zalups, R. K., Joshee, L., Bridges, C. C.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 10.09 MB

english, 2014

18

Altered Surfactant Homeostasis and Alveolar Epithelial Cell Stress in Amiodarone-Induced Lung Fibrosis

Mahavadi, P., Henneke, I., Ruppert, C., Knudsen, L., Venkatesan, S., Liebisch, G., Chambers, R. C., Ochs, M., Schmitz, G., Vancheri, C., Seeger, W., Korfei, M., Guenther, A.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 23.84 MB

english, 2014

19

Tissue Sensitivity of the Rat Upper and Lower Extrapulmonary Airways to the Inhaled Electrophilic Air Pollutants Diacetyl and Acrolein

Cichocki, J. A., Smith, G. J., Morris, J. B.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 2.93 MB

english, 2014

20

Contemporary Reviews in Toxicology

Johnson, J. A., Miller, G. W.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 120 KB

english, 2014

21

From the Editor's Desk

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 173 KB

english, 2014

22

AMP-Activated Protein Kinase Deficiency Rescues Paraquat-Induced Cardiac Contractile Dysfunction Through an Autophagy-Dependent Mechanism

Wang, Q., Yang, L., Hua, Y., Nair, S., Xu, X., Ren, J.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 12.98 MB

english, 2014

23

Cardiac Epithelial-Mesenchymal Transition Is Blocked by Monomethylarsonous Acid (III)

Huang, T., Barnett, J. V., Camenisch, T. D.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 6.72 MB

english, 2014

24

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

Clewell, R. A., Sun, B., Adeleye, Y., Carmichael, P., Efremenko, A., McMullen, P. D., Pendse, S., Trask, O. J., White, A., Andersen, M. E.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 2.84 MB

english, 2014

25

Systems Level Metabolic Phenotype of Methotrexate Administration in the Context of Non-alcoholic Steatohepatitis in the Rat

Kyriakides, M., Hardwick, R. N., Jin, Z., Goedken, M. J., Holmes, E., Cherrington, N. J., Coen, M.

Journal:

Toxicological Sciences

Year:

2014

Language:

english

File:

PDF, 4.34 MB

english, 2014