Toxicological Sciences

1

Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver Injury

Krauskopf, J., Caiment, F., Claessen, S. M., Johnson, K. J., Warner, R. L., Schomaker, S. J., Burt, D. A., Aubrecht, J., Kleinjans, J. C.

Journal:

Year:

2015

Language:

english

File:

PDF, 399 KB

english, 2015

2

Downregulation of Stanniocalcin 1 Is Responsible for Sorafenib-Induced Cardiotoxicity

Kawabata, M., Umemoto, N., Shimada, Y., Nishimura, Y., Zhang, B., Kuroyanagi, J., Miyabe, M., Tanaka, T.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 664 KB

english, 2015

3

Urinary Bile Acids as Biomarkers for Liver Diseases II. Signature Profiles in Patients

Bathena, S. P. R., Thakare, R., Gautam, N., Mukherjee, S., Olivera, M., Meza, J., Alnouti, Y.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 279 KB

english, 2015

4

Increased Micronucleus, Nucleoplasmic Bridge, and Nuclear Bud Frequencies in the Peripheral Blood Lymphocytes of Diesel Engine Exhaust-Exposed Workers

Zhang, X., Duan, H., Gao, F., Li, Y., Huang, C., Niu, Y., Gao, W., Yu, S., Zheng, Y.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 215 KB

english, 2015

5

Human Cell Line-Dependent WC-Co Nanoparticle Cytotoxicity and Genotoxicity: A Key Role of ROS Production

Paget, V., Moche, H., Kortulewski, T., Grall, R., Irbah, L., Nesslany, F., Chevillard, S.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

6

Role of Pregnane X Receptor and Aryl Hydrocarbon Receptor in Transcriptional Regulation of pxr, CYP2, and CYP3 Genes in Developing Zebrafish

Kubota, A., Goldstone, J. V., Lemaire, B., Takata, M., Woodin, B. R., Stegeman, J. J.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 784 KB

english, 2015

7

Biological Dose Response to PM2.5: Effect of Particle Extraction Method on Platelet and Lung Responses

Van Winkle, L. S., Bein, K., Anderson, D., Pinkerton, K. E., Tablin, F., Wilson, D., Wexler, A. S.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

8

In vitro Exposure to the Herbicide Atrazine Inhibits T Cell Activation, Proliferation, and Cytokine Production and Significantly Increases the Frequency of Foxp3+ Regulatory T Cells

Thueson, L. E., Emmons, T. R., Browning, D. L., Kreitinger, J. M., Shepherd, D. M., Wetzel, S. A.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 870 KB

english, 2015

9

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

Natsch, A., Emter, R., Gfeller, H., Haupt, T., Ellis, G.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 462 KB

english, 2015

10

Urinary Bile Acids as Biomarkers for Liver Diseases I. Stability of the Baseline Profile in Healthy Subjects

Bathena, S. P. R., Thakare, R., Gautam, N., Mukherjee, S., Olivera, M., Meza, J., Alnouti, Y.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 395 KB

english, 2015

11

Human Sex Hormone-Binding Globulin Binding Affinities of 125 Structurally Diverse Chemicals and Comparison with Their Binding to Androgen Receptor, Estrogen Receptor, and -Fetoprotein

Hong, H., Branham, W. S., Ng, H. W., Moland, C. L., Dial, S. L., Fang, H., Perkins, R., Sheehan, D., Tong, W.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

12

Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury

Xiao, J., Liong, E. C., Huang, H., On Tse, W., Lau, K. S., Pan, J., Nanji, A. A., Fung, M. L., Xing, F., Tipoe, G. L.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

13

Elevated Adult Neurogenesis in Brain Subventricular Zone Following In vivo Manganese Exposure: Roles of Copper and DMT1

Fu, S., O'Neal, S., Hong, L., Jiang, W., Zheng, W.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

14

Glucocorticoids Exert Direct Toxicity on Microvasculature: Analysis of Cell Death Mechanisms

El Zaoui, I., Behar-Cohen, F., Torriglia, A.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 825 KB

english, 2015

15

FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology

Knudsen, T. B., Keller, D. A., Sander, M., Carney, E. W., Doerrer, N. G., Eaton, D. L., Fitzpatrick, S. C., Hastings, K. L., Mendrick, D. L., Tice, R. R., Watkins, P. B., Whelan, M.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 839 KB

english, 2015

16

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

Moghe, A., Ghare, S., Lamoreau, B., Mohammad, M., Barve, S., McClain, C., Joshi-Barve, S.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 501 KB

english, 2015

17

Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson's Disease

De Miranda, B. R., Popichak, K. A., Hammond, S. L., Miller, J. A., Safe, S., Tjalkens, R. B.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

18

-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson's Disease

Harischandra, D. S., Jin, H., Anantharam, V., Kanthasamy, A., Kanthasamy, A. G.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.81 MB

english, 2015

19

AHR2-Mediated Transcriptomic Responses Underlying the Synergistic Cardiac Developmental Toxicity of PAHs

Jayasundara, N., Van Tiem Garner, L., Meyer, J. N., Erwin, K. N., Di Giulio, R. T.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 777 KB

english, 2015

20

Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo (IVIVE) Methods

Martin, S. A., McLanahan, E. D., Bushnell, P. J., Hunter, E. S., El-Masri, H.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

21

Cover

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 3.28 MB

english, 2015

22

Carbon Nanotubes Induce Apoptosis Resistance of Human Lung Epithelial Cells Through FLICE-Inhibitory Protein

Pongrakhananon, V., Luanpitpong, S., Stueckle, T. A., Wang, L., Nimmannit, U., Rojanasakul, Y.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

23

From the Editor's Desk, Editorial Highlights, Letter to the Editor

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 85 KB

english, 2015

24

Editorial Board

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 84 KB

english, 2015

25

Subscriptions

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 49 KB

english, 2015

27

Identification of Specific mRNA Signatures as Fingerprints for Carcinogenesis in Mice Induced by Genotoxic and Nongenotoxic Hepatocarcinogens

Kossler, N., Matheis, K. A., Ostenfeldt, N., Bach Toft, D., Dhalluin, S., Deschl, U., Kalkuhl, A.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 2.59 MB

english, 2015

28

Air Pollution as a Risk Factor for Type 2 Diabetes

Rao, X., Patel, P., Puett, R., Rajagopalan, S.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 571 KB

english, 2015

Volume 143; Issue 2

Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver Injury

Downregulation of Stanniocalcin 1 Is Responsible for Sorafenib-Induced Cardiotoxicity

Urinary Bile Acids as Biomarkers for Liver Diseases II. Signature Profiles in Patients

Increased Micronucleus, Nucleoplasmic Bridge, and Nuclear Bud Frequencies in the Peripheral Blood Lymphocytes of Diesel Engine Exhaust-Exposed Workers

Human Cell Line-Dependent WC-Co Nanoparticle Cytotoxicity and Genotoxicity: A Key Role of ROS Production

Role of Pregnane X Receptor and Aryl Hydrocarbon Receptor in Transcriptional Regulation of pxr, CYP2, and CYP3 Genes in Developing Zebrafish

Biological Dose Response to PM2.5: Effect of Particle Extraction Method on Platelet and Lung Responses

In vitro Exposure to the Herbicide Atrazine Inhibits T Cell Activation, Proliferation, and Cytokine Production and Significantly Increases the Frequency of Foxp3+ Regulatory T Cells

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

Urinary Bile Acids as Biomarkers for Liver Diseases I. Stability of the Baseline Profile in Healthy Subjects

Human Sex Hormone-Binding Globulin Binding Affinities of 125 Structurally Diverse Chemicals and Comparison with Their Binding to Androgen Receptor, Estrogen Receptor, and -Fetoprotein

Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury

Elevated Adult Neurogenesis in Brain Subventricular Zone Following In vivo Manganese Exposure: Roles of Copper and DMT1

Glucocorticoids Exert Direct Toxicity on Microvasculature: Analysis of Cell Death Mechanisms

FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson's Disease

-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson's Disease

AHR2-Mediated Transcriptomic Responses Underlying the Synergistic Cardiac Developmental Toxicity of PAHs

Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo (IVIVE) Methods

Cover

Carbon Nanotubes Induce Apoptosis Resistance of Human Lung Epithelial Cells Through FLICE-Inhibitory Protein

From the Editor's Desk, Editorial Highlights, Letter to the Editor

Editorial Board

Table of Contents

Subscriptions

Identification of Specific mRNA Signatures as Fingerprints for Carcinogenesis in Mice Induced by Genotoxic and Nongenotoxic Hepatocarcinogens

Air Pollution as a Risk Factor for Type 2 Diabetes