Volume 253; Issue 1-3

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Toxicology
Volume 253; Issue 1-3

Toxicology

Volume 253; Issue 1-3

1

Use of animal, human and mechanistic evidence for the prediction of hepatotoxicity

Lilia Fisk, Carol A. Marchant, Mukesh L. Patel

Journal:

Year:

2008

Language:

english

File:

PDF, 258 KB

english, 2008

2

DNA damage by single doses of five organophosphate pesticides to rats

Kathryn M. Atherton, Faith M. Williams, Samantha Jameson, Elaine Mutch

Journal:

Year:

2008

Language:

english

File:

PDF, 273 KB

english, 2008

3

The human karyopherin α2 promoter is responsive to oxidative stress

Manraj S. Cheema, G. Gordon Gibson, Nick Plant, Kathryn E. Plant

Journal:

Year:

2008

Language:

english

File:

PDF, 149 KB

english, 2008

4

Quantification of efflux by multidrug resistance-associated proteins (Mrps) in rat hepatocyte cultures

Lucy C.J. Ellis, Richard J. Weaver, Gabrielle M. Hawksworth

Journal:

Year:

2008

Language:

english

File:

PDF, 55 KB

english, 2008

5

Development of an EpiOral™ in vitro human tissue model for oral irritancy testing

Sarah J. Delves, Stephen P. Faux, Tajinder S. Jai, Tirukalikundram S. Kumaravel, Louise R. Neilson, Clive Meredith

Journal:

Year:

2008

Language:

english

File:

PDF, 74 KB

english, 2008

6

Risk assessment paradigms with tobacco smoke constituents

Clive Meredith, Fiona Cunningham, Eian D. Massey

Journal:

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

7

Investigations into the genotoxic potential of dichlorvos

S.E. Remington, P.A. Jowsey, F.M. Williams, P.G. Blain

Journal:

Year:

2008

Language:

english

File:

PDF, 168 KB

english, 2008

8

Inhibition of cell growth and glutathione depletion by calcium channel blockers

Moeed Akbar, Catherine Henderson, M. Helen Grant

Journal:

Year:

2008

Language:

english

File:

PDF, 169 KB

english, 2008

9

Uptake of chromium into red blood cells does not affect the ability of haemoglobin to bind oxygen

Grace A. Afolaranmi, Justice N.A. Tettey, John D.S. Gaylor, Helen M. Murray, R.M. Dominic Meek, M. Helen Grant

Journal:

Year:

2008

Language:

english

File:

PDF, 143 KB

english, 2008

10

Specialised drug delivery systems: A comparative continuous intravenous infusion study in the rat: Practical overview

Hans J.T. Van Wijk

Journal:

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

11

Standardization and validation of in vitro methods for risk prediction and benefit–risk assessment of pharmaceuticals: Report from ECVAM's activities in the action ValDrug

Laura Gribaldo, Pilar Prieto, Agnieszka Kinsner-Ovaskainen

Journal:

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

12

A preliminary study for assessing the feasibility of sebum sampling for monitoring human exposure to environmental chemicals following inadvertent or malicious release

James C. Wakefield, Kalwinder Kaur, Robert P. Chilcott

Journal:

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

13

Diquat alters the localisation of E-cadherin, β-catenin, occludin and ZO-1 in LLC-PK1 cells

Laura C. Young, Gabrielle M. Hawksworth, Carol A. Alderson

Journal:

Year:

2008

Language:

english

File:

PDF, 52 KB

english, 2008

14

Species differences in affinity of rat and human aryl hydrocarbon receptor for ligands

Ming Qi Fan, Tao Jiang, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 55 KB

english, 2008

15

Antitumour phenylbenzothiazoles: Species-specific agonism of the AhR

Rana Bazzi, Tracey D. Bradshaw, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 81 KB

english, 2008

16

Expression of the C. elegans aryl hydrocarbon receptor ligand-binding domain

Ahmed Helaly, Tao Jiang, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

17

Latrophilin is an essential gene and mediates the toxicity of black widow spider venom in C. elegans

Ademola A. Adenle, D. de Pomerai, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 89 KB

english, 2008

18

Optimisation and pre-validation of an in Vitro test strategy for predicting human acute toxicity: Progress of the “A-Cute-Tox” project

Agnieszka Kinsner-Ovaskainen, Sandra Coecke, Michael Sjöstrom, Erwin van Vliet, Pilar Prieto

Journal:

Year:

2008

Language:

english

File:

PDF, 49 KB

english, 2008

19

Relevance of PXR to Flucloxacillin-induced Liver Injury

Elise A.G. Andrews, Matthew C. Wright, Chris P. Day, Ann K. Daly

Journal:

Year:

2008

Language:

english

File:

PDF, 50 KB

english, 2008

20

Cyproterone acetate represses the human karyopherin α2 promoter by antagonism of the glucocorticoid receptor

Manraj S. Cheema, G. Gordon Gibson, Nick Plant, Kathryn E. Plant

Journal:

Year:

2008

Language:

english

File:

PDF, 145 KB

english, 2008

21

Skin Derived Fibroblasts Can Differentiate Into Hepatocyte-Like Cells

Karen Wallace, Muzlifah Haniffa, Matthew Collin, Matthew Wright

Journal:

Year:

2008

Language:

english

File:

PDF, 129 KB

english, 2008

22

Differential Allergenicity of Human Lactoferrin: Role of Glycosylation

Rebecca J. Dearman, Rachael J. Almond, Brian F. Flanagan, Ian Kimber

Journal:

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

23

DNA Damage In Horticultural Farmers With Chronic Exposure To Pesticide Mixtures, Including Organophosphate Pesticides

Elaine Mutch, Kathryn M. Atherton, Samantha Jameson, Faith M. Williams

Journal:

Year:

2008

Language:

english

File:

PDF, 87 KB

english, 2008

24

Automated Acute Toxicity Testing Using Fluorescent Transgenic Zebrafish Embryos

Peter M. Eimon, Timothy C. Baranowski, Jamil Haider, Yiting Zhang

Journal:

Year:

2008

Language:

english

File:

PDF, 67 KB

english, 2008

25

Evaluation of Global Transcriptomics Analysis to Provide New Molecular Insights into Consumer Safety Endpoints

Daniel J. Scott, Marie Plowman, Guy J. Warner, Andrew G. Garrow, Yeyejide A. Adeleye, Vicki L. Summerfield, Maja Aleksic, Brett C. Cochrane, Samantha T. Fletcher, Andrew White

Journal:

Year:

2008

Language:

english

File:

PDF, 51 KB

english, 2008

26

Comment on Viberg et al. (2008) “Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly”

Journal:

Year:

2008

Language:

english

File:

PDF, 127 KB

english, 2008

27

Response to the comment on Viberg et al. (2008) “Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly” by Ching-Hung Hsu

Journal:

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

28

Lipid peroxidation products do not activate hepatic stellate cells

Hsun-Lang Fang, Wen-Chuan Lin

Journal:

Year:

2008

Language:

english

File:

PDF, 2.05 MB

english, 2008

29

A quantitative inverse relationship between connexin32 expression and cell proliferation in a rat hepatoma cell line

Gareth Owain Edwards, Shrikant Jondhale, Tao Chen, J. Kevin Chipman

Journal:

Year:

2008

Language:

english

File:

PDF, 641 KB

english, 2008

30

Inhibition of cation channels and suicidal death of human erythrocytes by zidovudine

Yuliya Kucherenko, Corinna Geiger, Ekaterina Shumilina, Michael Föller, Florian Lang

Journal:

Year:

2008

Language:

english

File:

PDF, 713 KB

english, 2008

31

p,p′-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells

Yang Song, Xianmin Liang, Yafei Hu, Yinan Wang, Haige Yu, Kedi Yang

Journal:

Year:

2008

Language:

english

File:

PDF, 1.55 MB

english, 2008

32

A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein

Scott S. Auerbach, Joel Mahler, Gregory S. Travlos, Richard D. Irwin

Journal:

Year:

2008

Language:

english

File:

PDF, 368 KB

english, 2008

33

Hyperosmolar treatment of soman-induced brain lesions in mice: Evaluation of the effects through diffusion-weighted magnetic resonance imaging and through histology

Pierre Carpentier, Guy Testylier, Frédéric Dorandeu, Christoph Segebarth, Olivier Montigon, Annie Foquin, Hana Lahrech

Journal:

Year:

2008

Language:

english

File:

PDF, 964 KB

english, 2008

34

Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro

Maria Helfenstein, Michele Miragoli, Stephan Rohr, Loretta Müller, Peter Wick, Martin Mohr, Peter Gehr, Barbara Rothen-Rutishauser

Journal:

Year:

2008

Language:

english

File:

PDF, 2.05 MB

english, 2008

35

The acute lethality of acrylonitrile is not due to brain metabolic arrest

E. Cristian Campian, Frederick W. Benz

Journal:

Year:

2008

Language:

english

File:

PDF, 216 KB

english, 2008

36

Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells

Ritsuko Ohtani-Kaneko, Hidekatsu Tazawa, Makoto Yokosuka, Minoru Yoshida, Masahiko Satoh, Chiho Watanabe

Journal:

Year:

2008

Language:

english

File:

PDF, 829 KB

english, 2008

37

Impaired redox state and respiratory chain enzyme activities in the cerebellum of vitamin A-treated rats

Marcos Roberto De Oliveira, José Cláudio Fonseca Moreira

Journal:

Year:

2008

Language:

english

File:

PDF, 790 KB

english, 2008

38

Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes

D. Elgrabli, S. Abella-Gallart, F. Robidel, F. Rogerieux, J. Boczkowski, G. Lacroix

Journal:

Year:

2008

Language:

english

File:

PDF, 570 KB

english, 2008

39

Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals

Takeshi Nakamura, Yoshinao Katsu, Hajime Watanabe, Taisen Iguchi

Journal:

Year:

2008

Language:

english

File:

PDF, 1.87 MB

english, 2008

40

In vitro investigation of oxide nanoparticle and carbon nanotube toxicity and intracellular accumulation in A549 human pneumocytes

A. Simon-Deckers, B. Gouget, M. Mayne-L’Hermite, N. Herlin-Boime, C. Reynaud, M. Carrière

Journal:

Year:

2008

Language:

english

File:

PDF, 1.28 MB

english, 2008

41

Editorial Board Members

Journal:

Year:

2008

Language:

english

File:

PDF, 38 KB

english, 2008

42

Contents listing

Journal:

Year:

2008

Language:

english

File:

PDF, 48 KB

english, 2008

43

Genetic variants of hepatic transporters and susceptibility to drug induced liver injury

Pallav Bhatnagar, Chris P. Day, Guruprasad Aithal, Munir Pirmohamed, William Bernal, Ann K. Daly

Journal:

Year:

2008

Language:

english

File:

PDF, 136 KB

english, 2008

44

A functional PXR inhibits portal tract inflammation in a mouse model of cholangiopathy

David E. Cowie, Dimitrios Konstantinou, Matthew C. Wright

Journal:

Year:

2008

Language:

english

File:

PDF, 73 KB

english, 2008

45

Cytochrome P450s and glucuronosyl transferase in zebrafish larvae

Huw S. Jones, Grace H. Panter, Tom Hutchinson, Kevin J. Chipman

Journal:

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

46

Systematic review of epidemiological evidence for use in the framework approach for analysing the human relevance of an animal mode of action

Ehi Idahosa, Lesley Rushton, Alan R. Boobis

Journal:

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

47

p53 regulation of glycolytic enzymes

Michael D. Papaioannou, Nigel J. Gooderham

Journal:

Year:

2008

Language:

english

File:

PDF, 138 KB

english, 2008

48

Preclinical investigation of fibrodysplasia and its relevance to human musculo-skeletal syndrome

Michelle Coulson, Russell Westwood, Jonathan D. Tugwood, Rose A. Maciewicz, Jonathan Bowyer, Bob C. Scott

Journal:

Year:

2008

Language:

english

File:

PDF, 48 KB

english, 2008

49

Genetic polymorphisms and the development of cutaneous malignant melanoma: Association of the 609 C/T NAD(P)H: quinone oxidoreductase (NQO1) polymorphism

Sally E. Thomas, Anne E. Pheasant, Amanda J. Lee, Joanna M. Norman, Ryan P. Doran, Rhiannon M. David, Victoria Rawley, Adam Towler, Jerry Marsden, Nikolas J. Hodges

Journal:

Year:

2008

Language:

english

File:

PDF, 51 KB

english, 2008

50

Malaysian Kratom, a phyto-pharmaceutical of abuse: Studies on the mechanism of its cytotoxicity

Nor Aini Saidin, Thomas Randall, Hiromitsu Takayama, Elaine Holmes, Nigel J. Gooderham

Journal:

Year:

2008

Language:

english

File:

PDF, 194 KB

english, 2008

51

Uptake of Cr (VI) and Cr (III)–GSH complex across rat liver cell nuclei

Vijay Krishna Raghunathan, Justice N.A. Tettey, M. Helen Grant

Journal:

Year:

2008

Language:

english

File:

PDF, 188 KB

english, 2008

52

Validation of the in vitro skin irritation assay using the EPISKIN™ 3-D skin model and IL-1α cytokine analysis

Darren Kidd, Robert Smith

Journal:

Year:

2008

Language:

english

File:

PDF, 96 KB

english, 2008

53

Investigating the effects of NSAIDs on the expression of regulatory components of the polyamine pathway

Fiona R. Saunders, Alun Hughes, Heather M. Wallace

Journal:

Year:

2008

Language:

english

File:

PDF, 109 KB

english, 2008

54

Quantitation of the activation of AhR by induction of CYP1A1

Richard J. Wall, Rana Bazzi, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 94 KB

english, 2008

55

The endogenous role of the latrophilin receptor in C. elegans

Hao Lou, Ademola Adenle, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 93 KB

english, 2008

56

Effects of peroxisome proliferators on zonated DNA synthesis in rat and mouse liver

Abeer H. Amer, Abdullah M. Al-kholaifi, David R. Bell

Journal:

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

57

Changes In Antioxidant Status in HepG2, 1321N1 and HEK 293 Cells In Response To Cadmium Induced-oxidative Stress

Akeem O. Lawal, Elizabeth M. Ellis

Journal:

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

58

Receptor-selective TRAIL Mutants Target Lymphoid Tumor cells for Apoptosis via TRAIL-R1: Implications for Therapy

Marion MacFarlane, Susan L. Kohlhaas, Michael J. Sutcliffe, Martin J.S. Dyer, Gerald M. Cohen

Journal:

Year:

2008

Language:

english

File:

PDF, 80 KB

english, 2008

59

Effects of dichlorobenzene on acetylcholine receptors in human neuroblastoma SH-SY5Y cells

Ren-Ming Yan, Yin-Mei Chiung, Chien-Yuan Pan, Jenn-Hwa Liu, Pei-Shan Liu

Journal:

Year:

2008

Language:

english

File:

PDF, 599 KB

english, 2008

60

Enantioselective cytotoxicity of the insecticide bifenthrin on a human amnion epithelial (FL) cell line

Huigang Liu, Meirong Zhao, Cong Zhang, Yun Ma, Weiping Liu

Journal:

Year:

2008

Language:

english

File:

PDF, 861 KB

english, 2008

61

In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone tissue in rhesus monkeys

Sanne A.B. Hermsen, Sune Larsson, Akihiro Arima, Atsunobu Muneoka, Toshio Ihara, Hiroshi Sumida, Toshio Fukusato, Shunichiro Kubota, Mineo Yasuda, P. Monica Lind

Journal:

Year:

2008

Language:

english

File:

PDF, 352 KB

english, 2008

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