Toxicology and Applied Pharmacology

1

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

Koenig, Xaver, Kovar, Michael, Rubi, Lena, Mike, Agnes K., Lukacs, Peter, Gawali, Vaibhavkumar S., Todt, Hannes, Hilber, Karlheinz, Sandtner, Walter

Journal:

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

2

Safety pharmacology — Current and emerging concepts

Hamdam, Junnat, Sethu, Swaminathan, Smith, Trevor, Alfirevic, Ana, Alhaidari, Mohammad, Atkinson, Jeffrey, Ayala, Mimieveshiofuo, Box, Helen, Cross, Michael, Delaunois, Annie, Dermody, Ailsa, Govindap

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 981 KB

english, 2013

3

Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells

Person, Rachel J., Tokar, Erik J., Xu, Yuanyuan, Orihuela, Ruben, Ngalame, Ntube N. Olive, Waalkes, Michael P.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

4

Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain, optic nerve and retina

Rai, Nagendra Kumar, Ashok, Anushruti, Rai, Asit, Tripathi, Sachin, Nagar, Geet Kumar, Mitra, Kalyan, Bandyopadhyay, Sanghamitra

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 11.65 MB

english, 2013

5

Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells

Saquib, Quaiser, Al-Khedhairy, Abdulaziz A., Ahmad, Javed, Siddiqui, Maqsood A., Dwivedi, Sourabh, Khan, Shams T., Musarrat, Javed

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 2.19 MB

english, 2013

6

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Li, Yuan-Yuan, Yu, Li-Fang, Zhang, Li-Na, Qiu, Bei-Ying, Su, Ming-Bo, Wu, Fang, Chen, Da-Kai, Pang, Tao, Gu, Min, Zhang, Wei, Ma, Wei-Ping, Jiang, Hao-Wen, Li, Jing-Ya, Nan, Fa-Jun, Li, Jia

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 2.11 MB

english, 2013

7

Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury

Funk, Jason A., Schnellmann, Rick G.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 2.11 MB

english, 2013

8

Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: Relevance to human cancer risk

Labib, Sarah, Guo, Charles H., Williams, Andrew, Yauk, Carole L., White, Paul A., Halappanavar, Sabina

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.43 MB

english, 2013

9

Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression

Sharma, Deep Raj, Sunkaria, Aditya, Wani, Willayat Yousuf, Sharma, Reeta Kumari, Kandimalla, Ramesh J.L., Bal, Amanjit, Gill, Kiran Dip

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 3.27 MB

english, 2013

10

Proposed mechanistic description of dose-dependent BDE-47 urinary elimination in mice using a physiologically based pharmacokinetic model

Emond, Claude, Sanders, J. Michael, Wikoff, Daniele, Birnbaum, Linda S.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 910 KB

english, 2013

11

A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors

Zhou, Dan, Liu, Yuan, Ye, Josephine, Ying, Weiwen, Ogawa, Luisa Shin, Inoue, Takayo, Tatsuta, Noriaki, Wada, Yumiko, Koya, Keizo, Huang, Qin, Bates, Richard C., Sonderfan, Andrew J.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

12

Editorial Board

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 31 KB

english, 2013

14

Green tea polyphenol, (−)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling

Singh, Tripti, Katiyar, Santosh K.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

15

Carbon monoxide inhalation increases microparticles causing vascular and CNS dysfunction

Xu, Jiajun, Yang, Ming, Kosterin, Paul, Salzberg, Brian M., Milovanova, Tatyana N., Bhopale, Veena M., Thom, Stephen R.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 770 KB

english, 2013

16

DNA damage and apoptosis of endometrial cells cause loss of the early embryo in mice exposed to carbon disulfide

Zhang, Bingzhen, Shen, Chunzi, Yang, Liu, Li, Chunhui, Yi, Anji, Wang, Zhiping

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 640 KB

english, 2013

17

Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-β expression

Siddiqui, Shabeena, Ahsan, Haseeb, Khan, Mohammad Rashid, Siddiqui, Waseem A.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

18

Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways

Kakehashi, Anna, Hagiwara, Akihiro, Imai, Norio, Nagano, Kasuke, Nishimaki, Fukumi, Banton, Marcy, Wei, Min, Fukushima, Shoji, Wanibuchi, Hideki

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

19

Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation

Hossain, Muhammad M., Sonsalla, Patricia K., Richardson, Jason R.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

20

Corrigendum to “Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on 62]

Erkekoglu, Pinar, Rachidi, Walid, Yuzugullu, Ozge Gursoy, Giray, Belma, Favier, Alain, Ozturk, Mehmet, Hincal, Filiz

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

21

Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

Poon, Kirsten Achilles, Flagella, Kelly, Beyer, Joseph, Tibbitts, Jay, Kaur, Surinder, Saad, Ola, Yi, Joo-Hee, Girish, Sandhya, Dybdal, Noel, Reynolds, Theresa

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 935 KB

english, 2013

Volume 273; Issue 2

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

Safety pharmacology — Current and emerging concepts

Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells

Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain, optic nerve and retina

Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury

Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: Relevance to human cancer risk

Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression

Proposed mechanistic description of dose-dependent BDE-47 urinary elimination in mice using a physiologically based pharmacokinetic model

A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors

Contents

Editorial Board

Green tea polyphenol, (−)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling

Carbon monoxide inhalation increases microparticles causing vascular and CNS dysfunction

DNA damage and apoptosis of endometrial cells cause loss of the early embryo in mice exposed to carbon disulfide

Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-β expression

Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways

Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation

Corrigendum to “Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on 62]

Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability