Volume 42; Issue 2

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Xenobiotica
Volume 42; Issue 2

Xenobiotica

Volume 42; Issue 2

1

Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor

Duan, Jianmin, Yong, Chan-Loi, Garneau, Michel, Amad, Ma’an, Bolger, Gordon, De Marte, Josie, Montpetit, Hélène, Otis, Francois, Jutras, Martin, Rhéaume, Manon

Journal:

Year:

2012

Language:

english

File:

PDF, 771 KB

english, 2012

2

Effect of genistein on the activities of cytochrome P450 3A and P-glycoprotein in Chinese healthy participants

Xiao, C.-Q., Chen, R., Lin, J., Wang, G., Chen, Y., Tan, Z.-R., Zhou, H.-H.

Journal:

Year:

2012

Language:

english

File:

PDF, 683 KB

english, 2012

3

Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors

Brents, Lisa K., Medina-Bolivar, Fabricio, Seely, Kathryn A., Nair, Vipin, Bratton, Stacie M., Ñopo-Olazabal, Luis, Patel, Ronak Y., Liu, Haining, Doerksen, Robert J., Prather, Paul L., Radominska-Pan

Journal:

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

4

Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry

Sarda, Sunil, Page, Chris, Pickup, Kathryn, Schulz-Utermoehl, Timothy, Wilson, Ian

Journal:

Year:

2012

Language:

english

File:

PDF, 1.47 MB

english, 2012

5

Pharmacokinetic and pharmacodynamic properties of carvedilol in fructose hypertensive rats

Bertera, Facundo, Di Verniero, Carla Andrea, Mayer, Marcos Alejandro, Chiappetta, Diego, Buontempo, Fabián, Polizio, Ariel Héctor, Taira, Carlos Alberto, Höcht, Christian

Journal:

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

6

A high throughput in vitro mrp2 assay to predict in vivo biliary excretion

Colombo, Federico, Armstrong, Catherine, Duan, Jianmin, Rioux, Nathalie

Journal:

Year:

2012

Language:

english

File:

PDF, 711 KB

english, 2012

7

Evaluation of cytochrome P450-mediated drug–drug interactions based on the strategies recommended by regulatory authorities

Kosugi, Yohei, Hirabayashi, Hideki, Igari, Tomoko, Fujioka, Yasushi, Hara, Yoko, Okuda, Teruaki, Moriwaki, Toshiya

Journal:

Year:

2012

Language:

english

File:

PDF, 731 KB

english, 2012

8

The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: Application to the metabolism of diclofenac

Pickup, Kathryn, Gavin, Alex, Jones, Huw B., Karlsson, Elin, Page, Chris, Ratcliffe, Kerry, Sarda, Sunil, Schulz-Utermoehl, Timothy, Wilson, Ian

Journal:

Year:

2012

Language:

english

File:

PDF, 989 KB

english, 2012