Volume 44; Issue 4

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Xenobiotica
Volume 44; Issue 4

Xenobiotica

Volume 44; Issue 4

1

In vitro metabolism of a novel antithrombotic compound, S002-333, and its enantiomers: quantitative cytochrome P450 phenotyping, metabolic profiling and enzyme kinetic studies

Saxena, Amrita, Jain, Girish K., Siddiqui, Hefazat H., Bhunia, Shom S., Saxena, Anil K., Gayen, Jiaur R.

Journal:

Year:

2014

Language:

english

File:

PDF, 682 KB

english, 2014

2

Metabolism and mass balance of SGLT2 inhibitor tofogliflozin following oral administration to humans

Zell, Manfred, Husser, Christophe, Kuhlmann, Olaf, Schwab, Dietmar, Uchimura, Takahide, Kemei, Tomonori, Kawashima, Kosuke, Yamane, Mizuki, Pähler, Axel

Journal:

Year:

2014

Language:

english

File:

PDF, 344 KB

english, 2014

3

In vitro metabolism of monensin A: microbial and human liver microsomes models

Rocha, Bruno A., Assis, Marilda D., Peti, Ana P. F., Moraes, Luiz A. B., Moreira, Fernanda L., Lopes, Norberto P., Pospíšil, Stanislav, Gates, Paul J., de Oliveira, Anderson R. M.

Journal:

Year:

2014

Language:

english

File:

PDF, 539 KB

english, 2014

4

Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6

Livezey, Mara R., Briggs, Erran D., Bolles, Amanda K., Nagy, Leslie D., Fujiwara, Rina, Furge, Laura Lowe

Journal:

Year:

2014

Language:

english

File:

PDF, 761 KB

english, 2014

5

Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers

Ho, May Y. K., Morris, Michael J., Pirhalla, Jill L., Bauman, John W., Pendry, Carolyn B., Orford, Keith W., Morrison, Royce A., Cox, Donna S.

Journal:

Year:

2014

Language:

english

File:

PDF, 626 KB

english, 2014

6

Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases

Ai, Limei, Zhu, Liangliang, Yang, Lu, Ge, Guangbo, Cao, Yunfeng, Liu, Yong, Fang, Zhongze, Zhang, Yanyan

Journal:

Year:

2014

Language:

english

File:

PDF, 548 KB

english, 2014

7

Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish

Fay, Kellie A., Fitzsimmons, Patrick N., Hoffman, Alex D., Nichols, John W.

Journal:

Year:

2014

Language:

english

File:

PDF, 165 KB

english, 2014

8

Risk assessment of drug–drug interactions using hepatocytes suspended in serum during the drug discovery process

Kosugi, Yohei, Hirabayashi, Hideki, Igari, Tomoko, Fujioka, Yasushi, Okuda, Teruaki, Moriwaki, Toshiya

Journal:

Year:

2014

Language:

english

File:

PDF, 376 KB

english, 2014

9

Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol)

Kumar, Atul, Mann, Henry J., Remmel, Rory P., Beilman, Greg J., Kaila, Nitin

Journal:

Year:

2014

Language:

english

File:

PDF, 903 KB

english, 2014