Volume 45; Issue 2

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Xenobiotica
Volume 45; Issue 2

Xenobiotica

Volume 45; Issue 2

1

Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays

Nirogi, Ramakrishna, Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Srikakolapu, Surya Rao, Kalaikadhiban, Ilayaraja, Boggavarapu, Rajesh Kumar, Ponnamaneni, Ranjith Kumar,

Journal:

Year:

2015

Language:

english

File:

PDF, 870 KB

english, 2015

2

Effects of capsaicin on pharmacokinetics of pitavastatin in rats

Chen, Fen, Zhai, Xuejia, Zhu, Chaoran, Lu, Yongning

Journal:

Year:

2015

Language:

english

File:

PDF, 395 KB

english, 2015

3

Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture

Badolo, Lassina, Jensen, Bente, Säll, Carolina, Norinder, Ulf, Kallunki, Pekka, Montanari, Dino

Journal:

Year:

2015

Language:

english

File:

PDF, 344 KB

english, 2015

4

Mass balance, pharmacokinetics and metabolism of the selective S1P 1 receptor modulator ponesimod in humans

Reyes, Maribel, Hoch, Matthias, Brossard, Patrick, Wagner-Redeker, Winfried, Miraval, Tommaso, Dingemanse, Jasper

Journal:

Year:

2015

Language:

english

File:

PDF, 933 KB

english, 2015

5

In vitro and in vivo metabolism of 14 C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase

Guo, Jian, Joubran, Camil, Luzietti, Ricardo A., Zhou, Fei, Basarab, Gregory S., Vishwanathan, Karthick

Journal:

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

6

Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes

Lee, Sang Yoon, Jang, Himchan, Lee, Ji-Yoon, Ma, Jin Yeul, Oh, Soo Jin, Kim, Sang Kyum

Journal:

Year:

2015

Language:

english

File:

PDF, 677 KB

english, 2015

7

Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite

Krauser, Joel A., Jin, Yi, Walles, Markus, Pfaar, Ulrike, Sutton, James, Wiesmann, Marion, Graf, Daniel, Pflimlin-Fritschy, Veronique, Wolf, Thierry, Camenisch, Gian, Swart, Piet

Journal:

Year:

2015

Language:

english

File:

PDF, 1.16 MB

english, 2015

8

The metabolism and pharmacokinetics of [ 14 C]-S-777469, a new cannabinoid receptor 2 selective agonist, in healthy human subjects

Sekiguchi, Kazutaka, Fukumura, Kazuya, Hasegawa, Hiroshi, Kanazu, Takushi

Journal:

Year:

2015

Language:

english

File:

PDF, 657 KB

english, 2015

9

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine

Uehara, Shotaro, Murayama, Norie, Nakanishi, Yasuharu, Nakamura, Chika, Hashizume, Takanori, Zeldin, Darryl C., Yamazaki, Hiroshi, Uno, Yasuhiro

Journal:

Year:

2015

Language:

english

File:

PDF, 393 KB

english, 2015