Volume 18; Issue 10

Bioorganic & Medicinal Chemistry

Volume 18; Issue 10

1

Corrigendum to “Chemo-enzymatic synthesis of 1,4-oxazepanyl sugar as potent inhibitor of chitinase” [Bioorg. Med. Chem. 14 (2006) 2446]

Gang-Liang Huang, Da-Wei Zhang, Hong-Juan Zhao, Hou-Cheng Zhang, Peng-George Wang

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

File:

PDF, 89 KB

2010

2

In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr

Rostand M. Ngoumfo, Jean-Bosco Jouda, Ferdinand T. Mouafo, Justin Komguem, Céline D. Mbazoa, Tze Chieh Shiao, Mohammed I. Choudhary, Hartmut Laatsch, Jean Legault, André Pichette, René Roy

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 385 KB

english, 2010

3

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

Richard L. Mackman, Adrian S. Ray, Hon C. Hui, Lijun Zhang, Gabriel Birkus, Constantine G. Boojamra, Manoj C. Desai, Janet L. Douglas, Ying Gao, Deborah Grant, Genevieve Laflamme, Kuei-Ying Lin, David

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 430 KB

english, 2010

4

Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

Aleem Gangjee, Sonali Kurup, Michael A Ihnat, Jessica E. Thorpe, Satyendra S. Shenoy

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 776 KB

english, 2010

5

Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones

Y. Thirupathi Reddy, P. Narsimha Reddy, Srinivas Koduru, Chendil Damodaran, Peter A. Crooks

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

6

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity

Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, Nicoletta Cesari, Maria Paola Giovannoni, Agostino Cilibrizzi, Vittorio Dal Piaz, Claudia Vergelli, Letizia Crocetti, Maurizio Delcanale, E

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 520 KB

english, 2010

7

Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans

Barbara Czakó, János Marton, Sándor Berényi, Katarzyna Gach, Jakub Fichna, Martin Storr, Géza Tóth, Attila Sipos, Anna Janecka

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 597 KB

english, 2010

8

Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents

Federica Belluti, Gabriele Fontana, Laura Dal Bo, Nives Carenini, Chiara Giommarelli, Franco Zunino

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 491 KB

english, 2010

9

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

Simon J. Leiris, Omar M. Khdour, Zachary J. Segerman, Krystal S. Tsosie, Jean-Charles Chapuis, Sidney M. Hecht

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 927 KB

english, 2010

10

Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

Arindam Talukdar, Ekaterina Morgunova, Jianxin Duan, Winfried Meining, Nicolas Foloppe, Lennart Nilsson, Adelbert Bacher, Boris Illarionov, Markus Fischer, Rudolf Ladenstein, Mark Cushman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 927 KB

english, 2010

11

Isolation and characterization of enantioselective DNA aptamers for ibuprofen

Yeon Seok Kim, Chang Jun Hyun, In Ae Kim, Man Bock Gu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 829 KB

english, 2010

12

Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins

Zhichao Pei, Tobias Gustavsson, Robert Roth, Torbjörn Frejd, Cecilia Hägerhäll

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 508 KB

english, 2010

13

RNA interference with 2′,4′-bridged nucleic acid analogues

S.M. Abdur Rahman, Hiroyuki Sato, Naoto Tsuda, Sunao Haitani, Keisuke Narukawa, Takeshi Imanishi, Satoshi Obika

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 899 KB

english, 2010

14

Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents

Yong Ling, Xiaolei Ye, Hui Ji, Yihua Zhang, Yisheng Lai, Sixun Peng, Jide Tian

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 445 KB

english, 2010

15

Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors

Anita Büttner, Thomas Cottin, Jing Xu, Lito Tzagkaroulaki, Athanassios Giannis

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.33 MB

english, 2010

16

Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase

Young Ah Kim, Ravindra K. Rawal, Jakyung Yoo, Ashoke Sharon, Ashok K. Jha, Chung K. Chu, Reem H. Rais, Omar N. Al Safarjalani, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 478 KB

english, 2010

17

1-(3-Deoxy-3-fluoro-β-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies

Vicky G. Tsirkone, Evangelia Tsoukala, Christos Lamprakis, Stella Manta, Joseph M. Hayes, Vicky T. Skamnaki, Christina Drakou, Spyros E. Zographos, Dimitri Komiotis, Demetres D. Leonidas

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.85 MB

english, 2010

18

Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives

Omaima M. Abdelhafez, Kamelia M. Amin, Rasha Z. Batran, Timothy J. Maher, Somaia A. Nada, Shalini Sethumadhavan

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 402 KB

english, 2010

19

Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

Adam Jarmuła, Tomasz Frączyk, Piotr Cieplak, Wojciech Rode

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.83 MB

english, 2010

20

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 972 KB

english, 2010

21

Silica-supported fluoroboric acid (HBF4–SiO2) catalyzed highly productive synthesis of thiomorpholides as activators of l-asparaginase as well as the antioxidant agent

Babasaheb P. Bandgar, Shrikant S. Gawande, Suchita C. Warangkar, Jalinder V. Totre

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.55 MB

english, 2010

22

Design of new potent and selective secretory phospholipase A2 inhibitors. 6-Synthesis, structure–activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives

Nadia Meddad-Belhabich, Darina Aoun, Atimé Djimdé, Catherine Redeuilh, Georges Dive, France Massicot, François Chau, Françoise Heymans, Aazdine Lamouri

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.70 MB

english, 2010

23

Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles

Danuta Branowska, Abdelbasset A. Farahat, Arvind Kumar, Tanja Wenzler, Reto Brun, Yang Liu, W. David Wilson, David W. Boykin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 555 KB

english, 2010

24

Novel estrone mimetics with high 17β-HSD1 inhibitory activity

Alexander Oster, Tobias Klein, Ruth Werth, Patricia Kruchten, Emmanuel Bey, Matthias Negri, Sandrine Marchais-Oberwinkler, Martin Frotscher, Rolf W. Hartmann

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 941 KB

english, 2010

25

Targeting a ruthenium complex to the nucleus with short peptides

Cindy A. Puckett, Jacqueline K. Barton

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 577 KB

english, 2010

26

NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II

Deniz Ekinci, Hüseyin Çavdar, Oktay Talaz, Murat Şentürk, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 203 KB

english, 2010

27

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists

Pekka K. Poutiainen, Tuomas A. Venäläinen, Mikael Peräkylä, Juha M. Matilainen, Sami Väisänen, Paavo Honkakoski, Reino Laatikainen, Juha T. Pulkkinen

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 907 KB

english, 2010

28

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninergic ligands

Christophe Mésangeau, Basile Pérès, Carole Descamps-François, Philippe Chavatte, Valérie Audinot, Sophie Coumailleau, Jean A. Boutin, Philippe Delagrange, Caroline Bennejean, Pierre Renard, Daniel H.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 719 KB

english, 2010

29

Bioactive norditerpenoids from the soft coral Sinularia gyrosa

Shi-Yie Cheng, Cheng-Ta Chuang, Zhi-Hong Wen, Shang-Kwei Wang, Shu-Fen Chiou, Chi-Hsin Hsu, Chang-Feng Dai, Chang-Yih Duh

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 739 KB

english, 2010

30

Editorial board

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 48 KB

english, 2010

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