Volume 11; Issue 2

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Bioorganic & Medicinal Chemistry Letters
Volume 11; Issue 2

Bioorganic & Medicinal Chemistry Letters

Volume 11; Issue 2

1

Bioisosteres of 9-Carboxymethyl-4-oxo-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent In Vivo AMPA antagonists with longer durations of action

Patrick Jimonet, Georg Andrees Bohme, Jean Bouquerel, Alain Boireau, Dominique Damour, Marc Williams Debono, Arielle Genevois-Borella, Jean-Claude Hardy, Philippe Hubert, Franco Manfré, Patrick Nemece

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 212 KB

english, 2001

2

New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position

Aesop Cho, Tomasz W. Glinka, Maria Ludwikow, Andrew T. Fan, Michael Wang, Scott J. Hecker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

3

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure–activity relationships of apicidin. Part 1

Steven L Colletti, Robert W Myers, Sandra J Darkin-Rattray, Anne M Gurnett, Paula M Dulski, Stefan Galuska, John J Allocco, Michelle B Ayer, Chunshi Li, Julie Lim, Tami M Crumley, Christine Cannova, D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

4

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure–activity relationships of apicidin. Part 2

Steven L Colletti, Robert W Myers, Sandra J Darkin-Rattray, Anne M Gurnett, Paula M Dulski, Stefan Galuska, John J Allocco, Michelle B Ayer, Chunshi Li, Julie Lim, Tami M Crumley, Christine Cannova, D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

5

8-amido-bearing pseudomycin B (PSB) analogue: novel antifungal agents

Yan-Zhi Zhang, Xicheng Sun, Douglas J Zeckner, Roberta K Sachs, William L Current, Shu-Hui Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 122 KB

english, 2001

6

Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines

Laval Chan, Tomislav Stefanac, Jean-François Lavallée, Haolun Jin, Jean Bédard, Suzanne May, Guy Falardeau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 114 KB

english, 2001

7

A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase

Kevin J Kennedy, Jerome C Bressi, Michael H Gelb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 129 KB

english, 2001

8

Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C

Dawei Ma, Tao Zhang, Guoqiang Wang, Alan P Kozikowski, Nancy E Lewin, Peter M Blumberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 146 KB

english, 2001

9

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor

Wan Theng Sing, Cheng Leng Lee, Su Ling Yeo, Siew Pheng Lim, Mui Mui Sim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 168 KB

english, 2001

10

Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2,3-Gal-β-O-PNP

Jennifer A Harrison, K.P.Ravindranathan Kartha, W.Bruce Turnbull, Shona L Scheuerl, James H Naismith, Sergio Schenkman, Robert A Field

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 338 KB

english, 2001

11

Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5′-polyphosphates

William Pendergast, Benjamin R Yerxa, James G Douglass III, Sammy R Shaver, Robert W Dougherty, Catherine C Redick, Ingrid F Sims, Janet L Rideout

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

12

The synthesis of pseudomycin C′ via a novel acid promoted side-chain deacylation of pseudomycin A

Michael J Rodriguez, Matthew Belvo, Robert Morris, Douglas J Zeckner, William L Current, Roberta K Sachs, Mark J Zweifel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 178 KB

english, 2001

13

Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

James McNulty, Justin Mao, Romelo Gibe, Ruowei Mo, Sonja Wolf, George R. Pettit, Delbert L. Herald, Michael R. Boyd

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

14

Which aminoglycoside ring is most important for binding? a hydropathic analysis of gentamicin, paromomycin, and analogues

Derek J Cashman, Jason P Rife, Glen E Kellogg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 288 KB

english, 2001

15

Chemical synthesis of UDP-β-l-arabinofuranose and its turnover to UDP-β-l-arabinopyranose by UDP-galactopyranose mutase

Qibo Zhang, Hung-wen Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 200 KB

english, 2001

16

S-adenosylmethionine reverses ilimaquinone's vesiculation of the Golgi apparatus: A fluorescence study on the cellular interactions of ilimaquinone

Rebecca L Casaubon, Marc L Snapper

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 498 KB

english, 2001

17

Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC

Alex J. Zhang, Sangeeta Khare, Kuppan Gokulan, D.Scott Linthicum, Kevin Burgess

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 175 KB

english, 2001

18

Synthesis and antiparasitic activity of 2-(Trifluoromethyl)benzimidazole derivatives

Gabriel Navarrete-Vázquez, Roberto Cedillo, Alicia Hernández-Campos, Lilián Yépez, Francisco Hernández-Luis, Juan Valdez, Raúl Morales, Rafael Cortés, Manuel Hernández, Rafael Castillo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 122 KB

english, 2001

19

High-pressure synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines

Sally-Ann Poulsen, David J Young, Ronald J Quinn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

20

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

W.M Welch, F.E Ewing, J Huang, F.S Menniti, M.J Pagnozzi, K Kelly, P.A Seymour, V Guanowsky, S Guhan, M.R Guinn, D Critchett, J Lazzaro, A.H Ganong, K.M DeVries, T.L Staigers, B.L Chenard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 149 KB

english, 2001

21

Design and synthesis of sialyl lewis x mimics as e-selectin inhibitors

Neelu Kaila, Bert E. Thomas IV, Paresh Thakker, Juan C. Alvarez, Raymond T. Camphausen, Deidre Crommie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

22

3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors

Jeffrey W Corbett, Senliang Pan, Jay A Markwalder, Beverly C Cordova, Ronald M Klabe, Sena Garber, James D Rodgers, Susan K Erickson-Viitanen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 354 KB

english, 2001

23

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Anja Johansson, Ina Hubatsch, Eva Åkerblom, Gunnar Lindeberg, Susanne Winiwarter, U.Helena Danielson, Anders Hallberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 103 KB

english, 2001

24

Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K

Ashley E. Fenwick, Bénédicte Garnier, Andrew D. Gribble, Robert J. Ife, Anthony D. Rawlings, Jason Witherington

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 199 KB

english, 2001

25

Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K

Ashley E Fenwick, Andrew D Gribble, Robert J Ife, Nichola Stevens, Jason Witherington

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 158 KB

english, 2001

26

Synthesis and evaluation of caffeic acid amides as antioxidants

Padinchare Rajan, Irina Vedernikova, Paul Cos, Dirk Vanden Berghe, Koen Augustyns, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 158 KB

english, 2001

27

Solid-phase optimisation of achiral amidinobenzyl indoles as potent and selective factor Xa inhibitors

Uwe Heinelt, Silke Herok, Hans Matter, Peter Wildgoose

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

28

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams

Simon J.F Macdonald, Michael D Dowle, Lee A Harrison, Julie E Spooner, Pritom Shah, Martin R Johnson, Graham G.A Inglis, Geoffrey D.E Clarke, David J Belton, Robin A Smith, Christopher R Molloy, Mary

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 226 KB

english, 2001

29

Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand

Bruno Macchia, Luigi Cervetto, Gian Carlo Demontis, Paolo Domiano, Biancamaria Longoni, Marco Macchia, Filippo Minutolo, Elisabetta Orlandini, Gabriella Ortore, Chiara Papi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

30

2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Song Seok Shin, Min-Soo Noh, Young Joo Byun, Jin Kyu Choi, Ji Young Kim, Kyung Min Lim, Jun-Yong Ha, Jin Kwan Kim, Chang Hoon Lee, Shin Chung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

31

3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents1

Y. Kashiwada, J. Chiyo, Y. Ikeshiro, T. Nagao, H. Okabe, L.M. Cosentino, K. Fowke, K.H. Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 151 KB

english, 2001

32

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure–activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes

Conrad P. Dorn, Paul E. Finke, Bryan Oates, Richard J. Budhu, Sander G. Mills, Malcolm MacCoss, Lorraine Malkowitz, Martin S. Springer, Bruce L. Daugherty, Sandra L. Gould, Julie A. DeMartino, Salvato

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 218 KB

english, 2001

33

Structure–activity relationships of side-chain modified didemnins

Xiaobin Ding, Matthew D. Vera, Bo Liang, Yuming Zhao, Michael S. Leonard, Madeleine M. Joullié

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

34

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure–activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

Paul E Finke, Laura C Meurer, Bryan Oates, Sander G Mills, Malcolm MacCoss, Lorraine Malkowitz, Martin S Springer, Bruce L Daugherty, Sandra L Gould, Julie A DeMartino, Salvatore J Siciliano, Anthony

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 230 KB

english, 2001

35

3-Deoxy-3-substituted-d-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

Youhong Hu, Emmanuelle J. Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 162 KB

english, 2001

36

Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3′ residue

Chi Ching Mak, Van-Duc Le, Ying-Chuan Lin, John H Elder, Chi-Huey Wong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 148 KB

english, 2001

37

The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position

Jeremy I Levin, Mila T Du, John F DiJoseph, Loran M Killar, Amy Sung, Thomas Walter, Michele A Sharr, Catherine E Roth, Franklin J Moy, Robert Powers, Guixian Jin, Rebecca Cowling, Jerauld S Skotnicki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

38

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

Zhili Li, Michael W Fennie, Bruce Ganem, Matthew T Hancock, Muris Kobašlija, Donna Rattendi, Cyrus J Bacchi, Mary C O'Sullivan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 175 KB

english, 2001

39

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

Jeremy I Levin, Yansong Gu, Frances C Nelson, Arie Zask, John F DiJoseph, Michele A Sharr, Amy Sung, Guixian Jin, Rebecca Cowling, Pranab Chanda, Scott Cosmi, Chu-Lai Hsiao, Wade Edris, James Wilhelm,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

40

3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide

David Allsop, Gillian Gibson, Ian K. Martin, Susan Moore, Stuart Turnbull, Lance J. Twyman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 137 KB

english, 2001

41

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine

Ugo Gulini, Piero Angeli, Gabriella Marucci, Michela Buccioni, Dario Giardinà, Luciano Antolini, Silvia Franchini, Claudia Sorbi, Livio Brasili

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 203 KB

english, 2001

42

Liquid-Phase Parallel Synthesis of Ureas

Kuo-Ting Huang, Chung-Ming Sun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 114 KB

english, 2001

43

Synthesis and structure–activity analysis of novel dihydropyridine derivatives to overcome multidrug resistance

Shigeyuki Tasaka, Hiromasa Ohmori, Noriaki Gomi, Mayumi Iino, Tosiki Machida, Akira Kiue, Seiji Naito, Michihiko Kuwano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 129 KB

english, 2001

44

Cocaine catalytic antibodies: the primary importance of linker effects

Masayuki Matsushita, Timothy Z Hoffman, Jon A Ashley, Bin Zhou, Peter Wirsching, Kim D Janda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 170 KB

english, 2001

45

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 98 KB

english, 2001

46

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 874 KB

english, 2001

47

Instruction to Contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 98 KB

english, 2001

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