Volume 11; Issue 4

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Bioorganic & Medicinal Chemistry Letters
Volume 11; Issue 4

Bioorganic & Medicinal Chemistry Letters

Volume 11; Issue 4

1

Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives

Sulong Xiao, Wei Lin, Chao Wang, Ming Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 226 KB

english, 2001

2

Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine

Vladimir Bezuglov, Mikhail Bobrov, Natalia Gretskaya, Alla Gonchar, Galina Zinchenko, Dominique Melck, Tiziana Bisogno, Vincenzo Di Marzo, Dmitry Kuklev, Jean-Claude Rossi, Jean-Pierre Vidal, Thierry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

3

Photochemical N-demethylation of alkaloids

Justin A. Ripper, Edward R.T. Tiekink, Peter J. Scammells

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 143 KB

english, 2001

4

First tricyclic oximino derivatives as 5-HT3 ligands

I. Baglin, C. Daveu, J.C. Lancelot, R. Bureau, F. Dauphin, B. Pfeiffer, P. Renard, P. Delagrange, S. Rault

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 376 KB

english, 2001

5

Synthesis of sialyl lewisx mimics. Modifications of the 6-position of galactose

Rolf Bänteli, Beat Ernst

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 223 KB

english, 2001

6

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones

Silvana Grasso, Giovambattista De Sarro, Angela De Sarro, Nicola Micale, Santina Polimeni, Maria Zappalà, Giulia Puia, Mario Baraldi, Carlo De Micheli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

7

Protein phosphatase 1 catalyses the direct hydrolytic cleavage of phosphate monoester in a ternary complex mechanism

Jonathan Sanvoisin, David Gani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 316 KB

english, 2001

8

Identification and characterization of a potential ischemia-selective N-methyl-d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788

Seetharamaiyer Padmanabhan, Michael E Perlman, Lu Zhang, Deke Moore, Dan Zhou, James B Fischer, Graham J Durant, Robert N McBurney

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

9

Evidence for Gliotoxin–Glutathione conjugate adducts

Paul H. Bernardo, Christina L.L. Chai, Geoffrey J. Deeble, Xue-Ming Liu, Paul Waring

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 109 KB

english, 2001

10

A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

Xiang Y. Yu, Jason M. Hill, Guixue Yu, Yifeng Yang, Arthur F. Kluge, Dennis Keith, John Finn, Paul Gallant, Jared Silverman, Audrey Lim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

11

Semi-synthesis of 2-deoxo- and 3-epi-paraherquamide A

Byung H. Lee, Michael F. Clothier, Sandra S. Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

12

Modified synthesis and antiangiogenic activity of linomide

Saeed R. Khan, Annastasiah Mhaka, Roberto Pili, John T. Isaacs

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

13

Synthesis and monoamine transporter affinity of 3β-(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes and 3β-(5-Indolyl)-8-azabicyclo[3.2.1]octanes

Huw M.L Davies, Pingda Ren, Norman Kong, Tammy Sexton, Steven R Childers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

14

Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

Pauline C Ting, Joe F Lee, John C Anthes, Neng-Yang Shih, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

15

Pharmacophore-Based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors

Sukumar Sakamuri, Istvan J Enyedy, Alan P Kozikowski, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 411 KB

english, 2001

16

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

Biao Jiang, Xen-Nan Xiong, Cai-Guang Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 130 KB

english, 2001

17

Synthesis and biological activity of novel macrocyclic antifungals: acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469

David Barrett, Akira Tanaka, Keiko Harada, Hidenori Ohki, Etsuko Watabe, Katsuyuki Maki, Fumiaki Ikeda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

18

β-d-Glycosylamidines: potent, selective, and easily accessible β-glycosidase inhibitors

Wenfei Guo, Jun Hiratake, Koichi Ogawa, Mikio Yamamoto, Seung-Jin Ma, Kanzo Sakata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 126 KB

english, 2001

19

Initial structure–activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

Lin Chu, Jennifer E. Hutchins, Ann E. Weber, Jane-Ling Lo, Yi-Tien Yang, Kang Cheng, Roy G. Smith, Michael H. Fisher, Matthew J. Wyvratt, Mark T. Goulet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 212 KB

english, 2001

20

SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

Lin Chu, Jane-Ling Lo, Yi-Tien Yang, Kang Cheng, Roy G. Smith, Michael H. Fisher, Matthew J. Wyvratt, Mark T. Goulet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 153 KB

english, 2001

21

Targeting RNA with peptidomimetic oligomers in human cells

Natarajan Tamilarasu, Ikramul Huq, Tariq M. Rana

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 168 KB

english, 2001

22

Oxo-piperazine Derivatives of N-Arylpiperazinones as Inhibitors of Farnesyltransferase

Christopher J Dinsmore, Jeffrey M Bergman, Donna D Wei, C.Blair Zartman, Joseph P Davide, Ian B Greenberg, Dongming Liu, Timothy J O'Neill, Jackson B Gibbs, Kenneth S Koblan, Nancy E Kohl, Robert B Lo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 144 KB

english, 2001

23

Synthesis of analogues of the O-β-d-Ribofuranosyl nucleoside moiety of liposidomycins. Part 2: role of the hydroxyl groups upon the inhibition of MraY

C. Dini, N. Drochon, J.C. Guillot, P. Mauvais, P. Walter, J. Aszodi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

24

Synthesis of analogues of the O-β-d-Ribofuranosyl Nucleoside Moiety of Liposidomycins. Part 1: contribution of the amino group and the Uracil Moiety upon the inhibition of MraY

C Dini, N Drochon, S Feteanu, J.C Guillot, C Peixoto, J Aszodi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

25

4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a prodrug for its quinolizinium cation as a ligand to the open state of the TCP-binding site of NMDA receptors

Shigeki Sasaki, Takahiro Kanda, Nobuyasu Ishibashi, Fumihiko Yamamoto, Terushi Haradahira, Takashi Okauchi, Jun Meda, Kazutoshi Suzuki, Minoru Maeda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

26

Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

Haruhisa Ogita, Yoshiaki Isobe, Haruo Takaku, Rena Sekine, Yuso Goto, Satoru Misawa, Hideya Hayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 129 KB

english, 2001

27

Structure–activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-α production and T Cell proliferation

Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, Mitsuhiro Matsumoto, Fumihiro Obara, Takahiro Nagasaki, Hideya Hayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

28

Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3′ group chirality

M.Jonathan Fray, M.Frank Burslem, RogerP Dickinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 146 KB

english, 2001

29

Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (Stromelysin-1)

M.Jonathan Fray, RogerP Dickinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 165 KB

english, 2001

30

Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties

Andrea Scozzafava, Luca Menabuoni, Francesco Mincione, Giovanna Mincione, Claudiu T Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 258 KB

english, 2001

31

Development of novel telomerase inhibitors based on a Bisindole unit

Shigeki Sasaki, Takeru Ehara, Ikuhiro Sakata, Yasuhiro Fujino, Naozumi Harada, Junko Kimura, Hideo Nakamura, Minoru Maeda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 137 KB

english, 2001

32

Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative ‘Pyrrophenone’

Kaoru Seno, Takayuki Okuno, Koichi Nishi, Yasushi Murakami, Katsutoshi Yamada, Shozo Nakamoto, Takashi Ono

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

33

Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure–activity relationship

Young-Ger Suh, Young-Ho Kim, Mi-Hyoun Park, Young-Hoon Choi, Hye-Kyung Lee, Ju-Yeon Moon, Kyung-Hoon Min, Dong-Yun Shin, Jae-Kyung Jung, Ok-Hui Park, Ra-Ok Jeon, Hyung-Sup Park, Soon-Ah Kang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 504 KB

english, 2001

34

Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA–protein interactions derived from HIV-1 activators

Keita Hamasaki, Akihiko Ueno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 157 KB

english, 2001

35

Synthesis and antiviral activity of novel d- and l-2′-azido-2′,3′-dideoxyribofuranosyl-4′-thiopyrimidines and purines

Hea Ok Kim, Yun Ha Kim, Hwal Suh, Lak Shin Jeong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 223 KB

english, 2001

36

Controlled drug release: new water-soluble prodrugs of an HIV protease inhibitor

Hikaru Matsumoto, Youhei Sohma, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 190 KB

english, 2001

37

New 5-HT1A receptor agonists possessing 1,4-Benzoxazepine scaffold exhibit highly potent anti-ischemic effects

Katsuhide Kamei, Noriko Maeda, Ryoko Ogino, Makoto Koyama, Mika Nakajima, Toshio Tatsuoka, Tomochika Ohno, Teruyoshi Inoue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

38

Peptoids as endothelin receptor antagonists

Falguni Dasgupta, N. Gangadhar, M. Bruhaspathy, Ashwani K. Verma, Simi Sarin, Ashish K. Mukherjee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 158 KB

english, 2001

39

Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor

Richard B. Westkaemper, Scott P. Runyon, Jason E. Savage, Bryan L. Roth, Richard A. Glennon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 576 KB

english, 2001

40

Anti-HIV activity of aromatic and heterocyclic Thiazolyl Thiourea compounds

T.K. Venkatachalam, Elise A. Sudbeck, Chen Mao, Fatih M. Uckun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 192 KB

english, 2001

41

Contributors to the issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

File:

PDF, 54 KB

2001

42

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 94 KB

english, 2001

43

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 340 KB

english, 2001

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