Volume 11; Issue 8

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Bioorganic & Medicinal Chemistry Letters
Volume 11; Issue 8

Bioorganic & Medicinal Chemistry Letters

Volume 11; Issue 8

1

Novel inhibitors of leishmanial dihydrofolate reductase

Shafinaz F Chowdhury, Raffaella Di Lucrezia, Ramon Hurtado Guerrero, Reto Brun, Jonathan Goodman, Luis M Ruiz-Perez, Dolores Gonzalez Pacanowska, Ian H Gilbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 110 KB

english, 2001

2

Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Mee Kyoung Kang, Yeong Joon Jo, Sunghoon Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 282 KB

english, 2001

3

Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Yeong Joon Jo, Sunghoon Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 257 KB

english, 2001

4

Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth

Lixin Qiao, Lian-Yun Zhao, Suo-Bao Rong, Xiong-Wu Wu, Shaomeng Wang, Teruhiko Fujii, Marcelo G Kazanietz, Laura Rauser, Jason Savage, Bryan L Roth, Judith Flippen-Anderson, Alan P Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 537 KB

english, 2001

5

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors

Louise H Foley, Robert Palermo, Pete Dunten, Ping Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 510 KB

english, 2001

6

Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

James T. Link, Bryan Sorensen, Gang Liu, Zhonghua Pei, Edward B. Reilly, Sandra Leitza, Greg Okasinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 136 KB

english, 2001

7

Novel non-peptide ligands for the somatostatin sst3 receptor

Christophe Moinet, Marie-Odile Contour-Galcéra, Lydie Poitout, Barry Morgan, Tom Gordon, Pierre Roubert, Christophe Thurieau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

8

Stereocontrolled synthesis of LNA Dinucleoside phosphorothioate by the oxathiaphospholane approach

Bolesław Karwowski, Andrzej Okruszek, Jesper Wengel, Wojciech J Stec

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

9

New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice

Ikuko Kimura, Masayuki Yoshikawa, Shinjiro Kobayashi, Yoshitaka Sugihara, Miho Suzuki, Hideo Oominami, Toshiyuki Murakami, Hisashi Matsuda, Vijay V Doiphode

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 350 KB

english, 2001

10

Peptide synthesis in organic media with subtilisin 72 immobilized on poly(vinyl alcohol)-cryogel carrier

Anna V Bacheva, Fatima M Plieva, Elena N Lysogorskaya, Irina Yu Filippova, Vladimir I Lozinsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

11

Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux, Stéphanie Rolin, Jean-Michel Dogné, François Durant, Bernard Masereel, Jacques Delarge, Johan Wouters

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 260 KB

english, 2001

12

Study of aminoglycoside–nucleic acid interactions by an HPLC method

Violetta Constantinou-Kokotou, George Karikas, George Kokotos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 133 KB

english, 2001

13

3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

Haydn Beaton, Peter Hamley, David J Nicholls, Alan C Tinker, Alan V Wallace

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

14

Thienopyridines: nitric oxide synthase inhibitors with potent In vivo activity

Haydn Beaton, Nigel Boughton-Smith, Peter Hamley, Anant Ghelani, David J Nicholls, Alan C Tinker, Alan V Wallace

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 231 KB

english, 2001

15

Corrigendum to “Quantitative structure–Intestinal permeability relationship of benzamidine analogue thrombin inhibitor”: [Bioorg. Med. Chem. Lett. 10 (2000) 1939]

Kiyohiko Sugano, Shoshin Yoshida, Mikio Takaku, Masayuki Haramura, Ryoichi Saitoh, Yoshiaki Nabuchi, Hidetoshi Ushio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 63 KB

english, 2001

16

7,8-Dihydropterin-6-carboxylic acid as light emitter of luminous millipede, Luminodesmus sequoiae

Masaki Kuse, Akira Kanakubo, Sathorn Suwan, Kazushi Koga, Minoru Isobe, Osamu Shimomura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 613 KB

english, 2001

17

2-Acylimino-3H-thiazoline derivatives: A novel template for platelet GPIIb/IIIa receptor antagonists

Akira Manaka, Masakazu Sato, Mari Aoki, Makoto Tanaka, Tomotake Ikeda, Yoshihisa Toda, Yuuko Yamane, Shiro Nakaike

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 192 KB

english, 2001

18

Thiosugars. Part 9: Synthesis and Biological Evaluation of Some 4′-Thio-l-arabino Nucleoside Analogues

Jörn Wirsching, Jürgen Voss, Gunadi Adiwidjaja, Jan Balzarini, Erik De Clercq

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 143 KB

english, 2001

19

Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors

Matthew J Barnes, Nicola Cooper, Richard J Davenport, Hazel J Dyke, Fiona P Galleway, Frances C.A Galvin, Lewis Gowers, Alan F Haughan, Christopher Lowe, Johannes W.G Meissner, John G Montana, Trevor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 136 KB

english, 2001

20

Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) are powerful β-glucosidase inhibitors

Tanja M. Wrodnigg, Stephen G. Withers, Arnold E. Stütz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

21

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA

Carlo Ballatore, Christopher McGuigan, Erik De Clercq, Jan Balzarini

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

22

Design, Synthesis and Stability of N-Acyloxymethyl- and N-Aminocarbonyloxymethyl-2-azetidinones as Human Leukocyte Elastase Inhibitors

A Clemente, A Domingos, A.P Grancho, J Iley, R Moreira, J Neres, N Palma, A.B Santana, E Valente

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 293 KB

english, 2001

23

Heterocyclic Derivatives of 2-(3,5-Dimethylphenyl)tryptamine as GnRH Receptor Antagonists

Peter Lin, Mamta Parikh, Jane-Ling Lo, Yi Tien Yang, Kang Cheng, Roy G Smith, Michael H Fisher, Matthew J Wyvratt, Mark T Goulet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

24

2-(3,5-Dimethylphenyl)tryptamine Derivatives that Bind to the GnRH Receptor

Peter Lin, Dominick Marino, Jane-Ling Lo, Yi Tien Yang, Kang Cheng, Roy G Smith, Michael H Fisher, Matthew J Wyvratt, Mark T Goulet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 157 KB

english, 2001

25

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Nathalie Chauret, James A Yergey, Christine Brideau, Richard W Friesen, Joseph Mancini, Denis Riendeau, José Silva, Angela Styhler, Laird A Trimble, Deborah A Nicoll-Griffith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

26

Heterocycle-based MMP Inhibitors with P2′ Substituents

Stanislaw Pikul, Kelly McDow Dunham, Neil G Almstead, Biswanath De, Michael G Natchus, Yetunde O Taiwo, Lisa E Williams, Barbara A Hynd, Lily C Hsieh, Michael J Janusz, Fei Gu, Glen E Mieling

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 346 KB

english, 2001

27

Dimeric l-Dopa Derivatives as Potential Prodrugs

Antonio Di Stefano, Barbara Mosciatti, Gian Mario Cingolani, Gianfabio Giorgioni, Massimo Ricciutelli, Ivana Cacciatore, Piera Sozio, Francesco Claudi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

28

Solution-phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability

David L Selwood, David G Brummell, Robert C Glen, Maria C Goggin, Karen Reynolds, Mark A Tatlock, Grant Wishart

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

29

Antitumour Benzothiazoles. Part 15: The Synthesis and Physico-Chemical Properties of 2-(4-Aminophenyl)benzothiazole Sulfamate Salt Derivatives

Dong-Fang Shi, Tracey D Bradshaw, Mei-Sze Chua, Andrew D Westwell, Malcolm F.G Stevens

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 103 KB

english, 2001

30

Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands

Marcian E Van Dort, Yong-Woon Jung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 106 KB

english, 2001

31

New oxadiazolidinedione derivatives as potent and selective human β3 agonists

Baihua Hu, Michael Malamas, John Ellingboe, Elwood Largis, Stella Han, Ruth Mulvey, Jeff Tillett

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 163 KB

english, 2001

32

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new β-lactamase inhibitors

Vincent P. Sandanayaka, Gregg B. Feigelson, Amar S. Prashad, Youjun Yang, Peter J. Petersen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

33

The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus

Antonia A Nikitenko, Yuri E Raifeld, T.Z Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 165 KB

english, 2001

34

1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors

Annmarie L Sabb, Robert L Vogel, Michael G Kelly, Yvette Palmer, Deborah L Smith, Terrance H Andree, Lee E Schechter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

35

An improved method for the rapid preparation of 2-Amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one, a Novel Antitumor Agent

Akio Tomoda, Sadao Arai, Ryoji Ishida, Takashi Shimamoto, Kazuma Ohyashiki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 79 KB

english, 2001

36

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 40 KB

english, 2001

37

Instructions to Contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

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