Volume 12; Issue 1

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Bioorganic & Medicinal Chemistry Letters
Volume 12; Issue 1

Bioorganic & Medicinal Chemistry Letters

Volume 12; Issue 1

1

Minimal structural requirements for agonist activity of PAR-2 activating peptides

Vincenzo Santagada, Giuseppe Caliendo, Beatrice Severino, Elisa Perissutti, Ferdinando Fiorino, Carla Cicala, Vincenzo De Filippis, Giuseppe Cirino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 124 KB

english, 2002

2

Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents

Carla R Cardoso, Fernanda C.F de Brito, Kelli C.M da Silva, Ana L.P de Miranda, Carlos A.M Fraga, Eliezer J Barreiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 136 KB

english, 2002

3

Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors

Gerard F. Graminski, C.Lance Carlson, Josh R. Ziemer, Feng Cai, Nicolaas M.J. Vermeulen, Scott M. Vanderwerf, Mark R. Burns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

4

Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues

Jagabandhu Das, S.David Kimball, Joyce A. Reid, Tammy C. Wang, Wan F. Lau, Daniel G.M. Roberts, Steven M. Seiler, William A. Schumacher, Martin L. Ogletree

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

5

Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

Christopher A Willoughby, Steven M Hutchins, Keith G Rosauer, Madhumeeta J Dhar, Kevin T Chapman, Gary G Chicchi, Sharon Sadowski, David H Weinberg, Smita Patel, Lorraine Malkowitz, Jerry Di Salvo, St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

6

Non-Peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-Amino acids as aspartic acid replacements

Paul J Coleman, Karen M Brashear, Cecilia A Hunt, William F Hoffman, John H Hutchinson, Michael J Breslin, Carol A McVean, Ben C Askew, George D Hartman, Sevgi B Rodan, Gideon A Rodan, Chih-Tai Leu, T

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

7

Molecular design and structure–Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664

Jagabandhu Das, S.David Kimball, Steven E. Hall, Wen-Ching Han, Edwin Iwanowicz, James Lin, Robert V. Moquin, Joyce A. Reid, John S. Sack, Mary F. Malley, Chiehying Y. Chang, Saeho Chong, David B. Wan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 251 KB

english, 2002

8

Phthalazine PDE4 inhibitors. Part 3: The synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor

Mauro Napoletano, Gabriele Norcini, Franco Pellacini, Francesco Marchini, Gabriele Morazzoni, Raimondo Fattori, Pierpaolo Ferlenga, Lorenzo Pradella

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

9

Versatile synthesis of phenoxydiazirine-based fatty acid analogues and photoreactive galactosylceramide

Makoto Hashimoto, Yasumaru Hatanaka, Kensuke Nabeta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

10

4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors

Hiromasa Hashimoto, Kimiya Maeda, Koichi Ozawa, Jun-ichi Haruta, Korekiyo Wakitani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

11

Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds

Kiyoshi Tsuji, Glen W. Spears, Katsuya Nakamura, Takashi Tojo, Nobuo Seki, Aiko Sugiyama, Masaaki Matsuo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

12

Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARα-selective activators

Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Yukie Takahashi, Tomohiro Ide, Masaki Tsunoda, Koji Murakami, Katsuya Awano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 125 KB

english, 2002

13

New readily accessible peroxides with High Anti-malarial Potency

Nobutoshi Murakami, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

14

Copper(II)/H2O2-mediated DNA cleavage: involvement of a copper(III) species in H-atom abstraction of deoxyribose units

Amina Amine, Zidane Atmani, Abdelila El Hallaoui, Michel Giorgi, Marcel Pierrot, Marius Réglier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 174 KB

english, 2002

15

Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones

Helen F. Boyd, Stephen C.M. Fell, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, Colin H. Macphee, Kevin J. Milliner, Ivan L. Pinto, D.Anthony Rawlings, Stephen A. Smith, Ian G. Stansfield, Steve

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 127 KB

english, 2002

16

Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor

Lise B Christiansen, Martin Wenckens, Paul S Bury, Birgitte Gissel, Birgit S Hansen, Susan M Thorpe, Poul Jacobsen, Anders Kanstrup, Anker S Jørgensen, Lars Nærum, Karsten Wassermann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

17

Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties

Anna Palumbo, Alessandra Napolitano, Marco d'Ischia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 142 KB

english, 2002

18

Modifications and structure–activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists

Hiroshi Morimoto, Hideshi Shimadzu, Toshihiro Hosaka, Yasushi Kawase, Kosuke Yasuda, Kohei Kikkawa, Rikako Yamauchi-Kohno, Koichiro Yamada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 132 KB

english, 2002

19

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko, Shinya Tsutsumi, Junko Sone, Tomio Ishikawa, Takeshi Imanishi, Makoto Koizumi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 131 KB

english, 2002

20

3-D QSAR studies on new dibenzyltin(IV) anticancer agents by comparative molecular field analysis (CoMFA)

Purnima M Samuel, Dick de Vos, D Raveendra, J.A.R.P Sarma, Sujit Roy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 205 KB

english, 2002

21

2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine

Akimitsu Okamoto, Kazuo Tanaka, Isao Saito

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 106 KB

english, 2002

22

Synthesis of highly functionalised dibenzylglycine derivatives via the Suzuki–Miyaura coupling reaction

Sambasivarao Kotha, Manoranjan Behera, Ramanatham Vinod Kumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 132 KB

english, 2002

23

Nonpeptide αvβ3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

Robert S. Meissner, James J. Perkins, Le T. Duong, George D. Hartman, William F. Hoffman, Joel R. Huff, Nathan C. Ihle, Chih-Tai Leu, Rose M. Nagy, Adel Naylor-Olsen, Gideon A. Rodan, Sevgi B. Rodan,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

24

DNA cleavage by aromatic amines

Philip M. Warner, Jiwei Qi, Bin Meng, Gang Li, Longfei Xie, Ahmed El-Shafey, Graham B. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

25

Potent P1′ biphenylmethyl substituted aggrecanase inhibitors

Wenqing Yao, Michael Chao, Zelda R. Wasserman, Rui-Qin Liu, Maryanne B. Covington, Robert Newton, David Christ, Ruth R. Wexler, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

26

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 171 KB

english, 2002

27

Instructions to Contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 96 KB

english, 2002

28

Contributors to Issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 40 KB

english, 2002

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