Volume 12; Issue 10

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Bioorganic & Medicinal Chemistry Letters
Volume 12; Issue 10

Bioorganic & Medicinal Chemistry Letters

Volume 12; Issue 10

1

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Chi Choi, Jia-He Li, Mark Vaal, Christine Thomas, David Limburg, Yong-Qian Wu, Yi Chen, Raj Soni, Chad Scott, Douglas T Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 351 KB

english, 2002

2

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug

Jane M Berry, Philip W Howard, Lloyd R Kelland, David E Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

3

Shikonin derivatives: synthesis and inhibition of human telomerase

Qun Lu, Weijun Liu, Jian Ding, Junchao Cai, Wenhu Duan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 113 KB

english, 2002

4

Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives

Paul G Wyatt, Michael J Allen, Josie Chilcott, Alison Foster, David G Livermore, Jackie E Mordaunt, Jan Scicinski, Patrick M Woollard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 171 KB

english, 2002

5

Synthesis of highly potent and selective hetaryl ureas as integrin αVβ3-Receptor antagonists

Udo E.W. Lange, Gisela Backfisch, Jürgen Delzer, Hervé Geneste, Claudia Graef, Wilfried Hornberger, Andreas Kling, Arnulf Lauterbach, Thomas Subkowski, Christian Zechel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

6

Structure-based design of peptidomimetic antagonists of p56lck SH2 Domain

Christopher J. Hobbs, Rino A. Bit, Andrew D. Cansfield, Bill Harris, Christopher H. Hill, Katherine L. Hilyard, Ian R. Kilford, Eric Kitas, Antonin Kroehn, Peter Lovell, David Pole, Paul Rugman, Brad

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

7

Antifungal Sordarins. part 3: synthesis and structure–Activity relationships of 2′,3′-Fused oxirane derivatives

Julia Castro, Juan C Cuevas, José M Fiandor, Ma Teresa Fraile, Federico Gómez de las Heras, José R Ruiz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

8

A novel type of nonsteroidal estrone sulfatase inhibitors

Peter Jütten, Winfried Schumann, Albert Härtl, Lothar Heinisch, Udo Gräfe, Walter Werner, Hermann Ulbricht

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 111 KB

english, 2002

9

Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists

Steven M Bromidge, Stephen E Clarke, Frank D King, Peter J Lovell, Helen Newman, Graham Riley, Carol Routledge, Halina T Serafinowska, Douglas R Smith, David R Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

10

Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

Shinichi Uesato, Manabu Kitagawa, Yasuo Nagaoka, Taishi Maeda, Hiroshi Kuwajima, Takao Yamori

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

11

Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors

W. Lubisch, A. Möller

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

12

Structure-Based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-Like activity of the human 20S proteasome

Pascal Furet, Patricia Imbach, Peter Fuerst, Marc Lang, Maria Noorani, Johann Zimmermann, Carlos Garcı́a-Echeverrı́a

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 175 KB

english, 2002

13

Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands

Mi Young Cha, Byung Chul Choi, Kyung Ho Kang, Ae Nim Pae, Kung Il Choi, Yong Seo Cho, Hun Yeong Koh, Hee-Yoon Lee, Daeyoung Jung, Jae Yang Kong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

14

Heterocyclic nucleoside analogues: design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles

Yoon-Suk Lee, Byeang Hyean Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 119 KB

english, 2002

15

Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors

Michael A. Letavic, Matt Z. Axt, John T. Barberia, Thomas J. Carty, Dennis E. Danley, Kieran F. Geoghegan, Nadia S. Halim, Lise R. Hoth, Ajith V. Kamath, Ellen R. Laird, Lori L. Lopresti-Morrow, Kim F

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

16

A unique unnatural base pair between a C analogue, pseudoisocytosine, and an A analogue, 6-methoxypurine, in replication

Ichiro Hirao, Michiko Kimoto, Shun-ichi Yamakage, Masahide Ishikawa, Jun Kikuchi, Shigeyuki Yokoyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 132 KB

english, 2002

17

Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI)

Masakazu Fujita, Taketsugu Seki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 103 KB

english, 2002

18

Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation

Chunmei Zhou, Ying Shao, Richard A. Gibbs

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 125 KB

english, 2002

19

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 193 KB

english, 2002

20

Contributors to this Issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 41 KB

english, 2002

21

Solid-Phase synthesis of FKBP12 inhibitors: N-Sulfonyl and N-Carbamoylprolyl/pipecolyl amides

Ling Wei, Yong-Qian Wu, Douglas E Wilkinson, Yi Chen, Raj Soni, Chad Scott, Douglas T Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

22

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives

Paul G. Wyatt, Michael J. Allen, Josie Chilcott, Christopher J. Gardner, David G. Livermore, Jackie E. Mordaunt, Fabrizio Nerozzi, Mamta Patel, Marion J. Perren, Gordon G. Weingarten, Shalia Shabbir,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 166 KB

english, 2002

23

Design, synthesis and biochemical evaluation of aC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES)

Sabbir Ahmed, Karen James, Caroline P. Owen, Chirag K. Patel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

24

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Byeoung-Soo Park, Dae-Young Kim, Philip J Rosenthal, Sun-Chul Huh, Belinda J Lee, Eun-Ju Park, Sung-Min Kim, Jang-Eok Kim, Mi-Hee Kim, Tae-Lin Huh, Young-Jae Choi, Ki-Hyung Suh, Won-Sik Choi, Sung-Eun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

25

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck

Ping Chen, Derek Norris, Edwin J. Iwanowicz, Steven H. Spergel, James Lin, Henry H. Gu, Zhongqi Shen, John Wityak, Tai-An Lin, Suhong Pang, Henry F. De Fex, Sidney Pitt, Ding Ren Shen, Arthur M. Dowey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002