Volume 12; Issue 16

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Bioorganic & Medicinal Chemistry Letters
Volume 12; Issue 16

Bioorganic & Medicinal Chemistry Letters

Volume 12; Issue 16

1

Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5

W Lubisch, B Behl, C Henn, H.P Hofmann, J Reeb, F Regner, M Vierling

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

2

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38 MAP kinase inhibitors

Laszlo Revesz, Franco E. Di Padova, Thomas Buhl, Roland Feifel, Hermann Gram, Peter Hiestand, Ute Manning, Romain Wolf, Alfred G. Zimmerlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 128 KB

english, 2002

3

Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells

Asko Uri, Gerda Raidaru, Juhan Subbi, Kärt Padari, Margus Pooga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 186 KB

english, 2002

4

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase

Francesca Clerici, Maria Luisa Gelmi, Kohei Yokoyama, Donato Pocar, Wesley C. Van Voorhis, Frederick S. Buckner, Michael H. Gelb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

5

Identification of a novel 1′-[5-((3,5-Dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4′-bipiperidine) as a Dual NK1/NK2 antagonist

Pauline C Ting, Joe F Lee, Neng-Yang Shih, John J Piwinski, John C Anthes, Richard W Chapman, Charles A Rizzo, John A Hey, Kwokei Ng, Amin A Nomeir

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

6

Convenient synthesis of human calcitonin and its methionine sulfoxide derivative

Tiesheng Shi, Dallas L Rabenstein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

7

Synthesis and antiparasitic activity of 1H-benzimidazole derivatives

Juan Valdez, Roberto Cedillo, Alicia Hernández-Campos, Lilián Yépez, Francisco Hernández-Luis, Gabriel Navarrete-Vázquez, Amparo Tapia, Rafael Cortés, Manuel Hernández, Rafael Castillo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

8

Novel thiophene derivatives for the treatment of benign prostatic hyperplasia

Haripada Khatuya, Virginia L. Pulito, Linda K. Jolliffe, Xiaobing Li, William V. Murray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

9

Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines

Subramaniam Ananthan, Surendra K Saini, Rashmi Khare, Sarah D Clayton, Christina M Dersch, Richard B Rothman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 161 KB

english, 2002

10

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

William J. Pitts, Junqing Guo, T.G.Murali Dhar, Zhongqi Shen, Henry H. Gu, Scott H. Watterson, Mark S. Bednarz, Bang-Chi Chen, Joel C. Barrish, Donna Bassolino, Daniel Cheney, Catherine A. Fleener, Ka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

11

Synthesis and biological evaluation of 3′-Carboranyl thymidine analogues

Junhua Yan, Charlotta Naeslund, Ashraf S. Al-Madhoun, Jianghai Wang, Weihua Ji, Guirec Y. Cosquer, Jayaseharan Johnsamuel, Stefan Sjöberg, Staffan Eriksson, Werner Tjarks

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

12

Phosphonate and phosphinate analogues of N-Acylated γ-glutamylglutamate: potent inhibitors of glutamate carboxypeptidase II

Takashi Tsukamoto, Juliet M. Flanary, Camilo Rojas, Barbara S. Slusher, Nadya Valiaeva, James K. Coward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 119 KB

english, 2002

13

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

Christopher A. Willoughby, Herbert G. Bull, Margarita Garcia-Calvo, Joanne Jiang, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

14

Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases

Li Sun, Jean Cui, Congxin Liang, Yong Zhou, Asaad Nematalla, Xueyan Wang, Hui Chen, Cho Tang, James Wei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

15

Design and synthesis of novel inhibitors of gelatinase B

Xueqing Wang, Youngchool Choe, Charles S. Craik, Jonathan A. Ellman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

16

N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists

Bing Li, Stephen E de Laszlo, Theodore M Kamenecka, Ihor E Kopka, Philippe L Durette, Thomas Lanza, Jr, Malcolm MacCoss, Sharon Tong, Richard A Mumford, Ermengilda D McCauley, Gail Van Riper, John A S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 162 KB

english, 2002

17

Design, synthesis, and biological evaluation of novel, centrally-Acting thyrotropin-Releasing hormone analogues

Katalin Prokai-Tatrai, Pál Perjési, Alevtina D Zharikova, Xiaoxu Li, Laszlo Prokai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 109 KB

english, 2002

18

Synthesis and biological evaluation of 9-substituted tetracycline derivatives

Darrell J Koza, Yaw A Nsiah

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

19

Design, synthesis and structure–Activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Timothy D. Gross, Yun-Fei Zhu, John Saunders, Keith M. Wilcoxen, Yinghong Gao, Patrick J. Connors Jr., Zhiqiang Guo, R.Scott Struthers, Greg J. Reinhart, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 105 KB

english, 2002

20

A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones

Satoshi Sasaki, Toshihiro Imaeda, Yoji Hayase, Yoshiaki Shimizu, Shizuo Kasai, Nobuo Cho, Masataka Harada, Nobuhiro Suzuki, Shuichi Furuya, Masahiko Fujino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

21

Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Midori Itoh, Jun Kuwahara, Kohji Itoh, Yu-ichi Fukuda, Mikiko Kohya, Mitsuru Shindo, Kozo Shishido

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 608 KB

english, 2002

22

Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I

Tomoko Motoyama, Hiromi Yabunaka, Hideto Miyoshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

23

Efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha

Masahiro Nomura, Takahiro Tanase, Hiroyuki Miyachi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

24

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents

Takashi Owa, Hiroshi Yoshino, Tatsuo Okauchi, Tadashi Okabe, Yoichi Ozawa, Naoko Hata Sugi, Kentaro Yoshimatsu, Takeshi Nagasu, Nozomu Koyanagi, Kyosuke Kitoh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

25

Antibody-Based fluorescence detection of kinase activity on a peptide array

Marie-Laure Lesaicherre, Mahesh Uttamchandani, Grace Y.J Chen, Shao Q Yao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 139 KB

english, 2002

26

Developing site-Specific immobilization strategies of peptides in a microarray

Marie-Laure Lesaicherre, Mahesh Uttamchandani, Grace Y.J Chen, Shao Q Yao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 161 KB

english, 2002

27

4,4′-Benzophenone-O,O′-disulfamate: a potent inhibitor of steroid sulfatase

Peter Nussbaumer, Melitta Bilban, Andreas Billich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 92 KB

english, 2002

28

Biphenyl derivatives as novel dual NK1/NK2-receptor antagonists

Robert Mah, Marc Gerspacher, Andreas von Sprecher, Stefan Stutz, Vincenzo Tschinke, Gary P. Anderson, Claude Bertrand, Natarajan Subramanian, Howard A. Ball

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 142 KB

english, 2002

29

Contributors to this Issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

File:

PDF, 43 KB

2002

30

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 279 KB

english, 2002

31

Advert: International Symposium

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

File:

PDF, 215 KB

2002

32

Advert: BMC

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

File:

PDF, 289 KB

2002

33

Diboronic acids as fluorescent probes for cells expressing sialyl lewis X

Wenqian Yang, Shouhai Gao, Xingming Gao, Vishnu Vardhan Reddy Karnati, Weijuan Ni, Binghe Wang, W.Borden Hooks, John Carson, Brent Weston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 180 KB

english, 2002

34

Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides

James L Toth, Carly A Price, Erik C Madsen, Heather L Handl, Stephen J Hudson, Richard B Hubbard, III, J.Phillip Bowen, Konstantinos Kiakos, John A Hartley, Moses Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

35

Decoding region bubble size and aminoglycoside antibiotic binding

Do Hyun Ryu, Robert R Rando

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 109 KB

english, 2002

36

N-Thiolated β-Lactams: novel antibacterial agents for methicillin-Resistant Staphylococcus aureus

Edward Turos, Timothy E. Long, Monika I. Konaklieva, Cristina Coates, Jeung-Yeop Shim, Sonja Dickey, Daniel V. Lim, Andrew Cannons

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

37

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

Nathalie Chauret, Daniel Guay, Chun Li, Stephen Day, José Silva, Marc Blouin, Yves Ducharme, James A. Yergey, Deborah A. Nicoll-Griffith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

38

Antimalarial compounds from Parinari capensis

Arina C.U. Uys, Sarel F. Malan, Sandra van Dyk, Robyn L. van Zyl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 94 KB

english, 2002

39

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

Richard J. Sciotti, Marina Pliushchev, Paul E. Wiedeman, Darlene Balli, Robert Flamm, Angela M. Nilius, Kennan Marsh, DeAnne Stolarik, Robert Jolly, Roger Ulrich, Stevan W. Djuric∗

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 96 KB

english, 2002

40

Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase

Sven Guenther, Vasu Nair

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 295 KB

english, 2002

41

N-Aryl-prolyl-dipeptides as potent antagonists of VLA-4

Theodore M. Kamenecka, Thomas Lanza, Jr., Stephen E. de Laszlo, Bing Li, Ermengilda D. McCauley, Gail Van Riper, Linda A. Egger, Usha Kidambi, Richard A. Mumford, Sharon Tong, Malcolm MacCoss, John A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

42

3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: nonpeptide CRF-1 antagonists

Jun Yuan, Michael Gulianello, Stéphane De Lombaert, Robbin Brodbeck, Andrzej Kieltyka, Kevin J. Hodgetts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 108 KB

english, 2002

43

Rapid solid-Phase synthesis of DNA-Binding pyrrole-Imidazole polyamides

Peter O. Krutzik, A.Richard Chamberlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

44

Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody–multidrug immunoconjugates

Chengzao Sun, Peter Wirsching, Kim D. Janda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

45

Lipid A structures containing novel lipid moieties: synthesis and adjuvant properties

Zi-Hua Jiang, Mimi V Bach, Wladyslaw A Budzynski, Mark J Krantz, R.Rao Koganty, B.Michael Longenecker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

46

Antifungal activity of bifunctional sphingolipids. intramolecular synergism within long-chain α,ω-bis-aminoalcohols

Gillian M. Nicholas, Ronghua Li, John B. MacMillan, Tadeusz F. Molinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

47

Synthesis and initial structure–Activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Keith M. Wilcoxen, Yun-Fei Zhu, Patrick J. Connors Jr., John Saunders, Timothy D. Gross, Yinghong Gao, Greg J. Reinhart, R.Scott Struthers, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

48

Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids

Bertrand Cottineau, Patrick Toto, Christophe Marot, Aline Pipaud, Jacques Chenault

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

49

Tetrahedron Prize for Creativity in Organic Chemistry 2002

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 46 KB

english, 2002

50

Contents List

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

File:

PDF, 91 KB

2002

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