Volume 13; Issue 2

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Bioorganic & Medicinal Chemistry Letters
Volume 13; Issue 2

Bioorganic & Medicinal Chemistry Letters

Volume 13; Issue 2

1

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

John E. Stelmach, Luping Liu, Sangita B. Patel, James V. Pivnichny, Giovanna Scapin, Suresh Singh, Cornelis E.C.A. Hop, Zhen Wang, John R. Strauss, Patricia M. Cameron, Elizabeth A. Nichols, Stephen J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 172 KB

english, 2003

2

CRF Ligands via suzuki and negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine

Argyrios G. Arvanitis, Charles R. Arnold, Lawrence W. Fitzgerald, William E. Frietze, Richard E. Olson, Paul J. Gilligan, David W. Robertson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 130 KB

english, 2003

3

Identification of TNF-α inhibitors from a split-Pool library based on a tyrosine-Proline peptidomimetic scaffold

Randy W. Jackson, John C. Tabone, J.Jeffry Howbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

4

Affinity labeling of the nuclear vitamin D receptor with nonsteroidal alkylating agents

Ana Fernández-Gacio, Carlos Fernández-Marcos, Narasimha Swamy, Rahul Ray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

5

Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage

Anne Lauritsen, Britta M. Dahl, Otto Dahl, Birte Vester, Jesper Wengel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 143 KB

english, 2003

6

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2

Veronique Mesguiche, Rachel J Parsons, Christine E Arris, Johanne Bentley, F.Thomas Boyle, Nicola J Curtin, Thomas G Davies, Jane A Endicott, Ashleigh E Gibson, Bernard T Golding, Roger J Griffin, Phi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

7

[18F]FMDAA1106 and [18F]FEDAA1106: two positron-Emitter labeled ligands for peripheral benzodiazepine receptor (PBR)

Ming-Rong Zhang, Jun Maeda, Kenji Furutsuka, Yuichiro Yoshida, Masanao Ogawa, Tetsuya Suhara, Kazutoshi Suzuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

8

Anti-Hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action

Hiroshi Shimoda, Kiyofumi Ninomiya, Norihisa Nishida, Tomoe Yoshino, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 283 KB

english, 2003

9

Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole

Jun Ohwada, Masao Tsukazaki, Tadakatsu Hayase, Nobuhiro Oikawa, Yoshiaki Isshiki, Hiroshi Fukuda, Eisaku Mizuguchi, Masahiro Sakaitani, Yasuhiko Shiratori, Toshikazu Yamazaki, Shigeyasu Ichihara, Isao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 287 KB

english, 2003

10

A new series of potent benzodiazepine γ-secretase inhibitors

Ian Churcher, Kate Ashton, John W. Butcher, Earl E. Clarke, Timothy Harrison, Huw D. Lewis, Andrew P. Owens, Martin R. Teall, Susie Williams, Jonathan D.J. Wrigley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

11

The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K+ channels of the alga Nitella hookeri

Kristian R Giles, Mark Humphries, Andrew Abell, Ashley Garrill

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003

12

Design and synthesis of factor Xa inhibitors and their prodrugs

Yonghong Song, Lane Clizbe, Chhaya Bhakta, Willy Teng, Paul Wong, Brian Huang, Katherine Tran, Uma Sinha, Gary Park, Andrea Reed, Robert M Scarborough, Bing-Yan Zhu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

13

A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

Zacharia S Cheruvallath, Douglas L Cole, Vasulinga T Ravikumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 120 KB

english, 2003

14

The preparation of (S)-Aspartate semi-aldehyde appropriate for use in biochemical studies

Sarah J Roberts, Jonathan C Morris, Renwick C.J Dobson, Juliet A Gerrard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 103 KB

english, 2003

15

Discovery of a series of (4,5-Dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists

Vinod Parikh, Willard M Welch, Anne W Schmidt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 105 KB

english, 2003

16

Highly potent and selective αVβ3-receptor antagonists: solid-phase synthesis and SAR of 1-substituted 4-amino-1H-pyrimidin-2-ones

Christian Zechel, Gisela Backfisch, Jürgen Delzer, Hervé Geneste, Claudia Graef, Wilfried Hornberger, Andreas Kling, Udo E.W Lange, Arnulf Lauterbach, Werner Seitz, Thomas Subkowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 194 KB

english, 2003

17

Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the ‘Distal binding pocket’

Philip E.J. Sanderson, Kellie J. Cutrona, Dona L. Dyer, Julie A. Krueger, Lawrence C. Kuo, S.Dale Lewis, Bobby J. Lucas, Youwei Yan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 216 KB

english, 2003

18

Editorial Board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 54 KB

english, 2003

19

Contributors to this issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

File:

PDF, 42 KB

2003

20

Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases

Lisa J. Whalen, Kerry A. McEvoy, Randall L. Halcomb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

21

p38 MAP kinase inhibitors. part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold

Swaminathan R. Natarajan, David D. Wisnoski, Suresh B. Singh, John E. Stelmach, Edward A. O'Neill, Cheryl D. Schwartz, Chris M. Thompson, Catherine E. Fitzgerald, Stephen J. O'Keefe, Sanjeev Kumar, Co

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

22

Development of a presynaptic 5-HT1A antagonist

Ronald J Mattson, John D Catt, Charles P Sloan, Qi Gao, Richard B Carter, Anthony Gentile, Cathy D Mahle, F.Fatima Matos, Rachel McGovern, Cam P VanderMaelen, Frank D Yocca

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 136 KB

english, 2003

23

Dihydropyrimidinones—a new class of anti-Staphylococcal antibiotics

Michael Brands, Rainer Endermann, Reinhold Gahlmann, Jochen Krüger, Siegfried Raddatz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

24

Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties

Serge Auvin, Michel Auguet, Edith Navet, Jeremiah J Harnett, Isabelle Viossat, Jocelyne Schulz, Dennis Bigg, Pierre-E Chabrier

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 126 KB

english, 2003

25

β-Homolysine Oligomers: A New Class of Trojan Carriers

C Garcı́a-Echeverrı́a, Stephan Ruetz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 243 KB

english, 2003

26

Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor

Hyeung-geun Park, Mi-kyung Park, Ji-yeon Choi, Sea-hoon Choi, Jihye Lee, Young-ger Suh, Uhtaek Oh, Jeewoo Lee, Hee-Doo Kim, Young-Ho Park, Yeon Su Jeong, Jin Kyu Choi, Sang-sup Jew

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

27

Synthesis of non-competitive inhibitors of Sphingomyelinases with significant activity

Tsutomu Yokomatsu, Tetsuo Murano, Takeshi Akiyama, Junichi Koizumi, Shiroshi Shibuya, Yoshiaki Tsuji, Shinji Soeda, Hiroshi Shimeno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

28

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 3

Yasuyuki Takeda, Toshiharu Yoshino, Kouichi Uoto, Jun Chiba, Takashi Ishiyama, Michio Iwahana, Takeshi Jimbo, Noriko Tanaka, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 318 KB

english, 2003

29

Syntheses of sphingosine-1-phosphate stereoisomers and analogues and Their interaction with EDG receptors

Hyun-Suk Lim, Yong-Seok Oh, Pann-Ghill Suh, Sung-Kee Chung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 198 KB

english, 2003

30

Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid

Luc J. Farmer, Lin Zhi, Susan Jeong, William W. Lamph, Deborah L. Osburn, Glenn Croston, Karen S. Flatten, Rich A. Heyman, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

31

α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus

Laura Betti, Monia Floridi, Gino Giannaccini, Fabrizio Manetti, Giovannella Strappaghetti, Andrea Tafi, Maurizio Botta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

32

New arylpiperazine derivatives with high affinity for α1A, D2 and 5-HT2A receptors

J.C González-Gómez, L Santana, E Uriarte, J Brea, M Villazón, M.I Loza, M De Luca, M.E Rivas, G.Y Montenegro, J.A Fontenla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003

33

Contents List

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 229 KB

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34

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 243 KB

english, 2003

35

Instructions to Contributors

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 103 KB

english, 2003

36

Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template

John P Mogensen, Lone Jeppesen, Paul S Bury, Ingrid Pettersson, Jan Fleckner, Jan Nehlin, Klaus S Frederiksen, Tatjana Albrektsen, Nanni Din, Steen B Mortensen, L.Anders Svensson, Karsten Wassermann,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 180 KB

english, 2003