Volume 13; Issue 20

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Bioorganic & Medicinal Chemistry Letters
Volume 13; Issue 20

Bioorganic & Medicinal Chemistry Letters

Volume 13; Issue 20

1

1,2,5,6-Tetra-O-benzyl-d-mannitol derivatives as novel HIV protease inhibitors

Abderrahim Bouzide, Gilles Sauvé, Guy Sévigny, Jocelyn Yelle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 188 KB

english, 2003

2

Erratum to “Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1”: [Bioorg. Med. Chem. Lett. 13 (2003) 913]

Toshiki Murata, Mitsuyuki Shimada, Sachiko Sakakibara, Takashi Yoshino, Kiroshi Kadono, Tsutomu Masuda, Makoto Shimazaki, Takuya Shintani, Kinji Fuchikami, Katsuya Sakai, Hisayo Inbe, Keisuke Takeshit

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 68 KB

english, 2003

3

Lupane triterpenes and derivatives with antiviral activity

L.A. Baltina, O.B. Flekhter, L.R. Nigmatullina, E.I. Boreko, N.I. Pavlova, S.N. Nikolaeva, O.V. Savinova, G.A. Tolstikov

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

4

Synthesis of novel C2 and C2–C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

Ahmed Kamal, O. Srinivas, P. Ramulu, G. Ramesh, P.Praveen Kumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

5

Modified 3-Alkyl-1,8-dibenzylxanthines as GTP-Competitive inhibitors of phosphoenolpyruvate carboxykinase

Louise H. Foley, Ping Wang, Pete Dunten, Gwendolyn Ramsey, Mary-Lou Gubler, Stanley J. Wertheimer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 171 KB

english, 2003

6

A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors

Scott D Larsen, Carl F Stachew, Paula M Clare, Jerry W Cubbage, Karen L Leach

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 198 KB

english, 2003

7

Synthesis and testing of novel phenyl substituted side-Chain analogues of classical cannabinoids

Mathangi Krishnamurthy, Antonio M. Ferreira, Bob M. Moore II

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

8

Synthesis and biological evaluation of thymine nucleosides fused with 3′,4′-tetrahydrofuran ring

Myong Jung Kim, Hea Ok Kim, Hee-Doo Kim, Joong Hyup Kim, Lak Shin Jeong, Moon Woo Chun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

9

Complexation of cyclic dodecadepsipeptide, Cereulide with ammonium salts

Suthasinee Pitchayawasin, Masaki Kuse, Kazushi Koga, Minoru Isobe, Norio Agata, Michio Ohta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 494 KB

english, 2003

10

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

Kenneth E. Rittle, James C. Barrow, Kellie J. Cutrona, Kristen L. Glass, Julie A. Krueger, Lawrence C. Kuo, S.Dale Lewis, Bobby J. Lucas, Daniel R. McMasters, Matthew M. Morrissette, Philippe G. Nante

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 230 KB

english, 2003

11

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

Anastasia V. Velentza, Mark S. Wainwright, Magdalena Zasadzki, Salida Mirzoeva, Andrew M. Schumacher, Jacques Haiech, Pamela J. Focia, Martin Egli, D.Martin Watterson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 258 KB

english, 2003

12

Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative

Lei Tang, Juanhong Yu, Ying Leng, Ying Feng, Yushe Yang, Ruyun Ji

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

13

Design and synthesis of small chemical inhibitors containing different scaffolds for lck SH2 domain

See-Hyoung Park, Sun-Hee Kang, Sang-Hyeong Lim, Hyun-Sik Oh, Keun-Hyeung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

14

The packing of lipid chains changes the character of bacteriorhodopsin reconstituted in a model membrane

Hirotaka Sasaki, Mayumi Araki, Seketsu Fukuzawa, Kazuo Tachibana

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 131 KB

english, 2003

15

Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

Yonggang Li, Yufang Xu, Xuhong Qian, Baoyuan Qu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

16

Synthesis of C-8 methanesulphonate substituted pyrrolobenzodiazepines as potential antitumour agents

Ahmed Kamal, P Ramulu, O Srinivas, G Ramesh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

17

Concise synthesis and biological activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3

Shinobu Honzawa, Yoshitomo Suhara, Ken-ichi Nihei, Nozomi Saito, Seishi Kishimoto, Toshie Fujishima, Masaaki Kurihara, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 216 KB

english, 2003

18

Synthesis and AMPA receptor antagonistic activity of a novel class of quinoxalinecarboxylic acid with a substituted phenyl group at the C-7 position

Yasuo Takano, Futoshi Shiga, Jun Asano, Naoki Ando, Hideharu Uchiki, Tsuyosi Anraku

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

19

Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38

Miki Hara-Yokoyama, Hiromi Ito, Kaori Ueno-Noto, Keiko Takano, Hideharu Ishida, Makoto Kiso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 289 KB

english, 2003

20

Synthesis and glycosidase inhibitory activity of some N-Substituted 6-Deoxy-5a-carba-β-dl- and l-galactopyranosylamines

Seiichiro Ogawa, Shigeo Fujieda, Yuko Sakata, Masahiro Ishizaki, Seiichi Hisamatsu, Kensuke Okazaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

21

Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents

Ahmed Kamal, G. Ramesh, P. Ramulu, O. Srinivas, Tasneem Rehana, G. Sheelu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

22

Discovery of a novel potent Na+/Ca2+ exchanger inhibitor: design, synthesis and structure–activity relationships of 3,4-dihydro-2(1H)-quinazolinone derivatives

Hirohiko Hasegawa, Masami Muraoka, Kazuki Matsui, Atsuyuki Kojima

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 211 KB

english, 2003

23

Fungicide chinomethionate as a new family of photoinducible DNA-cleaving agents

Jianying Qi, Tianhu Li, Albert S.C Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 136 KB

english, 2003

24

Synthesis and structure–Activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists

Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Yun-Fei Zhu, R.Scott Struthers, John Saunders, Qiu Xie, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 221 KB

english, 2003

25

Structure–activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists

Richard L. Elliott, Robert M. Oliver, Janet A. LaFlamme, Melissa L. Gillaspy, Marlys Hammond, Richard F. Hank, Tristan S. Maurer, Demetria L. Baker, Paul A. DaSilva-Jardine, Ralph W. Stevenson, Christ

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

26

Design and synthesis of novel CCR3 antagonists

Leyi Gong, J.Heather Hogg, James Collier, Robert S. Wilhelm, Carol Soderberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 175 KB

english, 2003

27

Efficient oxidative decarboxylation of carboxylic acids with sodium periodate catalyzed by supported manganese (III) porphyrin

Valiollah Mirkhani, Shahram Tangestaninejad, Majid Moghadam, Zohreh Karimian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 134 KB

english, 2003

28

Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists

Dean G. Brown, Rebecca A. Urbanek, Thomas M. Bare, Frances M. McLaren, Carey L. Horchler, Megan Murphy, Gary B. Steelman, James R. Empfield, Janet M. Forst, Keith J. Herzog, Wenhua Xiao, Martin C. Dyr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

29

Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase

Kamil Kuča, Jiřı́ Bielavský, Jiřı́ Cabal, Jiřı́ Kassa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

30

Synthesis and evaluation of tripeptidyl α-Ketoamides as human rhinovirus 3C protease inhibitors

Shu-Hui Chen, Jason Lamar, Frantz Victor, Nancy Snyder, Robert Johnson, Beverly A. Heinz, Mark Wakulchik, Q.May Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 242 KB

english, 2003

31

NBS–DMSO as a nonaqueous nonbasic oxidation reagent for the synthesis of oligonucleotides

Matthew C. Uzagare, Kamlesh J. Padiya, Manikrao M. Salunkhe, Yogesh S. Sanghvi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

32

Structure–Activity relationships within a series of caspase inhibitors: effect of leaving group modifications

Brett R. Ullman, Teresa Aja, Thomas L. Deckwerth, Jose-Luis Diaz, Julia Herrmann, Vincent J. Kalish, Donald S. Karanewsky, Steven P. Meduna, Kip Nalley, Edward D. Robinson, Silvio P. Roggo, Robert O.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 178 KB

english, 2003

33

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain

Idan Chiyanzu, Elizabeth Hansell, Jiri Gut, Philip J. Rosenthal, James H. McKerrow, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

34

3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–Activity relationships

T.G. Murali Dhar, Zhongqi Shen, Henry H. Gu, Ping Chen, Derek Norris, Scott H. Watterson, Shelley K. Ballentine, Catherine A. Fleener, Katherine A. Rouleau, Joel C. Barrish, Robert Townsend, Diane L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 186 KB

english, 2003

35

4-(2-Pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists

Qun Sun, Laykea Tafesse, Khondaker Islam, Xiaoming Zhou, Sam F. Victory, Chongwu Zhang, Mohamed Hachicha, Lori A. Schmid, Aniket Patel, Yakov Rotshteyn, Kenneth J. Valenzano, Donald J. Kyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 186 KB

english, 2003

36

Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases

Fei Liu, Eric F Johnson, David J Austin, Karen S Anderson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 275 KB

english, 2003

37

α-Fluoro-substituted thalidomide analogues

Hon-Wah Man, Laura G Corral, David I Stirling, George W Muller

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

38

(R)-3-(N-Methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands

Ian Egle, Neil MacLean, Lidia Demchyshyn, Louise Edwards, Abdelmalik Slassi, Ashok Tehim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

39

Geraniol-derived 1,2,4-Trioxanes with potent in-vivo antimalarial activity

Chandan Singh, Nitin Gupta, Sunil K Puri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

40

Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists

Ranjit C. Desai, Dominick F. Gratale, Wei Han, Hiroo Koyama, Edward Metzger, Victoria K. Lombardo, Karen L. MacNaul, Thomas W. Doebber, Joel P. Berger, Kwan Leung, Ronald Franklin, David E. Moller, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 171 KB

english, 2003

41

Synthesis and pharmacological evaluation of (Z)-9-(Heteroarylmethylene)-7-azatricyclo[4.3.1.03,7]decanes: thiophene analogues as potent norepinephrine transporter inhibitors

Jia Zhou, Thomas Kläß, Ao Zhang, Kenneth M Johnson, Cheng Z Wang, Yanping Ye, Alan P Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 189 KB

english, 2003

42

Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties

Martin J. Di Grandi, Kevin J. Curran, Ellen Z. Baum, Geraldine Bebernitz, George A. Ellestad, Wei-Dong Ding, Stanley A. Lang, Miriam Rossi, Jonathan D. Bloom

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

43

Synthesis and in vitro analysis of atrial natriuretic peptide–albumin conjugates

Roger Léger, Martin Robitaille, Omar Quraishi, Elizabeth Denholm, Corinne Benquet, Julie Carette, Pieter van Wyk, Isabelle Pellerin, Nathalie Bousquet-Gagnon, Jean-Paul Castaigne, Dominique Bridon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 343 KB

english, 2003

44

5H-8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h]naphthyridin-6-ones and related compounds as TOP1-Targeting agents: influence of structure on the ternary cleavable complex formation

John E. Kerrigan, Daniel S. Pilch, Alexander L. Ruchelman, Nai Zhou, Angela Liu, Leroy Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 318 KB

english, 2003

45

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

Anthony K. Ogawa, Chris A. Willoughby, Raynald Bergeron, Kenneth P. Ellsworth, Wayne M. Geissler, Robert W. Myers, Jun Yao, Georgianna Harris, Kevin T. Chapman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 169 KB

english, 2003

46

Bis-pyrene labeled DNA aptamer as an intelligent fluorescent biosensor

Kazushige Yamana, Yusuke Ohtani, Hidehiko Nakano, Isao Saito

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

47

Histones accelerate the cyclic 1,N2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde

Magoichi Sako, Shinsuke Inagaki, Yukihiro Esaka, Yoshihiro Deyashiki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 108 KB

english, 2003

48

Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

Jeffrey Clough, Shaoqing Chen, Eric M. Gordon, Corinne Hackbarth, Stuart Lam, Joaquim Trias, Richard J. White, Gianpaolo Candiani, Stefano Donadio, Gabriella Romanò, Romeo Ciabatti, Jeffrey W. Jacobs

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 228 KB

english, 2003

49

Synthesis of para-Alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists

Jeremy J. Clemens, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 175 KB

english, 2003

50

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 58 KB

english, 2003

51

Contents List

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 115 KB

english, 2003

52

Contributors to this Issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

File:

PDF, 48 KB

2003

53

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 340 KB

english, 2003

54

Instructions to Contributors and GA example

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

55

Synthesis and anticancer effect of B-Ring trifluoromethylated flavonoids

Xing Zheng, Jian-Guo Cao, Wei-Dong Meng, Feng-Ling Qing

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

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