Volume 13; Issue 21

Main
Bioorganic & Medicinal Chemistry Letters
Volume 13; Issue 21

Bioorganic & Medicinal Chemistry Letters

Volume 13; Issue 21

1

Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline

Claire L.M. Goodyer, Edwin C. Chinje, Mohammed Jaffar, Ian J. Stratford, Michael D. Threadgill

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 127 KB

english, 2003

2

Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4)

Antoinette Chougnet, Catherine Stoessel, Wolf-D. Woggon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

3

High-Resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay

Young-Wan Ham, Winston C. Tse, Dale L. Boger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 166 KB

english, 2003

4

Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity

Diane H. Boschelli, Fei Ye, Biqi Wu, Yanong D. Wang, Ana Carolina Barrios Sosa, Deanna Yaczko, Dennis Powell, Jennifer M. Golas, Judy Lucas, Frank Boschelli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

5

Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-Diaryloxazolones using E-State index

Kunal Roy, Santanu Chakraborty, Achintya Saha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

6

The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents

Nicholas J. Lawrence, David Rennison, Alan T. McGown, John A. Hadfield

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

7

Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay

Bryan K.S. Yeung, Winston C. Tse, Dale L. Boger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 206 KB

english, 2003

8

Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives

Adina Ryckebusch, Rébecca Deprez-Poulain, Marie-Ange Debreu-Fontaine, Richard Vandaele, Elisabeth Mouray, Philippe Grellier, Christian Sergheraert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

9

New Benzylidenethiazolidinediones as Antibacterial Agents

Dirk A. Heerding, Lisa T. Christmann, Tammy J. Clark, David J. Holmes, Stephen F. Rittenhouse, Dennis T. Takata, Joseph W. Venslavsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

10

Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism

Min Chu, Ronald Mierzwa, Ling Xu, Shu-Wei Yang, Ling He, Mahesh Patel, Jill Stafford, David Macinga, Todd Black, Tze-Ming Chan, Vincent Gullo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 131 KB

english, 2003

11

A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

Yujia Dai, Yan Guo, Michael L. Curtin, Junling Li, Lori J. Pease, Jun Guo, Patrick A. Marcotte, Keith B. Glaser, Steven K. Davidsen, Michael R. Michaelides

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 173 KB

english, 2003

12

Photoregulation of deacylation rate of acyl trypsin derived from photoresponsive inverse substrate

Haruo Sekizaki, Asako Kumagai, Kunihiko Itoh, Eiko Toyota, Kiyoshi Horita, Yukari Noguchi, Kazutaka Tanizawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 159 KB

english, 2003

13

Substrate properties of C5-Substituted pyrimidine 2′-Deoxynucleoside 5′-Triphosphates for thermostable DNA polymerases during PCR

Masayasu Kuwahara, Yumi Takahata, Atsushi Shoji, Akiko N. Ozaki, Hiroaki Ozaki, Hiroaki Sawai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

14

Synthesis and X-ray crystal structures of substituted fluorobenzene and benzoquinone inhibitors of the tissue factor VIIa complex

John J. Parlow, Ravi G. Kurumbail, Roderick A. Stegeman, Anna M. Stevens, William C. Stallings, Michael S. South

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

15

Novel non-peptide inhibitors targeting death receptor-Mediated apoptosis

Hideaki Kakeya, Yasunobu Miyake, Mitsuru Shoji, Satoshi Kishida, Yujiro Hayashi, Takao Kataoka, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

16

A general synthesis of 1-aryl carbamoyl-2-alkyl-4-aryl substituted semicarbazides as nonbasic factor Xa inhibitors

Werner W.K.R. Mederski, Martina Germann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

17

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening

V.A. McNally, A. Gbaj, K.T. Douglas, I.J. Stratford, M. Jaffar, S. Freeman, R.A. Bryce

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 242 KB

english, 2003

18

Styrylheterocycles: A novel class of inhibitors on lipopolysaccharide-Induced nitric oxide production

Sang Kook Lee, Hye Young Min, Sun Kyung Huh, Eun-Young Kim, Eunjung Lee, Soyoung Song, Sanghee Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

19

Identification of novel inhibitors of BCR-ABL tyrosine kinase via virtual screening

Hui Peng, Niu Huang, Jing Qi, Ping Xie, Chen Xu, Jianxiang Wang, Chunzheng Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 382 KB

english, 2003

20

Synthesis of β-substituted cationic porphyrins and their interactions with DNA

Bo Chen, Wen Qin, Ping Wang, Tian Tian, Hongjuan Ma, Xiaoping Cao, Xiaojun Wu, Xiang Zhou, Xiao-Lian Zhang, Fang Liu, Fang Zheng, Xia Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

21

QSAR study on antibacterial activity of sulphonamides and derived Mannich bases

Sheela Joshi, Navita Khosla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

22

Nortropinyl-Arylsulfonylureas as novel, reversible inhibitors of human steroid sulfatase

Peter Nussbaumer, Dieter Geyl, Amarylla Horvath, Philipp Lehr, Barbara Wolff, Andreas Billich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 175 KB

english, 2003

23

Biological evaluation of sphingomyelin analogues as inhibitors of sphingomyelinase

Minoru Taguchi, Ken-ichi Goda, Kikuo Sugimoto, Tomoko Akama, Kyoko Yamamoto, Taizo Suzuki, Yasumitsu Tomishima, Mariko Nishiguchi, Koshi Arai, Kenzo Takahashi, Takeo Kobori

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

24

Novel chromene derivatives as TNF-α inhibitors

Jie-Fei Cheng, Akira Ishikawa, Yoshinori Ono, Thomas Arrhenius, Alex Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

25

Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: Synthesis and biological properties

Yasutsugu Ueda, John D Matiskella, Jerzy Golik, Timothy P Connolly, Thomas W Hudyma, Srini Venkatesh, Mandar Dali, Shin-Hong Kang, Nancy Barbour, Ravi Tejwani, Sailesh Varia, Jay Knipe, Ming Zheng, Ma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

26

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands

Xiaoqi Chen, Dale J. Kempf, Lin Li, Hing L. Sham, Sudthida Vasavanonda, Norman E. Wideburg, Ayda Saldivar, Kennan C. Marsh, Edith McDonald, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 176 KB

english, 2003

27

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

István Borza, Sándor Kolok, Anikó Gere, Éva Ágai-Csongor, Béla Ágai, Gábor Tárkányi, Csilla Horváth, Gizella Barta-Szalai, Éva Bozó, Csilla Kiss, Attila Bielik, József Nagy, Sándor Farkas, György Domá

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 136 KB

english, 2003

28

The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity

Jonathan J. Turnbull, Michael J. Nagle, Jürgen F. Seibel, Richard W.D. Welford, Guy H. Grant, Christopher J. Schofield

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 241 KB

english, 2003

29

X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines

Louise H. Foley, Ping Wang, Pete Dunten, Gwendolyn Ramsey, Mary-Lou Gubler, Stanley J. Wertheimer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 269 KB

english, 2003

30

Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors

Gérald Villeneuve, Danielle Cécyre, Hélène Lejeune, Marc Drouin, Ruoxi Lan, Rémi Quirion

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 232 KB

english, 2003

31

Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

David C. Limburg, Bert E. Thomas IV, Jia-He Li, Mike Fuller, Dawn Spicer, Yi Chen, Hongzhi Guo, Joseph P. Steiner, Gregory S. Hamilton, Yong-Qian Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

32

Sulphonamide-based small molecule VLA-4 antagonists

Marcin Stasiak, Christopher Mehlin, Erica Boni, Tomas Vaisar, Thomas Little, Hwa-Ok Kim, Maher Qabar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

33

Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors

Concha Sanchez-Martinez, Chuan Shih, Margaret M. Faul, Guoxin Zhu, Michael Paal, Carmen Somoza, Tiechao Li, Christine A. Kumrich, Leonard L. Winneroski, Zhou Xun, Harold B. Brooks, Bharvin K.R. Patel,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 195 KB

english, 2003

34

Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides

Concha Sanchez-Martinez, Chuan Shih, Guoxin Zhu, Tiechao Li, Harold B. Brooks, Bharvin K.R. Patel, Richard M. Schultz, Tammy B. DeHahn, Charles D. Spencer, Scott A. Watkins, Catherine A. Ogg, Eileen C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 309 KB

english, 2003

35

Structure–activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor

Michel Gallant, Michel Belley, Marie-Claude Carrière, Anne Chateauneuf, Danielle Denis, Nicolas Lachance, Sonia Lamontagne, Kathleen M. Metters, Nicole Sawyer, Deborah Slipetz, Jean François Truchon,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 189 KB

english, 2003

36

Aryl piperazine melanocortin MC4 receptor agonists

Brian Dyck, Jessica Parker, Teresa Phillips, Lee Carter, Brian Murphy, Robin Summers, Julia Hermann, Tracy Baker, Mary Cismowski, John Saunders, Val Goodfellow

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

37

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 58 KB

english, 2003

38

Contents List

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 115 KB

english, 2003

39

Contributors to this Issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

File:

PDF, 50 KB

2003

40

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 359 KB

english, 2003

41

Instructions to Contributors and GA example

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

42

Enantiomerically pure tetrahydroquinoline derivatives as in vivo potent antagonists of the glycine binding site associated to the NMDA receptor

Romano Di Fabio, Elvira Tranquillini, Barbara Bertani, Giuseppe Alvaro, Fabrizio Micheli, Fabio Sabbatini, Maria Domenica Pizzi, Giorgio Pentassuglia, Alessandra Pasquarello, Tommaso Messeri, Daniele

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

43

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats

Vincenzo Carelli, Felice Liberatore, Luigi Scipione, Gianfabio Giorgioni, Antonio Di Stefano, Mariannina Impicciatore, Vigilio Ballabeni, Francesco Calcina, Francesca Magnanini, Elisabetta Barocelli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

44

Synthesis and biological evaluation of 4-[(3-Methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor

Nan-Horng Lin, Le Wang, Jerry Cohen, Wen-Zhen Gu, David Frost, Haiying Zhang, Saul Rosenberg, Hing Sham

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

45

Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin

Daniela Arosio, Sergio Baretti, Stefania Cattaldo, Donatella Potenza, Anna Bernardi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 233 KB

english, 2003

46

Synthesis of a highly active new anti-HIV agent 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine

Kazuhiro Haraguchi, Shingo Takeda, Hiromichi Tanaka, Takao Nitanda, Masanori Baba, G.E. Dutschman, Yung-Chi Cheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

47

The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+

Donald M.N Sikazwe, Shouming Li, Margaret Lyles-Eggleston, Seth Y Ablordeppey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

48

A theoretical investigation on DPPH radical-Scavenging mechanism of edaravone

Lan-Fen Wang, Hong-Yu Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 135 KB

english, 2003

49

A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-Benzothiazepines

Michael B. Tollefson, Stephen A. Kolodziej, Theresa R. Fletcher, William F. Vernier, Judith A. Beaudry, Bradley T. Keller, David B. Reitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

50

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

Y.Krishna Reddy, L.Manmohan Reddy, Jorge H Capdevila, J.R Falck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 98 KB

english, 2003

51

Precursor-Directed polyketide biosynthesis in Escherichia coli

Kenji Kinoshita, Blaine A Pfeifer, Chaitan Khosla, David E Cane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 213 KB

english, 2003

52

Low molecular mass peptide dendrimers that express antimicrobial properties

Jolanta Janiszewska, Joanna Swieton, Andrzej W. Lipkowski, Zofia Urbanczyk-Lipkowska

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 108 KB

english, 2003

53

Corrigendum to ‘Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents’ [Bioorg. Med. Chem. Lett. 13 (2003) 2553]☆

Amruta R Poreddy, Otto F Schall, Garland R Marshall, Colin Ratledge, Urszula Slomczynska

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 94 KB

english, 2003

54

Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

Xian-dao Pan, Rui Han, Piao-yang Sun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

55

Biphenyl-Based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

Suzanne J Senior, Petr A Illarionov, Sudagar S Gurcha, Ian B Campbell, Merrill L Schaeffer, David E Minnikin, Gurdyal S Besra

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

56

Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I

David M Vigushin, Greg Brooke, David Willows, R.Charles Coombes, Christopher J Moody

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

57

Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells

Sangtae Oh, In Howa Jeong, Woon-Seob Shin, Seokjoon Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

58

Identification of potent and novel small-Molecule inhibitors of caspase-3

Darin A Allen, Phuongly Pham, Ingrid C Choong, Bruce Fahr, Matthew T Burdett, Willard Lew, Warren L DeLano, Eric M Gordon, Joni W Lam, Tom O'Brien, Dennis Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 246 KB

english, 2003

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Tor version

Z-Library

Z-Library Since 2009 support@z-lib.do

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски